Diabetes and Islet Biology最新文献

{"title":"The auditory P300 component of ERPs elicited during the oddball paradigm in type 2 diabetic patients","authors":"H. Teede, S. Kozica, C. Lombard, D. Ilić, S. Ng, C. Harrison","doi":"10.31579/2641-8975/005","DOIUrl":"https://doi.org/10.31579/2641-8975/005","url":null,"abstract":"Background: There is increasing interest in the impact of diabetes mellitus on cognitive functioning. Several studies found evidence of decreased cognitive performance in type 2 diabetics (T2DM). Since the P300 component of event-related potentials (ERPs) provides valuable information concerning cognition, we studied this component of ERPs in T2DM. Methods: Auditory P300 event-related potentials (P300) were elicited in 43 T2DM patients and 29 age and sex-matched healthy volunteers by use of the auditory oddball paradigm, taking into account the age of the subjects, disease duration and the metabolic control. Results: Compared with controls, diabetics had significantly longer P300 latencies (F= 5.05, p= 0.026) and lower P300 amplitudes both in Cz and Pz electrode positions (F= 8.01, p= 0.005 and F= 13.67, p= 0.000 respectively). In addition, a significant inverse correlation between P300 latency and amplitude was observed in diabetics both in Cz and Pz electrode positions (r= -0.43, p= 0.003 and r= -0.39, p= 0.01 respectively), whereas essentially no relationship between amplitude and latency was observed for the control group. N200 and P300 latencies and the reduction in their amplitudes in Cz and Pz leads were not related to either disease duration or metabolic control. Conclusions: The observed electrophysiological abnormalities may reflect impairment of information processing and working memory, possibly associated with an accelerated ageing process. Our findings suggest that surface-recorded ERPs may be useful for detecting and monitoring the changes in brain function associated with diabetes mellitus.","PeriodicalId":222395,"journal":{"name":"Diabetes and Islet Biology","volume":"158 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122059116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The A1c and blood glucose levels of the diabetic patients in the EG were lower of than those of the individuals in the CG","authors":"P. Aveyard","doi":"10.31579/2641-8975/008.2018","DOIUrl":"https://doi.org/10.31579/2641-8975/008.2018","url":null,"abstract":"*Corresponding Author: Paul Aveyard, University of Pittsburgh Diabetes Institute, OX2 6GG, UK. E-mail: paul.yard@phc.ox.ac.uk Received date: June 02, 2018;Accepted date : June 14, 2018; Published date: June 22, 2018. Citation : Paul Aveyard , The A1c and blood glucose levels of the diabetic patients in the EG were lower of than those of the individuals in the CG . J Diabetes and Islet Biology. Doi: 10.31579/2641-8975/009","PeriodicalId":222395,"journal":{"name":"Diabetes and Islet Biology","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125146793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SGLT2 inhibitors and Ketoacidosis: Epidemiology and Pathophysiology","authors":"U. Kabadi","doi":"10.31579/2641-8975/001.2018","DOIUrl":"https://doi.org/10.31579/2641-8975/001.2018","url":null,"abstract":"","PeriodicalId":222395,"journal":{"name":"Diabetes and Islet Biology","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128200319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sample of Aboriginal Australians, 2-hour post-load insulin concentrations are greatest between fasting plasma glucose values of 6.7-7.3 mmol/l","authors":"P. Aveyard","doi":"10.31579/2641-8975/009","DOIUrl":"https://doi.org/10.31579/2641-8975/009","url":null,"abstract":"Background: Prevention of diabetic complications requires good glycaemic control. This study aimed to provide type 2 diabetes patients with remote active care and glycaemic control through the use of videophone technology without the need for them to attend hospital. The literature recommends additional research to study the impact of technical innovations on improved disease self-management and medical outcome. This is the only study to be conducted in Turkey concerning patient monitoring using videophone technology. The aim of the study was to establish the effectiveness of the use of videophone technology in the glycaemic control of patients with diabetes living in remote areas. Methods: This is a prospective, randomized control study using the systematic sampling method (using half ratio), in which 24 patients were chosen for the Experimental Group (EG) and another 24 for the Control Group (CG). All of the patients agreed to participate in the study. Patients in the CG received routine care, while the glycaemic control and consultations for patients in the EG were conducted using videophone technology. The patients were monitored by videophone for a total of 6 months. The HbA1c and blood glucose values recorded over the 6 month monitoring period were analyzed to determine the effectiveness of using a videophone. Results: The mean age of the individuals in the EG was 54.41 ± 8.54 years (Min=43 Max=78) and in the CG it was 57.25 ± 9.61 (Min=40 Max=77). In both groups, 