Sriwijaya Journal of Ophthalmology最新文献

{"title":"Comparison of BCL-2 Ecpression in Periocular Basal Cell Carcinoma Aggressive and Non-Aggressive Types in Mohammad Hoesin Hospital Palembang","authors":"Fera Yunita Rodhiaty, Ika Kartika, Ibrahim","doi":"10.37275/sjo.v1i2.40","DOIUrl":"https://doi.org/10.37275/sjo.v1i2.40","url":null,"abstract":"Abstract \u0000Background: Basal cell carcinoma (BCC) is a malignant tumor originating from non- keratinizing cells originating from the basal layer of the epidermis. Basal cell carcinoma is the most common malignant tumor, nearly 90% of all non-melanoma skin cancers. Clinically, BCC is difficult to distinguish, final diagnosis determined based on histopathological examination of complete tumor tissue. Based on histological growth patterns, BCC is divided into two, non- aggressive type (nodular and superficial) and aggressive type (infiltration, micronodular, fibroepithelial, basoskuamosa, keratotic, adnexal differentiation). The examination technique by analyzing the proteins or genes involved is related to the aggressiveness of basal cell carcinoma. \u0000Objective: This study was conducted to determine the comparison of expression of Bcl-2 in periocular basal type aggressive and non-aggressive carcinomas in dr. Mohammad Hoesin Palembang. \u0000Methodology: A cross sectional analytic study from 26 periocular basal cell carcinoma patients in RSUP dr. Mohammad Hoesin Palembang, January 2014- June 2018. Histopathologic features were examined with hematoxylin-eosine staining and imunohistochemical were examined with Bcl-2 monoclonal antibody. Data were analyzed by bivariate analysis, using chi-square test and fisher exact test. \u0000Results: Positive Bcl-2 expression was more common in periocular basal cell carcinoma (93.8%) than aggressive (50%), and nodular type (93.8%) compared to other types of histological differentiation. Positive Bcl-2 expression was also higher in female patients (90.9%) than males (66.7%). There is a significant relationship between expression of Bcl-2 and growth patterns, differentiation of cell histology and also sex of patients with basal cell carcinoma. \u0000Conclusion: In this study, there was a significant correlation between expression of Bcl-2 and aggressive and non-aggressive periocular basal cell carcinoma in RSUP dr. Mohammad Hoesin Palembang.","PeriodicalId":22012,"journal":{"name":"Sriwijaya Journal of Ophthalmology","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75733353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Aloe Vera Extract to Extensive Lesion and Expression of Transforming Growth Factor (TGF-β) on Alkaline Chemical Trauma Cornea Model","authors":"Fahcreza, E. Iskandar, R. Hidayat, Petty Purwanita, Anang Tribowo, R. Erna","doi":"10.37275/sjo.v1i2.36","DOIUrl":"https://doi.org/10.37275/sjo.v1i2.36","url":null,"abstract":"Abstract \u0000Background: Chemical trauma to the cornea is an emergency condition of the eye that requires early diagnosis and good treatment. Alkaline have ability to saponify fatty acids in cells and cell membranes which can make penetration into the stroma and destroy proteoglycans and collagen in cells. Aloe vera (AV) contains several active substances that are reported to have anti-inflammatory, immunomodulatory, and wound healing effects. AV has been reported to accelerate the healing process of corneal epithelial defects by increasing fibroblast proliferation, collagen production and growth factor production. This study aims to determine the difference between the effect of aloe vera extract with a concentration of 10%, 20%, 40% and BSS on the healing of extensive corneal lesions in white wistar rats alkaline trauma models. \u0000Method: This study was an experimental study with a pre and posttest only with control group design in vivo approach to 30 Wistar white rats which were divided into 5 treatment groups for 3 days. Comparative analysis of effectiveness using the ANNOVA test or the Kruskal Wallis test and continued by the post hoc test. \u0000Results: Based on the one way ANOVA test there was a statistically significant difference in effectiveness between the five treatment groups on the percentage