ScienceRise: Pharmaceutical Science最新文献

{"title":"Studying the qualitative composition of substances obtained from poplar buds by extraction and barothermic methods","authors":"A. Mechshanova, V. Polyakov","doi":"10.15587/2519-4852.2023.271813","DOIUrl":"https://doi.org/10.15587/2519-4852.2023.271813","url":null,"abstract":"Among the most acute problems of the Republic of Kazakhstan, it should be noted that the creation and development of a pharmaceutical base that meets all international standards, the development of the production of original domestic drugs, and the creation of safe and environmentally friendly technologies for their production. In this direction, plants of the genus Populus (poplar) of the Salicaceae (willow) family have an advantage due to large reserves of renewable raw materials (poplar plantations in the North Kazakhstan region have industrial reserves of medicinal raw materials) and the content of various classes of compounds with a wide range of biological activity.\u0000The aim of this work was to study the qualitative composition of substances from the buds of balsam poplar Populus balsamifera obtained by extraction and barothermal methods.\u0000Objectives: to obtain the substance from the balsam poplar buds Populus balsamifera by extraction and barothermal methods; establish the qualitative composition of the obtained substances; compare the composition of substances obtained by extraction and barothermal methods.\u0000Materials and methods. Balsam poplar buds were collected in May 2021 near the village of Zarechny, North Kazakhstan region, Republic of Kazakhstan.\u0000A method for obtaining a substance from balsam poplar buds includes using freshly harvested balsam poplar buds and extraction with solvents with an increasing polarity gradient. There were used solvents: hexane, dichloromethane, and ethyl acetate. The resulting extract was evaporated.\u0000The results and conclusions: the results of the study showed the almost complete identity of the qualitative composition of the hexane extract of substances obtained by extraction and barothermal methods. In the case of ethyl acetate fractions, the difference is the presence of chalcones in the substance obtained by the barothermal method. Extraction with methylene chloride allows the separation of flavonoids, and subsequent extraction with ethyl acetate allows the separation of gibberellins","PeriodicalId":21674,"journal":{"name":"ScienceRise: Pharmaceutical Science","volume":"64 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90742995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obtaining the substance enoxaparin sodium equivalent to the original Clexane® and Lovenox®. Selection of technological parameters of the key stage of the synthesis","authors":"Yuliia Bovsunovska, V. Rudiuk, V. Mishchenko, V. Georgiyants","doi":"10.15587/2519-4852.2023.277735","DOIUrl":"https://doi.org/10.15587/2519-4852.2023.277735","url":null,"abstract":"The aim: to carry out the key stage of synthesis to obtain a substance equivalent to the original drugs Clexane® and Lovenox® by determining the technological parameters of the synthesis that are critical from the point of view of the formation of the molecule and studying the correlation between the structural characteristics of Enoxaparin samples and the experimental conditions of the technological process.\u0000Materials and methods: samples of the Enoxaparin sodium substance were synthesized according to the method described in the patent, as well as with a variation of the selected critical technological parameters. The obtained samples of Enoxaparin sodium were analyzed according to pharmacopoeial requirements, as well as by non-pharmacopoeial methods, such as two-dimensional NMR spectroscopy and size exclusion chromatography for detailed structural characterization of the molecule.\u0000Results: determination and variation of technological parameters critical for the formation of the molecule, such as temperature, the amount of alkali for the depolymerization reaction, and the reaction time of the reaction mass, were determined and varied. Enoxaparin sodium samples were developed according to the selected parameters and a detailed analysis of the structure of the obtained samples was carried out, followed by a comparison with the original Clexane® and Lovenox®. It was established that with an increase in the temperature of the reaction mass, the amount of alkali and the holding time individually and in combination, the degree of depolymerization increases, which makes the composition of the molecule unbalanced in comparison with the original drugs Clexane® and Lovenox®.