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the egyptian journal of histology最新文献

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A Histological Study of the Impact of Bone Marrow Mesenchymal Stem Cells- Derived Exosomes on the Corpus Callosum in a Cuprizone-Induced Mouse Model of Multiple Sclerosis 骨髓间充质干细胞衍生外泌体对铜皮酮诱导多发性硬化症小鼠胼胝体影响的组织学研究
the egyptian journal of histology Pub Date : 2025-03-23 DOI: 10.21608/ejh.2025.366901.2225
Brekhna Hassan, Nagwa Mohamed El Shakaa, Gehad A. Hammouda, Mona Ahmed
{"title":"A Histological Study of the Impact of Bone Marrow Mesenchymal Stem Cells- Derived Exosomes on the Corpus Callosum in a Cuprizone-Induced Mouse Model of Multiple Sclerosis","authors":"Brekhna Hassan, Nagwa Mohamed El Shakaa, Gehad A. Hammouda, Mona Ahmed","doi":"10.21608/ejh.2025.366901.2225","DOIUrl":"https://doi.org/10.21608/ejh.2025.366901.2225","url":null,"abstract":"Introduction: A chronic demyelinating disease that affects millions of peoples worldwide is multiple sclerosis (MS). There are currently no remyelination therapy for this disease, and exosomes are being explored as an alternative.Aim: to study how exosomes generated from bone marrow mesenchymal stem cells (BMSCs) affect the corpus callosum structure in male mice with cuprizone model of MS. Materials and methods: Forty-seven adult male mice were used in this work. Exosomes were isolated and extracted from five mice. Forty-two adult male mice were split into two equal groups randomly: Group I (Control): divided into three equal subgroups. Group II (Cuprizone-treated): which was treated with cuprizone, was given 400 mg/kg/day of the drug orally every day for 8 weeks. Then equally divided into three subgroups. Subgroup IIA: sacrificed 24 hours following the final cuprizone dosage. Subgroup IIB (Recovery): left without treatment for further 4 weeks, then were sacrificed. Following the final dose of cuprizone, subgroup IIC (exosomes treated): got a single intravenous injection of exosomes into tail vein, and were sacrificed 4 weeks later. After scarification, brains tissue were prepared using histological, immune-histochemical methods and histomorphometric studies.Results: Histological analysis of corpus callosum in subgroups IIA & IIB showed damaged nerve fibers by H&E with multiple vacuoles. Improvement of these changes was noticed in subgroup IIC. By luxol fast blue, nerve fibers stained deep blue in subgroup IIC & control group. While, in subgroups IIA & IIB, nerve fibers stained faint blue. Subgroups IIA & IIB showed marked rise in the number of GFAP and Iba1 positive cells.Conclusions: In the cuprizone model of MS, exosomes were demonstrated to improve demyelination of mice's corpus callosum. Exosomes may therefore offer a novel approach to MS treatment.","PeriodicalId":22420,"journal":{"name":"the egyptian journal of histology","volume":"0 0","pages":"0-0"},"PeriodicalIF":0.0,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147895658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Synergistic Cytotoxic Effect of Low-Level Laser Therapy and 5-Aminolevulinic Acid-Mediated Photodynamic Therapy on Tongue Squamous Cell Carcinoma Cell Line 低水平激光治疗和5-氨基乙酰丙酸介导的光动力治疗对舌鳞状细胞癌细胞的协同细胞毒作用
the egyptian journal of histology Pub Date : 2023-11-09 DOI: 10.21608/ejh.2023.231102.1939
Mariam Hamed, Rehab Fathi, Ali Saafan, Houry Baghdadi
