Scandinavian journal of haematology最新文献_第2页

Heterogeneity of T-lymphocyte chronic lymphatic leukaemia (CLL). Study with conventional surface markers and monoclonal antibodies. t淋巴细胞慢性淋巴白血病(CLL)的异质性。用常规表面标记和单克隆抗体进行研究。

Scandinavian journal of haematology Pub Date : 2009-04-24 DOI: 10.1111/J.1600-0609.1984.TB02178.X

A. Singh, P. Lewis, G. Wetherley‐Mein

{"title":"Heterogeneity of T-lymphocyte chronic lymphatic leukaemia (CLL). Study with conventional surface markers and monoclonal antibodies.","authors":"A. Singh, P. Lewis, G. Wetherley‐Mein","doi":"10.1111/J.1600-0609.1984.TB02178.X","DOIUrl":"https://doi.org/10.1111/J.1600-0609.1984.TB02178.X","url":null,"abstract":"Lymphocyte surface markers (E-SRBC, EAC, EA gamma and SmIg) and monoclonal antibodies (OKT3, OKT4, OKT8 and OKIa) were used to characterise the blood and bone marrow lymphocytes of T-cell CLL (8 patients). The diagnosis of T-cell CLL was made primarily as the majority of blood lymphocytes formed E-SRBC in each patient. Other markers-EAC, EA gamma and SmIg--showed different patterns of association with E-SRBC. These findings considered together described 4 different phenotypes amongst these patients: (a) E+ (3 patients), (b) E+, EAC+ (1 patient), (c) E+, EA gamma + (2 patients), and (d) E+, SmIg+ (2 patients). Similarly, 4 different groups were defined with the help of monoclonal antibodies. Helper T-cell (3 patients) and suppressor T-cell (1 patient) CLL showed predominantly helper T- and suppressor T-lymphocytes respectively. Mixed T-cell CLL (1 patient) comprised an equal proportion of both subpopulations, while the remaining 3 patients, with excess of one or other subpopulations along with a considerable proportion of Ia antigen-bearing lymphocytes, formed the indeterminate cell type CLL.","PeriodicalId":21489,"journal":{"name":"Scandinavian journal of haematology","volume":"50 1","pages":"195-206"},"PeriodicalIF":0.0,"publicationDate":"2009-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76158292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Activated partial thromboplastin time. A multicenter evaluation of 11 reagents in the screening of mild haemophilia A 活化部分凝血活酶时间。11种试剂在轻度血友病A筛查中的多中心评价

Scandinavian journal of haematology Pub Date : 2009-04-24 DOI: 10.1111/J.1600-0609.1981.TB01408.X

N. Ciavarella, S. Coccheri, P. Mannucci, M. Canciani, G. Mariani, P. Mori, M. Orlando, L. Tentori, O. Ponari

{"title":"Activated partial thromboplastin time. A multicenter evaluation of 11 reagents in the screening of mild haemophilia A","authors":"N. Ciavarella, S. Coccheri, P. Mannucci, M. Canciani, G. Mariani, P. Mori, M. Orlando, L. Tentori, O. Ponari","doi":"10.1111/J.1600-0609.1981.TB01408.X","DOIUrl":"https://doi.org/10.1111/J.1600-0609.1981.TB01408.X","url":null,"abstract":"An internationally standardized preparation and 10 commercial kits widely used to perform the activated partial thromboplastin time (APTT) were compared in 4 laboratories for the purpose of assessing their ability to detect mild deficiencies of factor VIII activity. The participating laboratories were asked to carry out with each APTT reagent quadruplicate readings of 3 coded lyophilized plasmas containing varying levels of factor VIII (109, 26 and 17 U/dl respectively). An analysis of variance of clotting times showed significant differences between reagents and laboratories. All the reagents detected the abnormality of the plasma containing 17 U/dl, whereas a number of failures were found when the plasma with 26 U/dl was tested. When analysis of variance was carried out on ratios of factor-VIII deficient to normal plasma clotting times, the results showed less difference between laboratories and reagents. Clotting times of plasma with normal factor VIII level (109 U/dl) usually fell within the normal range indicated by manufacturers of the commercial reagents.","PeriodicalId":21489,"journal":{"name":"Scandinavian journal of haematology","volume":"75 1","pages":"308-317"},"PeriodicalIF":0.0,"publicationDate":"2009-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76173380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Comments to the above letter 对上述信件的评论

Scandinavian journal of haematology Pub Date : 2009-04-24 DOI: 10.1111/J.1600-0609.1981.TB01655.X

L. Vilén, K. Fredén, J. Kutti

引用次数: 0

Antibody to Transcobalamin II in Patients Treated with Long Acting Vitamin B12 Preparations 长效维生素B12制剂治疗患者的转钴胺素II抗体