50% of the individuals were men and 50% were women. When the two groups were compared, it was was found that the preprandial blood glucose levels of the diabetic patients in the EG (mean 159.48 ± 40.71mg/dl) were lower by 13.55 ± 52.89 mg / dl than the preprandial blood glucose levels of the diabetic patients in the CG (mean 173.03 ± 65.07 mg/dl). It was determined at the end of the six-month monitoring that the A1c levels of the individuals in the EG were significinatly lowered by 0.49% in total, and that the A1c levels of the individuals in the CG were higher by 0.17 % in total. Conclusions: It was shown that videophone technology can be useful in the glycaemic control of diabetic patients in Turkey.","PeriodicalId":222395,"journal":{"name":"Diabetes and Islet Biology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129511375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The importance of multidisciplinary care of patients with Wolfram","authors":"R. Dennison","doi":"10.31579/2641-8975/006.2018","DOIUrl":"https://doi.org/10.31579/2641-8975/006.2018","url":null,"abstract":"Background: Wolfram syndrome is a genetic condition, which is typically inherited in autosomal recessive fashion, characterized by the combination of diabetes mellitus and optic atrophy. It is along a spectrum which encompasses DIDMOAD (Diabetes insipidus, diabetes mellitus, optic atrophy, and deafness). Profound hypoglycemic unawareness can be seen in this condition but is not commonly described as an associated feature in the literature. Case report: A 16 year old female with history of presumed type 1 diabetes presented to urology clinic with urinary incontinence. She was found to have profound dilation of the bladder and was admitted for bladder decompression. During the course of admission she was found to also have diabetes insipidus and optic atrophy. She had several severe hypoglycemic episodes with profound hypoglycemia unawareness during this admission. Genetic testing for Wolfram syndrome was positive. As an outpatient she was placed on a continuous glucose monitor to help manage her hypoglycemia. Addtionally, psychiatric support to manage her associated depression was an important aspect of her therapy. As her depression improved so did her ability to comply with the necessary therapies. Conclusions: Wolfram syndrome is a rare syndrome that has been well described. However, patients with this syndrome have frequent hypoglycemia unawareness and severe hypoglycemia likely related to the neurologic deterioration that occurs at the molecular level in the pathogenesis of Wolfram syndrome. Strategies must be put in to place to help prevent and quickly treat these hypoglycemic events.","PeriodicalId":222395,"journal":{"name":"Diabetes and Islet Biology","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124229187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilization of GTSN improved glycemic control and elevated GLP-1 release compared to a healthful breakfast food (oatmeal) and breakfast skipping without negatively impacting appetitive response or ene","authors":"Clarissa Lilli","doi":"10.31579/2641-8975/004","DOIUrl":"https://doi.org/10.31579/2641-8975/004","url":null,"abstract":"Background: For people with type 2 diabetes mellitus (T2DM), the frequency and/or composition of the morning meal may be especially important as the disease associated hormonal and metabolic perturbations contribute significantly to poor glucose control and weight gain. Few well-controlled studies have evaluated the effects of skipping breakfast and nutrient composition on metabolic outcomes in T2DM. This study evaluated the impact of consuming one of two convenient and healthful breakfast options versus skipping breakfast on postprandial blood glucose, insulin, glucagon-like peptide-1 (GLP-1), total energy intake and appetite. Materials and methods: This was a randomized, controlled, non-blinded, threetreatment, crossover study conducted at two sites. All subjects (n=32) had T2DM. On study day mornings, fasted subjects consumed each test meal in random order: the two nutritional interventions administered were (1) a typical whole food breakfast meal consisting of oatmeal (OAT; 200 kcals, 8g protein, 36g carbohydrate (CHO), 6g fiber, 4g fat) and (2) a calorically-matched glycemia-targeted specialized-nutrition (GTSN; 216 kcals, 10g protein, 29g CHO, 2g fiber and 8g fat) compared to (3) skipping breakfast (SBF). Blood samples for measurement of plasma glucose, insulin and GLP-1 and appetitive responses were collected at baseline (pre-meal) and after consumption of the test meal over 180 minutes. Results: Postprandial plasma glucose positive area under the curve (pAUC) mean was significantly reduced by 38% (based on individual percent changes) after GTSN compared to OAT. The SBF had the smallest glucose pAUC mean of all interventions. GLP-1 postprandial pAUC median of individual percent changes was significantly elevated after the consumption of GTSN by 280% compared to OAT and 995% compared to SBF. Subjective hunger pAUC mean was significantly elevated and fullness significantly lower after SBF compared to both the OAT