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Assessment of thyroid nodules by technetium-99m-tetrofosmin scintigraphy. 锝-99m-四氟氰闪光显像评价甲状腺结节。
The British journal of clinical practice Pub Date : 1997-01-01
G Akçay, H Uslu, E Varoglu, S B Tekin, C Gündogdu
{"title":"Assessment of thyroid nodules by technetium-99m-tetrofosmin scintigraphy.","authors":"G Akçay,&nbsp;H Uslu,&nbsp;E Varoglu,&nbsp;S B Tekin,&nbsp;C Gündogdu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Thyroid nodularity is a common finding. The incidence of thyroid cancer in the general population is estimated at 0.1%. Thyroid nodules are evaluated by palpation, ultrasonography, radionuclide scintigraphy and fine-needle aspiration cytology. Routine thyroid scintigraphy is made by using Tc-99m-pertechnetate or the I-131 and I-123 scintigraphic method. Tc-99m-tetrofosmin accumulates in the myocardium, skeletal muscle, liver, spleen breast tissue, kidney and normal and pathological thyroid tissue. We investigated 36 patients (28 females and 8 males) with solitary and/or multiple thyroid nodules. All the patients were euthyroid, and their thyroid nodules were diagnosed by palpation and ultrasound examination. Thyroid scintigraphy was applied by Tc-99m-pertechnetate, then thyroid fine-needle aspiration biopsy was performed. Finally, Tc-99m-tetrofosmin scintigraphy was carried out. Five patients (14.8%) had differential thyroid carcinoma, 23 (63.8%) had thyroid adenoma, 1 (0.02%) had Riedel's thyroiditis and 7 (19.4%) had follicular cyst. We detected 80% uptake in the early phase and 100% in the late phase by Tc-99m-tetrofosmin scintigraphy in the differentiated thyroid carcinoma group. In summary, we claim that Tc-99m-tetrofosmin may be an important scintigraphic method to identify thyroid malignancy from benign thyroid pathologies.</p>","PeriodicalId":22312,"journal":{"name":"The British journal of clinical practice","volume":"51 1","pages":"5-7"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20105767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Desmopressin and imipramine in the management of nocturnal enuresis: a multicentre study. 去氨加压素和丙咪嗪治疗夜间遗尿:一项多中心研究。
The British journal of clinical practice Pub Date : 1997-01-01
P Vertucci, C Lanzi, G Capece, M Fano, V Gallai, L Margari, G Mazzotta, E Menegati, S Ottaviano, A Perini, T Perniola, M Roccella, A Tiberti, A Vecchio, M Biraghi
{"title":"Desmopressin and imipramine in the management of nocturnal enuresis: a multicentre study.","authors":"P Vertucci,&nbsp;C Lanzi,&nbsp;G Capece,&nbsp;M Fano,&nbsp;V Gallai,&nbsp;L Margari,&nbsp;G Mazzotta,&nbsp;E Menegati,&nbsp;S Ottaviano,&nbsp;A Perini,&nbsp;T Perniola,&nbsp;M Roccella,&nbsp;A Tiberti,&nbsp;A Vecchio,&nbsp;M Biraghi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The efficacy and safety of desmopressin (Minirin/DDAVP) treatment compared with imipramine were investigated in a multicentre, open, cross-over design in 57 patients, aged 6-15 years, affected by nocturnal enuresis to establish the best therapeutic approach to this condition. After a two-weeks observation and control period, patients were randomised to one of two groups: intranasal administration of desmopressin, 30 micrograms/day for three weeks, followed by imipramine, 0.9 mg/kg for a further three weeks, or imipramine 0.9 mg/kg for three weeks, followed by desmopressin, 30 micrograms/day for a further three weeks. Following treatment, all patients were observed for a further two weeks. Administration of either treatment protocol resulted in a statistically significant decline in the number of enuretic episodes per week compared to the control. The greater antidiuretic effect observed in the group receiving imipramine followed by desmopressin suggests the two compounds have different profiles. Also, when the treatment period was compared with the follow-up, the antidiuretic effect had a longer duration in the group initially given imipramine. No further improvement was seen when desmopressin was administered first, with a mild worsening of the effect sometimes occurring, suggesting a different carry-over effect between the two treatments. This suggests that desmopressin offers a better approach to the management of nocturnal enuresis.</p>","PeriodicalId":22312,"journal":{"name":"The British journal of clinical practice","volume":"51 1","pages":"27-31"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20105674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A study of lipid profile before and after coronary artery bypass grafting. 冠状动脉旁路移植术前后血脂的研究。