\u0000Conclusions: As a result of the experiments, the technological parameters of the synthesis of a sample of Enoxaparin sodium were evaluated and determined, allowing to obtain a substance comparable to the originator in terms of chemical structure (alkali/ heparin benzyl ester ratio 0.06; temperature – 57 °C, reaction mixture holding time - 1.5 hours)","PeriodicalId":21674,"journal":{"name":"ScienceRise: Pharmaceutical Science","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74915023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the polyphenol composition of red oak (Quercus rubra L.) raw materials","authors":"O. Konovalova, Tetiana Omelkovets, Iryna Hurtovenko, N. Sydora, M. Kalista, O. Shcherbakova","doi":"10.15587/2519-4852.2023.277969","DOIUrl":"https://doi.org/10.15587/2519-4852.2023.277969","url":null,"abstract":"The aim of the work was to determine the main groups of polyphenolic compounds in Quercus rubra L. raw materials. \u0000Materials and methods. The leaves and annual shoots of Northern Red Oak used for research were collected in August in Lisnyky village of Obuhiv district of Kyiv Oblast (Ukraine). Determination of the component composition and quantitative content of flavonoids (including separately catechins), hydroxycinnamic acids, and phenolic acids were carried out in the samples of air-shade-dried crushed raw material to a particle size of 3 mm by the method of high-performance liquid chromatography (HPLC). Agilent Technologies 1200 liquid chromatograph was used for liquid chromatography.Results. Using the HPLC method, 18 polyphenolic compounds were identified in leaves and annual shoots of Northern Red Oak, in particular, flavonoids: rutin, quercetin-3-β-glucoside, luteolin, neohesperidin; catechins: catechin, epicatechin, epicatechin gallate, gallocatechin; hydroxycinnamic acids: chlorogenic, caffeic, trans-ferulic, trans-cinnamic, p-coumaric, hydroxyphenylacetic, benzoic, syringic, sinapic acids; phenolic acid is gallic acid. The dominant component among flavonoids is rutin (323.43 mg/100 g) (in the composition of catechins, epicatechin gallate (25.45 mg/100 g) prevails); among hydroxycinnamic acids in Northern Red Oak raw materials, chlorogenic acid (139.62 mg/100 g) and sinapic acid (74.64 mg/100 g) prevail.Conclusions. The obtained results point to the prospects of further phytochemical and pharmacological studies of Quercus rubra raw materials, with the aim of creating new plant substances based on it with antioxidant, anti-inflammatory, and antiviral activity","PeriodicalId":21674,"journal":{"name":"ScienceRise: Pharmaceutical Science","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76737896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-inflammatory activity of anthocyanin extract on diabetic and hypertensive patients","authors":"Dhafir Masheta, Shafq Al-azzawi, Sharara Fadhial Abbood","doi":"10.15587/2519-4852.2023.272061","DOIUrl":"https://doi.org/10.15587/2519-4852.2023.272061","url":null,"abstract":"Anthocyanins pigments are a major class of plant phenolic components, flavonoids‎. The distinctive purple or red colours of many fruits and vegetables are attributed to the presence of these flavonoids‎. They are highly water-soluble pigments and have been well known to possess general health-promoting characteristics.\u0000The aim: This study aimed to evaluate the anti-inflammatory and antioxidant activity of anthocyanin extract. It also looked at how the extract consumption affected people with hypertension and diabetes in terms of lowering blood pressure and blood glucose levels and in preventing their complications, including oxidative stress and inflammatory status.\u0000Material and method: The subjects included in the study were hypertensive and diabetic patients divided into control and test groups. Total reactive oxygen species concentrations and C-reactive protein levels were used to assess the oxidative stress and inflammatory status before and after consuming anthocyanin extract for thirty days using an enzyme-linked immunosorbent assay.\u0000Results: The results revealed that consumption of anthocyanin extracts for 30 days did not significantly lower blood pressure or blood glucose levels in comparison to the control group and also when compared with day zero values. However, quantitative analysis of the C-reactive protein levels for the inflammatory status and the overall oxidative stress levels measurements demonstrated a significant decline compared to both the control group (placebo) and baseline values (day zero).\u0000Conclusion: The findings highlighted the prophylactic, as anti-inflammatory, rather than the curative effects of anthocyanin extracts in preventing or delaying the complications associated with various chronic conditions, including hypertension and diabetes mellitus.","PeriodicalId":21674,"journal":{"name":"ScienceRise: Pharmaceutical Science","volume":"65 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85790068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Component composition and antimicrobial activity of subcritical CO2 extract of Ferula asafoetida L., growing in the territory of Kazakhstan","authors":"Nurgali Rakhymbayev, U. Datkhayev, B. Sagindykova, D. Myrzakozha, K. Zhakipbekov, Z. Iskakbayeva","doi":"10.15587/2519-4852.2023.266654","DOIUrl":"https://doi.org/10.15587/2519-4852.2023.266654","url":null,"abstract":"Ferula asafoetida L. has been studied for centuries by many scientists as food products and in traditional medicine, which are relevant for Kazakhstan as well. Recent studies have shown that Ferula asafoetida L. has neuroprotective, memory-enhancing, digestive enzymatic, antioxidant, antispasmodic, hypotensive, hepatoprotective, antimicrobial, antitumor, cytotoxic, and anthelmintic effects.