SKIN The Journal of Cutaneous Medicine最新文献_第6页

Intralesional Kenalog Injections for Recurrent Cutaneous Rosai-Dorfman Disease (RDD) in the Lower Extremity 治疗下肢复发性皮肤罗赛-多夫曼病（RDD）的 KENALOG 局内注射疗法

SKIN The Journal of Cutaneous Medicine Pub Date : 2024-05-13 DOI: 10.25251/skin.8.3.15

Victoria Jiminez, Lawangeen Zeb, Lauren Graham, Anna Gray

{"title":"Intralesional Kenalog Injections for Recurrent Cutaneous Rosai-Dorfman Disease (RDD) in the Lower Extremity","authors":"Victoria Jiminez, Lawangeen Zeb, Lauren Graham, Anna Gray","doi":"10.25251/skin.8.3.15","DOIUrl":"https://doi.org/10.25251/skin.8.3.15","url":null,"abstract":"Rosai-Dorfman disease (RDD) is a rare disorder of histiocytic origin with nodal, extranodal, and cutaneous classifications often presenting as eruptive rashes, most commonly affecting the face, trunk, and thigh. Due to its rarity, no consensus exists regarding standard of care for these lesions, as most knowledge regarding treatment is provided by case reports. To our knowledge, we report the first case of a patient with a recurrent lower extremity mass consistent with cutaneous RDD, despite surgical excision and topical steroids treatment. A 51-year-old female presented with recurrent RDD after failed treatment with clobetasol ointment and surgical excision at an outside practice. Examination revealed violaceous plaques with overlying scale, without lymphadenopathy. With the failure of the previous excision, the patient was prescribed 5 mg/ml intralesional Kenalog (ILK) injections to suppress inflammation of the lesion. She experienced improved clinical response to treatment and remission of active disease with residual post-inflammatory hyperpigmentation at 10 months after two rounds of injections, although the patient reported vast improvement at 5 months as well. Treatment of RDD is difficult due to its rarity, hindering clinical trial development. Therapeutics reported to be efficacious include topical, intralesional, and systemic steroids, retinoids, methotrexate, chemotherapy, cryotherapy, phototherapy, and radiation. Clinical management is variable and often requires multiple forms of treatment on a case-to-case basis, highlighting the need for larger clinical studies to establish a standard of care. Our case poses interest in the use of ILK for RDD and should be considered in recurrent cases after prior surgical excision.","PeriodicalId":22013,"journal":{"name":"SKIN The Journal of Cutaneous Medicine","volume":"10 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140982351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Merkel cell carcinoma primary sites and overall survival: The prognostic indications of head and neck tumors 梅克尔细胞癌原发部位和总生存率：头颈部肿瘤的预后指标

SKIN The Journal of Cutaneous Medicine Pub Date : 2024-05-13 DOI: 10.25251/skin.8.3.6

Marcus L Elias, Joshua Burshtein, Victoria R Sharon

引用次数: 0

Epithelioid Angiosarcoma: A Diagnostic Dilemma with Clinically and Histopathologically Overlapping Features 上皮样血管肉瘤：临床和组织病理学特征重叠的诊断难题

SKIN The Journal of Cutaneous Medicine Pub Date : 2024-05-13 DOI: 10.25251/skin.8.3.14

Jessica Forbes Kaprive, Romsin Zaya, Alexandra Loperfito, Craig J Garofola

{"title":"Epithelioid Angiosarcoma: A Diagnostic Dilemma with Clinically and Histopathologically Overlapping Features","authors":"Jessica Forbes Kaprive, Romsin Zaya, Alexandra Loperfito, Craig J Garofola","doi":"10.25251/skin.8.3.14","DOIUrl":"https://doi.org/10.25251/skin.8.3.14","url":null,"abstract":"Cutaneous angiosarcoma is a rare malignancy of endothelial cell origin that commonly presents in the head and neck region of elderly individuals and is known for high rates of lymph node metastasis and mortality. There is significant variability in the histopathologic features, and immunohistochemistry is necessary to help differentiate epithelioid angiosarcoma from lesions it may clinically mimic. Here, we report a rare case of poorly differentiated epithelioid angiosarcoma on the trunk initially diagnosed as poorly differentiated squamous cell carcinoma (SCC) on shave biopsy. A 56-year-old man presented for a full-body skin examination significant for a 5.6 x 2.8 mm brown-black macule on the left superomedial posterior trunk and a 5.0 x 2.7 mm pink, ulcerated papule on the right inferior posterior trunk. On histopathology, one lesion was found to be melanoma in situ, and the other showed ulcerated and infiltrative, poorly differentiated SCC. Post-excision histologic analysis of the right inferior back lesion revealed tumor cells immunoreactive to vimentin, ERG, and CD31 (PECAM-1). These findings suggested that the lesion previously diagnosed as SCC was an invasive, poorly differentiated epithelioid angiosarcoma. The patient underwent 40 sessions of radiotherapy. Epithelioid angiosarcoma occurring outside of the conventional epidemiologic profile is believed to portend higher mortality rates. This case highlights the importance of thorough clinical evaluation and appropriate histopathologic diagnosis of an aggressive neoplasm unlikely to present in this location. Further studies are required to explore potential risk factors, effective treatments, and long-term outcomes in patients with epithelioid angiosarcoma.","PeriodicalId":22013,"journal":{"name":"SKIN The Journal of Cutaneous Medicine","volume":"108 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140986005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Type I Collagen Matrix with Polyhexylmethylene Biguanide in a Chronic Lower Extremity Wound I 型胶原蛋白基质与聚己亚甲基双胍在慢性下肢伤口中的应用

