Systems and Synthetic Biology最新文献_第3页

TGF-β signaling and its role in the regulation of hematopoietic stem cells. TGF-β信号传导及其在造血干细胞调控中的作用。

Systems and Synthetic Biology Pub Date : 2015-06-01 Epub Date: 2015-01-29 DOI: 10.1007/s11693-015-9161-2

Anuradha Vaidya, Vaijayanti P Kale

引用次数: 57

Boolean network model for GPR142 against Type 2 diabetes and relative dynamic change ratio analysis using systems and biological circuits approach. GPR142抗2型糖尿病的布尔网络模型及基于系统和生物电路方法的相对动态变化比分析。

Systems and Synthetic Biology Pub Date : 2015-06-01 Epub Date: 2015-03-14 DOI: 10.1007/s11693-015-9163-0

Aman Chandra Kaushik, Shakti Sahi

{"title":"Boolean network model for GPR142 against Type 2 diabetes and relative dynamic change ratio analysis using systems and biological circuits approach.","authors":"Aman Chandra Kaushik, Shakti Sahi","doi":"10.1007/s11693-015-9163-0","DOIUrl":"https://doi.org/10.1007/s11693-015-9163-0","url":null,"abstract":"Systems biology addresses challenges in the analysis of genomics data, especially for complex genes and protein interactions using Meta data approach on various signaling pathways. In this paper, we report systems biology and biological circuits approach to construct pathway and identify early gene and protein interactions for predicting GPR142 responses in Type 2 diabetes. The information regarding genes, proteins and other molecules involved in Type 2 diabetes were retrieved from literature and kinetic simulation of GPR142 was carried out in order to determine the dynamic interactions. The major objective of this work was to design a GPR142 biochemical pathway using both systems biology as well as biological circuits synthetically. The term 'synthetically' refers to building biological circuits for cell signaling pathway especially for hormonal pathway disease. The focus of the paper is on logical components and logical circuits whereby using these applications users can create complex virtual circuits. Logic gates process represents only true or false and investigates whether biological regulatory circuits are active or inactive. The basic gates used are AND, NAND, OR, XOR and NOT gates and Integrated circuit composition of many such basic gates and some derived gates. Biological circuits may have a futuristic application in biomedical sciences which may involve placing a micro chip in human cells to modulate the down or up regulation of hormonal disease. ","PeriodicalId":22161,"journal":{"name":"Systems and Synthetic Biology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11693-015-9163-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33304195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

Computational identification of novel microRNAs and their targets in the malarial vector, Anopheles stephensi. 疟媒斯氏按蚊新型microrna及其靶标的计算鉴定。

Systems and Synthetic Biology Pub Date : 2015-06-01 Epub Date: 2015-02-21 DOI: 10.1007/s11693-014-9159-1

Remya Krishnan, Vinod Kumar, Vivek Ananth, Shailja Singh, Achuthsankar S Nair, Pawan K Dhar

{"title":"Computational identification of novel microRNAs and their targets in the malarial vector, Anopheles stephensi.","authors":"Remya Krishnan, Vinod Kumar, Vivek Ananth, Shailja Singh, Achuthsankar S Nair, Pawan K Dhar","doi":"10.1007/s11693-014-9159-1","DOIUrl":"https://doi.org/10.1007/s11693-014-9159-1","url":null,"abstract":"MicroRNAs are a ~22 nucleotide small non-coding RNAs found in animals, plants and viruses. They regulate key cellular processes by enhancing, degrading or silencing protein coding targets. Currently most of the data on miRNA is available from Drosophila . Given their important post-transcriptional role in several organisms, there is a need to understand the miRNA mediated processes in normal and abnormal conditions. Here we report four novel microRNAs ast - mir - 2502, ast - mir - 2559, ast - mir - 3868 and ast - mir - 9891 in Anopheles stephensi identified from a set of 3,052 transcriptome sequences, showing average minimum free energy of -31.8 kcal/mol of duplex formation with mRNA indicating their functional relevance. Phylogenetic study shows conservation of sequence signatures within the Class Insecta. Furthermore, 26 potential targets of these four miRNAs have been predicted that play an important role in the mosquito life-cycle. This work leads to novel leads and experimental possibilities for improved understanding of gene regulatory processes in mosquito. ","PeriodicalId":22161,"journal":{"name":"Systems and Synthetic Biology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11693-014-9159-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33304192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Diversity oriented synthesis for novel anti-malarials 面向多样性的新型抗疟疾药物合成

