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Guanidine-annelated Heterocycles XV. Synthesis of 2-Substituted 4-Phenylamino[1,2,4]triazolo-[2,3-a]quinazolin-5(4H)-ones as Potential Antihypertensive Agents^1 胍烷杂环化合物。2-取代4-苯基氨基[1,2,4]三唑啉-[2,3-a]喹唑啉-5(4H)- 1的合成
The Chinese Pharmaceutical Journal Pub Date : 2003-06-01 DOI: 10.7019/CPJ.200306.0185
W. Hsu, Jing-Min Hwang, L. Hsu, Yung-Yun Huang, Kang-chien Liu
{"title":"Guanidine-annelated Heterocycles XV. Synthesis of 2-Substituted 4-Phenylamino[1,2,4]triazolo-[2,3-a]quinazolin-5(4H)-ones as Potential Antihypertensive Agents^1","authors":"W. Hsu, Jing-Min Hwang, L. Hsu, Yung-Yun Huang, Kang-chien Liu","doi":"10.7019/CPJ.200306.0185","DOIUrl":"https://doi.org/10.7019/CPJ.200306.0185","url":null,"abstract":"Starting from isatoic anhydride (1) and via one-pot process to 2-methylthio-3-phenylamino-quinazolin-4(3H)-one (4) was isolated in excellent yield. Hydrazinolysis of 4 converted it into the hydrazino derivative 5. Cyclocondensation of 5 with appropriate carboxylic acid orthoesters 6a-c, N,N’-carbonyl-, N,N’-thiocarbonyldiimidazole (6d,e), ethyl chloroformate, carbon disulfide, trifluoro- and trichloroacetic anhydride (6h,i) under elevated temperature gave 4-phenylamino-1「1,2,4」triazolo「2,3-a」 quinazolin-5(4H)-one (8a) and its 2-substituted derivatives 8b-g in different yields. These compounds activated satisfactory antihypertensive activity after the pharmacological evaluation on anesthetized rats.","PeriodicalId":22409,"journal":{"name":"The Chinese Pharmaceutical Journal","volume":"15 1","pages":"185-196"},"PeriodicalIF":0.0,"publicationDate":"2003-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90660471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis of 5,6,7-Trimethoxyflavone as a Key Intermediate for the Preparation of Baicalein 制备黄芩素关键中间体5,6,7-三甲氧基黄酮的合成
The Chinese Pharmaceutical Journal Pub Date : 2003-04-01 DOI: 10.7019/CPJ.200304.0101
Wen‐Hsin Huang, C. Yang, P. Chien, A. Lee
{"title":"Synthesis of 5,6,7-Trimethoxyflavone as a Key Intermediate for the Preparation of Baicalein","authors":"Wen‐Hsin Huang, C. Yang, P. Chien, A. Lee","doi":"10.7019/CPJ.200304.0101","DOIUrl":"https://doi.org/10.7019/CPJ.200304.0101","url":null,"abstract":"Approaches towards the preparation of 5,6,7-trimethoxyflavone (8), a key intermediate for the synthesis of baicalein, are discussed. Of the synthetic routes, the most efficient was accomplished by direct Fries acylation of trimethoxyphenol (1) with cinnamoyl chloride followed by oxidative cyclization of the resulting chalcone 6 with I 2 /DMSO in good overall yields (70%). Demethylation of 8 using 47% HBr/AcOH readily produced baicalein. The chalcone 6 could also be prepared by Claisen-Schmidt condensation of acetophenone 2 with benzaldehyde catalyzed in alkali.","PeriodicalId":22409,"journal":{"name":"The Chinese Pharmaceutical Journal","volume":"15 1","pages":"101-107"},"PeriodicalIF":0.0,"publicationDate":"2003-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84322652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Two New Anthraquinones from Hemerocallis fulva 黄萱草中两个新的蒽醌类化合物
The Chinese Pharmaceutical Journal Pub Date : 2003-02-01 DOI: 10.7019/CPJ.200302.0083
Yu-Ling Huang, Fang-Hua Chow, B. Shieh, J. Ou, Chien‐Chih Chen
