Scandinavian Journal of Urology最新文献

Prospective validation study of a combined urine and plasma test for predicting high-grade prostate cancer in biopsy naïve men. 尿液和血浆联合检测预测活检中高度前列腺癌naïve男性的前瞻性验证研究。

IF 1.4 4区医学

Scandinavian Journal of Urology Pub Date : 2025-01-14 DOI: 10.2340/sju.v60.42752

Torben Brøchner Pedersen, Mads Hvid Poulsen, Martin Lund, Søren Feddersen, Maher Albitar, Charlotte Aaberg Poulsen, Lars Lund

{"title":"Prospective validation study of a combined urine and plasma test for predicting high-grade prostate cancer in biopsy naïve men.","authors":"Torben Brøchner Pedersen, Mads Hvid Poulsen, Martin Lund, Søren Feddersen, Maher Albitar, Charlotte Aaberg Poulsen, Lars Lund","doi":"10.2340/sju.v60.42752","DOIUrl":"https://doi.org/10.2340/sju.v60.42752","url":null,"abstract":"Objective: Early and accurate diagnosis of prostate cancer (PC) is crucial for effective treatment. Diagnosing clinically insignificant cancers can lead to overdiagnosis and overtreatment, highlighting the importance of accurately selecting patients for further evaluation based on improved risk prediction tools. Novel biomarkers offer promise for enhancing this diagnostic process. In this study, we aimed to externally validate a previously developed urine and plasma biomarker test in a biopsy-naïve population.Materials and methods: Urine and blood samples were prospectively collected from 362 biopsy-naïve men with suspected PC before they underwent transrectal prostate biopsies. The expression levels of a 10-gene mRNA panel were quantified using reverse transcription/quantitative polymerase chain reaction of both urine and plasma. These gene expression levels, combined with clinical features and plasma prostate-specific antigen (PSA) levels, were used to predict the presence of International Society of Urological Pathology grade group ≥ 2 PC.Results: Complete data were available for 314 patients. The sensitivity and specificity of the biomarker test were 87% (95% CI: 79-93%) and 42% (95% CI: 36-49%), respectively. The area under the curve was 0.76 (95% CI: 0.7-0.82) for the biomarker test probability and 0.65 (95% CI: 0.59-0.72) for PSA (p = 0.02). The test's negative predictive value was 89% (CI: 81-94%).Conclusion: This study did not replicate the previously reported high accuracy of the biomarker test, highlighting the need for further refinement and robust external validation to ensure reliable performance across diverse patient populations.","PeriodicalId":21542,"journal":{"name":"Scandinavian Journal of Urology","volume":"60 ","pages":"8-13"},"PeriodicalIF":1.4,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142979904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early experience of prostate artery embolization: a retrospective single-centre study. 前列腺动脉栓塞术的早期经验：一项回顾性单中心研究。

IF 1.4 4区医学

Scandinavian Journal of Urology Pub Date : 2025-01-02 DOI: 10.2340/sju.v60.42495

Emir Majbar, Jakob Swanberg, Farhood Alamdari, Ralph Peeker, Abbas Chabok

{"title":"Early experience of prostate artery embolization: a retrospective single-centre study.","authors":"Emir Majbar, Jakob Swanberg, Farhood Alamdari, Ralph Peeker, Abbas Chabok","doi":"10.2340/sju.v60.42495","DOIUrl":"10.2340/sju.v60.42495","url":null,"abstract":"Objective: The aim of this study was to evaluate the early experiences of prostate artery embolization (PAE) in patients with benign prostatic hyperplasia (BPH).Material and methods: This retrospective study included all patients treated for BPH who were referred to the radiology department for PAE in Västmanland between 2018 and 2021. Data were collected on patient demographics, International Prostate Symptom Score (IPSS), prostate-specific antigen level, and peri- and post-procedure outcomes. Clinical success was defined as a decrease in the IPSS by ≤3 points or catheter freedom.Results: A total of 96 patients (median age 74 years) underwent PAE. Before PAE, 65% of the patients were treated with α-blockers and 83% with 5α-reductase inhibitors. Clinical success was achieved in 60 patients (63%). Among catheterized patients, 33 (53%) achieved catheter freedom. In the non-catheterized group, 27 (79%) experienced clinical success. No significant differences in outcomes were observed based on the presence of a median lobe.Conclusions: PAE appears to be a viable treatment option for BPH and may provide substantial symptom relief and catheter freedom for most patients. These findings suggest that PAE may be an effective alternative to more invasive procedures. Further research is needed to refine the patient selection criteria.","PeriodicalId":21542,"journal":{"name":"Scandinavian Journal of Urology","volume":"60 ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

