Seminars in cutaneous medicine and surgery最新文献_第2页

Information technologies in health care delivery and policy: giant steps and missteps. 卫生保健服务和政策中的信息技术:巨大的进步和失误。

Seminars in cutaneous medicine and surgery Pub Date : 2019-03-01 DOI: 10.12788/j.sder.2019.005

Andrew J Park, Mario K Maruther, Robert A Swerlick

引用次数: 1

Emerging technologies for health information in dermatology: opportunities and drawbacks of web-based searches, social media, mobile applications, and direct-to-consumer genetic testing in patient care. 皮肤科健康信息的新兴技术:基于网络的搜索、社交媒体、移动应用程序和直接面向消费者的患者护理基因检测的机遇和缺点。

Seminars in cutaneous medicine and surgery Pub Date : 2019-03-01 DOI: 10.12788/j.sder.2019.002

Justin L Jia, Danielle J Polin, Kavita Y Sarin

引用次数: 8

Artificial intelligence and dermatology: opportunities, challenges, and future directions. 人工智能与皮肤病学:机遇、挑战和未来方向。

Seminars in cutaneous medicine and surgery Pub Date : 2019-03-01 DOI: 10.12788/j.sder.2019.

Daniel I Schlessinger, Guillaume Chhor, Olivier Gevaert, Susan M Swetter, Justin Ko, Roberto A Novoa

引用次数: 0

Systemic therapy for advanced cutaneous squamous cell carcinoma. 晚期皮肤鳞状细胞癌的全身治疗。

Seminars in cutaneous medicine and surgery Pub Date : 2019-03-01 DOI: 10.12788/j.sder.2019.010

Kelly Fitzgerald, Katy K Tsai

{"title":"Systemic therapy for advanced cutaneous squamous cell carcinoma.","authors":"Kelly Fitzgerald, Katy K Tsai","doi":"10.12788/j.sder.2019.010","DOIUrl":"https://doi.org/10.12788/j.sder.2019.010","url":null,"abstract":"The incidence of advanced cutaneous squamous cell carcinoma (cSCC) is increasing; of the 1.3 million nonmelanoma skin cancers that arise each year, approximately 20% are cSCC, and between 2-5% of these cases ultimately metastasize. However, there is no established consensus on first-line systemic treatment for those patients who have locally advanced or metastatic disease. Major classes of systemic agents include chemotherapy, epidermal growth factor receptor (EGFR)-targeted therapy, and immunotherapy; each is associated with a distinct set of adverse effects, and availability of data from randomized controlled trials (RCTs) to definitively guide treatment are limited. While several chemotherapeutic agents have been described in case studies or small patient cohorts, only one RCT has been conducted, demonstrating a 34% overall response rate for a cisplatin-based regimen. EGFR-inhibitors evaluated for use in cSCC by RCT include cetuximab, panitumumab, and gefitinib; response rates ranged from 15-31% for these agents. Inhibitors of the immune checkpoint programmed death-1 (PD-1) have yielded promising outcomes in advanced cSCC; indeed, the PD-1 inhibitor cemiplimab recently received FDA approval for use in advanced cSCC. Despite these advances, the preferred regimen for systemic treatment of cSCC remains unclear, particularly in immunocompromised populations. Herein we provide a review of the literature supporting the use of these modalities and a discussion of their clinical utility.","PeriodicalId":21714,"journal":{"name":"Seminars in cutaneous medicine and surgery","volume":"38 1","pages":"E67-E74"},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37206900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Vaginal wellness: whose turf is it? 阴道健康:这是谁的地盘?

Seminars in cutaneous medicine and surgery Pub Date : 2018-12-01 DOI: 10.12788/j.sder.2018.060

Min-Wei Christine Lee

引用次数: 0

Melasma: update on management. 黄褐斑:最新的管理情况。

Seminars in cutaneous medicine and surgery Pub Date : 2018-12-01 DOI: 10.12788/j.sder.2018.049

Amanda K Suggs, Selina S Hamill, Paul M Friedman

引用次数: 10

Device-based treatment for vaginal wellness. 基于器械的阴道健康治疗。

Seminars in cutaneous medicine and surgery Pub Date : 2018-12-01 DOI: 10.12788/j.sder.2018.052

Macrene Alexiades

{"title":"Device-based treatment for vaginal wellness.","authors":"Macrene Alexiades","doi":"10.12788/j.sder.2018.052","DOIUrl":"https://doi.org/10.12788/j.sder.2018.052","url":null,"abstract":"Genitourinary syndrome of menopause (GSM), encompassing the disorders of atrophic vaginitis, urinary incontinence, and pelvic prolapse, affects the majority of postmenopausal women, as well as patients who are undergoing breast cancer treatement, post-ovarectomy, post-radiation, and breast-feeding. There is a need for better treatment options for these common conditions that adversely affect physical function and quality of life and that are often underserved by existing options. Lasers have been used to treat genitourinary tissue for over 40 years, and over the past decade, several lasers and radiofrequency devices have been developed and clinically tested for the treatment of GSM, with an accumulating body of evidence demonstrating their safety and efficacy. Fractional lasers, including carbon dioxide, erbium: YAG and hybrid technologies, as well as monopolar radiofrequency devices, work by resurfacing and/or stimulating via heat the vaginal lining resulting in a re-epithelialization, neovascularization, and remodeling of the vaginal tissue from an atrophic postmenopausal state to a thickened, glycogen-rich and well-vascularized state similar to premenopausal vaginal lining. These changes are correlated clinically with improved function on a variety of validated vaginal health scales and urinary incontinence tests. Currently cleared for general application to genitourinary tissue, clinical trials are underway for FDA clearance or approval for specific GSM indications.","PeriodicalId":21714,"journal":{"name":"Seminars in cutaneous medicine and surgery","volume":"37 4","pages":"226-232"},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36764946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Treatment of female pattern hair loss with combination therapy. 综合疗法治疗女性型脱发。

Seminars in cutaneous medicine and surgery Pub Date : 2018-12-01 DOI: 10.12788/j.sder.2018.043

Rosalynn R Conic, Shilpi Khetarpal, Wilma Bergfeld

引用次数: 1

Aesthetic considerations in female skin of color: what you need to know. 有色人种女性皮肤的美学考虑：你需要知道的事。

Seminars in cutaneous medicine and surgery Pub Date : 2018-12-01 DOI: 10.12788/j.sder.2018.053

Michelle Henry, Neil Sadick

引用次数: 0

Vaginal rejuvenation: whose turf? 阴道再生:谁的地盘?

Seminars in cutaneous medicine and surgery Pub Date : 2018-12-01 DOI: 10.12788/j.sder.2018.059

Laura Schilling, Nazanin Saedi

引用次数: 0