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Rivista europea per le scienze mediche e farmacologiche = European review for medical and pharmacological sciences = Revue europeenne pour les sciences medicales et pharmacologiques最新文献

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Atrial natriuretic factor and sympathetic activation in human heart failure. 心房利钠因子与交感神经激活在人心力衰竭中的作用。
Rivista europea per le scienze mediche e farmacologiche = European review for medical and pharmacological sciences = Revue europeenne pour les sciences medicales et pharmacologiques Pub Date : 1994-05-01
A Liguori, F Di Gregorio, C Napoli, F P D'Armiento, T Posca, A Di Benedetto, N Di Ieso, E Di Paolo, A Ferrara
{"title":"Atrial natriuretic factor and sympathetic activation in human heart failure.","authors":"A Liguori,&nbsp;F Di Gregorio,&nbsp;C Napoli,&nbsp;F P D'Armiento,&nbsp;T Posca,&nbsp;A Di Benedetto,&nbsp;N Di Ieso,&nbsp;E Di Paolo,&nbsp;A Ferrara","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The neurohormonal changes occur early, have important prognostic value, and may play a role in the evolution and progression of heart failure in man. Atrial natriuretic factor (ANF) is a natriuretic and vasorelaxant peptide. Previous studies indicated that plasma ANF provides prognostic information and, ANF levels closely related to both severity of disease and catecholamine levels but, it is still unclear if high circulating levels of ANF, which are present in heart failure constantly, may be to correlate with sympathetic nervous activity in man. Thus, the aim of the present study was to investigate the relations between the release of ANF and the sympathetic system in human heart failure. We studied 18 patients with heart failure (CHF) and a control Group (n = 14) of healthy subjects. To induce adrenergic activation in physiologic way patients were underwent to a low-exercise by cycle-ergometer in supine position. Blood was collected at rest, and immediately after exercise for determination of plasma levels of ANF, norepinephrine and epinephrine levels. ANF values at rest were 35.9 +/- 19.2 pg/ml in controls and 190.7 +/- 34.2 pg/ml (p < 0.001 vs controls) in CHF patients. As well norepinephrine levels showed higher values in patients (295.7 +/- 47.8 pg/ml), than in normal subjects (143.5 +/- 33.3 pg/ml; p < 0.01). In CHF patients epinephrine levels were 100.1 +/- 21.2 pg/ml (p < 0.01 vs controls). ANF levels were in normal subjects 87.9 +/- 19.2 pg/ml (p < 0.01 vs rest) after exercise. In CHF patients ANF values were 275.3 +/- 59.8 pg/ml; p < 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)</p>","PeriodicalId":21382,"journal":{"name":"Rivista europea per le scienze mediche e farmacologiche = European review for medical and pharmacological sciences = Revue europeenne pour les sciences medicales et pharmacologiques","volume":"16 3-4","pages":"61-7"},"PeriodicalIF":0.0,"publicationDate":"1994-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18491793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A new dry chemistry immunoassay: comparison with a fluorescence polarization system. 一种新的干化学免疫分析法:与荧光偏振系统的比较。
Rivista europea per le scienze mediche e farmacologiche = European review for medical and pharmacological sciences = Revue europeenne pour les sciences medicales et pharmacologiques Pub Date : 1994-05-01
D Capone, V De Marino, N Pisanti, V De Marino
{"title":"A new dry chemistry immunoassay: comparison with a fluorescence polarization system.","authors":"D Capone,&nbsp;V De Marino,&nbsp;N Pisanti,&nbsp;V De Marino","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A new dry chemistry fluorescence immunoassay has been recently developed for therapeutic drug monitoring. In the present study we compared this new assay with a fluorescence polarization immunoassay. The drugs tested were carbamazepine, phenobarbital, phenytoin, theophylline and valproate. An high degree of correlation (coefficients ranging from 0.95 to 1.00) was obtained for all drugs tested.</p>","PeriodicalId":21382,"journal":{"name":"Rivista europea per le scienze mediche e farmacologiche = European review for medical and pharmacological sciences = Revue europeenne pour les sciences medicales et pharmacologiques","volume":"16 3-4","pages":"91-4"},"PeriodicalIF":0.0,"publicationDate":"1994-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18489573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute effects of alpha-1 adrenoceptor antagonist, doxazosin on circulating vasoactive hormones. α -1肾上腺素受体拮抗剂多沙唑嗪对循环血管活性激素的急性影响。
