ScienceRise: Medical Science最新文献

{"title":"The relation of atherosclerotic lesions of BCA against the background of COPD in patients aged 40-60 years. Review of the literature and retrospective analysis","authors":"I. Andrusyshyna, V. Batashova-Galinska, Tetiana Horbenko, L. Kholopov","doi":"10.15587/2519-4798.2021.246598","DOIUrl":"https://doi.org/10.15587/2519-4798.2021.246598","url":null,"abstract":"The aim: to determine the possible relationship between chronic obstructive pulmonary disease and the presence of atherosclerosis of the brachiocephalic vessels in persons aged 40–60 years for the possibility of early prevention of cardiovascular events. \u0000Materials and methods: to do this, we reviewed articles using open sources such as PubMED, Medscape and Cochrane library, highlighting the relationship between the development of atherosclerosis and the presence and severity of COPD. Also, based on the University Clinic of ONMedU and Military Clinical Center of the Southern Region, a retrospective analysis of patients with an inconclusively confirmed diagnosis of COPD and conducted biochemical blood tests was carried out in order to study changes in the lipid profile and the presence of BCS in these patients. \u0000Result: In the course of a retrospective analysis of patients, a relationship was found between the presence of BCA atherosclerosis and the presence of COPD, and based on the literature data, a parallel was drawn between changes in the lipid profile in patients with COPD. But, in view of the insufficient number of patients, this topic requires additional research. \u0000Conclusions: thus, based on the obtained data, it can be concluded that there is a connection between the presence of COPD, changes in the lipid profile, and the presence of BCА atherosclerosis. This connection can become one of the key mechanisms of early diagnosis of BCА atherosclerosis","PeriodicalId":21672,"journal":{"name":"ScienceRise: Medical Science","volume":"206 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80445992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current conception about the pathogenesis and intensive care of severe COVID-19 (review)","authors":"M. Georgiyants, V. Korsunov, S. Dubrov, O. Loskutov, N. Bohuslavska, Vadim Nikonov, L. Cherkashyna, O. Oparin, P. Nartov, M. Holianishchev","doi":"10.15587/2519-4798.2021.241456","DOIUrl":"https://doi.org/10.15587/2519-4798.2021.241456","url":null,"abstract":"The aim of the research. The aim of this work was to summarize the scientific literature data on the pathogenesis and intensive care of the severe course of coronavirus infection. \u0000Materials and methods. Databases such as PubMed, Google Scholar, Scopus and Web Of Science 2020-2021 were used for literary searches. \u0000Results. An intense inflammatory response against the SARS-CoV-2 virus in COVID-19 patients causes a cytokine storm and hypercoagulability with the development of acute respiratory distress syndrome (ARDS) and multiple organ failure. Approximately 17 % to 35 % of hospitalized patients with COVID-19 are treated in the intensive care unit, most often due to hypoxemic respiratory failure and the development of ARDS, and between 29 % and 91 % of patients in intensive care units require invasive ventilation. \u0000In addition to acute respiratory failure, hospitalized patients may have acute renal failure (9 %), liver dysfunction (19 %), coagulation disorders (10 %–25 %), and septic shock (6 %). \u0000More than 75 % of hospitalized patients require additional oxygen therapy. Respiratory support could vary from the need for oxygen supplementation through a nasal catheter to invasive ventilation or extracorporeal membrane oxygenation in patients with the most severe ARDS. \u0000The uncontrolled inflammation and coagulation seen in COVID-19 patients is similar to multifactorial ARDS, where a plethora of evidence has demonstrated the ability of long-term corticosteroid therapy (CST) to reduce inflammation-coagulation-fibroproliferation and accelerate recovery. \u0000With regard to the assessment of the benefits of therapeutic anticoagulation in patients with elevated D-dimer, the question has not yet been finally resolved, and research devoted to this is still ongoing. \u0000Conclusions. The approaches to respiratory, anticoagulant, anti-inflammatory therapy in critically ill patients with COVID-19 require further research to determine the optimal treatment tactics","PeriodicalId":21672,"journal":{"name":"ScienceRise: Medical Science","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84074106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coracoclavicular ligament augmentation at clavicle distal-third fracture treatment","authors":"B. Karslioglu, M. Uzun, S. Dedeoğlu, Y. Imren, A. Keskin","doi":"10.22141/1608-1706.2.22.2021.231953","DOIUrl":"https://doi.org/10.22141/1608-1706.2.22.2021.231953","url":null,"abstract":"The aim: type 2B clavicle fractures with conoid ligament rupture are considered unstable. Although surgical treatment is recommended as the standard treatment modality for type 2B fractures, there is no consensus about the type of operative treatment. We aimed to evaluate results of surgical treatment with an anatomical distal clavicle plate using CC ligament augmentation.