{"title":"Two New Anthraquinones from Hemerocallis fulva","authors":"Yu-Ling Huang, Fang-Hua Chow, B. Shieh, J. Ou, Chien‐Chih Chen","doi":"10.7019/CPJ.200302.0083","DOIUrl":"https://doi.org/10.7019/CPJ.200302.0083","url":null,"abstract":"Two new anthraquinones, 7-hydroxy-1,2,8-trimethoxy-3-methylanthraquinone (1) and 7,8-dihydroxy-1,2-dimethoxy-3-methylanthraquinone (2), were isolated from the roots of Hemerocallis fulva. Their structures were established on the basis of spectral evidence (NMR and MS).","PeriodicalId":22409,"journal":{"name":"The Chinese Pharmaceutical Journal","volume":"42 1","pages":"83-86"},"PeriodicalIF":0.0,"publicationDate":"2003-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81035512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antipyretic, Analgesic and Anti-inflammatory Activities of Strobilanthes formosanus 台北花的解热、镇痛和抗炎作用
The Chinese Pharmaceutical Journal Pub Date : 2003-02-01 DOI: 10.7019/CPJ.200302.0055
Kuo-Ching Kao, Yu‐Ling Ho, F. Chueh, Jih P. Wang, Yuan-Shiun Chang
{"title":"Antipyretic, Analgesic and Anti-inflammatory Activities of Strobilanthes formosanus","authors":"Kuo-Ching Kao, Yu‐Ling Ho, F. Chueh, Jih P. Wang, Yuan-Shiun Chang","doi":"10.7019/CPJ.200302.0055","DOIUrl":"https://doi.org/10.7019/CPJ.200302.0055","url":null,"abstract":"The methanolic extract of Strobilanthes formosanus was investigated for its antipyretic, analgesic and anti-inflammatory activities in animal models. In unanesthetized rats, the extract (100-1000 mg/kg, i.p.) caused a dose-related fall in colonic temperature at room temperature (24 ± 1℃). The fever induced by interleukin-1β(10 ng/10μL, lateral cerebral ventricle injection) was attenuated by treatment with the extract (50-1000 mg/kg, i.p.). However, the extract (1000 mg/kg) and acetaminophen (50 mg/kg) did not significantly attenuate pyrexia induced by PGE2 (200ng/10μL,i.c.v.). The extract significantly and dose-dependently inhibited the writhing response of mice and decreased the licking time in both the early and late phases of the formalin test. A significant (P＜0.05) inhibition of neutrophil degranulation induced by fMLP was also produced by the extract. This study established the antipyretic, analgesic and anti-inflammatory activities of S. formosanus.","PeriodicalId":22409,"journal":{"name":"The Chinese Pharmaceutical Journal","volume":"1 1","pages":"55-63"},"PeriodicalIF":0.0,"publicationDate":"2003-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88661412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Chemical constituents of Biophytum sensitivum 敏生植物的化学成分
The Chinese Pharmaceutical Journal Pub Date : 2003-02-01 DOI: 10.7019/CPJ.200302.0071
Yun-Lian Lin, Wan-Yi Wang
{"title":"Chemical constituents of Biophytum sensitivum","authors":"Yun-Lian Lin, Wan-Yi Wang","doi":"10.7019/CPJ.200302.0071","DOIUrl":"https://doi.org/10.7019/CPJ.200302.0071","url":null,"abstract":"Two biflavones, cupressuflavone (1) and amentoflavone (2), three flavonoids, luteolin 7-methyl ether (3), isoorientin (4) and 3'-methoxyluteolin 7-O-glucoside (5), as well as two acids, 4-caffeoylquinic acid (6) and 5-caffeoylquinic acid (7) were isolated from the aerial parts of Biophytum sensitivum. Their structures were established on the basis of spectroscopic data.","PeriodicalId":22409,"journal":{"name":"The Chinese Pharmaceutical Journal","volume":"4 1","pages":"71-75"},"PeriodicalIF":0.0,"publicationDate":"2003-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86582164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 32
