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The Chinese Pharmaceutical Journal最新文献

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Stable interference of serglycin enhances sensitivity to cisplatin in nasopharyngeal carcinoma highly metastatic cells 稳定干扰舍甘霉素增强鼻咽癌高转移细胞对顺铂的敏感性
The Chinese Pharmaceutical Journal Pub Date : 2015-04-22 DOI: 10.11669/CPJ.2015.08.005
Qiao-Qiao Chu, Tao Liu, S. Jia, B. Huang, Hong-Bing Huang
{"title":"Stable interference of serglycin enhances sensitivity to cisplatin in nasopharyngeal carcinoma highly metastatic cells","authors":"Qiao-Qiao Chu, Tao Liu, S. Jia, B. Huang, Hong-Bing Huang","doi":"10.11669/CPJ.2015.08.005","DOIUrl":"https://doi.org/10.11669/CPJ.2015.08.005","url":null,"abstract":"","PeriodicalId":22409,"journal":{"name":"The Chinese Pharmaceutical Journal","volume":"47 1","pages":"676-680"},"PeriodicalIF":0.0,"publicationDate":"2015-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81110382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmaceutical powders tabletability: influencing factors and improvement strategies 药粉的片性:影响因素及改进策略
The Chinese Pharmaceutical Journal Pub Date : 2013-06-08 DOI: 10.11669/CPJ.2013.11.002
Chenguang Wang, L. Deng, C. Shi
{"title":"Pharmaceutical powders tabletability: influencing factors and improvement strategies","authors":"Chenguang Wang, L. Deng, C. Shi","doi":"10.11669/CPJ.2013.11.002","DOIUrl":"https://doi.org/10.11669/CPJ.2013.11.002","url":null,"abstract":"","PeriodicalId":22409,"journal":{"name":"The Chinese Pharmaceutical Journal","volume":"54 1","pages":"845-849"},"PeriodicalIF":0.0,"publicationDate":"2013-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74111281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The progression and prospects in research of molecular targeted therapy for pancreatic cancer 胰腺癌分子靶向治疗的研究进展与展望
The Chinese Pharmaceutical Journal Pub Date : 2013-05-22 DOI: 10.11669/CPJ.2013.10.003
Song Gao, Zhengkun Chen
{"title":"The progression and prospects in research of molecular targeted therapy for pancreatic cancer","authors":"Song Gao, Zhengkun Chen","doi":"10.11669/CPJ.2013.10.003","DOIUrl":"https://doi.org/10.11669/CPJ.2013.10.003","url":null,"abstract":"","PeriodicalId":22409,"journal":{"name":"The Chinese Pharmaceutical Journal","volume":"71 1","pages":"763-767"},"PeriodicalIF":0.0,"publicationDate":"2013-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80313368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Compatibility study of insulin with polyene phosphatidylcholine in glucose injection 葡萄糖注射液中胰岛素与多烯磷脂酰胆碱的相容性研究
The Chinese Pharmaceutical Journal Pub Date : 2013-04-22 DOI: 10.11669/CPJ.2013.08.020
Juan Zhang, Qing Zhai
{"title":"Compatibility study of insulin with polyene phosphatidylcholine in glucose injection","authors":"Juan Zhang, Qing Zhai","doi":"10.11669/CPJ.2013.08.020","DOIUrl":"https://doi.org/10.11669/CPJ.2013.08.020","url":null,"abstract":"","PeriodicalId":22409,"journal":{"name":"The Chinese Pharmaceutical Journal","volume":"40 1","pages":"652-654"},"PeriodicalIF":0.0,"publicationDate":"2013-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83583132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antitubercular Resorcinols and Cytotoxic Alkyl Benzoquinones from Ardisia kusukuensis 紫荆的抗结核间苯二酚和细胞毒性烷基苯醌
The Chinese Pharmaceutical Journal Pub Date : 2009-12-01 DOI: 10.7019/TPJ.200912.0089
Tsao-Jun Su, Hsun-Shuo Chang, C. Peng, Shiow-Ju Lee, I. Chen
{"title":"Antitubercular Resorcinols and Cytotoxic Alkyl Benzoquinones from Ardisia kusukuensis","authors":"Tsao-Jun Su, Hsun-Shuo Chang, C. Peng, Shiow-Ju Lee, I. Chen","doi":"10.7019/TPJ.200912.0089","DOIUrl":"https://doi.org/10.7019/TPJ.200912.0089","url":null,"abstract":"","PeriodicalId":22409,"journal":{"name":"The Chinese Pharmaceutical Journal","volume":"44 1","pages":"89-105"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75921844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
A Highly Sensitive Method for the Analysis of Long-Chain Free Fatty Acids in Yogurt by High Performance Liquid Chromatography with Fluorimetric Detection 高效液相色谱-荧光检测法分析酸奶中游离长链脂肪酸
The Chinese Pharmaceutical Journal Pub Date : 2009-12-01 DOI: 10.7019/TPJ.200912.0065
Chi-Yu Lu, H. Kou, Chia-Hsien Feng, Hsiang-Ming Chen, Hsin‐Lung Wu