\u0000Materials and methods: 15 patients that diagnosed with distal clavicle fractures, who underwent surgery for unstable type 2 fractures. The average patient age was 38 years (range 24–52 years). All patients were male; the right clavicle was injured in 10 patients whereas the left clavicle was injured in 5 cases. Surgical treatment was done with a distal clavicle anatomic locked plate augmentation (ZipTight™) at all cases. The mean follow-up period was 24 months (range, 12–40 months).\u0000Results: bony union was achieved at a mean follow-up of 8 weeks (range 6-10 weeks). The mean Constant score was 97 (range, 92–100). There were no complications or no need to second operation. All patients achieved satisfactory full range of shoulder motion. Hardware removal was performed for prominence in one case after the union was completed.\u0000Conclusion: the augmented technique reported here, provides early motion, increased stability and anatomic healing compared to other conventional options. We recommend augmentative CC ligament repair techniques over the distal locking anatomic plate for type 2 fractures","PeriodicalId":21672,"journal":{"name":"ScienceRise: Medical Science","volume":"18 1","pages":"27-31"},"PeriodicalIF":0.0,"publicationDate":"2021-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72647247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cell-molecular mechanisms of progression of ophthalmological pathology on the background of influence of environmental factors. Literature review","authors":"Olga Nedtzvetskaya, I. Bagmut, I. Soboleva, I. Pastukh, N. Goncharova","doi":"10.15587/2519-4798.2021.223486","DOIUrl":"https://doi.org/10.15587/2519-4798.2021.223486","url":null,"abstract":"Modern scientists are increasingly paying attention to the molecular mechanisms of diseases of the visual organ in conditions of anthropogenic pollution. Environmental pollution is mainly due to atmospheric emissions from the metallurgical, automotive, aviation and petrochemical industries, waste from livestock farms and due to the use of mineral fertilizers and pesticides. Ukraine ranks one of the first in Europe in terms of the amount of industrial dirt per capita.\u0000The aim of this literature review was to analyze the role of extra- and intracellular protein structures and molecular mechanisms of some pathological processes of the visual organ that occur under the influence of anthropogenic stress on the human body.\u0000Material and methods. Scientific publications in foreign and Ukranian journals on relevant topics in the last 5 years, the Internet resources.\u0000Research results and their discussion. The literature review expanded the scientific understanding of the role of reparative enzyme (MGMT), vascular endothelial growth factor, Bcl-2 family proteins, p53 and Ki 67 proteins, matrix metalloproteinases in some ophthalmic pathology. Anthropoecological environmental factors have been shown to cause oxidative stress due to mitochondrial dysfunction and apoptosis, which are a component of a complex pathophysiological process in the most common diseases of the visual analyzer.\u0000Conclusions. The study of molecular mechanisms of occurrence and progression of diseases of the visual organ with the participation of protein factors makes it possible to expand the understanding of the pathogenetic links of their development in order to predict the course of the pathological process, adequate treatment and prevention","PeriodicalId":21672,"journal":{"name":"ScienceRise: Medical Science","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74442905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of different options of anti-inflammatory therapy in patients with severe COVID-19","authors":"V. Skoryk","doi":"10.15587/2519-4798.2021.241013","DOIUrl":"https://doi.org/10.15587/2519-4798.2021.241013","url":null,"abstract":"The aim of the study. To compare the effectiveness of methylprednisolone, dexamethasone and tocilizumab in patients with severe coronavirus disease. Identify the most appropriate treatment option. Materials and methods. Patients of group 1 (n=20) received for anti-inflammatory purposes