Translation: The University of Toledo Journal of Medical Sciences最新文献_第9页

“Clozapine & Valbenazine for Treatment of Tardive Cervical Dystonia: A Case Report” 氯氮平联合缬苯那嗪治疗迟发性颈肌张力障碍1例

Translation: The University of Toledo Journal of Medical Sciences Pub Date : 2023-07-06 DOI: 10.46570/utjms.vol11-2023-526

Chandani Lewis, C. Brennan

{"title":"“Clozapine & Valbenazine for Treatment of Tardive Cervical Dystonia: A Case Report”","authors":"Chandani Lewis, C. Brennan","doi":"10.46570/utjms.vol11-2023-526","DOIUrl":"https://doi.org/10.46570/utjms.vol11-2023-526","url":null,"abstract":"Cervical dystonia is a subtype of tardive dyskinesia characterized by smooth, sustained muscle contractions affecting the head, neck, and shoulders. This condition can be caused by antipsychotic medication exposure. It has a significant impact on the patient’s quality of life and represents a treatment challenge for providers. We present the case of a 26-year-old male with a history of schizophrenia treated with antipsychotic medications who presented with on and off smooth twisting movements of his neck and hand tremors. He was initially treated with benztropine and a decrease in the dose of his antipsychotic medications. However, when his symptoms continued to worsen, he was cross tapered to clozapine and valbenazine. Valbenazine is a VMAT2 inhibitor FDA approved for treatment of tardive dyskinesia, but there is little data regarding its use for tardive dystonia. The cervical dystonia impact profile-58 (CDIP-58) was administered to monitor the patient’s symptoms. Overall, there was a reduction in cervical dystonia symptoms within a 10-week period. This case illustrates the potential for clozapine plus valbenazine to treat tardive cervical dystonia.","PeriodicalId":220681,"journal":{"name":"Translation: The University of Toledo Journal of Medical Sciences","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115914185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel Gene Abnormality in Epilepsy with Myoclonic-Atonic Seizures (Doose Syndrome) 癫痫伴肌阵挛性失张力发作(Doose综合征)的新基因异常

Translation: The University of Toledo Journal of Medical Sciences Pub Date : 2023-07-06 DOI: 10.46570/utjms.vol11-2023-551

Rayan Magsi, Casey A Ryan, Ajaz Sheikh, M. Noor, N. Mahfooz

{"title":"Novel Gene Abnormality in Epilepsy with Myoclonic-Atonic Seizures (Doose Syndrome)","authors":"Rayan Magsi, Casey A Ryan, Ajaz Sheikh, M. Noor, N. Mahfooz","doi":"10.46570/utjms.vol11-2023-551","DOIUrl":"https://doi.org/10.46570/utjms.vol11-2023-551","url":null,"abstract":"Introduction: \u0000Doose Syndrome is a myoclonic-atonic seizure disorder most prominent in the pediatric population. Several common genetic mutations have been identified. However, SUOX gene mutations have not yet been correlated with Doose Syndrome. \u0000Case Report: \u0000At the age of 5, the patient presented with absence seizures followed by the development of generalized tonic-clonic and myoclonic-atonic seizures. She was diagnosed with Doose Syndrome based on her clinical presentation and EEG findings. An MRI found an incidental left choroidal fissure cyst. Multiple medical interventions failed to control seizures. To date, the patient has shown partial response to clobazam (40 mg/day), phenobarbital (97.5 mg/day), and a ketogenic diet. \u0000Conclusion: \u0000SUOX gene defects have been associated with isolated sulfite oxidase deficiency. However, our patient did not have the typical presentation, progression, and symptomology of this disorder. Instead, several possible sources for the seizures were identified; the mutation itself, focal seizures originating from the brain lesion which then generalizes mimicking Doose Syndrome, or a synergistic role between the cyst and genetic mutation.","PeriodicalId":220681,"journal":{"name":"Translation: The University of Toledo Journal of Medical Sciences","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132699175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Symptomatic Intracranial Hypertension Secondary to Superior Vena Cava Thrombosis as the First Manifestation of Behçet’s Disease 继发于上腔静脉血栓形成的症状性颅内高压是behet病的首要表现

Translation: The University of Toledo Journal of Medical Sciences Pub Date : 2023-07-06 DOI: 10.46570/utjms.vol11-2023-550

Payam Sadry, Rayan Magsi, Maahum Ahmed, Jennifer Amsdell, Talal Derani, N. Mahfooz, Ajaz Sheikh