Chemical Constituents and Pharmacology of the Formosan Aristolochia Species 台湾马兜铃属植物的化学成分及药理研究
The Chinese Pharmaceutical Journal Pub Date : 2003-02-01 DOI: 10.7019/CPJ.200302.0001
A. G. Damu, P. Kuo, Y. Leu, Y. Chan, Tian-Shung Wu
{"title":"Chemical Constituents and Pharmacology of the Formosan Aristolochia Species","authors":"A. G. Damu, P. Kuo, Y. Leu, Y. Chan, Tian-Shung Wu","doi":"10.7019/CPJ.200302.0001","DOIUrl":"https://doi.org/10.7019/CPJ.200302.0001","url":null,"abstract":"Aristolochia is an important genus widely cultivated and used in traditional Chinese medicine. The genus has attracted much interest and has been the subject of numerous chemical studies. In the last twelve years, all the Formosan species of Aristolochia have been investigated by our group for their chemical constituents and biological activities. They are sources of a number of physiologically active compounds of different classes, and various types of phenanthrene derivatives, terpenes, alkaloids, flavonoids, lignoids, benzenoids, and steroids have been isolated from Formosan Aristolochia species. The nature of these constituents is compiled in this review together with their bioactivities in an effort to show the rapid development in the phytochemistry and the therapeutic applications of the Aristolochia species.","PeriodicalId":22409,"journal":{"name":"The Chinese Pharmaceutical Journal","volume":"9 1","pages":"1-33"},"PeriodicalIF":0.0,"publicationDate":"2003-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74710872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
Chemical Constituents of Verbena bonariensis 马鞭草的化学成分
The Chinese Pharmaceutical Journal Pub Date : 2003-02-01 DOI: 10.7019/CPJ.200302.0065
Chien‐Chih Chen, Huimin Huang, Chien-Chang Shen, Yu-lin Huang, J. Ou
{"title":"Chemical Constituents of Verbena bonariensis","authors":"Chien‐Chih Chen, Huimin Huang, Chien-Chang Shen, Yu-lin Huang, J. Ou","doi":"10.7019/CPJ.200302.0065","DOIUrl":"https://doi.org/10.7019/CPJ.200302.0065","url":null,"abstract":"Four known flavone glucuronides, luteolin-7-O-β-D-glucuronide (8), apigenin-7-O-β-D-glucuronide (9), chrysoeriol-7-O-β-D-glucuronide (10) and hispidulin-7-O-β-D-glucuronide (11), and seven known phenolic compounds (1-7) were isolated from the whole plant of Verbena bonariensis. The structures of all compounds were determined by spectroscopic analysis.","PeriodicalId":22409,"journal":{"name":"The Chinese Pharmaceutical Journal","volume":"19 1","pages":"65-70"},"PeriodicalIF":0.0,"publicationDate":"2003-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90658387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Meroterpenes and C-Glucosylflavonoids from the Aerial Parts of Plumbago zeylanica 白花柏树地上部的萜类和c -葡萄糖基黄酮
The Chinese Pharmaceutical Journal Pub Date : 2003-02-01 DOI: 10.7019/CPJ.200302.0077
Lie-Chwen Lin, C. Chou