The British journal of clinical practice Pub Date : 1996-12-01
M Ooi, A Cooper, G Lloyd, G Jackson
{"title":"A study of lipid profile before and after coronary artery bypass grafting.","authors":"M Ooi,&nbsp;A Cooper,&nbsp;G Lloyd,&nbsp;G Jackson","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This study was undertaken to establish the variability in the levels of total cholesterol (TC), total triglyceride (TG), low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol before and after coronary artery bypass graft (CABG) surgery, in order to determine postoperatively when an accurate assessment can be made of the lipid status. During a prospective study over 4 months, fasting venous samples were taken pre- and postoperatively on day 5, and in the 4th, 8th and 12th weeks. Ninety-six patients admitted to the cardiothoracic and cardiac wards for CABG were recruited to the study. The mean preoperative levels were: TC 5.94 (+/- 0.1 mmol/l), LDL cholesterol 4.02 (+/- 0.09mmol/l) and HDL cholesterol 1.00 (+/- 0.03mmol/l). These were significantly different (p < 0.01) from the levels on the 5th postoperative day when the mean level of TC was 4.14 (+/- 0.084mmol/l), LDL cholesterol was 2.45 (+/- 0.07mmol/l) and HDL cholesterol was 0.74 (+/- 0.03mmol/l). By the 4th postoperative week, mean TC (5.73 +/- 0.13mmol/l), LDL cholesterol (3.79 +/- 0.14mmol/l) and HDL cholesterol (1.03 +/- 0.04mmol/l) did not vary significantly from the mean preoperative values. There was no significant difference in the mean TG levels pre- and postoperatively. The mean TC, LDL cholesterol and HDL cholesterol rise to preoperative levels by the 4th week after CABG. Thus, an accurate assessment of patients' lipid status can be made from this period. An earlier postoperative assessment may be falsely reassuring.</p>","PeriodicalId":22312,"journal":{"name":"The British journal of clinical practice","volume":"50 8","pages":"433-5"},"PeriodicalIF":0.0,"publicationDate":"1996-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19996015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Are intravenous cannulae still being misused? 静脉插管是否仍在被滥用?
The British journal of clinical practice Pub Date : 1996-12-01
T Smith, M Pritchard-Howarth, D King
{"title":"Are intravenous cannulae still being misused?","authors":"T Smith,&nbsp;M Pritchard-Howarth,&nbsp;D King","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We have surveyed the use of intravenous cannulae (IVC) in a district general hospital. Of 354 patients interviewed on various wards, 125 (35.3%) had IVC in situ. The wrist was the commonest location for the cannulae (41.6%). An indication for cannula insertion was present in the majority (93.7%) of patients. Cannulae were left in situ even after their use had ceased, most commonly on wards for the elderly, and on these wards complications were more common. Other wards had specific IVC documentation, which resulted in fewer complications. Cannulae should be used for specific indications and should be reviewed daily for the development of complications and the need for their continued presence.</p>","PeriodicalId":22312,"journal":{"name":"The British journal of clinical practice","volume":"50 8","pages":"466-7"},"PeriodicalIF":0.0,"publicationDate":"1996-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19998535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Healthcare for the millennium: can we prevent a funding nightmare? 千禧年的医疗保健:我们能防止一场资金噩梦吗?
The British journal of clinical practice Pub Date : 1996-12-01
G Jackson
{"title":"Healthcare for the millennium: can we prevent a funding nightmare?","authors":"G Jackson","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":22312,"journal":{"name":"The British journal of clinical practice","volume":"50 8","pages":"421"},"PeriodicalIF":0.0,"publicationDate":"1996-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19996011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How do general practitioners manage patients at risk from stroke? 全科医生如何管理有中风风险的病人?
