Sangyo igaku. Japanese journal of industrial health最新文献

Quantitative assessment of stressors and stress reaction: a review. 应激源与应激反应的定量评估综述。

Sangyo igaku. Japanese journal of industrial health Pub Date : 1994-11-01 DOI: 10.1539/joh1959.36.6_397

S Ezoe, K Morimoto

引用次数: 15

Analysis of toxic gas produced by heating tar epoxy resin paint to assess work atmosphere. 加热焦油环氧树脂涂料产生的有毒气体分析，以评估工作环境。

Sangyo igaku. Japanese journal of industrial health Pub Date : 1994-11-01 DOI: 10.1539/joh1959.36.6_412

T Sakai, S Araki, Y Nakano, F Sata, T Araki

引用次数: 0

[The frequency of glutathione-S-transferase M1 (GSTM1) gene deletion in patients with lung and oral cancer]. [肺癌和口腔癌患者谷胱甘肽- s转移酶M1 (GSTM1)基因缺失的频率]。

Sangyo igaku. Japanese journal of industrial health Pub Date : 1994-11-01 DOI: 10.1539/joh1959.36.6_435

T Katoh

{"title":"[The frequency of glutathione-S-transferase M1 (GSTM1) gene deletion in patients with lung and oral cancer].","authors":"T Katoh","doi":"10.1539/joh1959.36.6_435","DOIUrl":"https://doi.org/10.1539/joh1959.36.6_435","url":null,"abstract":"A homozygous gene deletion at the glutathione-S-transferase (GST) M1 locus of genomic DNA isolated from the peripheral blood was investigated for its relationship with lung and oral cancer using the polymerase chain reaction (RCR) technique. DNA samples were prepared from 91 healthy controls, 53 lung cancer patients and 48 oral cancer patients. As for the genotype, 38 of 91 healthy controls (41.7%), 27 of 53 lung cancer patients (50.9% [p > 0.05], odds ratio 1.45, 95% confidence interval 0.73-2.86) and 26 of 48 oral cancer patients (54.2% [p > 0.05], odds ratio 1.65, 95% confidence interval 0.82-3.32) were GSTM1 deletion types. When male-smoker patients and healthy controls were analyzed, the frequency of GSTM1 deletion genotype was 41.6% in the healthy controls and 52.2% (p > 0.05, odds ratio 1.53, 95% confidence interval 0.58-4.14), 54.5% (p > 0.05, odds ratio 1.68, 95% confidence interval 0.45-6.26), and 50.0% (p > 0.05, odds ratio 1.40, 95% confidence interval 0.55-3.60) in pulmonary squamous cell carcinoma, small cell carcinoma, intraoral squamous cell carcinoma patients, respectively. Thus, the GSTM1 deletion genotype as a host factor predisposing to lung and oral cancer could not be confirmed in this study.","PeriodicalId":21500,"journal":{"name":"Sangyo igaku. Japanese journal of industrial health","volume":"36 6","pages":"435-9"},"PeriodicalIF":0.0,"publicationDate":"1994-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1539/joh1959.36.6_435","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18844784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

[SGOMSEC and international cooperation]. [SGOMSEC和国际合作]。

Sangyo igaku. Japanese journal of industrial health Pub Date : 1994-11-01 DOI: 10.1539/joh1959.36.6_a121

H Satoh

引用次数: 0

[Analysis of acute toxicity (LD50-value) of organic chemicals to mammals by solubility parameter (delta) (3). Acute dermal toxicity to rabbits]. [用溶解度参数(δ)分析有机化学品对哺乳动物的急性毒性(ld50值)(3).对家兔的急性皮肤毒性]。

Sangyo igaku. Japanese journal of industrial health Pub Date : 1994-11-01 DOI: 10.1539/joh1959.36.6_428