{"title":"Symptomatic Intracranial Hypertension Secondary to Superior Vena Cava Thrombosis as the First Manifestation of Behçet’s Disease","authors":"Payam Sadry, Rayan Magsi, Maahum Ahmed, Jennifer Amsdell, Talal Derani, N. Mahfooz, Ajaz Sheikh","doi":"10.46570/utjms.vol11-2023-550","DOIUrl":"https://doi.org/10.46570/utjms.vol11-2023-550","url":null,"abstract":"Introduction: \u0000Behçet’s disease (BD) is a rare inflammatory autoimmune disorder characterized by recurrent oral and genital ulcers, uveitis, and other systemic manifestations. Reported neurological manifestations of BD include meningoencephalitis, cerebral venous thrombosis, intracranial hypertension (ICH), and cranial nerve palsies. Involvement of the superior vena cava (SVC) is rare but should be considered in patients with BD with suspected ICH. \u0000Case Report: \u0000A 32-year-old man presented with ICH as the initial manifestation of BD. He presented with a one-week history of facial and neck edema, headache, and blurry vision, followed by fever, sore throat, and oral blisters a few days later. Lumbar puncture (LP) was performed, and opening pressure was found to be elevated at >50 cmH2O and closing pressure of 36 cmH2O. The work-up included a chest CT, which identified thrombosis of the SVC extending into the brachiocephalic veins, and blood work which revealed elevated inflammatory markers. Further probing revealed a history of genital ulcers and a family history of a cousin with BD. The patient underwent mechanical thrombectomy and was treated with oral prednisone with symptom resolution. \u0000Conclusion: \u0000BD has a wide spectrum of symptomology and may present without common manifestations, making it challenging to diagnose. The aim of our report was to emphasize the importance exploring the rarer vascular, neurological, and cardiac symptoms of BD in order to avoid potentially dangerous sequala. A system approach may be necessary to diagnose and optimally treat these patients.","PeriodicalId":220681,"journal":{"name":"Translation: The University of Toledo Journal of Medical Sciences","volume":"9 4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116779907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ehrlichiosis in Southern Ohio: Two case reports and a review of the literature 俄亥俄州南部的埃利希体病:两例报告和文献综述

Translation: The University of Toledo Journal of Medical Sciences Pub Date : 2023-07-06 DOI: 10.46570/utjms.vol11-2023-360

R. Gotfried

{"title":"Ehrlichiosis in Southern Ohio: Two case reports and a review of the literature","authors":"R. Gotfried","doi":"10.46570/utjms.vol11-2023-360","DOIUrl":"https://doi.org/10.46570/utjms.vol11-2023-360","url":null,"abstract":"Tick-borne disease is becoming more commonplace as humans encroach on endemic regions with high tick preponderance. The incidence of ehrlichiosis is rising in conjunction with the increasing prevalence of its associated vector, Amblyomma americanum. In Ohio, populations of A. americanum have been expanding their range and growing in abundance and distribution. Southern Ohio in particular, has been identified as having a expanding population of E. chaffeensis infected ticks. The initial symptoms of ehrlichiosis are frequently vague and ill-defined. Often patients are not aware of having sustained a tick bite. Successful diagnosis and treatment of ehrlichiosis requires an index of suspicion, an awareness of local epidemiology, and prompt recognition of characteristic laboratory abnormalities consistent with E. chaffeensis infection. Patients in regions where these infections are known to exist, who present during tick season with fever, leukopenia and/or thrombocytopenia, and increased serum transaminase levels, should have ehrlichiosis included in the differential diagnosis. Left untreated, patients with ehrlichiosis can develop severe complications, including death. Doxycyline is the drug of choice for ehrlichiosis and should be initiated in symptomatic patients with a history of tick bite; it should not be withheld while awaiting lab results.","PeriodicalId":220681,"journal":{"name":"Translation: The University of Toledo Journal of Medical Sciences","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128522141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Paraoxanase 1 Regulation of Cardiac Inflammation and Fibrosis in a Dahl Salt-Sensitive Rat Model of Chronic Kidney Disease 在达尔盐敏感的慢性肾脏疾病大鼠模型中，对氧氧化酶1调节心脏炎症和纤维化

Translation: The University of Toledo Journal of Medical Sciences Pub Date : 2023-05-03 DOI: 10.46570/utjms.vol11-2023-646

A. Sood

引用次数: 0

Safety and Effectiveness of Endoluminal Vacuum-Assisted Closure for Esophageal Defects: 腔内真空辅助封闭治疗食管缺损的安全性和有效性

Translation: The University of Toledo Journal of Medical Sciences Pub Date : 2023-05-03 DOI: 10.46570/utjms.vol11-2023-675

M. Aziz

引用次数: 0

Use of Endoscopic Vacuum Therapy to Repair Colonic Anastomotic Leaks: 内镜下真空治疗修复结肠吻合口瘘的研究

Translation: The University of Toledo Journal of Medical Sciences Pub Date : 2023-05-03 DOI: 10.46570/utjms.vol11-2023-665

D. Farrow

引用次数: 0

Metastatic Renal Cell Carcinoma to the Descending Colon Presenting as Recurrent Hematochezia 肾细胞癌转移至降结肠，表现为复发性便血

Translation: The University of Toledo Journal of Medical Sciences Pub Date : 2023-05-03 DOI: 10.46570/utjms.vol11-2023-659

Sudheer M. Dhoop

引用次数: 0

The Efficacy of Cardiac Myosin Inhibitors Versus Placebo in Patients with Symptomatic Hypertrophic Cardiomyopathy 心肌肌球蛋白抑制剂与安慰剂对症状性肥厚性心肌病患者的疗效

Translation: The University of Toledo Journal of Medical Sciences Pub Date : 2023-05-03 DOI: 10.46570/utjms.vol11-2023-727

Mohammand Yassen

引用次数: 0

Use of Internal Standards to Develop Improved Methylation Detection in cfDNA 使用内部标准开发改进的cfDNA甲基化检测

Translation: The University of Toledo Journal of Medical Sciences Pub Date : 2023-05-03 DOI: 10.46570/utjms.vol11-2023-776

E. Crawford

引用次数: 0