{"title":"Meroterpenes and C-Glucosylflavonoids from the Aerial Parts of Plumbago zeylanica","authors":"Lie-Chwen Lin, C. Chou","doi":"10.7019/CPJ.200302.0077","DOIUrl":"https://doi.org/10.7019/CPJ.200302.0077","url":null,"abstract":"Two meroterpenes bakuchiol and 12-hydroxyisobakuchiol, and three C-glucosylflavonoids, saponaretin, isoorientin and isoaffinetin together with other constituents plumbagin, isoshinano-lone, xanthyletin, xanthoxyletin, psoralen, plumbagic acid, plumbagic acid butyl ester, β-sitosterol and β-sitosteryl glucoside have been isolated from the aerial part of Plumbago zeylanica. This is the first report of isolation of meroterpenes and C-glucosylflavonoids from Plumbago species.","PeriodicalId":22409,"journal":{"name":"The Chinese Pharmaceutical Journal","volume":"1 1","pages":"77-81"},"PeriodicalIF":0.0,"publicationDate":"2003-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88647906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
An efficient synthesis of antitumor 4-anilinofuro[2,3-b]quinoline derivatives 抗肿瘤4-苯胺呋喃[2,3-b]喹啉衍生物的高效合成
The Chinese Pharmaceutical Journal Pub Date : 2003-02-01 DOI: 10.7019/CPJ.200302.0049
I‐Li Chen, Yeh‐long Chen, C. Tzeng
{"title":"An efficient synthesis of antitumor 4-anilinofuro[2,3-b]quinoline derivatives","authors":"I‐Li Chen, Yeh‐long Chen, C. Tzeng","doi":"10.7019/CPJ.200302.0049","DOIUrl":"https://doi.org/10.7019/CPJ.200302.0049","url":null,"abstract":"We have described the partial synthesis of antitumor 4-anilinofuro [2, 3-b] quinoline derivatives from dictamnine, a natural alkaloid. Due to the limited supply of natural starting material, we report herein an efficient total synthesis of the title compounds from the known 3, 4-dichlorofuro [2, 3-b] quinoline in two steps.","PeriodicalId":22409,"journal":{"name":"The Chinese Pharmaceutical Journal","volume":"47 2 1","pages":"49-53"},"PeriodicalIF":0.0,"publicationDate":"2003-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89086947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Chemical Constituents from Dehaasia triandra. III. Bisbenzylisoquinoline Alkaloids from the Leaves and Their Conformational Analysis 黄花菜的化学成分。3叶中双苄基异喹啉类生物碱及其构象分析
The Chinese Pharmaceutical Journal Pub Date : 2003-02-01 DOI: 10.7019/CPJ.200302.0035
Chien-Kuang Chen, Shoei‐Sheng Lee, Chung-Hsiung Chen
{"title":"Chemical Constituents from Dehaasia triandra. III. Bisbenzylisoquinoline Alkaloids from the Leaves and Their Conformational Analysis","authors":"Chien-Kuang Chen, Shoei‐Sheng Lee, Chung-Hsiung Chen","doi":"10.7019/CPJ.200302.0035","DOIUrl":"https://doi.org/10.7019/CPJ.200302.0035","url":null,"abstract":"Continuing investigation of the chemical constituents of Dehaasia triandra Merr. Provided from the leaves eleven bisbenzylisoquinoline alkaloids, homoaromoline (1), daphnandrine (2), aromoline (3), daphnoline (4), pangkorimine (5), colorflammine (6), thalrugosine (7), obamegine (8), 2-norobamegine (9), dehatridine (10), and 1,2-dehydroapateline (11). The complete assignment of the 1H- and 13C-nmr data of these alkaloids was accomplished by 1D and 2D analyses. Conformational analysis of these alkaloids was performed by computer-assisted dynamic calculations supplemented with NOED and NOSEY analyses. Stable conformations were characterized for both the type VI and type VIII of bisbenzylisoquinoline diphenyl ether ring linkages that explained some special features in their 1H-NMR spectra as well as their CD absorptions.","PeriodicalId":22409,"journal":{"name":"The Chinese Pharmaceutical Journal","volume":"67 1","pages":"35-47"},"PeriodicalIF":0.0,"publicationDate":"2003-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78209904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
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