Seminars in arthritis and rheumatism最新文献

{"title":"Autoantibodies and damage in patients with idiopathic inflammatory myopathies: A longitudinal multicenter study from the MYONET international network","authors":"Fabricio Espinosa-Ortega ,&nbsp;Karin Lodin ,&nbsp;Maryam Dastmalchi ,&nbsp;Jiri Vencovsky ,&nbsp;Louise P Diederichsen ,&nbsp;Samuel Katsuyuki Shinjo ,&nbsp;Maria Giovanna Danieli ,&nbsp;Albert Selva-O'Callaghan ,&nbsp;Marianne de Visser ,&nbsp;Zoltan Griger ,&nbsp;Angela Ceribelli ,&nbsp;Diana Gómez-Martin ,&nbsp;Helena Andersson ,&nbsp;Mónica Vázquez-Del Mercado ,&nbsp;Hector Chinoy ,&nbsp;James B Lilleker ,&nbsp;Paul New ,&nbsp;Niels S Krogh ,&nbsp;Ingrid E Lundberg ,&nbsp;Helene Alexanderson","doi":"10.1016/j.semarthrit.2024.152529","DOIUrl":"10.1016/j.semarthrit.2024.152529","url":null,"abstract":"<div><h3>Objective</h3><p>To study the trajectories of changes in damage over time and explore associations with autoantibody defined subgroups using a large international cohort of patients with idiopathic inflammatory myopathies (IIM).</p></div><div><h3>Methods</h3><p>Data from the MYONET registry, including patients who were tested for autoantibodies and had at least one assessment of damage using the Myositis Damage Index (MDI), were analyzed. Patients were sub-grouped according to their autoantibody profiles (myositis-specific, myositis-associated, or seronegative). The index date was defined as the time point for the first registered MDI assessment. The longitudinal trajectories of damage with autoantibody status as the main predictor were analyzed using linear mixed models.</p></div><div><h3>Results</h3><p>A total of 757 adult patients were included in this study. Each year of disease duration since diagnosis had an estimated MDI score increase of 0.16 units for the seronegative group (reference). Compared with the seronegative group as reference, patients with dermatomyositis-specific autoantibodies developed less damage per year of follow-up since diagnosis (average 0.08 less score, <em>P</em> = 0.04), whereas patients with anti-PM/Scl autoantibodies developed more damage per year of follow-up since diagnosis (average 0.28 higher score, <em>P</em> = 0.03) independent of sex and age at diagnosis. The seronegative subgroup and the immune-mediated necrotizing myopathy autoantibody subgroup had the strongest correlation between severity of muscle damage and HAQ-DI scores at five years of follow-up, rho=0.84, <em>P</em> &lt; 0.001 and rho=0.72, <em>P</em> &lt; 0.001, respectively.</p></div><div><h3>Conclusion</h3><p>Our study is the first to describe patterns and trajectories of change in damage over time in relation to autoantibody defined subgroups in a large international multicenter cohort of patients with IIM. Patients with anti-PM/Scl scored a greater extent of damage, whereas patients with dermatomyositis-specific antibodies had less damage than seronegative patients. Severity in muscle damage had moderate to strong correlation with functional disability among the IMNM and seronegative subgroups with lower correlations for the other subgroups. These findings suggest that autoantibodies may be useful predictors of long-term damage.</p></div>","PeriodicalId":21715,"journal":{"name":"Seminars in arthritis and rheumatism","volume":"68 ","pages":"Article 152529"},"PeriodicalIF":4.6,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0049017224001690/pdfft?md5=476ba9d478051867d3e6bc859b44b852&pid=1-s2.0-S0049017224001690-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142047086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Large-vessel imaging in patients with giant cell arteritis with scalp involvement: A commentary on giant cell arteritis associated with scalp, tongue or lip necrosis in a French multi-center case control study","authors":"Daniel Montes ,&nbsp;Nicholas E. Bohrer ,&nbsp;Kenneth J. Warrington ,&nbsp;Matthew J. Koster","doi":"10.1016/j.semarthrit.2024.152512","DOIUrl":"10.1016/j.semarthrit.2024.152512","url":null,"abstract":"","PeriodicalId":21715,"journal":{"name":"Seminars in arthritis and rheumatism","volume":"68 ","pages":"Article 152512"},"PeriodicalIF":4.6,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142012020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minimally invasive interventional procedures for osteoarthritis and inflammatory arthritis: A systematic review and meta-analysis","authors":"Jacopo Ciaffi ,&nbsp;Nicolas Papalexis ,&nbsp;Elena Vanni ,&nbsp;Marco Miceli ,&nbsp;Cesare Faldini ,&nbsp;Lorenza Scotti ,&nbsp;Antonella Zambon ,&nbsp;Carlo Salvarani ,&nbsp;Roberto Caporali ,&nbsp;Giancarlo Facchini ,&nbsp;Francesco Ursini","doi":"10.1016/j.semarthrit.2024.152525","DOIUrl":"10.1016/j.semarthrit.2024.152525","url":null,"abstract":"<div><h3>Objective</h3><p>to summarize the evidence on the efficacy of minimally invasive interventional procedures such as radiofrequency ablation (RFA) and transcatheter arterial embolization (TAE) in patients with osteoarthritis or inflammatory arthritis.</p></div><div><h3>Methods</h3><p>a literature search was conducted in PubMed and Web of Science databases. Both randomized controlled trials (RCTs) and non-randomized studies of interventions (NRSI) were included. The results were organized according to the treated anatomical site: knee, hip, foot and ankle, shoulder, hand and wrist, sacroiliac joints. Data about treatment efficacy were extracted. The main outcome was change in pain intensity using the 0–10 visual analog scale (VAS) from baseline to 1 month. Additional timepoints at 3, 6 and 12 months were assessed. Change in functional status was evaluated. Pooled estimates were calculated as the mean difference (MD) and 95 % confidence interval relative to baseline. The meta-analyses of RCTs and NRSI were conducted separately.</p></div><div><h3>Results</h3><p>of the 4599 retrieved articles, 164 were included in the review and, considering all the established timepoints, 111 (38 RCTs and 73 NRSI) were selected for the meta-analysis. Only one article described patients with inflammatory arthritis. In the meta-analysis of RCTs, one month after the procedure, MD in VAS was -3.98 (-4.41 to -3.55; <em>k</em> = 21) for knee RFA, and -3.18 (-3.96 to -2.39; <em>k</em> = 8) for sacroiliac joints RFA. In the meta-analysis of NRSI, MD in VAS was -4.12 (-4.63 to -3.61; <em>k</em> = 23) for knee RFA, -3.84 (-4.77 to -2.92; <em>k</em> = 7) for knee TAE, -4.34 (-4.96 to -3.71; <em>k</em> = 2) for hip RFA, -3.83 (-4.52 to -3.15; <em>k</em> = 3) for shoulder RFA and -4.93 (-5.58 to -4.28; <em>k</em> = 14) for sacroiliac joints RFA. Significant decrease in pain intensity was found also at 3, 6 and 12 months. Additionally, functional status improved at all the assessed timepoints.</p></div><div><h3>Conclusion</h3><p>minimally invasive interventional procedures can improve pain and functional status of patients affected by OA or chronic sacroiliac pain of degenerative origin. Further research is warranted in the field of inflammatory rheumatic diseases.</p></div>","PeriodicalId":21715,"journal":{"name":"Seminars in arthritis and rheumatism","volume":"68 ","pages":"Article 152525"},"PeriodicalIF":4.6,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0049017224001653/pdfft?md5=48df68f3ff4538080053d0e62d95877a&pid=1-s2.0-S0049017224001653-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141976547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“It means almost forgetting that you've got a disease”: An OMERACT study to define independence in the context of rheumatoid arthritis remission from the patient perspective","authors":"Caroline A. Flurey ,&nbsp;Bethan Jones ,&nbsp;Ummugulsum Gazel ,&nbsp;Chikosolu Uzoka ,&nbsp;Kate Rosser ,&nbsp;Thomas Khoo ,&nbsp;Marieke Voshaar ,&nbsp;Wijnanda Hoogland ,&nbsp;Beverley Shea ,&nbsp;Lynn March ,&nbsp;Dorcas Beaton ,&nbsp;Peter Tugwell ,&nbsp;Susanna Proudman ,&nbsp;OMERACT remission in RA: Patient perspective working group","doi":"10.1016/j.semarthrit.2024.152526","DOIUrl":"10.1016/j.semarthrit.2024.152526","url":null,"abstract":"<div><h3>Aims</h3><p>Our previous work identified pain, fatigue, and independence as missing from the ACR/EULAR rheumatoid arthritis (RA) remission criteria from the patient perspective. Validated measures exist for pain and fatigue, but not for independence. As a first step towards developing such a measure, this study aimed to understand ‘Independence’ in the context of RA remission from the patient perspective.