and GTSN. No differences in hunger or fullness were observed between the GTSN and OAT interventions. Conclusion: This study demonstrated that utilization of GTSN improved glycemic control and elevated GLP-1 levels compared to a healthful breakfast food and breakfast skipping without negatively impacting appetitive response or energy intake. These results suggest that GTSN containing slowly digesting carbohydrates and monounsaturated fatty acids (MUFA) may provide additional metabolic benefits when used as a meal replacement compared to oatmeal and breakfast skipping for people with T2DM.","PeriodicalId":222395,"journal":{"name":"Diabetes and Islet Biology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130664189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tumor recognition and measurement from Sonography pictures of patients","authors":"F. Mnif","doi":"10.31579/2641-8975/002","DOIUrl":"https://doi.org/10.31579/2641-8975/002","url":null,"abstract":"Tumor Recognition and Measurement from Sonography Pictures of Patients Fatma MNIF*, Mohamed HSAIRI, Emna BENAISSA, Mohamed ABID Department of endocrinology CHU Hedi Chaker Sfax TUNISIA. *Corresponding Author : Fatma MNIF, Department of endocrinology CHU Hedi Chaker Sfax TUNISIA. E-mail: fatmamnif05@yahoo.fr. Received date: August 16, 2018; Accepted date : August 24, 2018; Published date: August 28, 2018. Citation for this Article: Fatma MNIF, Observational study of the Tunisian diabetic patients’ profile during the fasting of the holy month of Ramadan. J Diabetes and Islet Biology . Doi: 10.31579/2641-8975/002","PeriodicalId":222395,"journal":{"name":"Diabetes and Islet Biology","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122055941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review Article: SGLT2 inhibitors and Ketoacidosis: Epidemiology and Pathophysiology","authors":"U. Kabadi","doi":"10.31579/2641-8975/001","DOIUrl":"https://doi.org/10.31579/2641-8975/001","url":null,"abstract":"","PeriodicalId":222395,"journal":{"name":"Diabetes and Islet Biology","volume":"4226 4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127753350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real Time Clinical Safety and Effectiveness of Long Term Use of Saroglitazar in Indian Patients with Diabetic Dyslipidemia Having Abnormal Metabolic Parameters","authors":"S. Chatterjee","doi":"10.31579/2641-8975/003","DOIUrl":"https://doi.org/10.31579/2641-8975/003","url":null,"abstract":"Indian Patients with Diabetic Dyslipidemia Having Abnormal Metabolic Parameters Sanjay Chatterjee *, Majumder A , Ray S 1 and Bhattacharjee K . 1 Apollo Gleneagles Hospital, Kolkata, India. 2 KPC Medical College, Kolkata, India. 3 PhD Scholar, JJT University, India. *Corresponding Author : Sanjay Chatterjee, MD Consultant Diabetologist, Apollo Gleneagles Hospital, Kolkata, India. Email: Sanjay_doc@yahoo.co.in","PeriodicalId":222395,"journal":{"name":"Diabetes and Islet Biology","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129465149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Diabetes TRACK (by NEHEP) Vs Bangladesh","authors":"Abdul Kader Mohiuddin","doi":"10.31579/2641-8975/016","DOIUrl":"https://doi.org/10.31579/2641-8975/016","url":null,"abstract":"With the increasing burden of non-communicable diseases in low-income and middle-income countries (LMICs), biological risk factors, such as hyperglycemia, are a major public health concern in Bangladesh. Optimization of diabetes management by positive lifestyle changes is urgently required for prevention of comorbidities and complications, which in turn will reduce the cost. Diabetes had 2 times more days of inpatient treatment, 1.3 times more outpatient visits, and nearly 10 times more medications than non- diabetes patients, as reported by British Medical Journal. And surprisingly, 80% of people with this so called “Rich Man's Disease” live in low- and middle-income countries. According to a recent study of American Medical Association, China and India collectively are home of nearly 110 million diabetic patients. The prevalence of diabetes in this region is projected to increase by 71% by 2035. Bangladesh was ranked as the 8th highest diabetic populous country in the time period of 2010-2011. In Bangladesh, the estimated prevalence of diabetes among adults was 9.7% in 2011 and the number is projected to be 13.7 million by 2045. The cost of diabetes care is considerably high in Bangladesh, and it is primarily driven by the medicine and hospitalization costs. According to Bangladesh Bureau of Statistics, in 2017 the annual average cost per T2DM was $864.7, which is 52% of per capita GDP of Bangladesh and 9.8 times higher than the general health care cost. Medicine is the highest source of direct cost (around 85%) for patients without hospitalization. The private and public financing of diabetes treatment will be severely constrained in near future, representing a health threat for the Bangladeshi population.","PeriodicalId":222395,"journal":{"name":"Diabetes and Islet Biology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130082785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}