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Effect of intracerebral microinjection of naloxone on acupuncture- and morphine-analgesia in the rabbit. 脑内微注射纳洛酮对家兔针刺镇痛和吗啡镇痛的影响。
Scientia Sinica Pub Date : 1981-08-01
Z F Zhou, M Y Du, W Y Wu, Y Jiang, J S Han
{"title":"Effect of intracerebral microinjection of naloxone on acupuncture- and morphine-analgesia in the rabbit.","authors":"Z F Zhou,&nbsp;M Y Du,&nbsp;W Y Wu,&nbsp;Y Jiang,&nbsp;J S Han","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Although there are unequivocal evidences indicating the participation of endogenous opiate-like substances in acupuncture analgesia, their exact sites of action remain to be elucidated. From the results of localization studies by injecting minute amount of narcotic antagonist naloxone into discrete brain areas and assessing its effect on acupuncture analgesia in rabbits it is concluded that nuclei accumbens, amygdala, habenula and periaquaductal grey are the strategic sites for endogenous opioids to exert their analgesic effect. These brain areas are also of extreme importance for the realization of morphine analgesia.</p>","PeriodicalId":21694,"journal":{"name":"Scientia Sinica","volume":"24 8","pages":"1166-78"},"PeriodicalIF":0.0,"publicationDate":"1981-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17335184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Studies on incorporation of membrane protein into liposomes--effect of divalent cations on reconstitution of pig heart mitochondrial H+-ATPase into liposomes. 膜蛋白掺入脂质体的研究——二价阳离子对猪心脏线粒体H+- atp酶重构脂质体的影响。
Scientia Sinica Pub Date : 1981-07-01
F Y Yang, B Q Guo, Y G Huang, Y W Che
{"title":"Studies on incorporation of membrane protein into liposomes--effect of divalent cations on reconstitution of pig heart mitochondrial H+-ATPase into liposomes.","authors":"F Y Yang,&nbsp;B Q Guo,&nbsp;Y G Huang,&nbsp;Y W Che","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>During the process of reconstitution of pig heart mitochondrial H+-ATPase on liposomes by cholate dialysis method, 1 mM Mg2+ in the dialysis medium can obviously increase activities of the reconstituted H+-ATPase (32Pi-ATP exchange, enzyme activity and its sensitivity to oligomycin or DCCD and ATP-dependent ANS 1) fluorescence). Besides Mg2+, effects of other divalent cations and spermidine on the H+-ATPase reconstitution have been compared. The effectiveness of the divalent cation activation of 32Pi-ATP exchange of the reconstituted H+-ATPase, decreased in the order: Mg2+ greater than Ca2+ greater than Mn2+ greater than Sr2+, while that of increasing the sensitivity to the inhibitors: Ca2+ greater than Mg2+ greater than Mn2+ greater than Sr2+. No significant effect on the H+-ATPase reconstitution has been found with Cd2+, Zn2+ and spermidine3+. Mechanism of action of the divalent cations on reconstitution has been discussed.</p>","PeriodicalId":21694,"journal":{"name":"Scientia Sinica","volume":"24 7","pages":"989-96"},"PeriodicalIF":0.0,"publicationDate":"1981-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17513123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Isolation and partial characterization of two biologically active peptides from porcine spinal cord. 猪脊髓两种生物活性肽的分离及部分鉴定。
Scientia Sinica Pub Date : 1981-07-01
G L Xi, J C Hua, R L Chen, R B Zhang, G Zou, Y S Gao
{"title":"Isolation and partial characterization of two biologically active peptides from porcine spinal cord.","authors":"G L Xi,&nbsp;J C Hua,&nbsp;R L Chen,&nbsp;R B Zhang,&nbsp;G Zou,&nbsp;Y S Gao","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Two biologically active peptides designated SCP-1 and SCP-2 have been isolated and partially characterized from porcine spinal cord. The results of amino acid analysis, electrophoresis, isoelectric focusing and the chromatographic analysis of the dansylated derivatives indicate that these two peptides are homogeneous. The amino acid composition and apparent untriakontapeptide and SCP-2 is a pentacospeptide. The N-terminal amino acids of SCP-1 and SCP-2 are Arginine and Tryptophan respectively. SCP-1 can stimulate the contraction of isolated guinea pig ileum and SCP-2 induces hypotension in anesthetized rat. Both SCP-1 and SCP-2 show no morphine-like activity. The chemical composition and biological properties of SCP-1 and SCP-2 distinguish them from any known peptide.</p>","PeriodicalId":21694,"journal":{"name":"Scientia Sinica","volume":"24 7","pages":"1010-20"},"PeriodicalIF":0.0,"publicationDate":"1981-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18269009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Studies on mechanism of action of luteinizing releasing hormone (LH-RH) in ovulation of fish--intracellular distribution of LH-RH-A in pituitary gonadotrophs as revealed by electron-microscopic autoradiography. 促黄体释放激素(LH-RH)在鱼类排卵中的作用机制研究——电镜放射自显像显示LH-RH- a在垂体促性腺激素细胞内的分布。
Scientia Sinica Pub Date : 1981-07-01
X G Pan, D Y Chen, Z H Zhao, Y T Zhu, X K Zhao, H R Lin, Z S Liu, D Lin