of corneal wound healing area and TGF-β expression with an assessment of p = 0,000 each. The administration of alloevera (AV) concentration of 20% had a significant difference in percentage of healing of corneal lesions and TGF-β expression compared with other treatment groups with p = 0,000 each. Large differences in the area of corneal lesions in the 40% AV group were -0.45 in the BBS group, 0.146 in the 10% AV group, 0.493 in the 20% AV group. The difference in the AV group 10% was 0.30 in the BBS group, -064 in the AV group 20%, and -0.14 in the AV group 40%. However, TGFβ expression in the normal control group that did not receive treatment was 54.94 (53.21-56-12). TGFβ levels in the BSS group were 10.44, the 10% aloe vera group was 25.43, 47.99 for the 20% aloe vera group and 37.95 for the 40% aloe vera group. \u0000Conclusion: There is a difference between the effect of aloe vera extract with concentrations of 10%, 20%, 40% and BSS on the extensive healing of corneal lesions in white wistar rats with alkaline chemical trauma models.","PeriodicalId":22012,"journal":{"name":"Sriwijaya Journal of Ophthalmology","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90527710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P16INK4A Expression on Retinoblastoma at Mohammad Hoesin Hospital Palembang","authors":"Sri Tanty Fuji A Harahap, Ika Kartika, Rusdianto","doi":"10.37275/sjo.v1i1.37","DOIUrl":"https://doi.org/10.37275/sjo.v1i1.37","url":null,"abstract":"ABSTRACT \u0000Background: Retinoblastoma is a malignant tumor with an average incidence of one case per 15,000-20,000 births. Retinoblastoma is associated with the presence of the Rb1 gene mutation which has role in preventing DNA replication. Various studies have linked the existence of p16INK4A as a CDK inhibitor that inhibits Cyclin D and CDK4 so that the activity of the Rb1 gene is inhibited. \u0000Objective: This study was conducted to identify p16INK4A expression on Retinoblastoma at Mohammad Hoesin Hospital. \u0000Methodology: A descriptive study used on the paraffin blocks of 14 cases Retinoblastoma in Mohammad Hoesin Hospital Palembang from January 2014- July2018. Histopathologic feature were examined with Hematoxylin- Eosin staining and immunohistochemical were examined with p16INK4A antibody. Data were analyzed using SPSS version23 to identify histopathological feature of p16INK4A expression in Retinoblastoma \u0000Results: Most retinoblastoma samples in this study were expressed in p16INK4A (92.86%). The degree of differentiation of retinoblastoma with the largest number at Mohammad Hoesin Hospital is moderately differentiated (57.14%). Retinoblastoma invasion of the optic nerve and sclera in the study at Mohammad Hoesin Hospital, respectively at 57.14% and 42.86%. \u0000Conclusion: Most retinoblastoma samples in this study were expressed in p16INK4A.","PeriodicalId":22012,"journal":{"name":"Sriwijaya Journal of Ophthalmology","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78095571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Eight Weeks Pencil Push Up Therapy for Patients with Convergence Insufficieny in Mohammad Hoesin Hospital Palembang","authors":"Andrian Suner, Linda Trisna","doi":"10.37275/sjo.v1i1.42","DOIUrl":"https://doi.org/10.37275/sjo.v1i1.42","url":null,"abstract":"Abstract \u0000Background: Convergence Insufficiency (CI) is an inability to perform convergence movements when doing near activity. The prevalence of CI was estimated varying between 0.1%-8%. One of the easiest therapeutic attempts from some research have showed the effectiveness to overcome CI is by pencil push up therapy. This study is to determine the improvement of CI symptoms and signs in patients after performing the pencil push up exercise for 8 weeks. \u0000Methods: This clinical trial was conducted on October 2016-March 2017. Nineteen patients who met the inclusion criteria was obtained. The frequency and distribution of data is described in tabular form and the effectiveness of pencil push up therapy is analyzed with Paired T Test and Wilcoxon test. \u0000Result: Patients with CI had an average age of approximately 22 years, with the sex ratio of females