Stamford Journal of Pharmaceutical Sciences最新文献_第9页

Study on Oxidative Metabolic Changes to Differentiate Exudative from Transudative Pleural Effusions 氧化代谢变化鉴别渗出性和透出性胸腔积液的研究

Stamford Journal of Pharmaceutical Sciences Pub Date : 2009-01-06 DOI: 10.3329/SJPS.V1I1.1806

V Narsimha Reddy, V Anil Kumar, M. Srinivas, V Narayana Reddy

引用次数: 1

Formulation Development and In Vitro Evaluation of Metformin Hydrochloride Matrix Tablets Based on Hydroxypropyl Methyl Cellulose 羟丙基甲基纤维素基盐酸二甲双胍基质片的处方研制及体外评价

Stamford Journal of Pharmaceutical Sciences Pub Date : 2009-01-06 DOI: 10.3329/SJPS.V1I1.1808

A. Kabir, Tasbira Jeseem, R. Jahangir, D. M. Rahman, A. S. Rouf

{"title":"Formulation Development and In Vitro Evaluation of Metformin Hydrochloride Matrix Tablets Based on Hydroxypropyl Methyl Cellulose","authors":"A. Kabir, Tasbira Jeseem, R. Jahangir, D. M. Rahman, A. S. Rouf","doi":"10.3329/SJPS.V1I1.1808","DOIUrl":"https://doi.org/10.3329/SJPS.V1I1.1808","url":null,"abstract":"An attempt was to formulate the oral sustained release Metformin hydrochloride matrix tablets by using hydroxyl methyl cellulose polymer (HPMC) as rate controlling factor and to evaluate drug release parameters as per various release kinetic models. The tablets were prepared by direct compression method. The granules were evaluated for angle of repose, loose bulk density, tapped bulk density, compressibility index, total porosity, drug content etc. and showed satisfactory results. The tablets were subjected to thickness, weight variation test, drug content, hardness, friability and in vitro release studies. The in vitro dissolution study was carried out for 8 hours using United States Pharmacopoeia USP 22 (paddle-type dissolution apparatus) in phosphate buffer (pH 7.4) as dissolution media. All the tablet formulations showed acceptable pharmacotechnical properties and complied with pharmacopoeial specifications. The release mechanisms were explored and explained with zero order, first order, Higuchi, Korsmeyer and Hixson-Crowell equations. The results indicated that a decrease in release kinetics of the drug was observed by increasing the polymer concentration. Kinetic modeling of in vitro dissolution profiles revealed the drug release mechanism ranges from diffusion controlled or Fickian transport to anomalous type or non-Fickian transport, which was only dependent on the type and amount of polymer used. The drug release followed both diffusion and erosion mechanism in all cases. Besides, this study explored both of the optimum concentration and the effect of polymer on drug release pattern from the tablet matrix for 8 hours period.","PeriodicalId":21823,"journal":{"name":"Stamford Journal of Pharmaceutical Sciences","volume":"37 1","pages":"51-56"},"PeriodicalIF":0.0,"publicationDate":"2009-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73948966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Simultaneous Estimation of Naproxen and Ranitidine HCl by Using UV Spectrophotometer 紫外分光光度法同时测定萘普生和盐酸雷尼替丁的含量

Stamford Journal of Pharmaceutical Sciences Pub Date : 2009-01-06 DOI: 10.3329/SJPS.V1I1.1781

T. Haque, M. Talukder, S. Laila, K. Fatema, A. Kabir

引用次数: 20

Cytotoxicity, Antimicrobial and Antioxidant Studies of the Different Plant Parts of Mimosa Pudica 含羞草不同植物部位的细胞毒性、抗菌和抗氧化研究

Stamford Journal of Pharmaceutical Sciences Pub Date : 2009-01-06 DOI: 10.3329/SJPS.V1I1.1813