tocilizumab at a dose of 600–800 mg. Patients in group 2 (n=82) received pulse therapy with methylprednisolone. Patients in group 3 (n=20) received dexamethasone 6 mg / day. Data are presented as M [25–75]. Statistical analysis of the results was performed using the program \"Statistica 10\". Significance of differences in indicators was assessed using the nonparametric Wilcoxon test. The results were considered reliable at values of p <0.05. Results. The severe course of coronavirus disease with the development of cytokine storm and respiratory distress syndrome is characterized by an increase in markers of inflammation: in group 1 the median CRP was 89.2 g / l, in group 2 – 64.2 g / l, and in 3 – 76.2 g / l, and did not differ significantly between groups (p> 0.05). The level of IL-6 in group 1 was 61.8 pg / ml, in group 2 – 64.6 pg / ml, and in group 3 – 46.5 pg / ml without significant differences between groups (p> 0.05). The level of ferritin in all groups exceeded normal values. Conclusions The most favourable result was obtained when using methylprednisolone: it was possible to reduce the mortality rate to 59.8 %. The relative risk of developing VTE was significantly higher in groups 1 and 3 (RR12 6.8 [2.7–16.8] p12 <0.0001, RR23 0.15 [0.06–0.35] p23 <0.0001), which gives grounds to confirm the presence of anticoagulant activity in methylprednisolone","PeriodicalId":21672,"journal":{"name":"ScienceRise: Medical Science","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85110868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A descriptive study of COVID-19 at a tertiary care hospital","authors":"A. Mittal, Manoj Kumar Singh, Rajeev Kumar, D. Mandsorwale","doi":"10.15587/2519-4798.2021.238014","DOIUrl":"https://doi.org/10.15587/2519-4798.2021.238014","url":null,"abstract":"Coronavirus disease 2019 (abbreviated “COVID-19”) is an emerging respiratory disease that is caused by a novel coronavirus and was first detected in December 2019 in Wuhan, China. The cases of COVID-19 infection since then were showing increasing trend in all over the world. The aim: to study the epidemiological distribution and determinants of COVID-19 pandemic. Methods: it is a descriptive study carried out at a tertiary care hospital of India. The population comprised of patients admitted in the hospital. Sample size comprised of all the subjects admitted in the hospital with established COVID 19 +ve cases. The duration of study was April 2020 to June 2020. The study was approved by the Institutional Ethical committee and Informed consent was obtained from each subject before the conduct of the study. Data collection was done by a pre-structured questionnaire. Data entry and analysis was done using SPSS version 20 software. Results: out of total 38 COVID-19 +ve cases, 95 % were male and 5 % female ant the maximum numbers of cases ranges between 36–40 years of age group with the median age of 32 years.53 % of cases were Muslim and 47 % Hindu by religion. The median duration of stay in hospital of all COVID-19 +ve cases was11 day that on further differentiation with co-morbidity was 15 days and 11.5 without any co-morbidity. The median duration taken between 1st sample taken and report provided was 2 days, between 2nd sample taken and report provided 1 day and between 1st and 2nd sample taken was 11 days. Conclusions: present study concluded that middle age persons were affected in majority which may be due to more exposure to public places. Co-morbidities are strong predictors of requirement for admission and duration of stay at hospital","PeriodicalId":21672,"journal":{"name":"ScienceRise: Medical Science","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81334553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of ranolazine on exercise tolerance and arrhythmias in patients with INOCA","authors":"V. Tseluyko, Tetyana Pylova","doi":"10.15587/2519-4798.2021.241534","DOIUrl":"https://doi.org/10.15587/2519-4798.2021.241534","url":null,"abstract":"The aim of the study to evaluate the effect of supplementation of basic therapy by ranolazine in patients with INOCA on exercise test parameters and Holter ECG monitoring. Materials and methods. 