Rivista europea per le scienze mediche e farmacologiche = European review for medical and pharmacological sciences = Revue europeenne pour les sciences medicales et pharmacologiques Pub Date : 1994-05-01
F Veglio, D Schiavone, A Rossi, L Chiandussi
{"title":"Acute effects of alpha-1 adrenoceptor antagonist, doxazosin on circulating vasoactive hormones.","authors":"F Veglio,&nbsp;D Schiavone,&nbsp;A Rossi,&nbsp;L Chiandussi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The acute effects of doxazosin, a new selective alpha-1 adrenergic blocking agent, on blood pressure, heart rate, and on some circulating vasoactive hormones, such as plasma renin activity, catecholamines, serotonin and endothelin-1 in ten healthy normotensive volunteers and eight moderate-severe essential hypertensives were studied. Two milligrams doxazosin was administered orally in randomised fashion as compared to placebo and the acute effects were evaluated one half to four hours later. Doxazosin did not reduce blood pressure and did not increase heart rate in normotensive subjects as compared to placebo. A significant decrease in blood pressure was found in hypertensives after doxazosin (p < 0.01), without change in heart rate. Simultaneously, doxazosin did not modify plasma renin activity, catecholamines, serotonin and endothelin-1 concentrations both in normotensive and hypertensive subjects when compared with placebo administration. Thus, it appears that doxazosin does not influence local and systemic vasopressor hormones involving in the regulation of blood pressure. In conclusion, the lack of effects on plasma vasoactive factors confirms the selective alpha-1 postsynaptic antagonism of doxazosin and an effective antihypertensive action in the treatment of essential hypertension.</p>","PeriodicalId":21382,"journal":{"name":"Rivista europea per le scienze mediche e farmacologiche = European review for medical and pharmacological sciences = Revue europeenne pour les sciences medicales et pharmacologiques","volume":"16 3-4","pages":"85-90"},"PeriodicalIF":0.0,"publicationDate":"1994-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18491796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Cytomegalovirus infection in HIV]. [HIV巨细胞病毒感染]。
Rivista europea per le scienze mediche e farmacologiche = European review for medical and pharmacological sciences = Revue europeenne pour les sciences medicales et pharmacologiques Pub Date : 1994-05-01
U Ferone, C Cerimele, L Isceri, V Trinchieri, F Proietti, V Galati, M Monacelli
{"title":"[Cytomegalovirus infection in HIV].","authors":"U Ferone,&nbsp;C Cerimele,&nbsp;L Isceri,&nbsp;V Trinchieri,&nbsp;F Proietti,&nbsp;V Galati,&nbsp;M Monacelli","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The data are taken from a retrospective study of 24 patients with AIDS who developed CMV disease. This study was performed to detect the principal characteristics associated with the development of CMV disease. Age, sex, risk factors, the time interval between HIV seropositivity to CMV disease were examined, as well as efficacy of gancyclovir therapy in both groups of patients with symptomatic and asymptomatic retinitis. When the chorioretinitis is still asymptomatic the early treatment of CMV disease may suppress progression of retinic lesions and seems to be efficacious to prevent the evolution of CMV disease.</p>","PeriodicalId":21382,"journal":{"name":"Rivista europea per le scienze mediche e farmacologiche = European review for medical and pharmacological sciences = Revue europeenne pour les sciences medicales et pharmacologiques","volume":"16 3-4","pages":"55-60"},"PeriodicalIF":0.0,"publicationDate":"1994-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18488466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Theophylline in the treatment of the elderly with chronic obstructive pulmonary disease. 茶碱在老年慢性阻塞性肺疾病治疗中的应用。
Rivista europea per le scienze mediche e farmacologiche = European review for medical and pharmacological sciences = Revue europeenne pour les sciences medicales et pharmacologiques Pub Date : 1994-05-01
G Antognozzi, P Buzzo, M Mori, S Ellena, A Triolo
