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Unprecedented Year Story to Success 空前的成功之年
Journal of Regenerative Medicine & Biology Research Pub Date : 1900-01-01 DOI: 10.46889/jrmbr.2021.2204
L. Montaser
{"title":"Unprecedented Year Story to Success","authors":"L. Montaser","doi":"10.46889/jrmbr.2021.2204","DOIUrl":"https://doi.org/10.46889/jrmbr.2021.2204","url":null,"abstract":"I was thinking of finding what I would discuss in a 2 page new Editorial as I have several matters to say and then destiny made it easy by suddenly receiving three invitations to be nominated for three global awards. So, I have emphasized to write this paper highlighting the story from the start behind these invitations. This is the most recent upshot presage of success I gained after a one year journey from the fighting of COVID-19 pandemic by my unmatched notion to warfare the virus during the world shutdown and staying at home by acting from my home desk [1].","PeriodicalId":220256,"journal":{"name":"Journal of Regenerative Medicine & Biology Research","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128015917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Expression of Neuron Specific Neuronal Nuclei Protein (NeuNNP) by AAV2 Shows Diagnosis Ability in Spinal Cord Injury Using Neural Stem Cells AAV2表达神经元特异性神经细胞核蛋白(NeuNNP)对神经干细胞脊髓损伤的诊断价值
Journal of Regenerative Medicine & Biology Research Pub Date : 1900-01-01 DOI: 10.46889/jrmbr.2021.2202
P. Kr, Albert Alukkal
{"title":"Expression of Neuron Specific Neuronal Nuclei Protein (NeuNNP) by AAV2 Shows Diagnosis Ability in Spinal Cord Injury Using Neural Stem Cells","authors":"P. Kr, Albert Alukkal","doi":"10.46889/jrmbr.2021.2202","DOIUrl":"https://doi.org/10.46889/jrmbr.2021.2202","url":null,"abstract":"Fibroblast Growth Factor (FGF) shows promising therapy for Spinal Cord Injury (SCI). Neural stem transplantation has been on the role implementing tactics to repair SCI. Considering the hostile hypoxia condition in SCI, Adeno Associated Virus 2 (AAV2) a prototype to AAV is being used for most trials. Basic FGF gene was used in that hostile environment, results showed improved functional recovery in SCI. The regulation of this gene FGF is transduce to yield AAV2-5HRE-bFGF. The improved scores on inclined plane test of BBB (Basso-BettieBresnahan) scale and footprint analysis of functional recovery when compared with vehicle control of AAV2 treatment showed inclination in NeuNNP, neuromodelin GAP43 and neurofilament NF200 and declination in Glial Fibrillary Acidic Protein (GFAP). Other expressions such as LC3-II and Beclin 1 and autophagy-associated proteins all show decline,","PeriodicalId":220256,"journal":{"name":"Journal of Regenerative Medicine & Biology Research","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123941454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adipose-Derived Stem Migration in the Vascular System after Transplantation and the Potential Colonization of Ectopic Sites in Swine 脂肪来源的干细胞移植后在猪血管系统中的迁移和异位部位的潜在定植
Journal of Regenerative Medicine & Biology Research Pub Date : 1900-01-01 DOI: 10.46889/jrmbr.2021.2302
S. Wilson, M. Goldwasser, S. G. Clark, E. Monaco, Sandra Rodriguez-Zas, W. Hurley, M. Wheeler
{"title":"Adipose-Derived Stem Migration in the Vascular System after Transplantation and the Potential Colonization of Ectopic Sites in Swine","authors":"S. Wilson, M. Goldwasser, S. G. Clark, E. Monaco, Sandra Rodriguez-Zas, W. Hurley, M. Wheeler","doi":"10.46889/jrmbr.2021.2302","DOIUrl":"https://doi.org/10.46889/jrmbr.2021.2302","url":null,"abstract":"Background: Adipose-derived Stem Cells (ASC) are obtained from adipose tissue. They can be harvested by liposuction under local anesthesia, making these cells particularly desirable for use in tissue engineering or cell transplantation. However, little is known about the in-vivo characteristics of these cells post-transplantation. Methods and Findings: Here we evaluate the potential of ASC to migrate systemically and the potential for accumulation and colonization in ectopic tissues in a pig model. ASC injected via ear vein can travel through the entire vasculature of the pig within 60 seconds and the cells continue to be present in the bloodstream for at least 1-hour posttransplantation. However, labeled cells were not present in the bloodstream at 2 or 4 weeks after ASC injection. The injected ASC appear to travel to areas of induced trauma and are not observed in filtering tissues of the body such as the spleen, liver, lung and liver. Conclusion: These findings suggest that systemic administration of ASC could be a successful method of cell transplantation for tissue regeneration.","PeriodicalId":220256,"journal":{"name":"Journal of Regenerative Medicine & Biology Research","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132662179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
After Effects of COVID-19 and Repair of Lungs COVID-19的后效与肺部修复
Journal of Regenerative Medicine & Biology Research Pub Date : 1900-01-01 DOI: 10.46889/jrmbr.2021.2301
P. Kr
{"title":"After Effects of COVID-19 and Repair of Lungs","authors":"P. Kr","doi":"10.46889/jrmbr.2021.2301","DOIUrl":"https://doi.org/10.46889/jrmbr.2021.2301","url":null,"abstract":"Lung disease is the most effected organ in patients. Corona (CoV) targets the lungs and causes death of millions of patients across the globe. There has been increasing burden in lung associated disease due to the pandemic. CoV is a deadly pandemic that cause respiratory problems and affects trachea of lungs. CoV which enters the respiratory system, where enzyme is present, and destroy the respiratory organ, causing patients to face difficulty in breathing. There are two steps basically for virus to infect lungs. First pathogenesis converting enzyme to its protein, second cellular protease letting virus through respiratory system. The spike activates into membrane and releases the virus RNA. The present target for the virus is to infect the lungs, while T and B lymphocytes is always negative in ACE2. So proposed solution is stem cell treatment. The release of cytokines S1, S2 and RBD results in edena dysfunction of acute respiratory collapse and cardiac arrest.","PeriodicalId":220256,"journal":{"name":"Journal of Regenerative Medicine & Biology Research","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129589150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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