Clinical and Experimental Obstetrics & Gynecology最新文献

{"title":"Adverse Effects of Polycystic Ovary Syndrome on Pregnancy Outcomes in Women with Gestational Diabetes Mellitus: A Retrospective Study","authors":"Jue Wu, Jun Feng, Cuiyin Yan, Xiaojuan Jiang, Yanping Liu, Wenjie Hou","doi":"10.31083/j.ceog5105115","DOIUrl":"https://doi.org/10.31083/j.ceog5105115","url":null,"abstract":"","PeriodicalId":214595,"journal":{"name":"Clinical and Experimental Obstetrics & Gynecology","volume":"97 30","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140984302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Naringin Regulates the Growth and Apoptosis of Ovarian Cancer Cells via the TGF-β Signaling Pathway: A Prospective Laboratory Based Study","authors":"Xiaoni Zhou, Ying Yu, Bingqing Xie, Tingtao Chen, Liping Cai","doi":"10.31083/j.ceog5105111","DOIUrl":"https://doi.org/10.31083/j.ceog5105111","url":null,"abstract":"","PeriodicalId":214595,"journal":{"name":"Clinical and Experimental Obstetrics & Gynecology","volume":" 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140988812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preterm Birth: Thoughtful Strategies for Screening and Management of Risk Factors: A Descriptive Review","authors":"Sarah Harris, Andrew Greene, Sarah Downs, Allie Sakowicz, Kristen H. Quinn, Jeff M. Denney","doi":"10.31083/j.ceog5105110","DOIUrl":"https://doi.org/10.31083/j.ceog5105110","url":null,"abstract":"","PeriodicalId":214595,"journal":{"name":"Clinical and Experimental Obstetrics & Gynecology","volume":"122 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140987428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hsa_circFOXP1 Contributes to Breast Cancer Progression through Regulating miR-338-3p","authors":"Kaiding Wu, Kunkun Cheng","doi":"10.31083/j.ceog5105112","DOIUrl":"https://doi.org/10.31083/j.ceog5105112","url":null,"abstract":"","PeriodicalId":214595,"journal":{"name":"Clinical and Experimental Obstetrics & Gynecology","volume":" 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140988972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GCK rs1799884 Polymorphism and Gestational Diabetes Mellitus: A System Review and Meta-Analysis","authors":"Yong Hu, Ao Wang, Ke Yi","doi":"10.31083/j.ceog5105108","DOIUrl":"https://doi.org/10.31083/j.ceog5105108","url":null,"abstract":"Background : The correlation among Glucokinase ( GCK ) rs1799884 polymorphism and the risk of gestational diabetes mellitus (GDM) remains controversial, as previous studies have reported inconsistent findings. The potential relationship among the GCK rs1799884 polymorphism and GDM risk was examined by a meta-analysis. Methods : In order to find relevant studies for our investigation, we performed an extensive search across multiple databases, such as Ovid, PubMed, China National Knowledge Infrastructure, and Web of Science. Afterward, the link among the GDM risk and GCK rs1799884 polymorphism was evaluated by employing either random-effects models or fixed-effects to compute 95% confidence intervals (CIs) and pooled odds ratios (ORs). Results : This meta-analysis comprised a total of 11 studies. The findings revealed that the GCK rs1799884 polymorphism was linked to a decreased risk of GDM across all examined models. The pooled analysis demonstrated a substantial link, with the corresponding 95% CIs and the following ORs: Allele contrast: 0.80 (0.73–0.88), recessive model 0.81 (0.76–0.88), homozygote 0.60, (0.49–0.73), heterozygote 0.84, (0.78– 0.91), dominant model 0.59, (0.48–0.72). Conclusions : The GCK rs1799884 variant, according to the current meta-analysis, may act as a genetic biomarker of GDM. The investigation was registered on PROSPERO (https://www.crd.york.ac.uk/prospero/) under registration number CRD42023492185.","PeriodicalId":214595,"journal":{"name":"Clinical and Experimental Obstetrics & Gynecology","volume":" 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140990549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"De-Escalation of Surgical Treatment after Neoadjuvant Chemotherapy in Breast Cancer Patients","authors":"G. Franceschini, E. Di Guglielmo, Riccardo Masetti","doi":"10.31083/j.ceog5105107","DOIUrl":"https://doi.org/10.31083/j.ceog5105107","url":null,"abstract":"","PeriodicalId":214595,"journal":{"name":"Clinical and Experimental Obstetrics & Gynecology","volume":" 29","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140993845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Promoter Methylation Changes in DNA Damage-Response Genes in Ovarian Cancer and Their Correlation with Prognosis","authors":"Wanhong He, Haijun Zhu, Sufen Zhang, Guang Shu, Han Lei, Gang Yin, Xiaohua Ni, Maonan Wang, Qihan Wu","doi":"10.31083/j.ceog5105109","DOIUrl":"https://doi.org/10.31083/j.ceog5105109","url":null,"abstract":"Background : Ovarian cancer has a poor prognosis, and DNA damage-response (DDR) genes are associated with both its occurrence and prognosis. However, previous studies have mostly focused on genetic mutations, with no clear conclusions on epigenetic factors such as DNA methylation. Methods : In this study, we comprehensively investigated the relationship between promoter methylation of DDR genes and ovarian cancer prognosis. We performed combined multidata analysis of the promoter methylation, expression, homologous recombination defieiency (HRD) score, and drug sensitivity of 377 DDR genes in ovarian cancer by utilizing The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets. We then validated abnormal promoter methylation and its relationship with overall survival in clinical samples. Results : Our analysis identified 52 methylation-driven DDR genes that exhibited abnormal expression due to abnormal promoter methylation. These genes are mostly related to BRCA1 -related DNA damage repair and cell cycle regulatory pathways. Further studies revealed six of these genes, BRCA1 , PTTG1 , TTK , AURKA , CDC6 , and E2F1 , to be significantly associated with HRD scores. Among them, E2F1 , PTTG1 , and CDC6 are associated with drug sensitivity. Finally, we verified in 81 ovarian cancer samples that methylation of the promoter of these three genes was significantly associated with patient survival. Conclusions : Our study