Soft Materials最新文献_第10页

Phase transitions and phase coexistence: equilibrium systems versus externally driven or active systems - Some perspectives 相变与相共存:平衡系统与外部驱动或主动系统——一些观点

IF 1.2 4区材料科学

Soft Materials Pub Date : 2021-06-10 DOI: 10.1080/1539445X.2021.1906703

K. Binder, P. Virnau

引用次数: 7

Tannic acid-crosslinked chitosan matrices enhance osteogenic differentiation and modulate epigenetic status of cultured cells over glutaraldehyde crosslinking 单宁酸交联壳聚糖基质通过戊二醛交联促进细胞成骨分化并调节细胞表观遗传状态

IF 1.2 4区材料科学

Soft Materials Pub Date : 2021-06-04 DOI: 10.1080/1539445X.2021.1933032

Veena Acharya, Aritri Ghosh, A. Chowdhury, P. Datta

{"title":"Tannic acid-crosslinked chitosan matrices enhance osteogenic differentiation and modulate epigenetic status of cultured cells over glutaraldehyde crosslinking","authors":"Veena Acharya, Aritri Ghosh, A. Chowdhury, P. Datta","doi":"10.1080/1539445X.2021.1933032","DOIUrl":"https://doi.org/10.1080/1539445X.2021.1933032","url":null,"abstract":"ABSTRACT Tannic acid (TA) is a polyphenol with potential to crosslink biomacromolecules. Though, feasibility of TA crosslinking is known, the more toxic glutaraladehyde (GA) continue to be used extensively for developing novel chitosan-based scaffolds, hindering in vivo translation. Thus, a direct comparison between TA- and GA-crosslinked chitosan membranes with respect to physico-chemical, biocomptability and biofunctional properties is required. Role of TA to modulate epigenetic changes in cultured cells is also investigated. TA-crosslinked scaffolds differed from GA in contact angle and swelling by 20–25% while mechanical properties and degradation differed by 50%. Cell viability on TA-crosslinked scaffolds was ~1.4 times higher compared to GA-crosslinked samples, osteocalcin expression was two-fold higher and ROS and cox-2 expression was reduced by ~1.4 times (p < .01). TA crosslinking modulated epigenetic changes in cultured cells by evidencing global DNA hypomethylation. It is concluded that TA can provide a flexible scaffold with ability to modulate epigenetics and osteogeneticity.","PeriodicalId":22140,"journal":{"name":"Soft Materials","volume":"20 1","pages":"149 - 160"},"PeriodicalIF":1.2,"publicationDate":"2021-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/1539445X.2021.1933032","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46556063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Domain Growth in the Active Model B: Critical and Off-critical Composition 主动模型B中的域增长：临界和非临界组合

IF 1.2 4区材料科学

Soft Materials Pub Date : 2021-05-27 DOI: 10.1080/1539445X.2021.1937223

Sudipta Pattanayak, Shradha Mishra, S. Puri

{"title":"Domain Growth in the Active Model B: Critical and Off-critical Composition","authors":"Sudipta Pattanayak, Shradha Mishra, S. Puri","doi":"10.1080/1539445X.2021.1937223","DOIUrl":"https://doi.org/10.1080/1539445X.2021.1937223","url":null,"abstract":"ABSTRACT We study the ordering kinetics of an assembly of active Brownian particles (ABPs) on a two-dimensional substrate. We use a coarse-grained equation for the composition order parameter ,where and denote space and time, respectively. The model is similar to the Cahn-Hilliard equation orModel B (MB) for a conserved order parameter with an additional activity term of strength . This model has been introduced by Wittkowski et al., Nature Comm. 5, 4351 (2014), and is termed Active Model B (AMB). We study domain growth kinetics and dynamical scaling of the correlation function for the AMB with critical and off-critical compositions. The quantity governs the asymptotic growth kinetics for the off-critical AMB, where denotes the average order parameter. For negative ,the domain growth law is the usual Lifshitz-Slyozov growth law with . For positive ,the growth law shows a crossover to a novel growth law . Further, the correlation function shows good dynamical scaling for the off-critical AMB but the scaling function has a dependency on and . We also study the effects of both additive and multiplicative noise on the AMB.","PeriodicalId":22140,"journal":{"name":"Soft Materials","volume":"19 1","pages":"286 - 296"},"PeriodicalIF":1.2,"publicationDate":"2021-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/1539445X.2021.1937223","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47822363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Self-assembled peptide-conjugated rosemary extract derivatives as drug delivery vehicles for targeting tumor cells 自组装肽偶联迷迭香提取物衍生物作为靶向肿瘤细胞的药物递送载体