</p></div><div><h3>Methods</h3><p>International qualitative research study comprising five focus groups of 19 participants with RA. Data were analysed using reflexive thematic analysis.</p></div><div><h3>Results</h3><p>Five overarching themes were identified, underpinned by a construct of “stages of independence”. Independence means at least being ‘physically and functionally able’ but may go beyond this and enable ‘participation beyond function’, ‘cognitive independence’, and ‘having or taking control’. There was no agreement on whether assistance is an aid to independence or undermines ability to achieve independence (‘assistance is complicated’). The construct “Stages of independence” acknowledges that Independence may mean different things to different patients and there may be other factors beyond disease activity that hold patients in each of these stages.</p></div><div><h3>Conclusion</h3><p>These novel data suggest a desirable definition of independence includes full active participation without the need to consider or work around disease activity, and cognitive independence from thoughts of RA. Independence in RA remission is a complex concept and next steps will be to seek patient and professional agreement on the most important issues raised in these focus groups to take forward to developing a measure for independence in the context of RA remission from the patient perspective.</p></div>","PeriodicalId":21715,"journal":{"name":"Seminars in arthritis and rheumatism","volume":"68 ","pages":"Article 152526"},"PeriodicalIF":4.6,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0049017224001665/pdfft?md5=870f1a7769d0fd55e20652b34e7e72dd&pid=1-s2.0-S0049017224001665-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141913889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The immune pathology of bursitis in rheumatic inflammatory diseases, degenerative conditions and mechanical stress: A systematic review","authors":"Anqi Zhang ,&nbsp;Elisabeth Brouwer ,&nbsp;Maria Sandovici ,&nbsp;Arjan Diepstra ,&nbsp;William F. Jiemy ,&nbsp;Kornelis S.M. van der Geest","doi":"10.1016/j.semarthrit.2024.152527","DOIUrl":"10.1016/j.semarthrit.2024.152527","url":null,"abstract":"<div><h3>Objective</h3><p>To summarize current insights on the immune pathology of bursitis caused by rheumatic inflammatory diseases, degenerative conditions, or mechanical stress and identify knowledge gaps in this field. Data on tenosynovitis pathology was included for comparison.</p></div><div><h3>Methods</h3><p>We performed a systematic review encompassing an electronic database search of all published literatures in PubMed/MEDLINE from inception to February 13, 2023, investigating the immunological changes occurring in the bursa of patients with inflammatory rheumatic diseases, degenerative conditions or mechanical stress (e.g., impingement syndrome).</p></div><div><h3>Results</h3><p>Thirty-two articles provided data on the immune pathology of bursal tissue inflammation were identified. Histological and immunological perturbations included alterations of tissue morphology, infiltration of macrophages and some T cells, and enhanced expression of proinflammatory cytokines, such as interleukin (IL)-6, IL-1β and tumor necrosis factor alpha (TNF-α). These changes were described for all three underlying causes, although studies on bursitis associated with rheumatic inflammatory diseases were rare. Fibrosis was only reported in subacromial bursitis caused by mechanical stress within our included studies.</p></div><div><h3>Conclusion</h3><p>Current insights on bursitis were outdated and studies on bursitis associated with rheumatic inflammatory diseases are particularly lacking. Substantial overlap of enhanced expression of IL-6, IL-1β, TNF-α and infiltrating macrophages were found in bursitis irrespective of the underlying cause. In depth investigation on bursitis such as high throughput multi-omics are urgently needed to guide disease-specific therapeutic management.