{"title":"Studies on mechanism of action of luteinizing releasing hormone (LH-RH) in ovulation of fish--intracellular distribution of LH-RH-A in pituitary gonadotrophs as revealed by electron-microscopic autoradiography.","authors":"X G Pan,&nbsp;D Y Chen,&nbsp;Z H Zhao,&nbsp;Y T Zhu,&nbsp;X K Zhao,&nbsp;H R Lin,&nbsp;Z S Liu,&nbsp;D Lin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The results of competitive bending experiment and the electron-microscopic autoradiographic studies show that the peptide hormone, LH-RH-A (a nonapeptide), could be internalized into the gonadotrophs of the pituitary gland of the mud-carp (Cirrhrinus molitorella). It is demonstrated that the labeled peptide, 125I-LH-RH-A, is internalized not only into the cytoplasm, but also into the nucleus, apparently via the nuclear pores. It is, therefore, suggested that the peptide hormone might act directly on the genome either in the form of a hormone-receptor complex or of a single molecule.</p>","PeriodicalId":21694,"journal":{"name":"Scientia Sinica","volume":"24 7","pages":"982-8"},"PeriodicalIF":0.0,"publicationDate":"1981-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18068631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dynamic pupillary response to positive differential of light stimulus. 瞳孔对光刺激正微分的动态响应。
Scientia Sinica Pub Date : 1981-06-01
F C Sun, H K Liu, Y M Liu
{"title":"Dynamic pupillary response to positive differential of light stimulus.","authors":"F C Sun,&nbsp;H K Liu,&nbsp;Y M Liu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Under low background illumination, the pupil responds only to an increase in light intensity by a transient constriction when the extent and rate of the increase exceed a certain values. We term this response the dynamic papillary response in order to differentiate it from the much more sluggish and much less pronounced response moiety that governs the static pupil size according to the level of light adaptation. The characteristics of the dynamic response are studied in some detail. This virtually unidirectional rate sensitivity of pupil to light renders it difficult to be subjected to frequency-response analysis even by small signal approximation. Analysis of the experimental results suggests that this transient response is a light-precipitated confluence of few consecutive hippus.</p>","PeriodicalId":21694,"journal":{"name":"Scientia Sinica","volume":"24 6","pages":"872-84"},"PeriodicalIF":0.0,"publicationDate":"1981-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18271371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Studies on synthesis and relationship between analgesic activity and receptor affinity for 3-methyl fentanyl derivatives. 3-甲基芬太尼衍生物的合成及其镇痛活性与受体亲和力关系的研究。
Scientia Sinica Pub Date : 1981-05-01
W Q Jin, H Xu, Y C Zhu, S N Fang, X L Xia, Z M Huang, B L Ge, Z Q Chi
{"title":"Studies on synthesis and relationship between analgesic activity and receptor affinity for 3-methyl fentanyl derivatives.","authors":"W Q Jin,&nbsp;H Xu,&nbsp;Y C Zhu,&nbsp;S N Fang,&nbsp;X L Xia,&nbsp;Z M Huang,&nbsp;B L Ge,&nbsp;Z Q Chi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In the present paper, the synthesis and analgesic activity (mice, i.p. hot plate test) of the derivatives of 3-methyl fentanyl are briefly described. Compound 7302, cis-N-[1-(2-hydroxy-2-phenylethyl)-3-methyl-4-piperidyl]-N-phenylpropionamide (cis: 3-methyl/4-N-phenylpropionamide) is found to be the most potent analgesic agent in this series synthesized by our laboratory (ED50 = 0.0022 mg/kg). The analgesic activity of 7302 is 28 times more potent than that of fentanyl and 6300 times more than that of morphine. The partition coefficients of 10 compounds in the series are determined by high performance liquid chromatography (HPLC) and their log p values are about 3. There are no regular relationships between the analgesic activity and partition coefficients. Study on the specific binding of 8 out of the above 10 compounds to crude synaptic plasma membrane (P2-fraction) of mouse brain demonstrates that there is an excellent statistical linear correlation (r = 0.998) between the analgesic potency and the specific binding affinity. The result shows that the analgesic potency of the derivatives of this series is mainly dependent on binding affinity for opiate receptor.</p>","PeriodicalId":21694,"journal":{"name":"Scientia Sinica","volume":"24 5","pages":"710-20"},"PeriodicalIF":0.0,"publicationDate":"1981-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17326448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The occurrence of post-denervation hypertrophy in chick slow muscle fibres after complete elimination of stretch and tension. 鸡慢肌纤维在完全消除拉伸和张力后出现后去神经肥大。
Scientia Sinica Pub Date : 1981-04-01
D P Feng, W Y Wu, D X Lu
