The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association最新文献_第2页

Exploration of Genetic Variants of Non-syndromic Cleft Lip with or without Palate and Underlying Mechanisms. 有无腭的非综合征性唇裂的遗传变异及其机制的探讨。

The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association Pub Date : 2022-03-16 DOI: 10.3290/j.cjdr.b2752691

Yongchu Pan, Lan Ma, S. Lou, Guirong Zhu, Xin Yu, Lin Wang

{"title":"Exploration of Genetic Variants of Non-syndromic Cleft Lip with or without Palate and Underlying Mechanisms.","authors":"Yongchu Pan, Lan Ma, S. Lou, Guirong Zhu, Xin Yu, Lin Wang","doi":"10.3290/j.cjdr.b2752691","DOIUrl":"https://doi.org/10.3290/j.cjdr.b2752691","url":null,"abstract":"Non-syndromic cleft lip with/without cleft palate (NSCL/P) is one of the most common birth defects in humans with an overall prevalence of one per 1000 live births. Due to genetic and environmental influences, the fusion of the lips or palate may be interrupted at any stage and cause a cleft. Over decades, dozens of susceptible genes and loci have been identified using multiple genetic approaches. Our group has collected samples of NSCL/P patients since 2008 and established the biobank. We discovered numerous susceptible loci related to the occurrence of NSCL/P in the Chinese population, such as 16p13.3, 1q32.2, 10q25.3 and 17p13.1. In addition, we performed functional studies on related loci and genes by using molecular biology, cell biology, animal models and other methods to provide a basis for the construction of the NSCL/P genetic map in the Chinese population and help to implement individualised prophylaxis and treatment. Future efforts will focus on identifying functional variants, investigating pathways and other interactions, and including phenotypic and ethnic diversity in research.","PeriodicalId":22405,"journal":{"name":"The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association","volume":"62 1","pages":"21-27"},"PeriodicalIF":0.0,"publicationDate":"2022-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91200241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship between Presence of Third Molars and Prevalence of Periodontal Pathology of Adjacent Second Molars: a Systematic Review and Meta-analysis. 第三磨牙的存在与相邻第二磨牙牙周病变的关系:系统回顾和荟萃分析。

The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association Pub Date : 2022-03-16 DOI: 10.3290/j.cjdr.b2752683

Yang Yang, Yi Tian, Li Juan Sun, Honglei Qu, Fang Chen

{"title":"Relationship between Presence of Third Molars and Prevalence of Periodontal Pathology of Adjacent Second Molars: a Systematic Review and Meta-analysis.","authors":"Yang Yang, Yi Tian, Li Juan Sun, Honglei Qu, Fang Chen","doi":"10.3290/j.cjdr.b2752683","DOIUrl":"https://doi.org/10.3290/j.cjdr.b2752683","url":null,"abstract":"OBJECTIVE\u0000To estimate the mean prevalence of periodontal pathology of adjacent second molars (A-M2s) to third molars (M3s) and identify related confounding factors.\u0000\u0000\u0000METHODS\u0000Studies published before August 2020 were systematically searched in the Cochrane Library, EMBASE and MEDLINE databases. We included cross-sectional studies that evaluated the periodontal pathology of A-M2s based on clinical or radiographic examinations at the molar level. Studies employing similar periodontal parameters were pooled. Clinical attachment loss ≥ 3 mm, alveolar bone loss ≥ 3 mm or ≥ 20% root length were defined as early periodontal defects, and at least one site with probing depth ≥ 5 mm was considered as deep periodontal pockets around A-M2s in the data synthesis.\u0000\u0000\u0000RESULTS\u0000Nine studies (14,749 M3s) were ultimately included in the meta-analysis. On average, 19% of A-M2s showed distal early periodontal defects with the presence of M3s (95% confidence interval [95% CI] 9%-35%). Subgroup analyses suggested the prevalence was 32% (95% CI 16%-54%) in the mandible, and the prevalence was higher with nonimpacted M3s (25%, 95% CI 12%-47%) than with impacted M3s (19%, 95% CI 10%-35%). Additionally, the pooled prevalence for deep periodontal pockets around A-M2s was 52% (95% CI 39%-64%). Subgroup analyses suggested the prevalence was higher in the mandible (62%, 95% CI 45%-76%) than in the maxilla (43%, 95% CI 31%-56%), and for nonimpacted M3s the prevalence reached 50% (95% CI 36%-64%).\u0000\u0000\u0000CONCLUSION\u0000The presence of M3s, especially mandibular and nonimpacted M3s, negatively affects the periodontal status of A-M2s.","PeriodicalId":22405,"journal":{"name":"The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association","volume":"39 1","pages":"45-55"},"PeriodicalIF":0.0,"publicationDate":"2022-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89057171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Emerging Role of High Glucose Levels in Cancer Progression and Therapy. 高血糖水平在癌症进展和治疗中的新作用。