S. Chowdhury, J. Islam, M. Rahaman, M. Rahman, N. N. Rumzhum, R. Sultana, Most. Nazma Parvin

{"title":"Cytotoxicity, Antimicrobial and Antioxidant Studies of the Different Plant Parts of Mimosa Pudica","authors":"S. Chowdhury, J. Islam, M. Rahaman, M. Rahman, N. N. Rumzhum, R. Sultana, Most. Nazma Parvin","doi":"10.3329/SJPS.V1I1.1813","DOIUrl":"https://doi.org/10.3329/SJPS.V1I1.1813","url":null,"abstract":"Rebeka Sultana and Most Nazma Parvin - were added as authors on 13th September 2010. The petroleum ether, chloroform and methanol crude extracts of the two different plant parts (aerial part and root) of Mimosa pudica (Mimosaceae) were screened in vitro for cytotoxicity studies by brine shrimp lethality bioassay and antimicrobial screening by disc diffusion method. The methanol crude extract of the aerial part was screened in vitro for antioxidant activity using the 1, 1-diphenyl-2-picrylhydrazyl-hydrate (DPPH) free radical scavenging assay. The petroleum ether and methanol crude extracts of the root showed potential cytotoxic activities (LC 50 0.05 μg/ml and 0.035 μg/ml respectively) whereas the other extractives showed poor cytotoxicity. All the crude extracts showed poor activity or inactivity against the test microorganisms. On the other hand, the methanol crude extract of the aerial part showed moderate antioxidant activity (IC 50 296.92 μg/ml) compared to ascorbic acid (IC 50 131.29 μg/ml). The overall experimental results suggest the biologically active constituents present in the methanolic extract of Mimosa pudica and justify its use in folkloric remedies. Key Words: Mimosa pudica , Mimosaceae, Cytotoxicity, Antimicrobial, DPPH, Antioxidant. doi:10.3329/sjps.v1i1.1813 S. J. Pharm. Sci. 1(1&2): 80-84","PeriodicalId":21823,"journal":{"name":"Stamford Journal of Pharmaceutical Sciences","volume":"208 1","pages":"80-84"},"PeriodicalIF":0.0,"publicationDate":"2009-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75488986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 33

Cytotoxicity and Antioxidant Activity of Extractives from Mirabilis jalapa 紫茉莉提取物的细胞毒性及抗氧化活性研究

Stamford Journal of Pharmaceutical Sciences Pub Date : 2009-01-06 DOI: 10.3329/SJPS.V1I1.1814

N. N. Rumzhum, M Mostafizur Rahman, M Shahidul Islam, S. Chowdhury, R. Sultana, Most. Nazma Parvin

引用次数: 18

Evaluation of Aceclofenac Loaded Agarose Beads Prepared by Ionotropic Gelation Method 离子化凝胶法制备乙酰氯芬酸负载琼脂糖珠的性能评价

Stamford Journal of Pharmaceutical Sciences Pub Date : 2009-01-06 DOI: 10.3329/SJPS.V1I1.1780

F. Yesmin, M. Talukder, Muhammad Shahidul Islam, S. Laila, T. Haque

{"title":"Evaluation of Aceclofenac Loaded Agarose Beads Prepared by Ionotropic Gelation Method","authors":"F. Yesmin, M. Talukder, Muhammad Shahidul Islam, S. Laila, T. Haque","doi":"10.3329/SJPS.V1I1.1780","DOIUrl":"https://doi.org/10.3329/SJPS.V1I1.1780","url":null,"abstract":"Aceclofenac loaded agarose beads were prepared by ionotropic gelation method and drug release profile, swelling index (SI %) and entrapping efficiency (EE %) of aceclofenac were investigated. The drug was dissolved in melted 4 % agar solution in different ratios. Beads were prepared by dropping the hot aqueous solution into a beaker of different percentages of chilled CaCl2 solution followed by filtering the solution and drying at room temperature. The entrapment efficiency was 100±5 %. The swelling index was found to be highest (18.22 % in 4 hours) for beads containing aceclofenac-agar (1:2) in 4 % electrolyte solutions and the swelling property was decreased with increasing electrolyte concentration. In vitro dissolution of beads was carried out in USP apparatus-II (paddle method) at 75 rpm. The drug release was measured by using UVSpectrophotometer at λmax of 268 nm for acid media and 274 nm for buffer media. The dissolution data were treated with zero order, first order and Higuchi model. Half of the formulations were fitted to Higuchi model and rest half to first order model. Finally it can be concluded that with the increasing polymer (agar) concentration, the release rate of aceclofenac was decreased and swelling index was increased and with the increasing electrolyte concentration, the release rate was increased and swelling index was decreased.","PeriodicalId":21823,"journal":{"name":"Stamford Journal of Pharmaceutical Sciences","volume":"8 1","pages":"10-17"},"PeriodicalIF":0.0,"publicationDate":"2009-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78715025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Good Hospital Pharmacy Practices for Better Health Care of People 为人们提供更好的医疗保健的良好医院药房规范

Stamford Journal of Pharmaceutical Sciences Pub Date : 2009-01-06 DOI: 10.3329/SJPS.V1I1.1778

F. Ahmed

引用次数: 0

Design and In Vitro Evaluation of Chrono Modulated Theophylline Tablets 时间调节茶碱片的设计与体外评价

Stamford Journal of Pharmaceutical Sciences Pub Date : 2009-01-06 DOI: 10.3329/SJPS.V1I1.1782