IF 1.2 4区材料科学

Soft Materials Pub Date : 2021-05-21 DOI: 10.1080/1539445X.2021.1926282

Lucy R. Hart, Saige M. Mitchell, P. A. McCallum, Rachel E. Daso, I. Banerjee

{"title":"Self-assembled peptide-conjugated rosemary extract derivatives as drug delivery vehicles for targeting tumor cells","authors":"Lucy R. Hart, Saige M. Mitchell, P. A. McCallum, Rachel E. Daso, I. Banerjee","doi":"10.1080/1539445X.2021.1926282","DOIUrl":"https://doi.org/10.1080/1539445X.2021.1926282","url":null,"abstract":"ABSTRACT Self-assembled supramolecular structures have gained attention due to their wide range of applications. In this work, we have created two novel drug delivery systems for targeting MCF-7 breast cancer cells using polyphenols derived from rosemary extract. The assemblies were synthesized by conjugating rosmarinic acid (RMA) and carnosic acid (CSA) with the peptide sequence H-A-I-L-L-I-T-K-G-I-F-K known for its ability to target MCF-7 breast cancer cells. The products were self-assembled into nanofibers or oblong shaped nanoassemblies. The mechanism of self-assembly was probed by COSMOS-RS computational studies. The assemblies were utilized to entrap the drug topotecan. Entrapment efficiency varied based on the morphology of the assemblies and concentration (42.3% for carnosic acid-peptide assemblies and 59.11% for rosmarinic acid-peptide assemblies). Furthermore, the RMA-peptide and CSA-peptide assemblies were found to be cytotoxic toward MCF-7 breast cancer cells, with relatively higher cytotoxicity observed for the topotecan entrapped CSA-peptide assemblies compared to topotecan entrapped RMA-peptide assemblies. Docking studies were conducted to examine binding interactions of the RMA-peptide and CSA-peptide conjugates with Src kinase receptor and estrogen receptor. Furthermore, CSA-peptide assemblies induced apoptosis while RMA-peptide assemblies induced necrosis. Our results indicate that such new biomimetic materials derived from naturally occurring polyphenols may be developed for dual targeting tumor cells.","PeriodicalId":22140,"journal":{"name":"Soft Materials","volume":"20 1","pages":"109 - 128"},"PeriodicalIF":1.2,"publicationDate":"2021-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/1539445X.2021.1926282","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42542705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Langmuir and Langmuir–Blodgett films of aromatic amphiphiles 芳香两亲体的Langmuir膜和Langmuir - blodgett膜