\u0000The aim of this study is to determine the component composition by GC-MS method and to study the antimicrobial properties of Ferula asafoetida L. extract obtained by CO2 extraction, which grows in Kazakhstan.\u0000Materials and methods. To determine the possibility of using Ferula asafoetida L., we carried out the component composition of the extract obtained by CO2 extraction in subcritical conditions of the underground part of Ferula asafoetida L. by a certain GC-MS method and also investigated the antimicrobial effect of this extract.\u0000Results. The plant raw materials were collected in accordance with GACP requirements. Conducted subcritical CO2 extraction of plant raw materials showed a 2.5% extraction yield. The study of the component composition by GC-MS revealed 46.3% of sulfate compounds. The determination of antimicrobial activities showed high efficacy against gram-positive (Staphylococcus aureus subsp. Aureus, Bacillus subtilis subsp. Spizizenii), gram-negative bacteria (Escherichia coli, Klebsiella pneumoniae subsp. pneumoniae, Salmonella enterica subsp. enterica) and fungi (Candida albicans, Aspergillus niger).\u0000Conclusions. The possibility of using the obtained CO2 extract of Ferula asafoetida L. in the field of pharmaceutical products as a substance and a drug that has a huge antimicrobial effect","PeriodicalId":21674,"journal":{"name":"ScienceRise: Pharmaceutical Science","volume":"118 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87633185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the current state of the pharmaceutical market of the Republic of Kazakhstan","authors":"K. Zhakipbekov, O. Posylkina, Narbek Zhumabayev, U. Datkhayev, N. Zhumabayev, Almira Almurzaeva, Arailym Mukanova","doi":"10.15587/2519-4852.2023.267787","DOIUrl":"https://doi.org/10.15587/2519-4852.2023.267787","url":null,"abstract":"This article analyses the current state of the pharmaceutical market of the Republic of Kazakhstan for the period 2015-2021 and diagnoses the current problems of pharmaceutical production.\u0000The aim: to identify the current trends of the pharmaceutical market in the Republic of Kazakhstan, its specific features and prospects for the development of domestic pharmaceutical production.\u0000Materials and methods: statistical data, survey results, mathematical-statistical and analytical comparative methods, SWOT analysis.\u0000Research results: according to the results of statistical analysis, pharmaceutical production increased by 101.1 billion tenges in monetary terms compared to 2015, and the export of domestic products increased by 13.3 billion tenges. In 2020, the export of medical preparations due to supplies to Russia amounted to 76.5 %, to Kyrgyzstan 6.5 % and Uzbekistan 4.8 %, to other countries - 12.3 %. It is estimated that the volume of the pharmaceutical market of the Republic of Kazakhstan in 2020, compared with 2019, increased by 21.3 % as a result of the development of domestic production and the implementation of the state support program. The total number of medicines registered in the republic is 7449, and the share of domestic production is 13.1 % (978 medical preparations), and 6471 medicines, 86.9 %, are imported. In addition, 9154 medical devices have been registered, and the share of domestic products is 90 %.\u0000Online direct expert survey (questionnaire) indicates that the respondents are female pharmacists (74.5 %) aged 36 to 55 years old (52.3 %) with 26-30 years of work experience (32.3 %), who noted the strengths of the development of the pharmaceutical industry in Kazakhstan (U=1.35), as readiness for modernisation and state support (47 %), political stability (44 %), weaknesses (U=1.35) - insignificant capacity of the pharmaceutical market (55.5 %), limited range of domestic pharmaceutical products and substances (50.9 %), opportunities (U=1.4) - active investment policy (62.7 %), expansion of digital and remote channels (25.4 %), threats (U=1.4) – import dependence (69.9 %), high volatility of the tenge exchange rate (24.1 %).\u0000Based on the pharmaceutical market analysis and expert survey of specialists, a strategic matrix of SWOT analysis was built.