SKIN The Journal of Cutaneous Medicine Pub Date : 2024-05-13 DOI: 10.25251/skin.8.3.16

K. Aoki, Simona Bartos

引用次数: 0

Safety and Efficacy of Combination Therapy of Upadacitinib and Biologic Agents for Treatment-Resistant Psoriasis and Psoriatic Arthritis 乌达帕替尼和生物制剂联合疗法治疗耐药银屑病和银屑病关节炎的安全性和有效性

SKIN The Journal of Cutaneous Medicine Pub Date : 2024-05-13 DOI: 10.25251/skin.8.3.17

Shivkar Amara, Aarav Patel, M. Lebwohl

{"title":"Safety and Efficacy of Combination Therapy of Upadacitinib and Biologic Agents for Treatment-Resistant Psoriasis and Psoriatic Arthritis","authors":"Shivkar Amara, Aarav Patel, M. Lebwohl","doi":"10.25251/skin.8.3.17","DOIUrl":"https://doi.org/10.25251/skin.8.3.17","url":null,"abstract":"Importance: Although there are many available treatments for psoriasis and psoriatic arthritis (PsA), there are patients resistant to standard conventional therapy. For these patients, combination therapy of biologic agents and upadacitinib may be a viable alternative option; however, there is limited data on concomitant usage. \u0000Objective: To evaluate the safety and efficacy of combination therapy of upadacitinib and biologic agents for the treatment of refractory psoriasis and psoriatic arthritis. \u0000Design: We report the results of a retrospective chart review of 3 patients in a single practice treated with a combination of upadacitinib and biologics for psoriasis and PsA. The risks, benefits, and safety warnings of combination therapy of upadacitinib and biologic agents were discussed before initiation. After shared decision-making with the provider, patients were placed on a trial of combination therapy. \u0000Results: All three patients, previously refractory to monotherapy, experienced significant improvement of their symptoms while on combination therapy. No adverse reactions (malignancy, cardiovascular events, venous thromboembolism) occurred during treatment. However, one patient experienced a shingles outbreak and diverticulitis while on combination treatment. Further studies are needed to determine long-term efficacy with a larger sample size. \u0000 ","PeriodicalId":22013,"journal":{"name":"SKIN The Journal of Cutaneous Medicine","volume":"60 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140985083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Scratching the Surface: A Paraneoplastic Pruritus Phenomenon in a Mediastinal Mass 表面划痕：纵隔肿块中的副肿瘤性瘙痒现象

SKIN The Journal of Cutaneous Medicine Pub Date : 2024-05-13 DOI: 10.25251/skin.8.3.24

Devine Thomas, Yousef Salem, Naser Asfoor, Mohamad Jabin, Mojahed M. K. Shalabi, Stephen Baker, Shovendra Gautam

引用次数: 0

Unusual Presentation of Marginal Zone Lymphoma 边缘区淋巴瘤的不寻常表现

SKIN The Journal of Cutaneous Medicine Pub Date : 2024-05-13 DOI: 10.25251/skin.8.3.9

