Science Translational Medicine最新文献

{"title":"Erratum for the Review \"Engineering CAR-T therapies for autoimmune disease and beyond\" by E. P. English <i>et al</i>.","authors":"","doi":"10.1126/scitranslmed.adu4655","DOIUrl":"https://doi.org/10.1126/scitranslmed.adu4655","url":null,"abstract":"","PeriodicalId":21580,"journal":{"name":"Science Translational Medicine","volume":"16 777","pages":"eadu4655"},"PeriodicalIF":15.8,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased keratinocyte activity and PIEZO1 signaling contribute to paclitaxel-induced mechanical hypersensitivity","authors":"Alexander R. Mikesell, Elena Isaeva, Marie L. Schulte, Anthony D. Menzel, Anvitha Sriram, Megan M. Prahl, Seung Min Shin, Katelyn E. Sadler, Hongwei Yu, Cheryl L. Stucky","doi":"10.1126/scitranslmed.adn5629","DOIUrl":"https://doi.org/10.1126/scitranslmed.adn5629","url":null,"abstract":"Recent work demonstrates that epidermal keratinocytes are critical for normal touch sensation. However, it is unknown whether keratinocytes contribute to touch-evoked pain and hypersensitivity after tissue injury. Here, we used a mouse model of paclitaxel treatment to determine the extent to which keratinocyte activity contributes to the severe neuropathic pain that accompanies chemotherapy. We found that keratinocyte inhibition by either optogenetic or chemogenetic methods largely alleviated paclitaxel-induced mechanical hypersensitivity across acute and persistent time points from 2 days through 3 weeks. Furthermore, we found that paclitaxel exposure sensitized mouse and human keratinocytes to mechanical stimulation and enhanced currents of PIEZO1, a mechanosensitive channel highly expressed in keratinocytes. Deletion of PIEZO1 from keratinocytes alleviated paclitaxel-induced mechanical hypersensitivity in mice. These findings suggest that nonneuronal cutaneous cells contribute substantially to neuropathic pain and pave the way for the development of new pain relief strategies that target epidermal keratinocytes and PIEZO1.","PeriodicalId":21580,"journal":{"name":"Science Translational Medicine","volume":"9 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142809806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Agonism of the glutamate receptor GluK2 suppresses dermal mast cell activation and cutaneous inflammation","authors":"Youran R. Zhang, Swapnil Keshari, Kazuo Kurihara, James Liu, Lindsay M. McKendrick, Chien-Sin Chen, Yufan Yang, Louis D. Falo, Jishnu Das, Tina L. Sumpter, Daniel H. Kaplan","doi":"10.1126/scitranslmed.adq9133","DOIUrl":"https://doi.org/10.1126/scitranslmed.adq9133","url":null,"abstract":"Activation of dermal mast cells through the Mas-related G protein–coupled receptor B2 receptor (MrgprB2 in mice and MrgprX2 in humans) is a key component of numerous inflammatory skin diseases, including dermatitis and rosacea. Sensory neurons actively suppress mast cell activation through the regulated release of glutamate, resulting in reduced expression of <jats:italic>Mrgprb2</jats:italic> as well as genes associated with proteins found in mast cell granules. To determine whether exogenous glutamate receptor agonism could suppress mast cell function, we determined that mast cells have relatively selective expression of the glutamate receptor ionotropic, kainate 2 (GluK2). A GluK2-specific agonist, SYM2081, effectively inhibited mast cell degranulation in response to MrgprB2 agonism in both murine mast cells and human skin explants in vitro as well as in vivo after both intradermal and topical administration of SYM2081 to mice. Analyses of transcriptomic datasets from SYM2081-treated mast cells using standard differential expression approaches and an interpretable machine learning technique revealed a previously unrecognized cellular program coordinately regulated by GluK2 agonism. GluK2 agonism suppressed the expression of <jats:italic>Mrgprb2</jats:italic> and genes associated with mast cell proliferation. Suppression of mast cell proliferation by SYM2081 exposure was