\u0000Conclusion. As a result of the analysis, the dependence of the pharmaceutical industry and the pharmaceutical market on imported foreign medicines and substances were revealed. However, the volume of pharmaceutical products produced in the Republic of Kazakhstan increases annually. Therefore, for the further development of the pharmaceutical industry of the Republic of Kazakhstan, considering its import dependence, additional funding is needed for research and educational activities for the development of innovative medical preparations and substances","PeriodicalId":21674,"journal":{"name":"ScienceRise: Pharmaceutical Science","volume":"518 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77172045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research of prospects of involving pharmacists in ukraine to help patients trying to quit smoking","authors":"Оlena Shuvanova, Olha Rohulia, V. Malyi, O. Piven, A. Chehrynets","doi":"10.15587/2519-4852.2023.277731","DOIUrl":"https://doi.org/10.15587/2519-4852.2023.277731","url":null,"abstract":"The aim. The study aimed to determine the prevalence of tobacco smoking among pharmacy workers in Ukraine, their awareness of the harmfulness of certain types of cigarettes, the attitude of pharmacy managers and pharmacists towards their colleagues’ smoking, as well as the ability of pharmacists to provide effective help in smoking cessation and assessment of prospects for the participation of pharmacists in tobacco smoking control programs if such programs are to be implemented in Ukraine. \u0000Materials and methods. The survey involved 239 employees of Ukrainian pharmacies under the age of 30 working in different regions. According to the geographical structure, the respondents represent 22 regions of Ukraine. \u0000Results. The experience of countries where active assistance to those who want to quit smoking pharmacists are involved suggests that pharmacists' support can help increase adherence to smoking cessation drugs and provide additional behavioural support as an adjunct to pharmacotherapy, which is quite effective. Currently, there are no such programs in Ukraine. \u0000The survey results show that Ukrainian pharmacists under the age of 30 are aware of the dangers of smoking. Most of them assess the level of their training in smoking cessation assistance as sufficient, but they only mean advice on the use of drugs in smoking cessation. \u0000Conclusions. Thus, in order to introduce the services of active support by pharmacists for people trying to quit smoking in Ukraine, it is required to create the necessary conditions for the interest of pharmacies and pharmacists in carrying out this type of activity and the implementation of programs of additional training in methods of active support for people trying to quit smoking","PeriodicalId":21674,"journal":{"name":"ScienceRise: Pharmaceutical Science","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89348526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of the influence of ingredients on biopharmaceutical factors and pharmacological activity of a medicinal product with carrot extract and rutin","authors":"O. Ruban, Mohammad Al Sayasneh, I. Kovalevska, V. Grudko, D. Lytkin, O. Dunaіevska","doi":"10.15587/2519-4852.2023.277562","DOIUrl":"https://doi.org/10.15587/2519-4852.2023.277562","url":null,"abstract":"Aim. The work aimed to study the influence of the components of a soft rectal medicine with carrot root extract and rutin on biopharmaceutical parameters and its pharmacological activity. \u0000Materials and methods. The objects of the study were samples of soft pharmaceutical forms made on different bases. Pharmacological, biopharmaceutical, physicochemical and pharmacotechnological research methods were used in the study. \u0000The results. According to the data of organoleptic studies, determination of colloidal stability, and determination of pH, it was established that the studied samples were stable during the entire observation period. According to the data of rheological studies, it was established that all systems are thixotropic. However, the recovery time of the system is different, which is related to the physicochemical properties of auxiliary substances included in the samples. The performed spectral analysis of dialysate solutions of experimental samples of soft medicine indicates the possibility of quantitative determination of the number of flavonoids in dialysates in terms of rutin. The components of the base of the samples and the thick extract of carrot roots do not interfere with the determination of rutin in dialysates with pH 6.8 by the absorption spectrophotometry method at a wavelength of 352 nm. The analysis of the obtained results of the study of the release of rutin from samples into a phosphate buffer solution by dialysis through a semipermeable membrane shows that the complete release is provided by auxiliary substances used in the preparation of sample No. 4, which is an emulsion of the first kind. The obtained data from pharmacological studies on the dynamics of planimetric indicators on the model of stencil wounds in rats demonstrated a wound-healing effect in all the studied samples and the reference agent - Hemorol suppositories. However, using sample No. 4 in the treatment of a stencil wound promotes faster healing, which in clinical use can contribute to reducing the risk of infection, the spread of infection, and reducing the area of ​​the wound defect. \u0000Conclusions. According to the results of the complex studies, moderate advantages of sample No. 4 over the comparison drug and other samples have been established, determining the perspective of further research","PeriodicalId":21674,"journal":{"name":"ScienceRise: Pharmaceutical Science","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78810466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The