53 patients with stable coronary heart disease were examined, including 18 men (33.9 %) and 35 (66 %) women, the average age of patients was 57 (±9.68) years. According to the results of coronary angiography all patients had non-obstructive coronary arteries. In addition to physical and laboratory examination, bicycle ergometry, Holter ECG monitoring and echocardiography were included in the examination of patients. Patients were divided into 2 groups: group I - patients who in addition to standard therapy received ranolazine at a dose of 1000 mg twice a day for 6 months, and group II patients with standard coronary heart disease therapy. After 6 months from the beginning of the observation an objective examination, echocardiography, exercise test, Holter ECG monitoring were repeated. Results. The study found that patients receiving ranolazine in addition to standard therapy had a statistically significant increase in exercise duration after 6 months compared with baseline and group II. Before treatment in group I, the duration of the exercise test was 356.51±180.24s, and after treatment 414.32±142.10s (p=0.03). In group II, the duration of the test before treatment was 361.4±160.24 c, and after 380.5±152.2 s (p=0.15). It was also found that the duration of the test differed significantly in group I after treatment of patients from group II after treatment of patients with a standard treatment regimen (p=0.04). According to the results of Holter ECG monitoring in group I found a positive effect of ranolazine on the frequency of ventricular arrhythmias: before treatment n=1142 [30; 2012], after treatment n=729 [23; 1420], while in group II a significant difference between the number of extrasystoles before treatment and after not detected (n=1026 [17; 1920], n=985 [15; 1680], respectively) p=0.18. Conclusions. The addition of ranolazine to the basic therapy of patients with non-obstructive coronary arteries disease helps to increase exercise tolerance (according to the loading stress test) and contributes to a significant reduction in the number of ventricular arrhythmias (according to Holter-ECG) compared with both baseline and group II","PeriodicalId":21672,"journal":{"name":"ScienceRise: Medical Science","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76116427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histological study of the effect of bacterial lysates on the state of periodontal tissue in experimental periodontitis in rats","authors":"M. Ievtushenko, O. Koshova, S. Kryzhna","doi":"10.15587/2519-4798.2021.241983","DOIUrl":"https://doi.org/10.15587/2519-4798.2021.241983","url":null,"abstract":"The aim of the research: to experimentally study at the histological and morphological level the degree of the corrective effect of bacterial lysate of the disturbed non-specific defense of the body on the model of periodontitis based on the Central Research Laboratory of the National University of Pharmacy. Materials and methods: prospective study has been conducted on experimental periodontitis in 42 rats for 90 days. The animals were treated with «Respibron» and the reference drug «Imudon». Histological and morphometric studies were carried out according to standard methods. Micropreparations were viewed under a Granum DCM 310 digital video camera. All interventions and euthanasia of animals were carried out in compliance with the European principles. Results: by the end of 90 days of experimental periodontitis at the local level in the homogenate of animal gum tissue compensatory mechanisms are depleted and differed from the norm by 397 times. The dynamics of the studied morphometric and histological parameters of \"Respibron\" was similar to the \"Imudon\", but the magnitude of destruction was less pronounced and differed at the end of the experiment by 17.2 times in comparison with the intact control, and in the control group the results improved by 23.1 times. Conclusion: the obtained data from the study indicate a high decompensation of experimental periodontitis. It is characterized by the formation of periodontal pockets and inflammatory bone loss. The magnitude of destruction differed from the norm by 397 times. Applying of bacterial lysates led to the compensation of bacterial dysbiosis, restoration of the tissues of paradont. The therapeutic effect of \"Respibron\" can be assessed as more powerful in comparison with \"Imudon\" in terms of the studied morphometric and histological parameters: the magnitude of improvement \"Respibron\" was 3.72 times higher than the indicators of \"Imudon\". We should continue the study of experimental periodontitis as mechanisms of development, protection, and restoration of tissues under conditions of pharmacological correction by bacterial lysate \"Respibron\"","PeriodicalId":21672,"journal":{"name":"ScienceRise: Medical Science","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74659191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stabilometric assessment of vestibular function in children with a medium otitis","authors":"I. Lozova, G. Garyuk, I. Redka, Tatiana Pochuеva","doi":"10.15587/2519-4798.2021.241951","DOIUrl":"https://doi.org/10.15587/2519-4798.2021.241951","url":null,"abstract":"Otitis media is one of the most common infectious