2023/2024 update of the national prostate cancer guidelines in Sweden. 2023/2024瑞典国家前列腺癌指南的更新。

IF 1.4 4区医学

Scandinavian Journal of Urology Pub Date : 2024-12-23 DOI: 10.2340/sju.v59.42656

Johan Stranne

引用次数: 0

Assessment of variability in life expectancy in older men by use of new comorbidity indices. A nationwide population-based study. 使用新的合并症指数评估老年男性预期寿命的变异性。一项全国性的人口研究。

IF 1.4 4区医学

Scandinavian Journal of Urology Pub Date : 2024-12-20 DOI: 10.2340/sju.v59.42504

Marcus Westerberg, Mats Ahlberg, Andri Wilberg Orrason, Rolf Gedeborg

引用次数: 0

Time trends for the use of active surveillance and deferred treatment for localised prostate cancer in Sweden: a nationwide study. 瑞典局部前列腺癌使用主动监测和延迟治疗的时间趋势：一项全国性研究。

IF 1.4 4区医学

Scandinavian Journal of Urology Pub Date : 2024-12-19 DOI: 10.2340/sju.v59.40123

Jovana Maljkovic, Anna Bill-Axelson, Hampus Hållberg, Anders Berglund, Pär Stattin, Ola Bratt

{"title":"Time trends for the use of active surveillance and deferred treatment for localised prostate cancer in Sweden: a nationwide study.","authors":"Jovana Maljkovic, Anna Bill-Axelson, Hampus Hållberg, Anders Berglund, Pär Stattin, Ola Bratt","doi":"10.2340/sju.v59.40123","DOIUrl":"https://doi.org/10.2340/sju.v59.40123","url":null,"abstract":"Objective: Active surveillance (AS) is recommended for low-risk and some favourable intermediate-risk prostate cancers, but criteria for AS and deferred treatment have changed over time. We assessed time trends for the use of AS and deferred treatment.Material and methods: Nationwide Swedish register study of 76,191 men diagnosed with low- or intermediate-risk localised prostate cancer from 2008 to 2020. This study presents the proportion of men starting on AS, their clinical characteristics and proportion having deferred treatment. Cox regression was used to calculate hazard ratios for deferred treatment. Subgroup analyses were performed for men < 60 years with Charlson Comorbidity Index 0.Results: Overall use of AS increased from 2008-2010 to 2017-2020: any low-risk: 40% to 81%, very low-risk disease: 57% to 91%, other low-risk: 37% to 77% and intermediate-risk: 16% to 20%. The relative increase in the use of AS in men < 60 years with Charlson Comorbidity Index 0 was similar to, or greater than, the increase overall. A total of 28,211 men started on AS. The crude proportions of men receiving deferred treatment were relatively stable over time; 2017-2020: very low-risk disease 8%, other low-risk 16% and intermediate-risk 23%. After adjustment for clinical characteristics, deferred treatment within 2 years decreased over time for very low-risk, was stable for other low-risk and increased for intermediate-risk cancer.Conclusions: The use of AS greatly increased over time, not least amongst younger healthy men, whereas the use of deferred treatment was relatively stable. AS has been increasingly accepted as a safe approach for localised, favourable-risk prostate cancer.","PeriodicalId":21542,"journal":{"name":"Scandinavian Journal of Urology","volume":"59 ","pages":"200-206"},"PeriodicalIF":1.4,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exercise in primary care after robot-assisted radical cystectomy for urinary bladder cancer - effects on postoperative complications: a secondary analysis of a randomised controlled trial. 机器人辅助膀胱癌根治性膀胱切除术后初级保健中的锻炼-对术后并发症的影响：一项随机对照试验的二次分析