{"title":"The Synergistic Cytotoxic Effect of Low-Level Laser Therapy and 5-Aminolevulinic Acid-Mediated Photodynamic Therapy on Tongue Squamous Cell Carcinoma Cell Line","authors":"Mariam Hamed, Rehab Fathi, Ali Saafan, Houry Baghdadi","doi":"10.21608/ejh.2023.231102.1939","DOIUrl":"https://doi.org/10.21608/ejh.2023.231102.1939","url":null,"abstract":"","PeriodicalId":22420,"journal":{"name":"the egyptian journal of histology","volume":" 23","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135292081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Dehydroepiandrosterone (DHEA) Therapy on the Age-Related Changes of the Primary Auditory Cortex in Senile Male Albino Rats. A Histological and Immunohistochemical Study. 脱氢表雄酮(DHEA)治疗对老年雄性白化大鼠初级听觉皮层年龄相关变化的影响。组织学和免疫组织化学研究。
the egyptian journal of histology Pub Date : 2023-11-07 DOI: 10.21608/ejh.2023.234934.1945
Nada Magdy, Haidy Abd El Salam, Hala Shalan, Noha Gaber
{"title":"Effect of Dehydroepiandrosterone (DHEA) Therapy on the Age-Related Changes of the Primary Auditory Cortex in Senile Male Albino Rats. A Histological and Immunohistochemical Study.","authors":"Nada Magdy, Haidy Abd El Salam, Hala Shalan, Noha Gaber","doi":"10.21608/ejh.2023.234934.1945","DOIUrl":"https://doi.org/10.21608/ejh.2023.234934.1945","url":null,"abstract":"","PeriodicalId":22420,"journal":{"name":"the egyptian journal of histology","volume":"60 9","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135544828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Therapeutic Effect of Bone Marrow Derived Mesenchymal Stem Cells Versus Platelet Rich Plasma on Amiodarone Induced Lung Fibrosis in Adult Male Albino Rat: Histological Study. 骨髓间充质干细胞与富血小板血浆对胺碘酮诱导成年雄性白化大鼠肺纤维化的治疗作用:组织学研究。
the egyptian journal of histology Pub Date : 2023-11-01 DOI: 10.21608/ejh.2023.239456.1954
Wafaa Boughdady, Zeinab Hegab, Dina Mohamed
{"title":"Therapeutic Effect of Bone Marrow Derived Mesenchymal Stem Cells Versus Platelet Rich Plasma on Amiodarone Induced Lung Fibrosis in Adult Male Albino Rat: Histological Study.","authors":"Wafaa Boughdady, Zeinab Hegab, Dina Mohamed","doi":"10.21608/ejh.2023.239456.1954","DOIUrl":"https://doi.org/10.21608/ejh.2023.239456.1954","url":null,"abstract":"","PeriodicalId":22420,"journal":{"name":"the egyptian journal of histology","volume":"122 6","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135714857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The protective role of selenium against acrylamide-induced cerebellar neurotoxicity in adult male albino rats 硒对丙烯酰胺诱导的成年雄性白化大鼠小脑神经毒性的保护作用
the egyptian journal of histology Pub Date : 2023-10-26 DOI: 10.21608/ejh.2023.226438.1930
Alaa Abdullah, mohamed mohamed, Manal AL Badawi, Alsayed Abdelhady
{"title":"The protective role of selenium against acrylamide-induced cerebellar neurotoxicity in adult male albino rats","authors":"Alaa Abdullah, mohamed mohamed, Manal AL Badawi, Alsayed Abdelhady","doi":"10.21608/ejh.2023.226438.1930","DOIUrl":"https://doi.org/10.21608/ejh.2023.226438.1930","url":null,"abstract":"","PeriodicalId":22420,"journal":{"name":"the egyptian journal of histology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134906397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of the regenerative potential of human gingival mesenchymal stem cells’ secretome in rabbits’ tibial bone defects 人牙龈间充质干细胞分泌组在兔胫骨骨缺损中的再生潜力评价
the egyptian journal of histology Pub Date : 2023-10-25 DOI: 10.21608/ejh.2023.231494.1940
Dina Kamal, Sara El Moshy, Nermeen Ahmed, Samah Mehanny
{"title":"Evaluation of the regenerative potential of human gingival mesenchymal stem cells’ secretome in rabbits’ tibial bone defects","authors":"Dina Kamal, Sara El Moshy, Nermeen Ahmed, Samah Mehanny","doi":"10.21608/ejh.2023.231494.1940","DOIUrl":"https://doi.org/10.21608/ejh.2023.231494.1940","url":null,"abstract":"","PeriodicalId":22420,"journal":{"name":"the egyptian journal of histology","volume":"6 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135169110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative study of the therapeutic effect of platelet rich plasma versus bone marrow derived mesenchymal stem cells on acute skeletal muscle injury of adult male albino rats 富血小板血浆与骨髓间充质干细胞治疗成年雄性白化大鼠急性骨骼肌损伤的比较研究