{"title":"A Highly Sensitive Method for the Analysis of Long-Chain Free Fatty Acids in Yogurt by High Performance Liquid Chromatography with Fluorimetric Detection","authors":"Chi-Yu Lu, H. Kou, Chia-Hsien Feng, Hsiang-Ming Chen, Hsin‐Lung Wu","doi":"10.7019/TPJ.200912.0065","DOIUrl":"https://doi.org/10.7019/TPJ.200912.0065","url":null,"abstract":"The fat content in food is concerned by genera l public, because over uptake of some saturated fatty acids could lead to heart related disease. Therefore, practical method for the analysis of fatty acids in food is essential. In this article, a highly sensitive HPLC method is described for the quantitative analysis of long-chain free fatty acids in yogurt, including lauric, myristic, palmitic, stearic, palmitoleic, oleic and linoleic acids. The fatty acids were labeled with a fluorophore by reacting with 2-(2-naphthoxy) ethyl 2-(piperidino) ethanesulfonate (NOEPES) at 95℃ for 0.5 h in the presence of 18-crown-6 and solid potassium carbonate. The resulting naphthoxyethyl derivatives were separated on a C8 column with a mobile phase of methanol-water (92:8, v/v) and detected fluorimetrically (excitation at 235 nm and detection at 350 nm). Before labeling, the fatty acids in yogurt were extracted with toluene and the resulting toluene extract was directly subject to the labeling without time-consuming steps of solvent evaporation and solvent replacement. The fluorimetric HPLC analysis of fatty acids could be measured at few μ M levels in yogurt. The results indicate that the content of free fatty acids in low-fat yogurt is lower than that in plain yogurt from the same food producer.","PeriodicalId":22409,"journal":{"name":"The Chinese Pharmaceutical Journal","volume":"29 1","pages":"65-72"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83096087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevention and Monitoring of Hepatotoxicity among Patients Receiving Antituberculosis Medications 抗结核药物治疗患者肝毒性的预防和监测
The Chinese Pharmaceutical Journal Pub Date : 2009-12-01 DOI: 10.7019/TPJ.200912.0107
F. Hsiao, Y. Yen, Chun-Nin Lee, Weng‐Foung Huang, Hsiang-Yin Chen
{"title":"Prevention and Monitoring of Hepatotoxicity among Patients Receiving Antituberculosis Medications","authors":"F. Hsiao, Y. Yen, Chun-Nin Lee, Weng‐Foung Huang, Hsiang-Yin Chen","doi":"10.7019/TPJ.200912.0107","DOIUrl":"https://doi.org/10.7019/TPJ.200912.0107","url":null,"abstract":"Antituberculosis therapy frequently causes hepatotoxicity. The study is to evaluate the appropriateness of liver function monitoring during antituberculosis therapy. Two hundred forty five patients treated with antituberculosis agents were included. Abnormal baseline liver function (LFT) was the most significant risk factor for developing hepatotoxicity during the therapy (adjusted OR 23.48; 95% CI: 9.74-56.61). However, the baseline aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were only checked in 76.2% and 75.4% subjects in the hepatotoxic group; and even lower to 58.5% and 57.8% for the non-hepatotoxic group. Although smoking, severe drinking, age, gender and concurrent diseases were significant risk factors, the logistic regression showed that only abnormal baseline LFT (adjusted OR 2.21; 95% CI: 1.22-4.02) and age (adjusted OR 1.02; 95% CI: 1.01-1.04) were determinants of patients receiving follow-up liver function tests (LFTs). Effective strategies to improve the monitoring of liver function should be established to ensure patient safety.","PeriodicalId":22409,"journal":{"name":"The Chinese Pharmaceutical Journal","volume":"7 1","pages":"107-114"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82291854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Application of Cobalt (II)-EDTA Complex as a Reductant for Molybdophosphoric Acid Used for the Spectrophotometric Assay of Aciclovir, Fluconazole, Ramipril and Secnidazole 钴(II)-EDTA配合物作为钼磷酸还原剂在阿昔洛韦、氟康唑、雷米普利和塞克硝唑的分光光度测定中的应用
The Chinese Pharmaceutical Journal Pub Date : 2009-09-01 DOI: 10.7019/TPJ.200909.0043
M. El-Azazy, Magda Y El-Mammli, A. Shalaby, M. Ayad
{"title":"Application of Cobalt (II)-EDTA Complex as a Reductant for Molybdophosphoric Acid Used for the Spectrophotometric Assay of Aciclovir, Fluconazole, Ramipril and Secnidazole","authors":"M. El-Azazy, Magda Y El-Mammli, A. Shalaby, M. Ayad","doi":"10.7019/TPJ.200909.0043","DOIUrl":"https://doi.org/10.7019/TPJ.200909.0043","url":null,"abstract":"A new spectrophotometric method has been described for the assay of aciclovir, fluconazole, ramipril and secnidazole based on formation of insoluble molecular complexes with molybdophosphoric acid (MPA) under acidic conditions. As a second step, a colour reaction has been combined to determine MI’A, released from the complex (and the studied drugs in turn), using a chromogenic reductant; cobalt (Ⅱ)-EDTA complex to produce molybdenum blue Mo(subscript 5+). The colour of the produced Mo(subscript 5+) is measured at 700-710 nm. Appropriate conditions were