IF 1.4 4区医学

Scandinavian Journal of Urology Pub Date : 2024-12-18 DOI: 10.2340/sju.v59.42589

Andrea Porserud, Markus Aly, Hanna Steinertz, Elisabeth Rydwik, Maria Hagströmer

{"title":"Exercise in primary care after robot-assisted radical cystectomy for urinary bladder cancer - effects on postoperative complications: a secondary analysis of a randomised controlled trial.","authors":"Andrea Porserud, Markus Aly, Hanna Steinertz, Elisabeth Rydwik, Maria Hagströmer","doi":"10.2340/sju.v59.42589","DOIUrl":"10.2340/sju.v59.42589","url":null,"abstract":"Objective: An exercise programme in primary care soon after radical cystectomy for urinary bladder cancer was previously evaluated regarding its effects on physical function. A secondary aim, presented herein, was to evaluate the programme in terms of its effect on postoperative complications.Materials and methods: Patients who were planned for robot-assisted radical cystectomy for urinary bladder cancer at Karolinska University Hospital between September 2019 and October 2022 were invited to participate. At discharge from hospital, they were randomised to intervention group including aerobic and resistance exercises with physiotherapist in primary care twice a week for 12 weeks and daily walks, or to unsupervised home-based exercise including daily walks. Readmission rates between 30 and 90 days after discharge, and complications according to Clavien Dindo were collected from the medical records and analysed.Results: Ninety patients were randomised, with a mean (SD) age of 72 (9) years. Readmission rates between 30 and 90 days showed no difference between the groups. For readmitted patients, the intervention group had significantly fewer complications reported as Clavien Dindo grade 2 compared to the control group. Conclusion: An exercise programme in primary care soon after robot-assisted radical cystectomy appears to be safe for patients, as measured by hospital readmission rates. Trial registration: Clinical Trials (NCT03998579).","PeriodicalId":21542,"journal":{"name":"Scandinavian Journal of Urology","volume":"59 ","pages":"193-199"},"PeriodicalIF":1.4,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How to improve cancer care by use of guidelines and quality registers. 如何通过使用指南和质量登记册来改善癌症护理。

IF 1.4 4区医学

Scandinavian Journal of Urology Pub Date : 2024-12-12 DOI: 10.2340/sju.v59.42272

Pär Stattin Md PhD

引用次数: 0

Primary and revision artificial urinary sphincter for stress urinary incontinence post-radical prostatectomy: a surgery with high rewards but high risks? 根治性前列腺切除术后压力性尿失禁人工尿道括约肌的初治和复治：高回报但高风险的手术？

IF 1.4 4区医学

Scandinavian Journal of Urology Pub Date : 2024-12-10 DOI: 10.2340/sju.v59.42340

Ingunn Roth, Karin Margrethe Hjelle, Charlotte Josefine Johansen, Christian Arvei Moen, Christian Beisland, Patrick Juliebø-Jones