</p></div>","PeriodicalId":21715,"journal":{"name":"Seminars in arthritis and rheumatism","volume":"68 ","pages":"Article 152527"},"PeriodicalIF":4.6,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0049017224001677/pdfft?md5=1a9606a1942069ea00001dc1a1641360&pid=1-s2.0-S0049017224001677-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141985664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of synovitis patterns in early RA supports the importance of joint-specific factors","authors":"Laura Bricman ,&nbsp;Clément Triaille ,&nbsp;Emilie Sapart ,&nbsp;Tatiana Sokolova ,&nbsp;Aleksandra Avramovska ,&nbsp;Francesco Natalucci ,&nbsp;Thomas Kirchgesner ,&nbsp;Patrick Durez","doi":"10.1016/j.semarthrit.2024.152524","DOIUrl":"10.1016/j.semarthrit.2024.152524","url":null,"abstract":"<div><h3>Background</h3><p>Rheumatoid arthritis (RA) is classically considered a systemic disorder, but the role of local factors in driving synovial inflammation is increasingly being recognized. These joint-specific factors may consequently modulate disease phenotype.</p></div><div><h3>Objectives</h3><p>Our goal was to study the spatial distribution of swelling, tenderness and erosions in a large cohort of early RA (ERA) patients, to assess for patterns of simultaneously-involved joint clusters. We also aimed to investigate the link between arthritis localization and phenotypic features such as bone erosions and response to methotrexate therapy.</p></div><div><h3>Methods</h3><p>DMARD-naive patients from the ERA UCLouvain Brussels cohort were included. Forty-four joints were clinically assessed for swelling and tenderness before treatment, and 6 months later for methotrexate-treated patients. Clusters of joints were identified using Principal component analysis and Cramer's correlation coefficients. Frequency of bone erosions and joint-specific response to methotrexate were compared across different clusters.</p></div><div><h3>Results</h3><p>452 ERA patients were included. Analysis of the spatial distribution of swelling and tenderness allowed for the identification of 3 joint clusters that showed significant simultaneous involvement: (i) MTP1–5 joints, (ii) hand joints (MCPs and PIPs), and (iii) larger joints. These clusters were associated with different susceptibility to bone erosions and distinct clinical features, but similar local response (joint swelling resolution) to methotrexate.</p></div><div><h3>Conclusion</h3><p>This is the first study investigating the spatial distribution of arthritis in a large cohort of early RA using an unbiased approach. We identify clusters of simultaneously involved joints, supporting the importance of local factors in driving synovitis in RA.</p></div>","PeriodicalId":21715,"journal":{"name":"Seminars in arthritis and rheumatism","volume":"68 ","pages":"Article 152524"},"PeriodicalIF":4.6,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141978862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum uric acid, a potential biomarker for interstitial lung disease in anti-MDA5 antibody-positive dermatomyositis","authors":"Huaiya Xie,&nbsp;Junping Fan","doi":"10.1016/j.semarthrit.2024.152510","DOIUrl":"10.1016/j.semarthrit.2024.152510","url":null,"abstract":"","PeriodicalId":21715,"journal":{"name":"Seminars in arthritis and rheumatism","volume":"69 ","pages":"Article 152510"},"PeriodicalIF":4.6,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141838709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"OMERACT systemic lupus erythematosus domain survey","authors":"Wils Nielsen ,&nbsp;Vibeke Strand ,&nbsp;Lee Simon ,&nbsp;Ellie Pinsker ,&nbsp;Dennisse Bonilla ,&nbsp;Eric Morand ,&nbsp;Julian Thumboo ,&nbsp;Martin Aringer ,&nbsp;Marta Mosca ,&nbsp;Ian Bruce ,&nbsp;Ioannis Parodis ,&nbsp;Alfred Kim ,&nbsp;Maya Desai ,&nbsp;Yvonne Enman ,&nbsp;Beverley Shea ,&nbsp;Daniel J. Wallace ,&nbsp;Yashaar Chaichian ,&nbsp;Sandra Navarra ,&nbsp;Cynthia Aranow ,&nbsp;Meggan Mackay ,&nbsp;Zahi Touma","doi":"10.1016/j.semarthrit.2024.152520","DOIUrl":"10.1016/j.semarthrit.2024.152520","url":null,"abstract":"<div><h3>Background</h3><p>Since the development of the OMERACT Systemic Lupus Erythematosus (SLE) Core Outcome Set (COS) in 1998, many new SLE domains have been identified and measures developed, creating a need to update the SLE COS. To revisit the 1998 SLE COS and research agenda domains, and generate new candidate domains, we conducted this study of patients with SLE and collaborators.