diseases of the middle ear in preschool age, but its relationship with vestibular dysfunction remains controversial. The aim of the study was to carry out a comparative analysis of stabilometric indicators of preschool children with suppurative and non-suppurative otitis media. Materials and methods: 22 children with suppurative otitis media and 22 children with non-suppurative otitis media at the age from 4 to 7 years were examined by the method of static stabilometry on the device “MPFI Stabilograph 1” (LLC \"ASTER IT\", Kharkov, Ukraine). We took into account the indices of variation and distribution of the center of pressure, spectral and correlation indices of the stabilogram, as well as integral indices of stability (length, velocity and angle of postural oscillations) and the quality of the balance function in two sensory states (open and closed eyes), which were calculated in the software providing StabiliS. Results. In children with non-suppurative otitis media, the coordinates of the center-of-pressure corresponded (7.04 [2.16–10.09]; -1.14 [-28.90–9.11]), and with suppurative otitis media – (7.04 [3.30–16.16]; -13.72 [(-25.17)–(-10.30)]) with closed eyes. The averaged figure of the projection of the center-of-pressure in the test with eyes closed is actually represented by a circle in both groups, but with open eyes it is represented by an ellipse, which, in case of non-suppurative otitis media, is stretched along the sagittal axis, and in case of suppurative otitis media, along the frontal axis. In both sensory states, children with non-suppurative otitis media were characterized by large (p≤0.05) values of KurtosisX, Length and lower (p≤0.05) values of CC0X, Pup2Sigma compared with non-purulent otitis media. Conclusions: In preschool age, suppurative otitis media more significantly disrupts the balance function compared with non-suppurative otitis media, which was manifested by a significant decrease in the stability of the main stance and the predictability of oscillatory movements compared with non-suppurative otitis media","PeriodicalId":21672,"journal":{"name":"ScienceRise: Medical Science","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75078057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Markers of atherosclerosis lipoprotein-associated phospholipase A2 and E-selectin and vascular risk factors in patients with carotid stenosis","authors":"O. Dubenko, V. Anysienkova","doi":"10.15587/2519-4798.2021.241147","DOIUrl":"https://doi.org/10.15587/2519-4798.2021.241147","url":null,"abstract":"The aim of this study is to evaluate serum level biomarkers of atherosclerosis lipoprotein-associated phospholipase A2 and E-selectin in patients with atherosclerotic carotid stenosis with different clinical manifestation in associated with vascular risk factors. Materials and methods: A total 106 patients with atherosclerotic carotid stenosis (74 men and 32 women, aged from 31 to 74 years, mean 62.6±0.9) were included: with acute ipsilateral atherothrombotic stroke (35), history of stroke and carotid endarterectomy (41) and 30 patients with asymptomatic carotid stenosis. The control group consist of 20 health subjects without cardiovascular disease. All participants underwent duplex sonography. Lipoprotein-associated phospholipase A2 and E-selectin was measured using commercially available (ELISA) kit. Results: The level of lipoprotein-associated phospholipase A2 was in general 55.664±3.537 ng/ml, which was significantly higher (M-W U=10, p=1.023136´10-11 <0.05) than in the control group (9.296±0.935 ng/ml). Level was significantly higher in groups of symptomatic patients who underwent carotid endarterectomy (p=0.04893), and proportion patients with high degree stenosis >70 % was greater in this group. The level of E-selectin in the study patients was significantly higher (7.653±0.246 pg/ml) than in the control group (3.101±0.503 pg/ml) p<0.05. No association the serum level of lipoprotein-associated phospholipase A2 and E-selectin with common stroke risk factor such as hypercholesterinemia, smoking and body mass index were found, but positive correlation of lipoprotein-associated phospholipase A2 with E-selectin was significant (p=0.00085). Conclusions: Increasing plasma level lipoprotein-associated phospholipase A2 and E-selectin in patients with the carotid atherosclerotic stenosis were observe. Statistically significant correlation between the level of lipoprotein-associated phospholipase A2 and E-selectin were found in symptomatic carotid atherosclerotic stenosis","PeriodicalId":21672,"journal":{"name":"ScienceRise: Medical Science","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80842527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}