confirmed on the basis of reduced Ki-67 expression and BrdU incorporation in vitro and in vivo. Last, pretreatment with SYM2081 reduced skin inflammation in murine models of dermatitis and rosacea. Thus, agonism of GluK2 represents a promising approach to suppress mast cell activation and may prove beneficial as therapy for inflammatory diseases in which mast cell activation is pathogenic.","PeriodicalId":21580,"journal":{"name":"Science Translational Medicine","volume":"28 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142809861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glp1r-Lepr coexpressing neurons modulate the suppression of food intake and body weight by a GLP-1/leptin dual agonist","authors":"Joseph Polex-Wolf, Kristine Deibler, Wouter Frederik Johan Hogendorf, Sarah Bau, Tine Glendorf, Carsten Enggaard Stidsen, Christian Wenzel Tornøe, Dong Tiantang, Sofia Lundh, Charles Pyke, Abigail J. Tomlinson, Stace Kernodle, Irwin Jack Magrisso, Kilian W. Conde-Frieboes, Martin G. Myers, Lotte Bjerre Knudsen, Randy J. Seeley","doi":"10.1126/scitranslmed.adk4908","DOIUrl":"https://doi.org/10.1126/scitranslmed.adk4908","url":null,"abstract":"Glucagon-like peptide-1 (GLP-1) and leptin signal recent feeding and long-term energy stores, respectively, and play complementary roles in the modulation of energy balance. Previous work using single-cell techniques in mice revealed the existence of a population of leptin receptor ( <jats:italic>Lepr</jats:italic> )–containing dorsomedial hypothalamus (DMH) neurons marked by the expression of GLP-1 receptor ( <jats:italic>Glp1r</jats:italic> ; LepR <jats:sup>Glp1r</jats:sup> neurons) that play important roles in the control of feeding and body weight by leptin. Here, we demonstrate the existence of a population of LepR <jats:sup>Glp1r</jats:sup> neurons in the DMHs of nonhuman primates (NHPs), suggesting the potential translational relevance of these neurons. Consequently, we developed a GLP-1R/LepR dual agonist and demonstrated the physiological activity of both components in vivo using leptin-deficient and <jats:italic>Lepr-</jats:italic> deficient murine models. We further found roles for LepR <jats:sup>Glp1r</jats:sup> neurons in mediating the dual agonist’s efficacy on food intake and body weight loss. Ablating <jats:italic>Lepr</jats:italic> in <jats:italic>Glp1r</jats:italic> -expressing neurons (Lepr <jats:sup>Glp1r</jats:sup> KO mice) abrogated the suppression of food intake by the dual agonist. Furthermore, reactivation of <jats:italic>Glp1r</jats:italic> expression in <jats:italic>Lepr</jats:italic> neurons on an otherwise <jats:italic>Glp1r</jats:italic> -null background (Glp1r <jats:sup>Lepr</jats:sup> Re mice) was sufficient to permit the suppression of food intake and body weight by the dual agonist. Hence, LepR <jats:sup>Glp1r</jats:sup> neurons represent targets for a GLP-1R/LepR dual agonist that potently reduces food intake and body weight.","PeriodicalId":21580,"journal":{"name":"Science Translational Medicine","volume":"2666 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142776504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diverse NKT cells regulate early inflammation and neurological outcomes after cardiac arrest and resuscitation.","authors":"Tomoyoshi Tamura, Changde Cheng, Ana B Villaseñor-Altamirano, Kohei Yamada, Kohei Ikeda, Kei Hayashida, Jaivardhan A Menon, Xi Dawn Chen, Hattie Chung, Jack Varon, Jiani Chen, Jiyoung Choi, Aidan M Cullen, Jingyu Guo, Xi Lin, Benjamin A Olenchock, Mayra A Pinilla-Vera, Reshmi Manandhar, Muhammad Dawood Amir Sheikh, Peter C Hou, Patrick R Lawler, William M Oldham, Raghu R Seethala, Rebecca M Baron, Erin A Bohula, David A Morrow, Richard S Blumberg, Fei Chen, Louis T Merriam, Alexandra J Weissman, Michael B Brenner, Xiang Chen, Fumito Ichinose, Edy Y Kim","doi":"10.1126/scitranslmed.adq5796","DOIUrl":"https://doi.org/10.1126/scitranslmed.adq5796","url":null,"abstract":"<p><p>Neurological injury drives most deaths and morbidity among