B. V. Kumar, B. Nagaraj, B. Agaiah, D. Rambhau

引用次数: 2

In Vitro Nitric Oxide Scavenging Activity of Ethanol Leaf Extracts of Four Bangladeshi Medicinal Plants 四种孟加拉药用植物乙醇叶提取物体外清除一氧化氮活性研究

Stamford Journal of Pharmaceutical Sciences Pub Date : 2009-01-06 DOI: 10.3329/SJPS.V1I1.1809

M. Saha, R. Jahangir, M. Vhuiyan, I. J. Biva

{"title":"In Vitro Nitric Oxide Scavenging Activity of Ethanol Leaf Extracts of Four Bangladeshi Medicinal Plants","authors":"M. Saha, R. Jahangir, M. Vhuiyan, I. J. Biva","doi":"10.3329/SJPS.V1I1.1809","DOIUrl":"https://doi.org/10.3329/SJPS.V1I1.1809","url":null,"abstract":"The ethanol leaf extracts of four medicinal plants named Hibiscus mutabilis, Leucas aspera, Ixora coccinea and Polyalthia longifolia were examined for their possible regulatory effect on nitric oxide (NO) levels using sodium nitroprusside as a NO donor in vitro. Most of the extracts tested demonstrated direct scavenging of NO and exhibited significant activity and the potency of scavenging activity was in the following order: Leucas aspera > Ixora coccinea > Hibiscus mutabilis> Polyalthia longifolia. All the evaluated extracts exhibited a dose-dependent NO scavenging activity. The ethanolic leaf extract of Leucas aspera showed the greatest NO scavenging effect of 80.50% at 320 µg/ml with IC50 value of 94.15 µg/ml as compared to the positive control ascorbic acid where 74.56 % scavenging was observed at similar concentration with IC50 value of 62.48 µg/mL. The maximum NO scavenging of Ixora coccinea, Hibiscus mutabilis and Polyalthia longifolia were 79.65 %, 78.60% and 70.67 % with IC50 values of 43.72 µg/ml, 147.64 µg/ml and 167.08 µg/ml respectively. The present results suggest that these plants might be potent and novel therapeutic agents for scavenging of NO and the regulation of pathological conditions caused by excessive generation of NO and its oxidation product.","PeriodicalId":21823,"journal":{"name":"Stamford Journal of Pharmaceutical Sciences","volume":"40 1","pages":"57-62"},"PeriodicalIF":0.0,"publicationDate":"2009-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85094042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20

Rapid Method for Species-Specific Identification and Determination of Toxigenicity of Vibrio Cholerae from Natural Aquatic Environment 天然水生环境中霍乱弧菌种特异性快速鉴定及毒力测定方法

Stamford Journal of Pharmaceutical Sciences Pub Date : 2009-01-06 DOI: 10.3329/SJPS.V1I1.1811

B. Chakraborty, K. Zaman, Majibur Rahman

{"title":"Rapid Method for Species-Specific Identification and Determination of Toxigenicity of Vibrio Cholerae from Natural Aquatic Environment","authors":"B. Chakraborty, K. Zaman, Majibur Rahman","doi":"10.3329/SJPS.V1I1.1811","DOIUrl":"https://doi.org/10.3329/SJPS.V1I1.1811","url":null,"abstract":"Cholera caused by toxigenic Vibrio cholerae is a major public health problem confronting developing countries, where outbreaks occur in a regular seasonal pattern and are particularly associated with poverty and poor sanitation. It is generally accepted that seven distinct pandemics of cholera have occurred since the onset of the first pandemic in 1817. Again Vibrio cholerae is capable of surviving in aquatic environments for extended periods and is considered as autochthonous species in estuarine and brackish waters. Therefore, the present study was designed to isolate V. cholerae from natural environmental samples subsequently identified by conventional and molecular biological techniques. A total number of 10 isolates were included randomly in this study based on their initial identification. The serotypes of the isolates were determined by serological test (slide agglutination) and the number of serotypes O1, O139 and non-O1/O139 were 3, 2 and 5 respectively which were reconfirmed by PCR method. Finally, the toxigenicity of the isolates was analyzed by multiplex PCR method and five (5) isolates were found to contain the ctx gene, the major virulence factor of V. cholerae. Key Words: Vibrio cholerae, Simplex PCR, Multiplex PCR, Serotypes, Toxigenicity. Â doi:10.3329/sjps.v1i1.1811 S. J. Pharm. Sci. 1(1&2): 69-75","PeriodicalId":21823,"journal":{"name":"Stamford Journal of Pharmaceutical Sciences","volume":"51 1","pages":"69-75"},"PeriodicalIF":0.0,"publicationDate":"2009-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91319191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5