H Nishimura, S Saito, F Kishida, M Matsuo

{"title":"[Analysis of acute toxicity (LD50-value) of organic chemicals to mammals by solubility parameter (delta) (3). Acute dermal toxicity to rabbits].","authors":"H Nishimura, S Saito, F Kishida, M Matsuo","doi":"10.1539/joh1959.36.6_428","DOIUrl":"https://doi.org/10.1539/joh1959.36.6_428","url":null,"abstract":"Acute dermal toxicity (LD50-value) of organic chemicals to rabbits was analyzed by using solubility parameter (delta c), a thermodynamic parameter, of the chemicals. As it was observed in the previous studies with rats and mice, parabolic correlations were also established between logarithm of LD50-value (mmol/kg body weight, rabbits) and delta c of all the collected chemicals (n = 56, R = 0.498), alcohols (n = 19, R = 0.857), ketones (n = 7, R = 0.711), aldehydes (n = 7, R = 0.633) and aromatics (n = 20, R = 0.613). Introduction of molar volume (Vc) to the above equations did not improve the correlations. In the study, we assumed that chemicals absorbed dermally by the mammals similarly disturb the homeostasis, as in acute oral toxicities of organic chemicals to rats and mice. We successfully confirmed the theoretical equation regardless of species and routes of administration by establishing statistically significant correlations with all the collected chemicals, alcohols and aromatics. By analysis, we could determine the solubility parameter of 2.24 x 10(4) (J/m3)1/2 for the biological membrane (absorption site) of rabbits. As the dermal delta c-values which dip the LD50-values for rabbits are approximately the same as in acute oral toxicities with rats and mice, common deleterious effects and mechanism may be working at the common target sites. The regression curves of LD50-values of rabbits, however, are slightly higher than those of rats and mice, which may reflect the difference in amounts of the chemicals absorbed by the body.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":21500,"journal":{"name":"Sangyo igaku. Japanese journal of industrial health","volume":"36 6","pages":"428-34"},"PeriodicalIF":0.0,"publicationDate":"1994-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1539/joh1959.36.6_428","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18844783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

[One opinion on the handling of problem drinkers within corporations--based on three actual cases]. [关于处理企业内部酗酒问题的一个意见——基于三个实际案例]。

Sangyo igaku. Japanese journal of industrial health Pub Date : 1994-11-01 DOI: 10.1539/joh1959.36.6_450

T Manome, T Okano, K Shimoyamada, S Ookoshi, Y Satou, E Suzuki, Y Kaneko

引用次数: 0

[HCV antibody positive rate observed in periodic checkup in Kitakyushu]. [北九州地区定期体检HCV抗体阳性率观察]。

Sangyo igaku. Japanese journal of industrial health Pub Date : 1994-11-01 DOI: 10.1539/joh1959.36.6_446

R Ueda, K Fujishiro, T Mizoue, K Takada

引用次数: 2

A simple apparatus using inclinometer for monitoring working postures. 一种简单的用倾斜仪监测工作姿势的装置。

Sangyo igaku. Japanese journal of industrial health Pub Date : 1994-11-01 DOI: 10.1539/joh1959.36.6_406

A Seo, S Tsuru, M Kakehashi, F Yoshinaga

{"title":"A simple apparatus using inclinometer for monitoring working postures.","authors":"A Seo, S Tsuru, M Kakehashi, F Yoshinaga","doi":"10.1539/joh1959.36.6_406","DOIUrl":"https://doi.org/10.1539/joh1959.36.6_406","url":null,"abstract":"A new apparatus was developed for evaluating a load on the low back caused by working postures by measuring upper body inclination. This apparatus consists of an inclinometer and a portable unit. The inclinometer that uses a magnetic resistance sensor is attached to the upper body of the subject. The portable unit, controlled by a one-chip CPU, is enclosed in a cloth case and carried by the subject on his waist belt. The inclination is measured at a certain interval and recorded in the memory of the portable unit. All the recorded data are later transferred to a host computer and then analyzed. According to the theoretical analysis by using a simple mathematical model, upper body inclination changes according to the height of work places, and one cm difference in height causes more than one degree of upper body inclination. A model work of material handling was carried out to collect sample data. Two male subjects lifted ten boxes onto a platform from a stand in several heights. Both stooped and squat lifting methods were used as the lifting protocol. The mean and standard deviation (SD) of the upper body inclination during work decreased according to the lift distance only in stooped lifting. As a practical application, working postures during the task of changing diapers for handicapped people were analyzed with out apparatus. A female subject changed diapers eight times at different height of beds. The mean value of inclination decreased according to the height of the beds.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":21500,"journal":{"name":"Sangyo igaku. Japanese journal of industrial health","volume":"36 6","pages":"406-11"},"PeriodicalIF":0.0,"publicationDate":"1994-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1539/joh1959.36.6_406","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18844780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