The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association Pub Date : 2022-03-16 DOI: 10.3290/j.cjdr.b2752695

Xinjia Cai, Jian Yun Zhang, A. Zhang, Xuan Zhou, H. Zhang, Tie Li

引用次数: 2

Management of Separated Instruments Extruded into the Maxillary Sinus and Soft Tissue: a Case Series. 分离器械挤进上颌窦和软组织的处理:一个病例系列。

The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association Pub Date : 2022-03-16 DOI: 10.3290/j.cjdr.b2752707

Q. Liao, Ziyao Han, Ru Zhang, B. Hou

引用次数: 1

Microspheres and their Potential in Endodontic Regeneration Application. 微球及其在牙髓再生中的应用潜力。

The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association Pub Date : 2022-03-16 DOI: 10.3290/j.cjdr.b2752709

Ting Yang, Li Xie, Ruitao Zhang, W. Tian

引用次数: 0

Near Infrared Laser Photobiomodulation of Periodontal Ligament Stem Cells. 近红外激光对牙周韧带干细胞的光生物调节作用。

The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association Pub Date : 2022-03-16 DOI: 10.3290/j.cjdr.b2752657

Mohammd Ayyoub Rigi-Ladez, S. S. Hendi, Alireza Mirzaei, L. Gholami, R. Fekrazad

{"title":"Near Infrared Laser Photobiomodulation of Periodontal Ligament Stem Cells.","authors":"Mohammd Ayyoub Rigi-Ladez, S. S. Hendi, Alireza Mirzaei, L. Gholami, R. Fekrazad","doi":"10.3290/j.cjdr.b2752657","DOIUrl":"https://doi.org/10.3290/j.cjdr.b2752657","url":null,"abstract":"OBJECTIVE\u0000To determine the effect of different energy densities of near infrared diode lasers with wavelengths of 810 or 940 nm on the proliferation and survival of periodontal ligament derived stem cells (PDLSCs).\u0000\u0000\u0000METHODS\u0000After isolation and characterisation, PDLSCs were cultured in clear 96-well plates. Each well was irradiated by either 810 nm (L1) or 940 nm (L2) lasers, with energy densities of 0.5, 1.5 and 2.5 J/cm2 and an output power of 100 mW. A non-irradiated well was used as a control. Cellular viability was measured 24 hours after irradiation using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay and proliferation was measured 24, 48 and 72 hours after irradiation using trypan blue staining and counting. Propidium iodide (PI) staining was used to identify any pyknotic nuclei or nuclear fragmentation 72 hours after irradiation.\u0000\u0000\u0000RESULTS\u0000An increase in viability was observed only in the group with the 940 nm laser irradiation at energy density of 2.5 J/cm2 (P < 0.001). The proliferation of cells was significantly increased in the group with 940 nm laser irradiation at energy density of 2.5 J/cm2 at all the time points examined in comparison to other groups (P < 0.001). PI staining showed no change in cell nuclei in any of the groups.\u0000\u0000\u0000CONCLUSION\u0000Irradiation of PDLSCs with a 940 nm laser at an energy density of 2.5 J/cm2 could promote efficient cell proliferation.","PeriodicalId":22405,"journal":{"name":"The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association","volume":"17 1","pages":"57-65"},"PeriodicalIF":0.0,"publicationDate":"2022-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85095263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Local Administration of Stem Cells from Human Exfoliated Primary Teeth Attenuate Experimental Periodontitis in Mice. 局部施用人脱落乳牙干细胞可减轻小鼠实验性牙周炎。