patients hospitalized for out-of-hospital cardiac arrest (OHCA). Despite its clinical importance, there are no effective pharmacological therapies targeting post-cardiac arrest (CA) neurological injury. Here, we analyzed circulating immune cells from a large cohort of patients with OHCA, finding that lymphopenia independently associated with poor neurological outcomes. Single-cell RNA sequencing of immune cells showed that T cells with features of both innate T cells and natural killer (NK) cells were increased in patients with favorable neurological outcomes. We more specifically identified an early increase in circulating diverse NKT (dNKT) cells in a separate cohort of patients with OHCA who had good neurological outcomes. These cells harbored a diverse T cell receptor repertoire but were consistently specific for sulfatide antigen. In mice, we found that sulfatide-specific dNKT cells trafficked to the brain after CA and resuscitation. In the brains of mice lacking NKT cells (<i>Cd1d</i>^-/-), we observed increased inflammatory chemokine and cytokine expression and accumulation of macrophages when compared with wild-type mice. <i>Cd1d</i>^-/- mice also had increased neuronal injury, neurological dysfunction, and worse mortality after CA. To therapeutically enhance dNKT cell activity, we treated mice with sulfatide lipid after CA, showing that it improved neurological function. Together, these data show that sulfatide-specific dNKT cells are associated with good neurological outcomes after clinical OHCA and are neuroprotective in mice after CA. Strategies to enhance the number or function of dNKT cells may thus represent a treatment approach for CA.</p>","PeriodicalId":21580,"journal":{"name":"Science Translational Medicine","volume":"16 776","pages":"eadq5796"},"PeriodicalIF":15.8,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142780562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RANKL treatment restores thymic function and improves T cell–mediated immune responses in aged mice","authors":"Jérémy C. Santamaria, Jessica Chevallier, Léa Dutour, Amandine Picart, Camille Kergaravat, Agata Cieslak, Mourad Amrane, Renaud Vincentelli, Denis Puthier, Emmanuel Clave, Arnauld Sergé, Martine Cohen-Solal, Antoine Toubert, Magali Irla","doi":"10.1126/scitranslmed.adp3171","DOIUrl":"https://doi.org/10.1126/scitranslmed.adp3171","url":null,"abstract":"Age-related thymic involution, leading to reduced T cell production, is one of the major causes of immunosenescence. This results in an increased susceptibility to cancers, infections, and autoimmunity and in reduced vaccine efficacy. Here, we identified that the receptor activator of nuclear factor κB (RANK)–RANK ligand (RANKL) axis in the thymus is altered during aging. Using a conditional transgenic mouse model, we demonstrated that endothelial cells depend on RANK signaling for their cellularity and functional maturation. Decreased RANKL availability during aging resulted in a decline in cellularity and function of both endothelial cells and thymic epithelial cells, contributing to thymic involution. We then found that, whereas RANKL neutralization in young mice mimicked thymic involution, exogenous RANKL treatment in aged mice restored thymic architecture as well as endothelial cell and epithelial cell abundance and functional properties. Consequently, RANKL improved T cell progenitor homing to the thymus and boosted T cell production. This cascade of events resulted in peripheral T cell renewal and effective antitumor and vaccine responses in aged mice. Furthermore, we conducted a proof-of-concept study that showed that RANKL stimulates endothelial cells and epithelial cells in human thymic organocultures. Overall, our findings suggest that targeting the RANK-RANKL axis through exogenous RANKL administration could represent a therapeutic strategy to rejuvenate thymic function and improve T cell immunity during aging.","PeriodicalId":21580,"journal":{"name":"Science Translational Medicine","volume":"74 