</p></div><div><h3>Objective</h3><p>(1) To evaluate existing candidate SLE domains for inclusion in the SLE COS. (2) To generate additional candidate SLE domains for COS consideration. (3) To engage SLE collaborators, including patients, in developing the updated SLE COS.</p></div><div><h3>Methods</h3><p>The OMERACT SLE Working Group's steering committee developed a survey to assess the importance of candidate SLE domains and generate additional domains for consideration towards the SLE COS. Patients with SLE followed at the University of Toronto Lupus Clinic (patient group) and members of the OMERACT SLE Working Group (collaborator group) were invited to complete the survey between August 2022 and February 2023.</p></div><div><h3>Results</h3><p>A total of 175 patients were invited and 100 completed the survey. Of 178 collaborators invited, 145 completed the survey. Patients tended to prioritize life-impact domains while collaborators prioritized clinical domains. Both patients and collaborators recommended additional domains to those included in the 1998 SLE COS and research agenda.</p></div><div><h3>Conclusion</h3><p>The domain inclusion and importance results demonstrate that patients and collaborators prioritize different domains, so capturing the perspectives of both groups is essential to ensure a holistic assessment of SLE. The results of the study identify domains that already have a high level of agreement for potential inclusion in the SLE COS, domains that require further explanation, and novel domains that warrant consideration.</p></div>","PeriodicalId":21715,"journal":{"name":"Seminars in arthritis and rheumatism","volume":"68 ","pages":"Article 152520"},"PeriodicalIF":4.6,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141770864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning in the prediction of treatment response in rheumatoid arthritis: A systematic review","authors":"Claudia Mendoza-Pinto ,&nbsp;Marcial Sánchez-Tecuatl ,&nbsp;Roberto Berra-Romani ,&nbsp;Iván Daniel Maya-Castro ,&nbsp;Ivet Etchegaray-Morales ,&nbsp;Pamela Munguía-Realpozo ,&nbsp;Maura Cárdenas-García ,&nbsp;Francisco Javier Arellano-Avendaño ,&nbsp;Mario García-Carrasco","doi":"10.1016/j.semarthrit.2024.152501","DOIUrl":"10.1016/j.semarthrit.2024.152501","url":null,"abstract":"<div><h3>Objective</h3><p>This study aimed to investigate the current status and performance of machine learning (ML) approaches in providing reproducible treatment response predictions.</p></div><div><h3>Methods</h3><p>This systematic review was conducted in accordance with the PRISMA statement and the CHARMS checklist. We searched PubMed, Cochrane Library, Web of Science, Scopus, and EBSCO databases for cohort studies that derived and/or validated ML models focused on predicting rheumatoid arthritis (RA) treatment response. We extracted data and critically appraised studies based on the Transparent Reporting of a Multivariable Prediction Model for Individual Prognosis or Diagnosis (TRIPOD) and Prediction Model Risk of Bias Assessment Tool (PROBAST) guidelines.</p></div><div><h3>Results</h3><p>From 210 unduplicated records identified by the literature search, we retained 29 eligible studies. Of these studies, 10 developed a predictive model and reported a mean adherence to the TRIPOD guidelines of 45.6 % (95 % CI: 38.3–52.8 %). The remaining 19 studies not only developed a predictive model but also validated it externally, with a mean adherence of 42.9 % (95 % CI: 39.1–46.6 %). Most of the articles had an unclear risk of bias (41.4 %), followed by a high risk of bias, which was present in 37.9 %.