The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association Pub Date : 2019-01-01 DOI: 10.3290/j.cjdr.a43109

Y. Qiao, Ling Zhu, S. Cui, Ting Zhang, Ruili Yang, Yanheng Zhou

{"title":"Local Administration of Stem Cells from Human Exfoliated Primary Teeth Attenuate Experimental Periodontitis in Mice.","authors":"Y. Qiao, Ling Zhu, S. Cui, Ting Zhang, Ruili Yang, Yanheng Zhou","doi":"10.3290/j.cjdr.a43109","DOIUrl":"https://doi.org/10.3290/j.cjdr.a43109","url":null,"abstract":"OBJECTIVE To evaluate the therapeutic effect of local injection of stem cells from human exfoliated primary teeth (SHED) on periodontitis in mice. METHODS Fifteen female mice were randomly divided into three groups: normal control group, periodontitis group and SHED treatment group. A periodontitis model was established by ligating a 0.2 mm orthodontic ligation wire to the maxillary first molar. The SHED group was injected with SHED at 3 weeks post-ligation. All mice were sacrificed and their maxillae were dissected five weeks post-ligation. Clinical assessments, micro-computed tomography (micro-CT) scanning, and histologic examination were used to evaluate the outcome of tissue regeneration. RESULTS Micro-CT analysis showed that SHED administration significantly increased periodontal regeneration and decreased the distance between the cemento-enamel junction and the alveolar bone crest. In addition, histopathological photomicrographs showed new regenerated bone, the number of TNF-α-positive, IFN-γ-positive and CD4+ cells decreased, and osteoclasts-positive decreased in the periodontal defect area in the SHED group compared with the periodontitis group. CONCLUSION SHED administration suppresses the expression of inflammatory factors, inhibits the production of osteoclasts, and promotes the regeneration of periodontal tissues.","PeriodicalId":22405,"journal":{"name":"The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association","volume":"27 1","pages":"157-163"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78566610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Fracture Resistance of Roots in Mandibular Premolars Following Root Canal Instrumentation of Different Sizes. 下颌前磨牙不同大小根管预备后牙根抗折性的研究。

The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association Pub Date : 2019-01-01 DOI: 10.3290/j.cjdr.a43114