established for the precipitation and the colour reactions to obtain maximum sensitivity. Under the proposed conditions, this method is applicable over concentration range of 40-580μg ML^(-1). The results demonstrated that the proposed method is equally accurate, precise and reproducible as the official or reported methods thus it is recommended for quality control and routine analysis where time, cost effectiveness and high specificity of analytical techniques are of great importance.","PeriodicalId":22409,"journal":{"name":"The Chinese Pharmaceutical Journal","volume":"272 1","pages":"43-51"},"PeriodicalIF":0.0,"publicationDate":"2009-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77098601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Metabolism of a Calcium Entry Blocker, Arylalkylamine Analogue, in the In-Vitro Rat Hepatic System 一种钙进入阻滞剂芳烷基胺类似物在体外大鼠肝脏系统中的代谢
The Chinese Pharmaceutical Journal Pub Date : 2009-09-01 DOI: 10.7019/TPJ.200909.0053
W. Wu, L. A. Mckown
{"title":"The Metabolism of a Calcium Entry Blocker, Arylalkylamine Analogue, in the In-Vitro Rat Hepatic System","authors":"W. Wu, L. A. Mckown","doi":"10.7019/TPJ.200909.0053","DOIUrl":"https://doi.org/10.7019/TPJ.200909.0053","url":null,"abstract":"The In vitro metabolism of an arylalkylamine analogue (McN-5691), a calcium entry blocker, was conducted after 0 min and 60 min incubations with the rat hepatic S9 fraction in the presence of an NADPH-generating system. Unchanged McN-5691 (31% of the sample) plus 15 metabolites from the 60min incubation were profiled, quantified, and tentatively identified on the basis of API-MS and MS/MS data. The formation McN-5691 metabolites are via the following four metabolic pathways: A. N-demethylation, B. O-demethylation, C. phenylhydroxylation, and D. oxidative N-dealkylation. Pathways A to C formed 9 major/moderate/minor metabolites, N-desmethyl (MI, 42% of the sample), 4-O-desmethyl (M2, 6%), 4'-O-desmethyl (M3, 6%), OH-phenyl (M4, 1%), O,O-didesmethyl (M5, 1%), and OH-phenyl-M1 (M6, 1%) McN-5691s, and 3 other minor phenylhydroxyl/N-desmethyl/O-desmethyl-combined McN-5691 metabolites (M7-M9, ≤ 1%). Pathway C produced a N-dealkylated metabolite, M10 (2%); in conjunction with pathways A to C yielded 5 minor oxidized N-dealkylated metabolites M11-M15 (each, ≤ 1-2%). Rat appeared to metabolize McN-5691 extensively in this hepatic system.","PeriodicalId":22409,"journal":{"name":"The Chinese Pharmaceutical Journal","volume":"67 1","pages":"53-64"},"PeriodicalIF":0.0,"publicationDate":"2009-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88410601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Difference of Gene Expression between Morphine and Codeine on Ramos Cells 吗啡与可待因对拉莫斯细胞基因表达的影响
The Chinese Pharmaceutical Journal Pub Date : 2009-09-01 DOI: 10.7019/TPJ.200909.0001
Shu-fen Lee, Yiji Chen, Choung-Hui Lee, Chiareiy Liu
{"title":"The Difference of Gene Expression between Morphine and Codeine on Ramos Cells","authors":"Shu-fen Lee, Yiji Chen, Choung-Hui Lee, Chiareiy Liu","doi":"10.7019/TPJ.200909.0001","DOIUrl":"https://doi.org/10.7019/TPJ.200909.0001","url":null,"abstract":"The purpose of this study was to investigate the discrepancy of gene expression of cells treated with heroin or morphine and codeine. Firstly, microarray was used to screen for the difference of genes, which are different in expression between heroin and non-drug users. Compared to non- drug user, 80 genes were distinctly induced in drug users. Only one gene, APOBEC3A gene was up-regulation, and the others were down-regulation. The expressions of seven out of the eighty affected genes, including CAMP, MPP1, OGFR, PARP10 RGS12, HES7, and, APOBEC3A were then validated by real-time RT-PCR amplification by using a cultured cell model. Ramos cells treated with morphine and codeine indicated that both drugs could down regulate CAMP gene expression. Ramos cells treated with morphine showed that the expression of MPP1, RGSI2, OGFR, P4RP10, and HES7 resulted in down-regulation, but cells treated with codeine revealed no induction. The APOBEC3A mRNA was not influenced in Ramos cells treated with morphine, but up-regulated in codeine-treated cells. According to these results, we hypothesize that there arc different gene expressions between cells exposed to morphine and codeine.","PeriodicalId":22409,"journal":{"name":"The Chinese Pharmaceutical Journal","volume":"13 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2009-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83799515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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