Technometrics最新文献

Spatiotemporal Interactive Modeling of Event-based Dynamic Networks. 基于事件的动态网络的时空交互建模。

IF 2.5 3区工程技术

Technometrics Pub Date : 2025-01-01 Epub Date: 2025-01-30 DOI: 10.1080/00401706.2024.2441679

Di Wang, Xiaochen Xian, Haidong Li

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引用次数: 0

Bayesian Model Calibration and Sensitivity Analysis for Oscillating Biological Experiments. 生物振荡实验贝叶斯模型标定及灵敏度分析。

IF 2.5 3区工程技术

Technometrics Pub Date : 2025-01-01 Epub Date: 2025-02-03 DOI: 10.1080/00401706.2024.2444310

Youngdeok Hwang, Hang J Kim, Won Chang, Christian Hong, Steven N MacEachern

{"title":"Bayesian Model Calibration and Sensitivity Analysis for Oscillating Biological Experiments.","authors":"Youngdeok Hwang, Hang J Kim, Won Chang, Christian Hong, Steven N MacEachern","doi":"10.1080/00401706.2024.2444310","DOIUrl":"10.1080/00401706.2024.2444310","url":null,"abstract":"Understanding the oscillating behaviors that govern organisms' internal biological processes requires interdisciplinary efforts combining both biological and computer experiments, as the latter can complement the former by simulating perturbed conditions with higher resolution. Harmonizing the two types of experiment, however, poses significant statistical challenges due to identifiability issues, numerical instability, and ill behavior in high dimension. This article devises a new Bayesian calibration framework for oscillating biochemical models. The proposed Bayesian model is estimated relying on an advanced Markov chain Monte Carlo (MCMC) technique which can efficiently infer the parameter values that match the simulated and observed oscillatory processes. Also proposed is an approach to sensitivity analysis based on the intervention posterior. This approach measures the influence of individual parameters on the target process by using the obtained MCMC samples as a computational tool. The proposed framework is illustrated with circadian oscillations observed in a filamentous fungus, Neurospora crassa.","PeriodicalId":22208,"journal":{"name":"Technometrics","volume":"67 2","pages":"333-343"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12720118/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145820718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Note on the Equivalence of Orthogonalizing EM and Proximal Gradient Descent. 关于正交化EM与近端梯度下降的等价性的注记。

IF 2.5 3区工程技术

Technometrics Pub Date : 2025-01-01 Epub Date: 2024-12-23 DOI: 10.1080/00401706.2024.2430204

James Yang, Trevor Hastie

引用次数: 0

Bayesian sequential design of computer experiments for quantile set inversion 用于量子集合反演的计算机实验的贝叶斯序列设计

IF 2.5 3区工程技术

Technometrics Pub Date : 2024-08-23 DOI: 10.1080/00401706.2024.2394475

Romain Ait Abdelmalek-Lomenech, Julien Bect, Vincent Chabridon, Emmanuel Vazquez