{"title":"The occurrence of post-denervation hypertrophy in chick slow muscle fibres after complete elimination of stretch and tension.","authors":"D P Feng,&nbsp;W Y Wu,&nbsp;D X Lu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>With the slow muscle fibres in the pure slow muscle ALD as well as in two mixed muscles, flexor metacarpi ulnaris and sartorius, it is demonstrated that the phenomenon of postdenervation hypertrophy still occurs under conditions preventing stretch of muscle after denervation or even in tenotomized muscles in shortened state relieved of tension. Striking differences between the slow fibres of the ALD and those of the mixed muscles are seen, both with respect to their histochemical property and to the degree of development of post-denervation hypertrophy. The slow fibres in the mixed muscles show the phenomenon of post-denervation hypertrophy in a much more striking form than the ALD fibres and should be made more use of in further studies on the phenomenon.</p>","PeriodicalId":21694,"journal":{"name":"Scientia Sinica","volume":"24 4","pages":"554-62"},"PeriodicalIF":0.0,"publicationDate":"1981-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18271370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of gossypol on ATPase activity of the kidney. 棉酚对肾脏atp酶活性的影响。
Scientia Sinica Pub Date : 1981-04-01
X F Bi, Y J Zheng, H F Yang, Z R Zhang
{"title":"The effect of gossypol on ATPase activity of the kidney.","authors":"X F Bi,&nbsp;Y J Zheng,&nbsp;H F Yang,&nbsp;Z R Zhang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The results of the present study have shown no change in the activity of ATPase of the renal cortex of rats administered gossypol for half a year. The Na+, K+-ATPase activity of the cellular membrane of renal cortex of guinea pigs fed with gossypol for 5 or 9 weeks is significantly altered. It seems possible to diminish or to delay the inhibition by allowing the guinea pigs a potassium-rich diet ad libitum. In vitro, gossypol inhibits significantly the activity of ATPase of the brain and the kidney of rats and guinea pigs uncompetitively. However, the inhibition of the ATPase of human fetus kidney is of a mixed type.</p>","PeriodicalId":21694,"journal":{"name":"Scientia Sinica","volume":"24 4","pages":"573-80"},"PeriodicalIF":0.0,"publicationDate":"1981-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17328547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A well-preserved cranium of an archaic type of early Homo sapiens from Dali, China. 中国大理出土的一具保存完好的古代早期智人头盖骨。
Scientia Sinica Pub Date : 1981-04-01
X Z Wu
{"title":"A well-preserved cranium of an archaic type of early Homo sapiens from Dali, China.","authors":"X Z Wu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This paper deals with a well-preserved human cranium of late Middle Pleistocene, belonging to a young male individual. It has many characters identical to those of early Homo sapiens or intermediate between Homo erectus and modern man. It possesses also some features similar to those of modern man, and close to Homo erectus in some respects. So it probably belongs to an archaic type to early Homo sapiens. Taken with other Chinese human fossils it is on the continuous human evolutionary line in China. The cranium differs from Neanderthals in a number of racial characteristics. It is therefore considered here a new subspecies: Homo sapiens daliensis.</p>","PeriodicalId":21694,"journal":{"name":"Scientia Sinica","volume":"24 4","pages":"530-41"},"PeriodicalIF":0.0,"publicationDate":"1981-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17842066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acoustic signals and acoustic behaviour of Chinese river dolphin (Lipotes vexillifer). 中国江豚(Lipotes vexillifer)的声信号和声行为。
Scientia Sinica Pub Date : 1981-03-20 DOI: 10.1360/YA1981-24-3-407
Xian-Yang Jing, You-Fu Xiao, Rong-Cai Jing
{"title":"Acoustic signals and acoustic behaviour of Chinese river dolphin (Lipotes vexillifer).","authors":"Xian-Yang Jing, You-Fu Xiao, Rong-Cai Jing","doi":"10.1360/YA1981-24-3-407","DOIUrl":"https://doi.org/10.1360/YA1981-24-3-407","url":null,"abstract":"Chinese river dolphin's (Lipotes vexillifer) underwater acoustic signals can be divided into two classes, short-duration signal (pulse train or single pulses) and long-duration signal (whistle). In this paper, time waveforms of these signals are presented and the characteristics of the signals are discussed. The experimental results on this dolphin's acoustic behaviour are given. A sinusoidal pulse with duration of about 300 ms is used as the calling signal. In a certain frequency range, as soon as a calling signal is transmitted the dolphin answers with 2 or 3 whistles. The frequency range of sensitive response is from 4 to 7 KHz, in which the answering rate reaches 100%. When the dolphin's acoustic signals recorded on the tape are transmitted into the water it swims directly toward the transducer. When noise and music are transmitted the dolphin does not respond at all.","PeriodicalId":21694,"journal":{"name":"Scientia Sinica","volume":"145 1","pages":"407-15"},"PeriodicalIF":0.0,"publicationDate":"1981-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75503539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
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