{"title":"Theophylline in the treatment of the elderly with chronic obstructive pulmonary disease.","authors":"G Antognozzi,&nbsp;P Buzzo,&nbsp;M Mori,&nbsp;S Ellena,&nbsp;A Triolo","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The authors describe the pharmacological effects of theophylline and elucidate its mechanisms of action according to latest hypothesis. The narrow therapeutic range of the drug and the existence of factors capable of modifying its distribution and clearance in the elderly, are taken into consideration, as well. The behaviour of theophylline concentrations in two groups of elderly subjects affected by chronic bronchitis, treated respectively with intravenous aminophylline and anhydrous theophylline administered orally are assessed. Usefulness of associating the two routes of administration is underlined. In fact, the delay in the achievement of the therapeutic range observed after oral intake can be made up for by the initial peak induced by intravenous injection. Our observations in the elderly are consistent with the necessity of therapeutic monitoring. In addition, a careful dosage of the drug can avoid the occurrence of untoward effects.</p>","PeriodicalId":21382,"journal":{"name":"Rivista europea per le scienze mediche e farmacologiche = European review for medical and pharmacological sciences = Revue europeenne pour les sciences medicales et pharmacologiques","volume":"16 3-4","pages":"69-72"},"PeriodicalIF":0.0,"publicationDate":"1994-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18491794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Long-term therapy in chronic hepatitis C with recombinant alpha interferon]. 重组α干扰素长期治疗慢性丙型肝炎
Rivista europea per le scienze mediche e farmacologiche = European review for medical and pharmacological sciences = Revue europeenne pour les sciences medicales et pharmacologiques Pub Date : 1994-05-01
R Siciliano, B A Trovato, M Romano, A Pantò, G Seminara, M Malaguarnera
{"title":"[Long-term therapy in chronic hepatitis C with recombinant alpha interferon].","authors":"R Siciliano,&nbsp;B A Trovato,&nbsp;M Romano,&nbsp;A Pantò,&nbsp;G Seminara,&nbsp;M Malaguarnera","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The dosage and duration of Chronic Hepatitis (CH) C therapy with alpha (alpha-IFN) is still an unresolved problem. Considering mainly antiviral activity of alpha-IFN, the authors carried out research on 35 patients with CH-C to evaluate the efficacy and safety of long term therapy and to compare recombinant alpha-IFN-2a with recombinant alpha-IFN-2b. 21 patients (Group A: 20 males, 1 female, mean age 48.8 years, 14.2% CPH, 76% CAH, 9.5% AC) were treated with r-alpha-IFN-2a; 14 patients (Group B: 7 males, 7 females, mean age 45.2 years, 7.1% CPH, 78.5% CAH, 14.3% AC) were treated with r-alpha-IFN-2b, at a dosage of 3 MU thrice weekly (TIW) for 12 months; the follow-up was from 6 to over 24 months. Complete Response (CR) was achieved in 49.3% of the patients treated, Long Term Response (LTCR) in 19.3%, Partial Response (PR) in 29% and No Response (NR) in 22.6%), Delayed CR in 6.5%. The authors found a similar number of CR and LTRC in group A and group B; a greater percentage of PR in group A and a greater percentage of NR in group B. Early and serious side effects in 4 patients, late and serious side effects in 2 patients were observed. The date suggest that the long term therapy of CH with r-alpha IFN is effective in inducing clinical and biochemical remission in a large portion of patients and a greater number of sustained response, with respect to a therapy schedule of 6 months even at greater dosages.</p>","PeriodicalId":21382,"journal":{"name":"Rivista europea per le scienze mediche e farmacologiche = European review for medical and pharmacological sciences = Revue europeenne pour les sciences medicales et pharmacologiques","volume":"16 3-4","pages":"73-8"},"PeriodicalIF":0.0,"publicationDate":"1994-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18491795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Gynecologic problems in aging: clinical-statistical considerations]. [老年妇科问题:临床统计学考虑]。
Rivista europea per le scienze mediche e farmacologiche = European review for medical and pharmacological sciences = Revue europeenne pour les sciences medicales et pharmacologiques Pub Date : 1994-01-01
A Castellano, C Lattavo, L Bartolomucci, L Domenici, P Venanzi
{"title":"[Gynecologic problems in aging: clinical-statistical considerations].","authors":"A Castellano,&nbsp;C Lattavo,&nbsp;L Bartolomucci,&nbsp;L Domenici,&nbsp;P Venanzi","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":21382,"journal":{"name":"Rivista europea per le scienze mediche e farmacologiche = European review for medical and pharmacological sciences = Revue europeenne pour les sciences medicales et pharmacologiques","volume":"16 1-2","pages":"45-50"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18763217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Amylasemia in uremics: a complex interpretation]. [尿毒症中的淀粉酶血症:一个复杂的解释]。