S. Tian, W. Bai, Weihao Jiang, Yu-Hong Liang

{"title":"Fracture Resistance of Roots in Mandibular Premolars Following Root Canal Instrumentation of Different Sizes.","authors":"S. Tian, W. Bai, Weihao Jiang, Yu-Hong Liang","doi":"10.3290/j.cjdr.a43114","DOIUrl":"https://doi.org/10.3290/j.cjdr.a43114","url":null,"abstract":"OBJECTIVE To measure the fracture resistance of mandibular premolar roots following root canal instrumentation with different sizes. METHODS A total of 100 human permanent mandibular premolars with a straight single canal were decoronated and assigned to 10 groups (n = 10) by block randomisation. In the control group, the roots were uninstrumented, whereas roots in the nine experimental groups were instrumented to different master apical files (MAF) and tapers (MAF/taper): 40/0.05, 45/0.05, 50/0.05, 55/0.05, 60/0.05, 40/0.10, 40/0.15, 45/0.10 and 45/0.15. All roots were subjected to vertical loading until fracture. RESULTS Fracture load values for instrumented roots were lower than the intact roots of the control group. In 50/0.05, 55/0.05, 60/0.05, 40/0.15 and 45/0.15 groups, the fracture load values were significantly lower than the fracture load value for the control group (P < 0.05) with a 30% decrease. No significant differences in the fracture modes were detected among the 10 groups (P > 0.05). CONCLUSION Mechanical instrumentation adversely affects the fracture resistance of roots. When the roots of mandibular premolars were instrumented to a MAF equal to or larger than 50 with a taper of 0.05 or to a MAF of 40 or 45 with a taper of 0.15, the fracture load values significantly decreased.","PeriodicalId":22405,"journal":{"name":"The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association","volume":"44 2 1","pages":"197-202"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85289056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Effects of Periodontal Intervention on Levels of Serum High-sensitivity C-reactive Protein and Interleukin 6, and on Carotid Artery in Rats with Chronic Periodontitis and Hyperlipidemia. 牙周干预对慢性牙周炎合并高脂血症大鼠血清高敏c反应蛋白、白细胞介素6及颈动脉的影响

The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association Pub Date : 2019-01-01 DOI: 10.3290/j.cjdr.a43115

Miaolei Wang, Yong Zhao, Chong Wang, Xuexue Shi, Jinmao Gao, X. Ren

{"title":"Effects of Periodontal Intervention on Levels of Serum High-sensitivity C-reactive Protein and Interleukin 6, and on Carotid Artery in Rats with Chronic Periodontitis and Hyperlipidemia.","authors":"Miaolei Wang, Yong Zhao, Chong Wang, Xuexue Shi, Jinmao Gao, X. Ren","doi":"10.3290/j.cjdr.a43115","DOIUrl":"https://doi.org/10.3290/j.cjdr.a43115","url":null,"abstract":"OBJECTIVE To investigate the effects of nonsurgical periodontal therapy on the serum interleukin 6 (IL-6) and high-sensitivity C-reactive protein (hsCRP) and on the carotid artery in rats with chronic periodontitis (CP) and with or without hyperlipidemia (HL). METHODS A total of 29 Sprague-Dawley rats were randomly divided into two groups: group A (CP, n = 14) and B (CP + HL, n = 15), and subjected to the corresponding treatment. Groups A and B were further divided into groups A1/B1 (without periodontal interventions) and A2/B2 (with periodontal interventions). The serum IL-6 and hsCRP levels were evaluated before periodontal intervention and at 1, 3, 5, and 7 weeks after periodontal intervention. The rats were euthanised 8 weeks after the periodontal intervention and the histopathologic changes in the carotid artery were observed. RESULTS The serum hsCRP and serum IL-6 levels in groups A1 and B1 were elevated with time; they were significantly higher in group B1 than in group A1 (P < 0.001) at all time points. The hsCRP and IL-6 levels in groups A2 and B2 increased with time and reached the maximum level 1 week after the second intervention, and then gradually decreased. Atherosclerotic plaques, fibrous cap, and calcium salt deposits were apparent in the rats of group B1, whereas no obvious atherosclerotic changes were observed in the rats of groups A2 and B2. CONCLUSION Periodontal interventions resulted in acute, short-term systemic inflammation. However, it was beneficial in long-term as it improved the carotid artery integrity.","PeriodicalId":22405,"journal":{"name":"The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association","volume":"14 1","pages":"203-209"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88977793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Changes of Microbial Community in Treated Peri-implantitis Sites: An Experimental Study in Beagle Dogs. Beagle犬种植体周围部位微生物群落变化的实验研究

The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association Pub Date : 2019-01-01 DOI: 10.3290/j.cjdr.a43110

Yu Wei Wu, Hui Zheng, Xue Li, Hui Lu, Songhe Lu, Xu Hong Liu, Qiang Zeng, Feng Chen, Jiuxiang Lin, Zhi-hui Tang

引用次数: 1