</p></div><div><h3>Conclusions</h3><p>In recent years, ML methods have been increasingly used to predict treatment response in RA. Our critical appraisal revealed unclear and high risk of bias in most of the identified models, suggesting that researchers can do more to address the risk of bias and increase transparency, including the use of calibration measures and reporting methods for handling missing data.</p></div><div><h3>Funding</h3><p>None.</p></div>","PeriodicalId":21715,"journal":{"name":"Seminars in arthritis and rheumatism","volume":"68 ","pages":"Article 152501"},"PeriodicalIF":4.6,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0049017224001410/pdfft?md5=8c5c0cc16bb161ec1cfa1a22e67d7aa7&pid=1-s2.0-S0049017224001410-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141770862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subcutaneous vs intravenous abatacept in rheumatoid arthritis-interstitial lung disease. National multicentre study of 397 patients","authors":"Marta López-Maraver ,&nbsp;Ana Serrano-Combarro ,&nbsp;Belén Atienza-Mateo ,&nbsp;Natividad del Val ,&nbsp;Ivette Casafont-Solé ,&nbsp;Rafael B. Melero-Gonzalez ,&nbsp;Alba Pérez-Linaza ,&nbsp;Jerusalem Calvo Gutiérrez ,&nbsp;Natalia Mena-Vázquez ,&nbsp;Nuria Vegas-Revenga ,&nbsp;Lucía Domínguez-Casas ,&nbsp;Jesús Loarce Martos ,&nbsp;Cilia Amparo Peralta Ginés ,&nbsp;Carolina Diez Morrondo ,&nbsp;Lorena Pérez Albaladejo ,&nbsp;Rubén López Sánchez ,&nbsp;Mª Guadalupe Manzano Canabal ,&nbsp;Anahy Mª Brandy-García ,&nbsp;Patricia López Viejo ,&nbsp;Gema Bonilla ,&nbsp;Ricardo Blanco","doi":"10.1016/j.semarthrit.2024.152517","DOIUrl":"10.1016/j.semarthrit.2024.152517","url":null,"abstract":"<div><h3>Background</h3><p>Evidence on abatacept (ABA) utility for rheumatoid arthritis (RA) – associated interstitial lung disease (ILD) is growing. Clinical trials have shown equivalence in subcutaneous (SC) and intravenous (IV) administration of ABA for articular manifestations. However, this has not been studied in respiratory outcomes.</p></div><div><h3>Objective</h3><p>To compare the effectiveness of ABA in RA-ILD patients according to the route of administration.</p></div><div><h3>Methods</h3><p>National retrospective multicentre study of RA-ILD patients on treatment with ABA. They were divided into 2 groups: <strong>a)</strong> IV, and <strong>b)</strong> SC. The following outcomes were analysed from baseline to final follow-up using linear mixed models: <strong>a)</strong> forced vital capacity (FVC), <strong>b)</strong> diffusing capacity of the lungs for carbon monoxide (DLCO), <strong>c)</strong> chest high resolution computed tomography (HRCT), <strong>d)</strong> dyspnoea, <strong>e)</strong> RA activity, and <strong>f)</strong> sparing corticosteroids effect.</p></div><div><h3>Results</h3><p>A total of 397 patients were included (94 IV-ABA and 303 SC-ABA), median follow-up of 24 [10–48] months. After adjustment for possible confounders, FVC and DLCO remained stable during the first 24 months without differences between IV-ABA and SC-ABA (<em>p</em> = 0.6304 and 0.5337). Improvement/ stability of lung lesions in HRCT was observed in 67 % of patients (75 % IV-ABA, 64 % SC-ABA; <em>p</em> = 0.07). Dyspnoea stabilized/ improved in 84 % of patients (90 % IV-ABA, 82 % SC-ABA; <em>p</em> = 0.09). RA - disease activity improved in both groups. No statistically significant differences regarding any of the variables studied between the two groups were found. ABA was withdrawn in 87 patients (21.9 %), 45 % IV-ABA and 37 % SC-ABA (<em>p</em> = 0.29). ILD worsening and articular inefficacy were the most common reasons for ABA discontinuation.</p></div><div><h3>Conclusion</h3><p>In patients with RA-ILD, ABA seems to be equally effective regardless of the route of administration.</p></div>","PeriodicalId":21715,"journal":{"name":"Seminars in arthritis and rheumatism","volume":"68 ","pages":"Article 152517"},"PeriodicalIF":4.6,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141770861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}