the egyptian journal of histology Pub Date : 2023-10-23 DOI: 10.21608/ejh.2023.234951.1944
Rana Saad, Wahid Stefanos, Anisa Meleise, Samar Ibrahim, Iman Nabil
{"title":"Comparative study of the therapeutic effect of platelet rich plasma versus bone marrow derived mesenchymal stem cells on acute skeletal muscle injury of adult male albino rats","authors":"Rana Saad, Wahid Stefanos, Anisa Meleise, Samar Ibrahim, Iman Nabil","doi":"10.21608/ejh.2023.234951.1944","DOIUrl":"https://doi.org/10.21608/ejh.2023.234951.1944","url":null,"abstract":"","PeriodicalId":22420,"journal":{"name":"the egyptian journal of histology","volume":"89 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135460252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Placenta Previa Changes Among Egyptian Women: A Morphological, Histological and Immunohistochemical Study 埃及妇女前置胎盘的改变:形态学、组织学和免疫组织化学研究
the egyptian journal of histology Pub Date : 2023-10-22 DOI: 10.21608/ejh.2023.223620.1922
Heshmat Haroun, Mohammed Shehata, Motaz Elghnam, Hossam Sayed, Mohamed Kotb, Ahmed Bayoumi
{"title":"Placenta Previa Changes Among Egyptian Women: A Morphological, Histological and Immunohistochemical Study","authors":"Heshmat Haroun, Mohammed Shehata, Motaz Elghnam, Hossam Sayed, Mohamed Kotb, Ahmed Bayoumi","doi":"10.21608/ejh.2023.223620.1922","DOIUrl":"https://doi.org/10.21608/ejh.2023.223620.1922","url":null,"abstract":"","PeriodicalId":22420,"journal":{"name":"the egyptian journal of histology","volume":"7 5","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135463031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of Glimepiride in Ameliorating Histological Changes in kidney of Experimentally Induced Diabetes mellitus in Rats 格列美脲对实验性糖尿病大鼠肾脏组织改变的改善作用
the egyptian journal of histology Pub Date : 2023-10-21 DOI: 10.21608/ejh.2023.237766.1950
MOHAMED HAMAMA
{"title":"Role of Glimepiride in Ameliorating Histological Changes in kidney of Experimentally Induced Diabetes mellitus in Rats","authors":"MOHAMED HAMAMA","doi":"10.21608/ejh.2023.237766.1950","DOIUrl":"https://doi.org/10.21608/ejh.2023.237766.1950","url":null,"abstract":"","PeriodicalId":22420,"journal":{"name":"the egyptian journal of histology","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135513872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Possible Protective Role of Levothyroxine Sodium and Nigella Sativa Oil on Cerebellar Cortex of Adult Male Albino Rat in Carbimazole-induced Hypothyroidism: Histo-Biochemical Study 左旋甲状腺素钠和黑草油对成年雄性白化大鼠卡马唑所致甲状腺功能减退的保护作用:组织生化研究
the egyptian journal of histology Pub Date : 2023-10-17 DOI: 10.21608/ejh.2023.236390.1948
Amany Hamoud, Basma Elareef, Hoda Al Aasar, . Mogeda Nasrallah, Mohamed Kotb
{"title":"Possible Protective Role of Levothyroxine Sodium and Nigella Sativa Oil on Cerebellar Cortex of Adult Male Albino Rat in Carbimazole-induced Hypothyroidism: Histo-Biochemical Study","authors":"Amany Hamoud, Basma Elareef, Hoda Al Aasar, . Mogeda Nasrallah, Mohamed Kotb","doi":"10.21608/ejh.2023.236390.1948","DOIUrl":"https://doi.org/10.21608/ejh.2023.236390.1948","url":null,"abstract":"","PeriodicalId":22420,"journal":{"name":"the egyptian journal of histology","volume":"102 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136077619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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