IF 1.2 4区材料科学

Soft Materials Pub Date : 2021-05-16 DOI: 10.1080/1539445X.2021.1922443

R. S. Singh

{"title":"Langmuir and Langmuir–Blodgett films of aromatic amphiphiles","authors":"R. S. Singh","doi":"10.1080/1539445X.2021.1922443","DOIUrl":"https://doi.org/10.1080/1539445X.2021.1922443","url":null,"abstract":"ABSTRACT Amphiphiles are molecules that contain two discrete segments – a water-soluble hydrophilic part (head-group) and a water-insoluble hydrophobic part (tail). The structural variations possible with the head-group part are enormous and numerous amphiphiles have been designed in this way. On the other hand, the structural variations feasible for the hydrophobic tail part are rather limited. Saturated aliphatic hydrocarbon chains are predominantly found in most of the amphiphiles. Unsaturated aliphatic hydrocarbon chains (n-alkenyl or n-alkynyl chains) also serve as the hydrophobic tail part in many of the amphiphiles. Amphiphiles, wherein the hydrophobic tail part is made up of aromatic moieties (alone or in combination with aliphatic chains) are less frequently encountered compared to the other two types. Many of these aromatic amphiphiles, the focus of this review article, are known to form different types of assemblies including Langmuir and Langmuir-Blodgett (LB) films. In this review, we will provide an account of the different types of aromatic amphiphiles that have been reported and highlight their properties and applications at the air–water and air–solid interfaces.","PeriodicalId":22140,"journal":{"name":"Soft Materials","volume":"20 1","pages":"57 - 98"},"PeriodicalIF":1.2,"publicationDate":"2021-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/1539445X.2021.1922443","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43666369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Electric-field-guided 3D manipulation of liquid metal microfleas 电场引导的液态金属微流控芯片的三维操作

IF 1.2 4区材料科学

Soft Materials Pub Date : 2021-05-15 DOI: 10.1080/1539445X.2021.1926283

Yongxin Wang, Yanbing Kuai, G. Zhang, Hairui Zhang, J. Cong, Yunli Xu, Lizhi Yi, Min Liu, Yiman Liu

{"title":"Electric-field-guided 3D manipulation of liquid metal microfleas","authors":"Yongxin Wang, Yanbing Kuai, G. Zhang, Hairui Zhang, J. Cong, Yunli Xu, Lizhi Yi, Min Liu, Yiman Liu","doi":"10.1080/1539445X.2021.1926283","DOIUrl":"https://doi.org/10.1080/1539445X.2021.1926283","url":null,"abstract":"ABSTRACT Liquid metal micromotors have attracted mounting interest over the past decade, but their property of sticking to many surfaces has limited their controllable manipulation in three dimensions (3-D). In this work, we demonstrate a versatile and generic approach in manipulating Gallium-based liquid metal microfleas (LMMFs) on solid surfaces by strategically applied electric (E-) fields, in which the adhesion of LMMFs to solid surfaces is greatly reduced by tailoring the thickness of the oxide skins of the liquid metal. Numerical simulations and experimental demonstrations illustrate that the LMMFs can be readily driven to jump along prescribed trajectories with high localization accuracy (the order of ~10 microns). The prowess of the precision manipulation of LMMFs is further demonstrated in several practical applications, including the walking of LMMFs on the stairs, the micro-welding for cracked conducting wire, as well as the on-demand jumping of LMMFs on a “mini-piano.” Such a proposed approach provides a convenient, rather generic, E-field-based strategy for manipulation of LMMFs in non-liquid environments with a configurable, switchable, and programmable fashion, offering considerable potential for diverse practical applications in the near future.","PeriodicalId":22140,"journal":{"name":"Soft Materials","volume":"20 1","pages":"129 - 136"},"PeriodicalIF":1.2,"publicationDate":"2021-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/1539445X.2021.1926283","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45606868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Preparation and characterization of polyvinyl alcohol/ sodium alginate/carboxymethyl cellulose composite hydrogels with oriented structure 定向结构聚乙烯醇/海藻酸钠/羧甲基纤维素复合水凝胶的制备与表征