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142776505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myeloid cell–specific loss of NPC1 in mice recapitulates microgliosis and neurodegeneration in patients with Niemann-Pick type C disease","authors":"Lina Dinkel, Selina Hummel, Valerio Zenatti, Mariagiovanna Malara, Yannik Tillmann, Alessio Colombo, Laura Sebastian Monasor, Jung H. Suh, Todd Logan, Stefan Roth, Lars Paeger, Patricia Hoffelner, Oliver Bludau, Andree Schmidt, Stephan A. Müller, Martina Schifferer, Brigitte Nuscher, Jasenka Rudan Njavro, Matthias Prestel, Laura M. Bartos, Karin Wind-Mark, Luna Slemann, Leonie Hoermann, Sebastian T. Kunte, Johannes Gnörich, Simon Lindner, Mikael Simons, Jochen Herms, Dominik Paquet, Stefan F. Lichtenthaler, Peter Bartenstein, Nicolai Franzmeier, Arthur Liesz, Antje Grosche, Tatiana Bremova-Ertl, Claudia Catarino, Skadi Beblo, Caroline Bergner, Susanne A. Schneider, Michael Strupp, Gilbert Di Paolo, Matthias Brendel, Sabina Tahirovic","doi":"10.1126/scitranslmed.adl4616","DOIUrl":"https://doi.org/10.1126/scitranslmed.adl4616","url":null,"abstract":"Niemann-Pick type C (NPC) disease is an inherited lysosomal storage disorder mainly driven by mutations in the <jats:italic>NPC1</jats:italic> gene, causing lipid accumulation within late endosomes/lysosomes and resulting in progressive neurodegeneration. Although microglial activation precedes neuronal loss, it remains elusive whether loss of the membrane protein NPC1 in microglia actively contributes to NPC pathology. In a mouse model with depletion of NPC1 in myeloid cells, we report severe alterations in microglial lipidomic profiles, including the enrichment of bis(monoacylglycero)phosphate, increased cholesterol, and a decrease in cholesteryl esters. Lipid dyshomeostasis was associated with microglial hyperactivity, marked by an increase in translocator protein 18 kDa (TSPO). These hyperactive microglia initiated a pathological cascade resembling NPC-like phenotypes, including a shortened life span, motor impairments, astrogliosis, neuroaxonal pathology, and increased neurofilament light chain (NF-L), a neuronal injury biomarker. As observed in the mouse model, patients with NPC showed increased NF-L in the blood and microglial hyperactivity, as visualized by TSPO-PET imaging. Reduced TSPO expression in blood-derived macrophages of patients with NPC was measured after <jats:italic>N</jats:italic> -acetyl- <jats:sc>l</jats:sc> -leucine treatment, which has been recently shown to have beneficial effects in patients with NPC, suggesting that TSPO is a potential marker to monitor therapeutic interventions for NPC. Conclusively, these results demonstrate that myeloid dysfunction, driven by the loss of NPC1, contributes to NPC disease and should be further investigated for therapeutic targeting and disease monitoring.","PeriodicalId":21580,"journal":{"name":"Science Translational Medicine","volume":"262 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142776503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-cell profiling of acral melanoma infiltrating lymphocytes reveals a suppressive tumor microenvironment","authors":"Tomoyuki Minowa, Kenji Murata, Yuka Mizue, Aiko Murai, Munehide Nakatsugawa, Kenta Sasaki, Serina Tokita, Terufumi Kubo, Takayuki Kanaseki, Tomohide Tsukahara, Toshiya Handa, Sayuri Sato, Kohei Horimoto, Junji Kato, Tokimasa Hida, Yoshihiko Hirohashi, Hisashi Uhara, Toshihiko Torigoe","doi":"10.1126/scitranslmed.adk8832","DOIUrl":"https://doi.org/10.1126/scitranslmed.adk8832","url":null,"abstract":"Acral lentiginous melanoma (ALM) is the most common melanoma subtype in non-Caucasians. Despite advances in cancer immunotherapy, current immune checkpoint inhibitors remain unsatisfactory for ALM. Hence, we conducted comprehensive immune profiling using single-cell phenotyping with reactivity screening of the T cell receptors of tumor-infiltrating T lymphocytes (TILs) in ALM. Compared with cutaneous melanoma, ALM showed a lower frequency of