Scandinavian journal of haematology Pub Date : 2009-04-24 DOI: 10.1111/J.1600-0609.1968.TB01712.X

H. Olesen, B. Hom, M. Schwartz

引用次数: 5

Sickle-cell anaemia in Turkey. Evaluation of 97 cases (with parents' findings). 土耳其的镰状细胞贫血症。97例病例评价(附家长结果)。

Scandinavian journal of haematology Pub Date : 2009-04-24 DOI: 10.1111/J.1600-0609.1977.TB02723.X

S. Özsoylu, Necdet ALTINÖZd

引用次数: 0

Lymphopenia: a bad prognostic factor in Hodgkin's disease. 淋巴细胞减少:霍奇金病的一个不良预后因素。

Scandinavian journal of haematology Pub Date : 2009-04-24 DOI: 10.1111/J.1600-0609.1982.TB00582.X

B. Hancock, I. Dunsmore, H. Swan

引用次数: 8

Pyridoxine-responsive primary acquired sideroblastic anaemia. In vitro and in vivo effects of vitamin B6 on decreased 5-aminolaevulinate synthase activity. 吡哆酮反应性原发性获得性铁母细胞贫血。体外和体内维生素B6对降低5-氨基乙酰戊酸合成酶活性的影响。

Scandinavian journal of haematology Pub Date : 2009-04-24 DOI: 10.1111/J.1600-0609.1982.TB00617.X

P. Meier, J. Fehr, U. Meyer

引用次数: 9

Studies on lymphocytes XIII. Nuclear volume measurement as a rapid approach to estimate proliferative fraction. 淋巴细胞的研究13。核体积测量作为快速估计增殖分数的方法。

Scandinavian journal of haematology Pub Date : 2009-04-24 DOI: 10.1111/J.1600-0609.1976.TB01138.X

C. Sipe, A. Chanana, E. Cronkite, G. L. Gulliani, D. Joel

引用次数: 10

Unique multimeric pattern of von Willebrand factor in a patient with a benign monoclonal gammopathy. 良性单克隆伽玛病患者中血管性血友病因子的独特多聚体模式。

Scandinavian journal of haematology Pub Date : 2009-04-24 DOI: 10.1016/0049-3848(86)91547-1

M. López-Fernández, C. López-Berges, R. Martín, J. Nieto, F. del Río, A. López‐borrasca, J. Batlle

引用次数: 8

Chronic lymphocytic leukaemia of T cell origin. Clinical variation possibly due to involvement of different T lymphocyte subpopulations. T细胞源性慢性淋巴细胞白血病。临床差异可能是由于不同T淋巴细胞亚群的参与。

Scandinavian journal of haematology Pub Date : 2009-04-24 DOI: 10.1111/J.1600-0609.1983.TB01517.X

C. Geisler, E. Ralfkiaer, L. Astrup, I. Christensen, E. Dickmeiss, M. Hansen, J. Larsen, J. Petersen, T. Plesner

{"title":"Chronic lymphocytic leukaemia of T cell origin. Clinical variation possibly due to involvement of different T lymphocyte subpopulations.","authors":"C. Geisler, E. Ralfkiaer, L. Astrup, I. Christensen, E. Dickmeiss, M. Hansen, J. Larsen, J. Petersen, T. Plesner","doi":"10.1111/J.1600-0609.1983.TB01517.X","DOIUrl":"https://doi.org/10.1111/J.1600-0609.1983.TB01517.X","url":null,"abstract":"Based on the literature and 2 patients studied, we suggest that at least 2 different clinical entities are included in the concept of T CLL: (i) a clinical variant characterized by a relatively benign course, splenomegaly without lymphadenopathy, low lymphocyte count and granulocytopenia; the proliferating lymphocyte is morphologically mature, of medium size and a cytoplasm with azurophilic granules staining positively for acid phosphatase and corresponding to parallel tubular arrays as demonstrated by electron microscopy. The cells form E-rosettes, have no surface-membrane-bound Ig, but Fc-receptors for IgG. With monoclonal antibodies, the phenotype is OKT3+, OKT4- and OKT8+, theoretically corresponding to the suppressor/cytotoxic T lymphocyte subset, but functionally the cells demonstrate killer cell (responsible for ADCC), but not natural or suppressor cell activity. (ii) another clinical variant with an aggressive course, massive hepato-splenomegaly, lymph node enlargement and very high lymphocyte counts; the lymphocytes are small without cytoplasmic granules; their immunological and functional characteristics have not been determined, but morphologically the cells correspond to the T helper/inducer lymphocyte subset. Thus, involvement of different T lymphocyte subsets may be the reason for the clinical variation in T CLL.","PeriodicalId":21489,"journal":{"name":"Scandinavian journal of haematology","volume":"53 1","pages":"109-21"},"PeriodicalIF":0.0,"publicationDate":"2009-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88925823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8