IF 1.2 4区材料科学

Soft Materials Pub Date : 2021-05-12 DOI: 10.1080/1539445X.2021.1926281

Kai Chen, Tian-Xiang Zong, Qin Chen, Siyu Liu, Linmin Xu, Dekun Zhang

{"title":"Preparation and characterization of polyvinyl alcohol/ sodium alginate/carboxymethyl cellulose composite hydrogels with oriented structure","authors":"Kai Chen, Tian-Xiang Zong, Qin Chen, Siyu Liu, Linmin Xu, Dekun Zhang","doi":"10.1080/1539445X.2021.1926281","DOIUrl":"https://doi.org/10.1080/1539445X.2021.1926281","url":null,"abstract":"ABSTRACT In order to control complex motion behavior in organisms, most biological tissues have highly oriented structures and anisotropic mechanical properties, such as articular cartilage, muscle, skin and blood vessel. In this study, inspired by the directional structure and excellent mechanical properties of biological soft tissues, polyvinyl alcohol/carboxymethyl cellulose hydrogels with different contents of sodium alginate were prepared by combining freeze-thaw and prestretching methods. Compared with SEM images without pre-stretch hydrogels, there are obvious ordered pore structures in the pre-stretch samples along the tensile direction, and the network structure becomes denser. XRD and FTI R results indicate that the introduction of SA and CMC increases the number of internal hydrogen bond and forms new covalent bonds. The tensile strength of the hydrogel without annealing and stretching treatments is only 0.41MPa. After annealing and stretching treatments, the tensile strength of the hydrogel is increased to 0.93MPa. Furthermore, the creep deformation of hydrogel was reduced from 1.08 mm to 0.27 mm by annealing and stretching treatments. To sum up, these results suggested that PVA/SA/CMC composite hydrogels with oriented structure might have potential applications in soft tissue repair and other biomaterials.","PeriodicalId":22140,"journal":{"name":"Soft Materials","volume":"20 1","pages":"99 - 108"},"PeriodicalIF":1.2,"publicationDate":"2021-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/1539445X.2021.1926281","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47982286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Morphology and cellular-traction of fibroblasts on 2D silk-fibroin hydrogel substrates 成纤维细胞在二维丝-纤维蛋白水凝胶基质上的形态和细胞牵引

IF 1.2 4区材料科学

Soft Materials Pub Date : 2021-05-01 DOI: 10.1080/1539445X.2021.1918719

P. Edwin, N. R. Rajagopalan, S. Bajpai

{"title":"Morphology and cellular-traction of fibroblasts on 2D silk-fibroin hydrogel substrates","authors":"P. Edwin, N. R. Rajagopalan, S. Bajpai","doi":"10.1080/1539445X.2021.1918719","DOIUrl":"https://doi.org/10.1080/1539445X.2021.1918719","url":null,"abstract":"ABSTRACT Development of clinically amenable bio-implants with silk-fibroin (SF) necessitates characterization of cellular-traction generated between cells and the substrate. However, studies on the biomechanical response of cells on SF substrates are limited. In this study, we prepared SF hydrogels of varying compliance (SF30 and SF50) and varying surface-ligands (derivatized with poly-L-lysine (PLL) or Arg-Gly-Asp (RGD) peptide). Subsequently, NIH-3T3 fibroblast cells were grown on these substrates, and the morphological changes was examined. It was observed that the increase in SF stiffness from 0.7 kPa to 3.1 kPa decreased nucleus-to-cytoplasm area-ratio and increased asymmetricity along the major-axis of cells. Moreover, while functionalization of SF with RGD induced increase in cell-area and circularity, functionalization with PLL did not cause any change. Next, using traction-force-microscopy (TFM), we quantified 2D cell-traction for NIH-3T3 cells cultured on SF hydrogels. Cells plated on SF50 hydrogel exhibited significantly high traction stress as compared to SF30; change of functionalization did not show significant change. Also, protrusion traction stress was found to be greater than nuclear traction stress. Put together, our results suggest that surface-stiffness of SF-hydrogel, rather than nature of surface-ligand, regulates both cellular morphology and cellular traction stresses.","PeriodicalId":22140,"journal":{"name":"Soft Materials","volume":"20 1","pages":"45 - 56"},"PeriodicalIF":1.2,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/1539445X.2021.1918719","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49199361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

A study of thickness dependent microstructure of poly (3-hexylthiophene) thin films using grazing incidence x-ray diffraction 用掠入射x射线衍射研究聚(3-己基噻吩)薄膜的厚度相关微观结构

