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Technological Innovation in Pharmaceutical Research Vol. 3最新文献

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Research on Transungual Delivery of Ciclopirox is Increased 3–4-Fold by Mechanical Fenestration of Human Nail Plate in an in vitro Model 体外人甲板机械开窗使环吡肟经口给药量增加3 - 4倍的研究
Technological Innovation in Pharmaceutical Research Vol. 3 Pub Date : 2021-05-12 DOI: 10.9734/bpi/tipr/v3/1705f
D. Díaz, M. E. Iglesias, R. B. Vallejo, M. Díaz
{"title":"Research on Transungual Delivery of Ciclopirox is Increased 3–4-Fold by Mechanical Fenestration of Human Nail Plate in an in vitro Model","authors":"D. Díaz, M. E. Iglesias, R. B. Vallejo, M. Díaz","doi":"10.9734/bpi/tipr/v3/1705f","DOIUrl":"https://doi.org/10.9734/bpi/tipr/v3/1705f","url":null,"abstract":"Onychomycosis is a fungal infection of nails that is widespread and difficult to treat because of the impermeable nature of human nails. Topically applied anti-fungal agents cannot penetrate this structure, and treatment regimens often resort to systemic antifungals with concomitant side effects. One recent clinical study suggested that mechanical fenestration of the nail using an intelligent nail drill might be a possible solution to this problem. In this work, an in vitro model of the transungual delivery of antifungal agents is presented, which utilizes real nail tissue and an inline flow system. This system was deployed to measure transungual delivery of ciclopirox and determined that nail fenestration improved drug delivery by 3–4-fold after 42 days. This study bolsters the argument that nail fenestration should be accepted as a pretreatment for onychomycosis and offers a way of evaluating new drugs or formulations designed to combat this condition. The in vitro model described herein would be an excellent system to directly measure transungual delivery of antifungal agents prior to clinical trials.","PeriodicalId":22329,"journal":{"name":"Technological Innovation in Pharmaceutical Research Vol. 3","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79365929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Recent Study on Development and Validation of Loperamide Hydrochloride Tablet Analysis Method with Absorbance and Area under Curve Methods Spectrophotometrically 盐酸洛哌丁胺片剂吸光度法和曲线下面积法分析方法的建立与验证
Technological Innovation in Pharmaceutical Research Vol. 3 Pub Date : 2021-05-12 DOI: 10.9734/bpi/tipr/v3/1696c
H. Rivai, Renny Puspita, Sesry Misfadhila
{"title":"Recent Study on Development and Validation of Loperamide Hydrochloride Tablet Analysis Method with Absorbance and Area under Curve Methods Spectrophotometrically","authors":"H. Rivai, Renny Puspita, Sesry Misfadhila","doi":"10.9734/bpi/tipr/v3/1696c","DOIUrl":"https://doi.org/10.9734/bpi/tipr/v3/1696c","url":null,"abstract":"Development and validation of loperamide hydrochloride tablet method of analysis have been done by using the absorbance method and area under the curve method. This study used methanol and hydrochloric acid 0.1 N (9:1) as the best solvent with maximum absorption at wavelength 259.00 nm. The linearity of loperamide hydrochloride was obtained in the concentration range 200-600 ppm with a correlation coefficient value with the absorbance method and the areas under the curve method were 0.9998 and 0.9865, respectively. The results showed that the levels of loperamide hydrochloride in generic tablets obtained by absorbance method and the area under the curve method were 105.71% and 96.20%, respectively. The results of determination of loperamide levels in tablets of trademark obtained by absorbance method and the area under the curve method were 102.85% and 98.57%, respectively. The level of both samples met the requirements of Pharmacopoeia Indonesia edition V that is 90% -110%. The analysis of loperamide hydrochloride in tablets by ultraviolet-visible spectrophotometry by absorbance method is valid while the area under the curve method is invalid for analysis of loperamide hydrochloride in tablets.","PeriodicalId":22329,"journal":{"name":"Technological Innovation in Pharmaceutical Research Vol. 3","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83662562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Karen activism at the Thai-Burma borderlands 泰缅边境的克伦激进主义
Technological Innovation in Pharmaceutical Research Vol. 3 Pub Date : 2020-12-15 DOI: 10.51142/issues-journal-3-1-5
R. Sharples