identified a large number of methylation-driven aberrantly expressed DDR genes in ovarian cancer, some of which affect disease prognosis. Levels of methylation of these gene promoters may serve as potential prognostic markers.","PeriodicalId":214595,"journal":{"name":"Clinical and Experimental Obstetrics & Gynecology","volume":" 46","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140992648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Management of Amniotic Fluid Embolism from the ICU Perspective","authors":"Ming-wang Jia, Jialin Yang, Biying Luo, Yihuan Lai, Ying Yang, Yichun Wang","doi":"10.31083/j.ceog5105106","DOIUrl":"https://doi.org/10.31083/j.ceog5105106","url":null,"abstract":"Objective : This review provides a comprehensive intensive care unit (ICU) perspective on amniotic fluid embolism (AFE), encompassing its epidemiology, pathophysiology, diagnosis, and management. Mechanism : AFE is an abrupt and perilous condition. The enhancement of diagnostic criteria, starting from the understanding of pathologic physiology, can facilitate the development of more specialized disease management approaches and targeted interventions. Findings in Brief : Significant research advancements have improved the timeliness and accuracy of clinical diagnosis and treatment for AFE, leading to the development of several effective rescue procedures. Progress is expected to be made in various aspects including a comprehensive exploration of pathophysiological mechanisms, identification and utilization of biomarkers, innovation in treatment methods, enhancement of personnel training and collaboration within treatment teams, as well as the application of big data technology. Conclusions : The recent research has greatly contributed to substantial progress in the clinical diagnosis and treatment for AFE. However, further research holds potential to provide even greater benefits for","PeriodicalId":214595,"journal":{"name":"Clinical and Experimental Obstetrics & Gynecology","volume":" 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140995720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gene Expression Profiles Infer — The Landscape of Tumor-Infiltrating Immune Cells in Ovarian Cancer and their Clinical Significance","authors":"Caiyun Ding, Li Wang, Qiang Ma, Can Shen, Lu Xi, Guantai Ni, Jin Ding","doi":"10.31083/j.ceog5105105","DOIUrl":"https://doi.org/10.31083/j.ceog5105105","url":null,"abstract":"Background : Infiltration of immune cells associated with tumor clinical results affects different cancers. However, the composition and the clinical significance of tumor-infiltrated immune cells in epithelial ovarian cancer has not been completely investigated. Methods : The metagene deconvolution algorithm (Cell type Identification by Estimating Relative Subsets of known RNA Transcripts (CIBER-SORT)) was used to analyze gene expression profiles in public databases (GEO and TCGA) to infer the composition of 22 immune cell subgroups in ovarian tumors. The proportions obtained in this study were used to investigate the association between each cell type and the clinical outcomes for ovarian cancer diagnosis and prognosis. Quantitative real-time polymerase chain reaction (qRT-PCR) was used for detecting the expression levels of related genes. Results : The profiles of immune cells infiltration were altered in malignant ovarian neoplastic tissue. Ovarian cancer tissues contained higher proportion of T follicular helper cells (Tfh) and macrophages (M0 and M1) rather than the normal ovarian tissue. Meanwhile, lower proportion of monocytes and neutrophils was also observed in ovarian cancer tissues compared with normal tissues. The qRT-PCR test confirmed the conclusion that the contents of CD80 (M1 cells) and CD4+ (Tfh cells) were high in the interstitium of ovarian cancer tissue, while the contents of CD21 (B cells) and CD66b (neutrophil) were low. Interestingly, immune cell infiltration was observed to be correlated with the change in clinical outcome. The activated mast cell subpopulation was associated with poor prognosis, while the subpopulation of resting dendritic cells was correlated with pathological grade of the ovarian cancer. Conclusions : Our bioanalysis revealed that the composition of tumor-infiltrating immune cells was closely related to the clinical outcome of ovarian cancer, which was also validated in clinical samples. These results provide a new strategic basis for the prognosis and treatment of ovarian cancer.","PeriodicalId":214595,"journal":{"name":"Clinical and Experimental Obstetrics & Gynecology","volume":" 21","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140996417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Standardization of Marking of the Surgical Borders According to the Fibonacci (Golden) Ratio in Female Genital Aesthetic Surgery: Presentation of a Novel Marking Gadget","authors":"Erhan Okuyan, Emre Gunakan, Nurullah Peker","doi":"10.31083/j.ceog5105104","DOIUrl":"https://doi.org/10.31083/j.ceog5105104","url":null,"abstract":"The anatomy of the female external genitalia may differ due to developmental or acquired events. However, several anatomical landmarks such as the anterior and posterior commissures, glans clitoridis, and perineal body do not differ across most patients and can be used to evaluate post-surgical tissue symmetry and proportion. Patient preference seems to be subjective; interestingly, however, the desired post-surgical appearance is very similar in itself, almost to the standard in most patients. In addition, surgeons may change the entire process according to their individual aesthetic perceptions and experience. Thus, the outcomes of genital aesthetic surgery may be affected by multiple factors, with patient preference and surgical evaluation and approach appearing to be the most person-dependent. From this perspective, we defined a sticker model for marking the external female genitalia in genital aesthetic surgery. Inspired by the golden ratio, we incorporated the Fibonacci spiral in the stickers.","PeriodicalId":214595,"journal":{"name":"Clinical and Experimental Obstetrics & Gynecology","volume":" 23","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140996190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}