tumor-reactive CD8 clusters and an enrichment of regulatory T cells with direct tumor recognition ability, suggesting a suppressive immune microenvironment in ALM. Tumor-reactive CD8 TILs showed heterogeneous expression of coinhibitory molecules, including <jats:italic>KLRC1</jats:italic> (NKG2A), in subpopulations with therapeutic implications. Overall, our study provides a foundation for enhancing the efficacy of immunotherapy in ALM.","PeriodicalId":21580,"journal":{"name":"Science Translational Medicine","volume":"222 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142776500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting the next round of drugs for Medicare price negotiation","authors":"Matthew Vogel, Adam Tellier, Rena M. Conti","doi":"10.1126/scitranslmed.adq5711","DOIUrl":"https://doi.org/10.1126/scitranslmed.adq5711","url":null,"abstract":"There is uncertainty regarding which brand-name prescription drugs will have their prices negotiated by Medicare in 2025. This Viewpoint analyzes the process that will be used to select the next 15 drugs for price negotiation.","PeriodicalId":21580,"journal":{"name":"Science Translational Medicine","volume":"89 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142776501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sexually dimorphic differences in angiogenesis markers are associated with brain aging trajectories in humans","authors":"Abel Torres-Espin,&nbsp;Hannah L. Radabaugh,&nbsp;Scott Treiman,&nbsp;Stephen S. Fitzsimons,&nbsp;Danielle Harvey,&nbsp;Austin Chou,&nbsp;Cutter A. Lindbergh,&nbsp;Kaitlin B. Casaletto,&nbsp;Lauren Goldberger,&nbsp;Adam M. Staffaroni,&nbsp;Pauline Maillard,&nbsp;Bruce L. Miller,&nbsp;Charles DeCarli,&nbsp;Jason D. Hinman,&nbsp;Adam R. Ferguson,&nbsp;Joel H. Kramer,&nbsp;Fanny M. Elahi","doi":"10.1126/scitranslmed.adk3118","DOIUrl":"10.1126/scitranslmed.adk3118","url":null,"abstract":"<div >Aberrant angiogenesis could contribute to the development of cognitive impairment and represent a therapeutic target for preventing dementia. However, most studies addressing angiogenesis and cognitive impairment focus on model organisms. To test the relevance of angiogenesis to human cognitive aging, we evaluated associations of circulating blood markers of angiogenesis with brain aging trajectories in a pooled two-center sample from deeply phenotyped longitudinal human cohorts (<i>n</i> = 435; female = 207, age = 74 ± 9) using cognitive assessments, biospecimens, structural brain imaging, and clinical data. Blood markers included ligands involved in angiogenesis and vascular function such as basic fibroblast growth factor (bFGF), members of the vascular endothelial growth factor family (VEGFA, VEGFB, and VEGFC), and placental growth factor (PlGF), in addition to their receptors VEGF receptor 1 (VEGFR1) and tyrosine kinase with immunoglobulin and EGF homology domain 2 (Tie2). Machine learning and traditional statistics revealed sexually dimorphic associations of plasma angiogenic growth factors with brain aging outcomes, including executive function and gray matter atrophy. Specifically, markers of angiogenesis were associated with higher executive function and less brain atrophy in younger women (not men), a directionality of association that reversed around age 75. Higher concentrations of bFGF, known for pleiotropic effects on multiple cell types, predicted favorable cognitive trajectories in both women and men. An independent sample from a multicenter dataset (MarkVCID; <i>n</i> = 80; female = 30, age = 73 ± 9) was used to externally validate these findings. In conclusion, this analysis demonstrates the association of angiogenesis to human brain aging, with potential therapeutic implications for vascular cognitive impairment and dementia.</div>","PeriodicalId":21580,"journal":{"name":"Science Translational Medicine","volume":"16 775","pages":""},"PeriodicalIF":15.8,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142740594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}