Systems and Synthetic Biology Pub Date : 2015-05-10 DOI: 10.1007/s11693-015-9171-0

C. Bathula, Shailja Singh, S. Sen

引用次数: 2

Innovative techniques to discover novel antimalarials 发现新型抗疟药的创新技术

Systems and Synthetic Biology Pub Date : 2015-04-19 DOI: 10.1007/s11693-015-9170-1

Santanu Hati, S. Bhattacharya, S. Sen

引用次数: 1

In silico characterization of Plasmodium falciparum purinergic receptor: a novel chemotherapeutic target 恶性疟原虫嘌呤能受体的计算机表征:一种新的化疗靶点

Systems and Synthetic Biology Pub Date : 2015-04-09 DOI: 10.1007/s11693-015-9165-y

Sonal Gupta, D. Singh, Shailja Singh

引用次数: 5

Structural insights into a key carotenogenesis related enzyme phytoene synthase of P. falciparum: a novel drug target for malaria 恶性疟原虫关键胡萝卜素生成相关酶植物烯合成酶的结构见解:一种新的疟疾药物靶点

Systems and Synthetic Biology Pub Date : 2015-04-09 DOI: 10.1007/s11693-015-9168-8

Shalini Agarwal, Shalini Agarwal, Vijeta Sharma, S. Phulera, M. Abdin, R. Ayana, Shailja Singh

引用次数: 5

In silico analysis of calcium binding pocket of perforin like protein 1: insights into the regulation of pore formation 孔蛋白样蛋白1的钙结合袋的硅分析:孔形成调控的见解

Systems and Synthetic Biology Pub Date : 2015-04-08 DOI: 10.1007/s11693-015-9166-x

S. Garg, Vijeta Sharma, Dandugudumula Ramu, Shailja Singh

引用次数: 6

Visualization and quantification of Plasmodium falciparum intraerythrocytic merozoites 恶性疟原虫红细胞内分裂子的可视化和定量

Systems and Synthetic Biology Pub Date : 2015-04-05 DOI: 10.1007/s11693-015-9167-9

S. Garg, Shalini Agarwal, S. Dabral, Naveen Kumar, Seema Sehrawat, Shailja Singh

引用次数: 12

Computational model for monitoring cholesterol metabolism. 监测胆固醇代谢的计算模型。

Systems and Synthetic Biology Pub Date : 2014-12-01 Epub Date: 2014-08-01 DOI: 10.1007/s11693-014-9152-8

R Selvakumar, M Rashith Muhammad, G Poornima Devi

{"title":"Computational model for monitoring cholesterol metabolism.","authors":"R Selvakumar, M Rashith Muhammad, G Poornima Devi","doi":"10.1007/s11693-014-9152-8","DOIUrl":"https://doi.org/10.1007/s11693-014-9152-8","url":null,"abstract":"A non-deterministic finite automaton is designed to observe the cholesterol metabolism with the states of acceptance and rejection. The acceptance state of the automaton depicts the normal level of metabolism and production of good cholesterol as an end product. The rejection state of this machine shows the inhibition of enzymatic activity in cholesterol synthesis and removal of free fatty acids. The deficiency in human cholesterol metabolism pathway results in abnormal accumulation of cholesterol in plasma, arterial tissues leading to diseases such as hypercholesterolemia, atherosclerosis respectively and formation of gallstones. The designed machine can be used to monitor the cholesterol metabolism at molecular level through regulation of enzymes involved in the biosynthesis and metabolism of cholesterol for the treatment of diseases incident due to the respective metabolic disorder. In addition, an algorithm for this machine has been developed to compare the programmed string with the given string. This study demonstrates the construction of a machine that is used for the development of molecular targeted therapy for the disorders in cholesterol metabolism. ","PeriodicalId":22161,"journal":{"name":"Systems and Synthetic Biology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11693-014-9152-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34094482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1