{"title":"Karen activism at the Thai-Burma borderlands","authors":"R. Sharples","doi":"10.51142/issues-journal-3-1-5","DOIUrl":"https://doi.org/10.51142/issues-journal-3-1-5","url":null,"abstract":"","PeriodicalId":22329,"journal":{"name":"Technological Innovation in Pharmaceutical Research Vol. 3","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78033179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Cloud, geographical advantage, and the metaphors of the Earth 云，地理优势，和地球的隐喻
Technological Innovation in Pharmaceutical Research Vol. 3 Pub Date : 2020-12-15 DOI: 10.51142/issues-journal-3-1-2
A. Pollio
{"title":"The Cloud, geographical advantage, and the metaphors of the Earth","authors":"A. Pollio","doi":"10.51142/issues-journal-3-1-2","DOIUrl":"https://doi.org/10.51142/issues-journal-3-1-2","url":null,"abstract":"","PeriodicalId":22329,"journal":{"name":"Technological Innovation in Pharmaceutical Research Vol. 3","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88436138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Resisting a riot in Bodoland, Northeast India 在印度东北部的博德兰抵抗暴乱
Technological Innovation in Pharmaceutical Research Vol. 3 Pub Date : 2020-12-15 DOI: 10.51142/issues-journal-3-1-4
R. K. Thakur
{"title":"Resisting a riot in Bodoland, Northeast India","authors":"R. K. Thakur","doi":"10.51142/issues-journal-3-1-4","DOIUrl":"https://doi.org/10.51142/issues-journal-3-1-4","url":null,"abstract":"","PeriodicalId":22329,"journal":{"name":"Technological Innovation in Pharmaceutical Research Vol. 3","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79446075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A view from the Roof: Space and politics in South Asia 从屋顶上看:南亚的空间与政治
Technological Innovation in Pharmaceutical Research Vol. 3 Pub Date : 2020-12-15 DOI: 10.51142/issues-journal-3-1-1
Layli Uddin
{"title":"A view from the Roof: Space and politics in South Asia","authors":"Layli Uddin","doi":"10.51142/issues-journal-3-1-1","DOIUrl":"https://doi.org/10.51142/issues-journal-3-1-1","url":null,"abstract":"","PeriodicalId":22329,"journal":{"name":"Technological Innovation in Pharmaceutical Research Vol. 3","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77485905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
FRONT MATTER 前页
Technological Innovation in Pharmaceutical Research Vol. 3 Pub Date : 2020-03-01 DOI: 10.1142/9789811211461_fmatter
{"title":"FRONT MATTER","authors":"","doi":"10.1142/9789811211461_fmatter","DOIUrl":"https://doi.org/10.1142/9789811211461_fmatter","url":null,"abstract":"","PeriodicalId":22329,"journal":{"name":"Technological Innovation in Pharmaceutical Research Vol. 3","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72575379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
INNOVATION AS A PROCESS 创新是一个过程
Technological Innovation in Pharmaceutical Research Vol. 3 Pub Date : 2020-03-01 DOI: 10.1142/9789811211461_0002
Juan Vicente García Manjón
{"title":"INNOVATION AS A PROCESS","authors":"Juan Vicente García Manjón","doi":"10.1142/9789811211461_0002","DOIUrl":"https://doi.org/10.1142/9789811211461_0002","url":null,"abstract":"The following sections are included:The Process and Management of InnovationInnovation ModelsReferences","PeriodicalId":22329,"journal":{"name":"Technological Innovation in Pharmaceutical Research Vol. 3","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79094059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
BACK MATTER 回到问题
Technological Innovation in Pharmaceutical Research Vol. 3 Pub Date : 2020-03-01 DOI: 10.1142/9789811211461_bmatter
{"title":"BACK MATTER","authors":"","doi":"10.1142/9789811211461_bmatter","DOIUrl":"https://doi.org/10.1142/9789811211461_bmatter","url":null,"abstract":"","PeriodicalId":22329,"journal":{"name":"Technological Innovation in Pharmaceutical Research Vol. 3","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76545404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phytochemical Examination and Hepatoprotective Impact of Stem Bark of Oroxylum indicum (L) Vent. on Carbon Tetrachloride Induced Hepatotoxicity in Rat 芡实茎皮的植物化学检测及保肝作用。四氯化碳对大鼠肝毒性的影响
Technological Innovation in Pharmaceutical Research Vol. 3 Pub Date : 1900-01-01 DOI: 10.9734/bpi/tipr/v3/4069d
B. Tripathy, S. Panda, S. Sahoo, S. K. Mishra, L. Nayak
{"title":"Phytochemical Examination and Hepatoprotective Impact of Stem Bark of Oroxylum indicum (L) Vent. on Carbon Tetrachloride Induced Hepatotoxicity in Rat","authors":"B. Tripathy, S. Panda, S. Sahoo, S. K. Mishra, L. Nayak","doi":"10.9734/bpi/tipr/v3/4069d","DOIUrl":"https://doi.org/10.9734/bpi/tipr/v3/4069d","url":null,"abstract":"","PeriodicalId":22329,"journal":{"name":"Technological Innovation in Pharmaceutical Research Vol. 3","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81874828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
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