study of carbohydrates of corn raw materials","authors":"U. Karpiuk, V. Kyslychenko, I. Hnoievyі, T. Buhay, Z. Abudayeh, A. Fedosov","doi":"10.15587/2519-4852.2023.274698","DOIUrl":"https://doi.org/10.15587/2519-4852.2023.274698","url":null,"abstract":"The aim. The aim of the study was to study the content of polysaccharide fractions depending on the dissolution, qualitative composition and quantitative content of sugars in corn silk, leaves and roots. \u0000Materials and methods. To study different fractions of polysaccharides - water-soluble polysaccharides (WSPS), pectin substances (PS), hemicelluloses A (HC A) and B (HM B) used a gravimetric method based on the extraction of polysaccharide fractions with a suitable solvent followed by sedimentation and weighing of the sediment. Determination of the qualitative composition and quantitative content of monosaccharides in corn medicinal plant materials (MPM) was carried out by the method of gas chromatography-mass spectrometry (GC/MS). \u0000Results. Conducted studies of corn silk, leaves and roots carbohydrates using the fractionation method indicate the following trend of BAS accumulation in the studied raw materials: the content of WSPS and PS in corn silk exceeded the content of these compounds in other types of raw materials – 4.07±0.14 % and 7.20±0.29 %, respectively; leaves accumulated the most HC A and HC B compared to the content of these fractions in other samples - 6.81±0.21 % and 21.20±0.84 %, respectively. It was established by the GC/MS method that 4 substances were identified in corn silk in the free state: arabinose, glucose, galactose and fructose. After hydrolysis 5 substances were identified in corm silk - arabinose, xylose, mannose, glucose, galactose. Among the free sugars 3 compounds were found in corn leaves - glucose, fructose and sucrose. After hydrolysis, 4 compounds were identified in in corn leaves – arabinose, xylose, glucose and galactose. In corn roots 3 compounds are found in a free form - glucose, fructose and sucrose. After hydrolysis 4 compounds were identified in corn roots - arabinose, xylose, glucose and galactose. \u0000Conclusions. The obtained results indicate a significant content of polysaccharides and sugars in the raw materials of corn, which makes it possible to predict the anti-inflammatory, detoxifying, adsorbing, energetic activity of the studied types of corn plant raw materials","PeriodicalId":21674,"journal":{"name":"ScienceRise: Pharmaceutical Science","volume":"274 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81789111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The pharmaceutical market of medicines containing retinoids for the treatment of psoriasis in Ukraine, Poland and Kazakhstan","authors":"O. Shtrimaitis, O. Kukhtenko, O. Sadovnyk, H. Kukhtenko","doi":"10.15587/2519-4852.2023.274776","DOIUrl":"https://doi.org/10.15587/2519-4852.2023.274776","url":null,"abstract":"The aim of the work is to analyze the use of medicines containing retinoids for the treatment of psoriasis on the example of Ukraine, Poland and Kazakhstan. \u0000Materials and methods. The object of the study was antipsoriatic drugs, which are used for the treatment of psoriasis of local and systemic action, and are included in the official register of drugs of the studied countries. Regulatory documents of the State Expert Center of the Ministry of Health of Ukraine were involved in the analysis of the use of medicines for the treatment of psoriasis in Ukraine. \u0000The analysis of the availability of the considered medicines on pharmaceutical markets was carried out according to the data of the official websites of the State Register of Medicines (Ukraine), the Register of Medicines of Poland (Republic of Poland), data of the National Center for Expertise of Medicines and Medical Devices of the Republic of Kazakhstan (Republic of Kazakhstan). \u0000The following methods of logical and meaningful formulation of the problem, office marketing research, content analysis of publications in scientific and practically oriented medical and pharmaceutical publications, comparative analysis, tabular and graphic means of visual presentation of the obtained data were used in the work. \u0000The results. According to the results of the obtained data, an assortment of medicinal products containing retinoids of the studied countries, used for the treatment of psoriasis, was determined. The fate of domestic production in the countries was analyzed, the main active components from the group of retinoids used for the treatment of psoriasis in preparations of systemic and local action were updated. \u0000Conclusions. The role of retinoids in the treatment of psoriasis in Ukraine, Poland and Kazakhstan and the need to develop modern domestic medicines containing retinoids for the treatment of psoriasis have been determined","PeriodicalId":21674,"journal":{"name":"ScienceRise: Pharmaceutical Science","volume":"113 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79754737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}