[Analysis of acute toxicity (LD50-value) or organic chemicals to mammals by solubility parameter (delta) (2). Acute oral toxicity to mice]. [通过溶解度参数(δ)分析有机化学品对哺乳动物的急性毒性(ld50值)(2).对小鼠的急性口服毒性]。

Sangyo igaku. Japanese journal of industrial health Pub Date : 1994-11-01 DOI: 10.1539/joh1959.36.6_421

H Nishimura, S Saito, F Kishida, M Matsuo

{"title":"[Analysis of acute toxicity (LD50-value) or organic chemicals to mammals by solubility parameter (delta) (2). Acute oral toxicity to mice].","authors":"H Nishimura, S Saito, F Kishida, M Matsuo","doi":"10.1539/joh1959.36.6_421","DOIUrl":"https://doi.org/10.1539/joh1959.36.6_421","url":null,"abstract":"Acute oral toxicity (LD50-value) of organic chemicals to mice was analyzed by using solubility parameter (delta c), a thermodynamic parameter, of the chemicals. As it was observed in the previous study with rats, parabolic correlations were established between logarithm of LD50-value (mmol/kg body weight, mice) and delta c of all the collected chemicals (n = 85, R = 0.626), alcohols (n = 10, R = 0.683), ketones (n = 7, R = 0.631) and aromatics (n = 62, R = 0.645). Introducing molar volume (Vc) to the above equations did not improve the correlations. Although statistically significant correlations were not found in alcohols and ketones with mice, we successfully assured the theoretical equation regardless of species difference by establishing significant correlations with all the collected chemicals and aromatics. By analysis, we could determine the solubility parameter of 2.27 x 10(4) (J/m3)1/2 for the biological membrane (absorption site) of mice. As the delta c-values which dip the LD50-values are approximately the same for mice and rats, common deleterious effects and mechanism may be working at common target sites. In addition, no species difference in sensitivity (toxicity) was found for the aromatics. For comparison, log P was used to describe LD50 of all the collected chemicals, but no correlation was established (R = 0.004-0.418).","PeriodicalId":21500,"journal":{"name":"Sangyo igaku. Japanese journal of industrial health","volume":"36 6","pages":"421-7"},"PeriodicalIF":0.0,"publicationDate":"1994-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1539/joh1959.36.6_421","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18844782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

[Exercise-induced ST segment change and coronary risk factors in apparently healthy men]. 运动引起的ST段改变与冠状动脉危险因素的关系

Sangyo igaku. Japanese journal of industrial health Pub Date : 1994-11-01 DOI: 10.1539/joh1959.36.6_440

K Kawakubo, R Yanagibori, A Gunji

{"title":"[Exercise-induced ST segment change and coronary risk factors in apparently healthy men].","authors":"K Kawakubo, R Yanagibori, A Gunji","doi":"10.1539/joh1959.36.6_440","DOIUrl":"https://doi.org/10.1539/joh1959.36.6_440","url":null,"abstract":"Exercise stress test is useful for the early detection of coronary artery disease and is recommended as a medical clearance test before the initiation of exercise training. However, when applied to apparently healthy people, there are many false positive results. It is therefore necessary to determine indications for stress testing, but few data are available in Japan. In this study, we performed exercise stress test in apparently healthy men to investigate the incidence of exercise-induced ST segment changes and their relationship to coronary risk factors. The subjects were 2,187 men who underwent symptom-limited exercise stress test at a health-promotion center in Tokyo. Those with a history of cardiovascular disease were excluded. They underwent symptom-limited exercise stress test on a treadmill with a modified Bruce protocol or on a cycle ergometer with a ramp protocol (20 watts per minute). Twelve-lead electrocardiogram was recorded every 3 min. Cardiologists evaluated the exercise ECG responses, and advised those with abnormal ST segment changes (Group A) to undergo further examinations at a cardiovascular hospital. The results of further examination such as exercise scintigraphy and/or coronary angiography were obtained. Twice the number of subjects with normal exercise responses were selected as age-matched controls (Group N) to compare the coronary risk factors between the two groups. Twenty-nine subjects had abnormal ST segment changes (1.33% of the total subjects) (Group A). Their mean age was 57 years (38 to 76). Among these, 27 had ST segment depression and 2 had ST elevation.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":21500,"journal":{"name":"Sangyo igaku. Japanese journal of industrial health","volume":"36 6","pages":"440-5"},"PeriodicalIF":0.0,"publicationDate":"1994-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1539/joh1959.36.6_440","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18844785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0