and males being 3:2. After 8 weeks of pencil push up therapy, there was a significant decrease of Convergence Insufficiency Symptom Survey (CISS) value from 25.2±3.72 to 15.7±5.64 (p=0.000), significantly decreased Near Point Convergence (NPC) value from 13.7±1.88 cm to 9.05±2.99 cm (p=0.000), significantly decreased Red Blue Test (RBT) value from 14.2±1.84 to 9,36±3.22 cm (p=0.000), and significantly decreased Penlight Red/Green Test (PLT) from 16.7±2.69 to 10.7±4.13 cm (p=0.000). A number of Alternate Cover Test (ACT) positives also decreased from 4 to 2 samples but not significant (p=0,500). Symptoms and signs of CI were improved in 14 samples (73.7%). \u0000Conclusion: Pencil push up therapy for 8 weeks is effective to improve symptoms and signs of convergence insufficiency.","PeriodicalId":22012,"journal":{"name":"Sriwijaya Journal of Ophthalmology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80823512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinometry : a Literature Review","authors":"Febrina Art, Ramzi Amin, Ak Ansyori","doi":"10.37275/sjo.v1i1.31","DOIUrl":"https://doi.org/10.37275/sjo.v1i1.31","url":null,"abstract":"Sharp vision is a major concern in cataract cases. Sharp improvement in vision is the expected outcome of the management of cataract cases, namely by operative measures. Before surgery, there are several ophthalmological examinations that must be performed. Quantitative instruments have been developed to determine the visual potential of eyes that experience turbidity of refractive media. One examination that can be done is a retinometry examination that is the examination of the sharp potential of vision with a retinometer. \u0000Retinometry is a process of measuring sharp eyes using a retinometer to determine the potential for sharp eyesight.  Retinometer is one tool that uses the principle of interference fringes to assess the patient's sharp vision through a cloudy lens. On a retinometer, a light source is split into two rays which then enter the least turbid lens area so that interference grating is formed on the retina. The lattice can have a vertical, horizontal or oblique meridian orientation","PeriodicalId":22012,"journal":{"name":"Sriwijaya Journal of Ophthalmology","volume":"87 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90933399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect Anti VEGF Intravitreal to Central Retinal Vein Occlusion","authors":"Tiara Mayasari, Ramzi Amin, Ak Ansyori","doi":"10.37275/sjo.v1i1.8","DOIUrl":"https://doi.org/10.37275/sjo.v1i1.8","url":null,"abstract":"Introduction. The cause of blood vessels abnormalities in the retina in addition to diabetes is obstruction in the veins. In general, retinal vein blockages are distinguished in two types i.e. blockage of retinal veins (BRVO) and obstruction of the central vein of the retina (CRVO). Reported a case of a central retinal vein occlusion with intravitreal anti-injection treatment of a VEGF Bevacizumab. \u0000Case presentation. A man, Mr. T, aged 52 years, with an address outside the city, the work of the foreman, came to RSMH's eye on October 2014. Anamnesis the main complaint of the right eye eyesight was suddenly dark since, one day before. One day before go to hospital, the sufferer complained about the right eye suddenly until it felt dark. He also complain often headaches without nausea and vomiting since before his right eye vision becomes blurred. Intravitreal anti-VEGF injection in these patients is planned to be re-done 4-6 weeks after the first injection if there has been no improvement in his vision. Evaluation of the effectiveness of intravitreal Bevacizumab anti-VEGF therapy through sharp improvement of vision, clinical features and anatomical improvement. \u0000Conclusion. A case of central retinal vein occlusion was reported in a 52-year-old male. After anamnesis, ophthalmologic examination and investigations, a diagnosis of CRVO is managed by intravitreal Anti VEGF injection.","PeriodicalId":22012,"journal":{"name":"Sriwijaya Journal of Ophthalmology","volume":"81 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77116024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}