Rivista europea per le scienze mediche e farmacologiche = European review for medical and pharmacological sciences = Revue europeenne pour les sciences medicales et pharmacologiques Pub Date : 1994-01-01
M Buemi, M Molinaro, R Timpanelli, C Villari, C Conti, C Aloisi, N Morabito, P Venuto, N Frisina
{"title":"[Amylasemia in uremics: a complex interpretation].","authors":"M Buemi,&nbsp;M Molinaro,&nbsp;R Timpanelli,&nbsp;C Villari,&nbsp;C Conti,&nbsp;C Aloisi,&nbsp;N Morabito,&nbsp;P Venuto,&nbsp;N Frisina","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Plasmatic amylase increases quite often in uremia. Hyperparathyroidism is also present in uremic patients and it is thought to be the main factor of an increased of amylase; its effect is mediated by an increase of cytosolic calcium. The authors measured the plasmatic level of amylase, lipase, calcium phosphates and parathormone before and after administration of Ca-antagonists (Verapamil and Diltiazem). The results did not shown any correlation. Hyperparathyroidism increased the pancreatic secretion but don't influences the amount of enzymes.</p>","PeriodicalId":21382,"journal":{"name":"Rivista europea per le scienze mediche e farmacologiche = European review for medical and pharmacological sciences = Revue europeenne pour les sciences medicales et pharmacologiques","volume":"16 1-2","pages":"21-5"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18546965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Biophysical control of pregnancies at risk: our experience]. [危险怀孕的生物物理控制:我们的经验]。
Rivista europea per le scienze mediche e farmacologiche = European review for medical and pharmacological sciences = Revue europeenne pour les sciences medicales et pharmacologiques Pub Date : 1994-01-01
A Castellano, S Grossi, L Bartolomucci, F S Adamo
{"title":"[Biophysical control of pregnancies at risk: our experience].","authors":"A Castellano,&nbsp;S Grossi,&nbsp;L Bartolomucci,&nbsp;F S Adamo","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The perinatal medicine has substantially improved the monitoring of the risk pregnancy thanks to the biological control of the pregnancy and labour. After examining the main systems of fetal monitoring, the authors report their own case load related to the monitoring and to the result of 100 postdate pregnancies examined at their ward.</p>","PeriodicalId":21382,"journal":{"name":"Rivista europea per le scienze mediche e farmacologiche = European review for medical and pharmacological sciences = Revue europeenne pour les sciences medicales et pharmacologiques","volume":"16 1-2","pages":"41-4"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18763216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The modification of lipids in a secondary prevention program by general practice physicians]. [全科医生在二级预防项目中对血脂的修改]。
Rivista europea per le scienze mediche e farmacologiche = European review for medical and pharmacological sciences = Revue europeenne pour les sciences medicales et pharmacologiques Pub Date : 1994-01-01
S Guistini, P Mandelli, U Bartoli, G Pastacaldi, C Pasticci, D Fronges, M Quattrocchi
{"title":"[The modification of lipids in a secondary prevention program by general practice physicians].","authors":"S Guistini,&nbsp;P Mandelli,&nbsp;U Bartoli,&nbsp;G Pastacaldi,&nbsp;C Pasticci,&nbsp;D Fronges,&nbsp;M Quattrocchi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This study follows a cognitive investigation about risk factor for ischemic heart disease performed in 1990 by a group of general practitioners in Pistoia, Italy. From this investigation we selected subjects with hypercholesterolemia; we also considered the association with other risk factors for ischemic heart disease. According to the frequency of risk factors subjects received a low-fat diet or diet plus cholesterol-lowering drug therapy (simvastatin). We describe changes on total cholesterol and its fractions by these therapeutic regimens.</p>","PeriodicalId":21382,"journal":{"name":"Rivista europea per le scienze mediche e farmacologiche = European review for medical and pharmacological sciences = Revue europeenne pour les sciences medicales et pharmacologiques","volume":"16 1-2","pages":"7-11"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18763220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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