Akash Rau, Anne Opalikhin, Kaitlin Kreuser, R. Ashack, Kurt Ashack

{"title":"Unusual Presentation of Marginal Zone Lymphoma","authors":"Akash Rau, Anne Opalikhin, Kaitlin Kreuser, R. Ashack, Kurt Ashack","doi":"10.25251/skin.8.3.9","DOIUrl":"https://doi.org/10.25251/skin.8.3.9","url":null,"abstract":"Primary cutaneous B-cell lymphomas (pcBCLs) are non-Hodgkin lymphomas that present with exclusive cutaneous disease at the time of diagnosis. The lesions may be indolent, subtle, or waxing and waning, making the diagnosis challenging. The ear is an uncommon location, and its frequency of involvement remains unknown. A retrospective analysis of a single patient with primary cutaneous marginal zone lymphoma of the ear. The patient was a 44-year-old male who presented with erythematous tender nodules on the left superior posterior helix. Shave biopsy revealed mixed dermal lymphoid infiltrate with eosinophils and telangiectasias. The patient was diagnosed with angiolymphoid hyperplasia with eosinophilia. Multiple treatment regiments were trialed but failed due to lack of therapeutic response, relapse, and clinical progression. The patient ultimately underwent Mohs surgery with biopsy findings that demonstrated CD-20 positive cells. Evaluation with B-cell histopathology and gene rearrangement studies confirmed the diagnosis of marginal zone lymphoma. This case report shows a unique presentation of marginal zone lymphoma of the ear, initially diagnosed as angiolymphoid hyperplasia with eosinophilia. Our findings demonstrate a relatively rare presentation for this disease and highlight the challenges in diagnosing primary cutaneous marginal zone lymphoma.","PeriodicalId":22013,"journal":{"name":"SKIN The Journal of Cutaneous Medicine","volume":"119 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140985591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary Cutaneous Apocrine Carcinoma: Diagnostic and Management Difficulties of an Uncommon Neoplasm 原发性皮肤腺分泌癌：一种不常见肿瘤的诊断和管理难题

SKIN The Journal of Cutaneous Medicine Pub Date : 2024-05-13 DOI: 10.25251/skin.8.3.20

Mounia Sidki, M. Aboudourib, Maryam El Ouazzani, A. Belbachir, H. Rais, Yassine Benchamkha, O. Hocar, S. Amal

{"title":"Primary Cutaneous Apocrine Carcinoma: Diagnostic and Management Difficulties of an Uncommon Neoplasm","authors":"Mounia Sidki, M. Aboudourib, Maryam El Ouazzani, A. Belbachir, H. Rais, Yassine Benchamkha, O. Hocar, S. Amal","doi":"10.25251/skin.8.3.20","DOIUrl":"https://doi.org/10.25251/skin.8.3.20","url":null,"abstract":"Primary cutaneous apocrine carcinoma (PCAC) is a rare adnexal neoplasm. Due to its clinical presentation, it can mimic other tumors, especially metastasis. We present a case of primary apocrine carcinoma of the axilla mimicking breast carcinoma metastasis in a 54-year-old woman. The patient presented with a painless, lobed, and erythematous nodule in the left axilla of one year duration. We suspected an adnexal neoplasm but also considered metastasis from breast carcinoma. Histological examination revealed apocrine proliferation. Immunohistochemistry stains of tumor cells were positive for AE1/AE3, and negative for CK7, CK20, p63 and GATA3. Radiological explorations did not reveal any signs of malignancy. Considering all these features, the conclusive diagnosis was primary cutaneous apocrine carcinoma. Treatment was wide excision without adjuvant therapy, and no recurrence was noted. Due to the rarity of this carcinoma, its various clinical presentations, and histological overlaps with breast cancer metastasis, making the diagnosis may be challenging. A comprehensive evaluation of all findings is necessary to rule out other tumors. There is any consensus on the management strategy. The standard treatment is surgical excision, but adjuvant therapies such as radiotherapy or chemotherapy can be proposed in advanced stage disease.","PeriodicalId":22013,"journal":{"name":"SKIN The Journal of Cutaneous Medicine","volume":"77 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140983239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incontinentia Pigmenti In a Female Infant: A Case Report 一名女婴的猪尿失禁：病例报告

SKIN The Journal of Cutaneous Medicine Pub Date : 2024-05-13 DOI: 10.25251/skin.8.3.11

Rebecca Lapides, Hannah J Porter, Deborah Cook, Keith Morley

引用次数: 0

Eruptive Epidermal Inclusion Cysts in a Renal Transplant Patient on Tacrolimus 一名服用他克莫司的肾移植患者出现的溃疡性表皮包涵囊肿

SKIN The Journal of Cutaneous Medicine Pub Date : 2024-05-13 DOI: 10.25251/skin.8.3.13

Meredith Burns, Hoang Ho-Pham, Lauren Kole

引用次数: 0