IF 1.2 4区材料科学

Soft Materials Pub Date : 2021-04-26 DOI: 10.1080/1539445X.2021.1909621

Manoj Kumar, Srihari Velaga, Amarjeet Singh

{"title":"A study of thickness dependent microstructure of poly (3-hexylthiophene) thin films using grazing incidence x-ray diffraction","authors":"Manoj Kumar, Srihari Velaga, Amarjeet Singh","doi":"10.1080/1539445X.2021.1909621","DOIUrl":"https://doi.org/10.1080/1539445X.2021.1909621","url":null,"abstract":"ABSTRACT Thin films of poly (3-hexylthiophene), abbreviated as P3HT, are widely used systems of semiconducting polymer for applications in organic electronic devices. We studied the microstructure of spin-coated thin films of P3HT using grazing incidence x-ray diffraction (GID) by combining high-resolution vertical scan with 2D intensity maps obtained using area detector. Microstructure of the films was quantitatively analyzed in terms of relative crystalline density, texture and coherence length. The structure of the films was relaxed by annealing at 110°C. The relaxed microstructure shows strong thickness dependence. Thick film (61 nm) was highly crystalline and textured. For thin film (32 nm), relative crystalline density was very weak but the coherence length of crystallites was larger and the orientation of crystallites was even more strongly textured. For thick film, the strong increase of crystalline density takes place through fresh nucleation and reorientation of crystallites already present in the films. For thin films, the substrate interaction induced very strong alignment of lamellar crystallites through degeneration of off-oriented crystallites and increased lamellar crystalline coherence. The drastic change of microstructure within a small thickness range is an important aspect to be considered while preparing thin film devices.","PeriodicalId":22140,"journal":{"name":"Soft Materials","volume":"20 1","pages":"24 - 34"},"PeriodicalIF":1.2,"publicationDate":"2021-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/1539445X.2021.1909621","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46111729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Chitosan-coated poly(є-caprolactone) nanocapsules for mucoadhesive applications of perillyl alcohol 壳聚糖包被聚(є-caprolactone)纳米胶囊紫苏醇粘接应用

IF 1.2 4区材料科学

Soft Materials Pub Date : 2021-04-21 DOI: 10.1080/1539445X.2021.1906702

Larissa Penteado, V. F. Lopes, T. K. Karam, C. Nakamura, N. Khalil, R. Mainardes

{"title":"Chitosan-coated poly(є-caprolactone) nanocapsules for mucoadhesive applications of perillyl alcohol","authors":"Larissa Penteado, V. F. Lopes, T. K. Karam, C. Nakamura, N. Khalil, R. Mainardes","doi":"10.1080/1539445X.2021.1906702","DOIUrl":"https://doi.org/10.1080/1539445X.2021.1906702","url":null,"abstract":"ABSTRACT Perillyl alcohol (POH) is an essential oil found in several plants and presents significant therapeutic and chemo-preventive activity against some tumors. However, it exhibits low aqueous solubility and thereby reduced oral absorption and bioavailability. Nanoencapsulation of POH can be an important tool to overcome such limitations. In this work, chitosan was used for coating poly (ε-caprolactone) nanocapsules for mucoadhesive applications of POH. The nanocapsules were obtained by the nanoprecipitation method and presented a mean diameter of about 330 nm, spherical morphology, polydispersity index of 0.14, zeta potential of +32 mV, and POH encapsulation efficiency of 56%. POH was prolonged released from nanocapsules. In mucoadhesion studies, nanocapsules showed higher adsorption to mucin compared to free POH, possibly due to electrostatic interactions between chitosan and mucin. In the cytotoxicity assay, POH-loaded nanocapsules presented higher IC50 than free POH; however, they were more selective for HT-29 tumor cells than for normal Vero cells. The results demonstrate the potential application of chitosan-coated nanocapsules for the oral administration of POH intended for cancer therapy.","PeriodicalId":22140,"journal":{"name":"Soft Materials","volume":"20 1","pages":"1 - 11"},"PeriodicalIF":1.2,"publicationDate":"2021-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/1539445X.2021.1906702","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46939565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4