The British journal of clinical practice Pub Date : 1996-12-01
G E Mead, H Murray, C N McCollum, P A O'Neill
{"title":"How do general practitioners manage patients at risk from stroke?","authors":"G E Mead,&nbsp;H Murray,&nbsp;C N McCollum,&nbsp;P A O'Neill","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This study assessed by means of a postal questionnaire how general practitioners (GPs) manage patients at risk from stroke. Of the 640 GPs sent a questionnaire, 294 (46%) replied. In patients with a recent transient ischaemic attack or minor ischaemic stroke, 24% of responding GPs would not arrange any investigations. Sixty-one per cent refer under half of their patients for further investigation, although 99% of GPs would commence aspirin. Seventy-seven per cent of GPs were aware of the benefits of carotid surgery. For patients in atrial fibrillation, most GPs (77%) thought that warfarin reduced stroke rates, but only 20% would consider commencing warfarin, although 26% would commence aspirin. In hypertensive patients, the GPs' threshold for treatment ranged from 135 to 200mmHg systolic (median 160mmHg), and from 90 to 110mmHg diastolic (median 100mmHg). Most GPs (84%) would treat isolated systolic hypertension with a median threshold of 180mmHg (range 140-240mmHg). The results of this study suggest that some patients at risk from stroke may not receive optimal investigation and treatment in the community.</p>","PeriodicalId":22312,"journal":{"name":"The British journal of clinical practice","volume":"50 8","pages":"426-30"},"PeriodicalIF":0.0,"publicationDate":"1996-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19996013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Variations of invasive Salmonella infection in elderly people. 老年人侵袭性沙门氏菌感染的变异。
The British journal of clinical practice Pub Date : 1996-12-01
P N Bruce-Jones, S C Allen
{"title":"Variations of invasive Salmonella infection in elderly people.","authors":"P N Bruce-Jones,&nbsp;S C Allen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Four cases of elderly people with differing forms of invasive salmonella infection are presented. Vulnerability factors and patterns of presentation are discussed.</p>","PeriodicalId":22312,"journal":{"name":"The British journal of clinical practice","volume":"50 8","pages":"470-1"},"PeriodicalIF":0.0,"publicationDate":"1996-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19998537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aneurysmal bone cyst of the clavicle in a child. 儿童锁骨动脉瘤样骨囊肿。
The British journal of clinical practice Pub Date : 1996-12-01
R Vedantam, A H Crawford, S S Kuwajima
{"title":"Aneurysmal bone cyst of the clavicle in a child.","authors":"R Vedantam,&nbsp;A H Crawford,&nbsp;S S Kuwajima","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We report a case of an aneurysmal bone cyst (ABC) of the clavicle in a 9-year-old boy, which initially presented as a pathological fracture of a benign cystic lesion. ABC of the clavicle is rare in children less than 10 years old and radiological diagnosis may prove difficult in the early stages of presentation.</p>","PeriodicalId":22312,"journal":{"name":"The British journal of clinical practice","volume":"50 8","pages":"474-6"},"PeriodicalIF":0.0,"publicationDate":"1996-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19998539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fentanyl therapy controls autonomic hyperactivity in tetanus. 芬太尼治疗控制破伤风的自主神经亢进。
The British journal of clinical practice Pub Date : 1996-12-01
A V Moughabghab, G Prevost, C Socolovsky
{"title":"Fentanyl therapy controls autonomic hyperactivity in tetanus.","authors":"A V Moughabghab,&nbsp;G Prevost,&nbsp;C Socolovsky","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This report describes the use of fentanyl in severe tetanus after failure of established therapeutic modalities (heavy sedation, neuromuscular blockade and ventilation). Cardiovascular instability accompanying severe tetanus secondary to sympathetic overactivity and raised catecholamine levels is associated with a mortality of over 50%. In this clinical situation, a variety of drugs with a primary or secondary action on the cardiovascular system has been used with varying success. The following case of severe generalised tetanus in the adult associated with autonomic hyperactivity, was successfully managed with large doses of intravenous fentanyl.</p>","PeriodicalId":22312,"journal":{"name":"The British journal of clinical practice","volume":"50 8","pages":"477-8"},"PeriodicalIF":0.0,"publicationDate":"1996-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19998540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bone mineral density in premenopausal women with oestrogen deficiency and symptomatic coronary heart disease. 绝经前雌激素缺乏和症状性冠心病妇女的骨矿物质密度。
The British journal of clinical practice Pub Date : 1996-12-01
B Bruck, D Seitz, S Hanke, K Lange, W Schmah, R Haasis, H Hanke
{"title":"Bone mineral density in premenopausal women with oestrogen deficiency and symptomatic coronary heart disease.","authors":"B Bruck,&nbsp;D Seitz,&nbsp;S Hanke,&nbsp;K Lange,&nbsp;W Schmah,&nbsp;R Haasis,&nbsp;H Hanke","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Serum oestrogen deficiency is one of the main causes of osteoporosis in post-menopausal women. In premenopausal women, oestrogen deficiency is rare. In 13 premenopausal women with symptomatic coronary heart disease (CHD) and significantly reduced serum oestrogen levels, bone mineral density, determined by quantitative computed tomography (QCT), was not reduce. In these women, oestrogen deficiency was probably one risk factor for the development of CHD. The level of serum oestrogen that protects women from the development of CHD might be different from the level that protects them from early loss of bone mineral density. Seven of the 13 women had a history of tubal sterilisation. This might be a possible risk factor, causing ovarial dysfunction and oestrogen deficiency.</p>","PeriodicalId":22312,"journal":{"name":"The British journal of clinical practice","volume":"50 8","pages":"450-3"},"PeriodicalIF":0.0,"publicationDate":"1996-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19998533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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