{"title":"Primary and revision artificial urinary sphincter for stress urinary incontinence post-radical prostatectomy: a surgery with high rewards but high risks?","authors":"Ingunn Roth, Karin Margrethe Hjelle, Charlotte Josefine Johansen, Christian Arvei Moen, Christian Beisland, Patrick Juliebø-Jones","doi":"10.2340/sju.v59.42340","DOIUrl":"https://doi.org/10.2340/sju.v59.42340","url":null,"abstract":"Objectives: To evaluate the efficacy of artificial urinary sphincter (AUS) implantation in men with stress urinary incontinence post-radical prostatectomy and the complication burden with a focus on identifying potential risk factors for reoperation as well as determining the fate of revision surgeries.Methods: Retrospective analysis of consecutive patients undergoing primary AUS (pAUS) and revision AUS (rAUS) implantation at a tertiary centre. Logistic regression was employed to identify risk factors for reoperation associated with non-mechanical failures. Kaplan Meier method was applied to generate implant patency curves.Results: Over 11-years, 108 and 28 patients underwent pAUS and rAUS, respectively. Amongst the former group, a 30-day complication rate of 20.4% was found with a complete (zero pad) dryness rate at follow-up of 49.1%. Post-operative infection was the commonest occurring complication in 7.4%. After pAUS, 27.8% underwent reoperation with cuff erosion being the top indication in 46.7%. Diabetes was a significant predictor for reoperation with an associated 3.6-fold increased risk. The 3-year and 5-year device survival rates without reoperation for pAUS were 80% and 76%, respectively. For rAUS, complete dryness rates achieved were lower at 32.1%. The rate of reoperation was higher at 42.9% with a significantly worse survival probability compared to pAUS (p = 0.024).Conclusions: Whilst men may achieve complete dryness after pAUS, the potential complication burden and risk of reoperation are not low, and patients need to be counselled regarding this. Chances of continence success are lower when revision surgery is performed with a worse implant survival probability.","PeriodicalId":21542,"journal":{"name":"Scandinavian Journal of Urology","volume":"59 ","pages":"185-189"},"PeriodicalIF":1.4,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142802218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The difficulty of studying the association between pathway delays and survival in cancer - an example from bladder cancer. 以膀胱癌为例，探讨癌症治疗路径延迟与生存之间的关系。

IF 1.4 4区医学

Scandinavian Journal of Urology Pub Date : 2024-10-30 DOI: 10.2340/sju.v59.42176

Beth Russell, Oskar Hagberg, Christel Häggstrom, Lars Holmberg, Mieke Van Hemelrijck, Fredrik Liedberg

引用次数: 0

The Stockholm Spinal Cord Uro Study: Changing patterns of urological surgery in a regional prevalence group through 50 years - Outcomes and lessons learned. 斯德哥尔摩脊髓泌尿系统研究：50 年来一个地区流行群体泌尿外科手术模式的变化--结果和经验教训。

IF 1.4 4区医学

Scandinavian Journal of Urology Pub Date : 2024-10-24 DOI: 10.2340/sju.v59.40326

Elisabeth Farrelly, Lena Lindbo, Åke Seiger

{"title":"The Stockholm Spinal Cord Uro Study: Changing patterns of urological surgery in a regional prevalence group through 50 years - Outcomes and lessons learned.","authors":"Elisabeth Farrelly, Lena Lindbo, Åke Seiger","doi":"10.2340/sju.v59.40326","DOIUrl":"https://doi.org/10.2340/sju.v59.40326","url":null,"abstract":"Aims: To examine the number and types of urological surgical procedures carried out in a regional prevalence population of patients with traumatic spinal cord injury (SCI) during five decades, evaluate objective and patient-reported outcomes and to consider lessons learned for further improvement of surgical treatment in this patient group.Methods: In a cross-sectional study of 412 patients with traumatic SCI, one-third had undergone urological surgery through a period of up to 50 years. Data on types of surgery, complications, follow-up and outcomes were collected in a retrospective review of patient files. S-creatinine, S-cystatin-C, renal ultrasound and a questionnaire regarding complications during the preceding year were assembled as part of a yearly follow-up. Descriptive statistics were calculated. Logistic regression was used to determine risk profiles for the incidence of urological surgery.Results: A total of 137 patients had undergone 262 urological surgical interventions. The incidence was highest amongst persons with a cervical-thoracic neurological level of spinal cord lesion and during the first 2 years after SCI. Surgery for urinary stones constituted 29% of all procedures. One-fourth of the patients had undergone 47% of all procedures, notably urinary diversion and ensuing complications, implants and revisions, repeated stone interventions or bladder outlet procedures. After reconstructive surgery functional outcomes and patient-reported satisfaction were generally favourable, but long-term signs of renal complications were frequent.Conclusions: Urological surgery after SCI involves imperative as well as reconstructive procedures, some of which are challenging and call for centralisation to devoted teams. Prospective studies of reconstructive urology are warranted, including more extensive patient-reported outcomes.","PeriodicalId":21542,"journal":{"name":"Scandinavian Journal of Urology","volume":"59 ","pages":"173-180"},"PeriodicalIF":1.4,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142507071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0