Revista medica de Chile最新文献_第3页

[A registry of out-of-hospital cardiac arrest in Chile]. [智利院外心脏骤停登记]。

IF 0.6 4区医学

Revista medica de Chile Pub Date : 2022-10-01 DOI: 10.4067/S0034-98872022001001283

Bárbara Lara, Joaquín Chuecas, Vicente Schild, Jorge Musso, Jerónimo Rojas, Pablo Aguilera

{"title":"[A registry of out-of-hospital cardiac arrest in Chile].","authors":"Bárbara Lara, Joaquín Chuecas, Vicente Schild, Jorge Musso, Jerónimo Rojas, Pablo Aguilera","doi":"10.4067/S0034-98872022001001283","DOIUrl":"https://doi.org/10.4067/S0034-98872022001001283","url":null,"abstract":"Background: The rate of survival to hospital discharge is less than 10% for out-of-hospital cardiac arrest (OHCA).Aim: To develop and implement a Chilean prospective, standardized cardiac arrest registry following the Utstein criteria.Material and methods: We conducted a prospective registry for patients presenting at an urban, academic, high complexity emergency department (ED) after having an OHCA. The facility serves approximately 10% of the national population. Data were registered and analyzed following the Utstein criteria for reporting OHCA.Results: For three years, 289 patients aged 59 ± 19 years (63% men) were included. Fifty seven percent of patients were taken to a health care facility for the first medical assessment by relatives or witnesses and 34% was assisted and transferred by prehospital personnel. In the subgroup of non-traumatic OHCA, 28% (n = 54) received bystander cardiopulmonary resuscitation (CPR). The registered cardiac rhythms were asystole (61%), pulseless electrical activity (PEA) (25%) and ventricular tachycardia (VT) or ventricular fibrillation (VF) (11%). The overall survival rate to discharge from the hospital was 10%, while survival with mRankin score 0-1 was 5%. The median hospitalization length of stay was 18 days among those who survived, compared with five days for the group of patients that died during the hospital stay.Conclusions: OHCA is an important cause of death in Chile. The development of a national registry that follows the International Liaison Committee on Resuscitation guidelines is the first step to assess the profile of OHCA in the region. It will provide crucial information to identify prognostic factors and variables that can help develop standards of care and set up the basis to optimize cardiac arrest management within our country and region.","PeriodicalId":21360,"journal":{"name":"Revista medica de Chile","volume":"150 10","pages":"1283-1290"},"PeriodicalIF":0.6,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10044951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Prostate cancer mortality trends in Chile (1955-2019)]. [智利前列腺癌死亡率趋势(1955-2019)]。

IF 0.6 4区医学

Revista medica de Chile Pub Date : 2022-10-01 DOI: 10.4067/S0034-98872022001001370

J Francisco López, Mario I Fernández, Fernando Coz

{"title":"[Prostate cancer mortality trends in Chile (1955-2019)].","authors":"J Francisco López, Mario I Fernández, Fernando Coz","doi":"10.4067/S0034-98872022001001370","DOIUrl":"https://doi.org/10.4067/S0034-98872022001001370","url":null,"abstract":"Background: Prostate cancer is the tumor with the highest incidence among men and one of Chile's leading causes of death.Aim: To analyze temporal trends in prostate cancer mortality in Chile.Material and methods: Mortality rates in Chile for the period between 1955 and 2019 were calculated. The number of deaths was obtained from the national demographic yearbooks and the Ministery of Health mortality registries. Population estimates from the demographic center of the Economic Commission for Latin America and the Caribbean of the United Nations were used. Chilean census population of 2017 was used as reference to calculate adjusted rates. Trends were analyzed using a join point regression.Results: Crude mortality rates of prostatic cancer increased between 1995 and 2012 in three different phases, namely between 1955 and 1989 with a 2.7% annual increase, between 1989 and 1996 at a 6.8% annual rate, and between 1996 to 2012 with a 2.8% annual increase. From 2012 the rate remained stable. Adjusted mortality rates increased slowly at a 1.7% rate from 1955 to 1993, accelerating between 1993 and 1996, when they increased 12.1% per year. From 1996 onwards there was a significant decrease in mortality at a 1.2% annual rate. This decrease was significant and observed within all age groups but more importantly at older ages.Conclusions: Prostate cancer mortality in Chile has decreased significantly during the last two decades, like that observed in developed nations.","PeriodicalId":21360,"journal":{"name":"Revista medica de Chile","volume":"150 10","pages":"1370-1379"},"PeriodicalIF":0.6,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9689321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Biological effects due to exposure to different concentrations of oxygen from hypo to hyperoxemia]. [暴露于从低氧到高氧的不同氧浓度的生物效应]。

IF 0.6 4区医学

Revista medica de Chile Pub Date : 2022-10-01 DOI: 10.4067/S0034-98872022001001351

Rodrigo L Castillo, Yury Salinas, Daniel Ramos

{"title":"[Biological effects due to exposure to different concentrations of oxygen from hypo to hyperoxemia].","authors":"Rodrigo L Castillo, Yury Salinas, Daniel Ramos","doi":"10.4067/S0034-98872022001001351","DOIUrl":"https://doi.org/10.4067/S0034-98872022001001351","url":null,"abstract":"The systemic effects of oxygen deficiency or excess are not thoroughly described. Knowledge is evolving towards the description of beneficial and detrimental effects of both extremes of partial pressure of oxygen (PaO2). The cellular and tissue mediators derived from the modulation of the oxidative tone and the production of reactive oxygen species (ROS) are widely characterized biochemically, but the pathophysiological characterization is lacking. Preclinical models support the use of hypobaric hypoxia preconditioning, based on its beneficial effects on ventricular function or its reduction in infarct size. A very important use of oxygen today is in commercial diving. However, novel clinical indications for oxygen such as the healing of diabetic foot ulcers and bone injury caused by radiotherapy are increasingly used. On the other hand, the modulation of the hypoxic response associated with exposure to high altitude environments (hypobaric), favors Chile and its highlands as a natural laboratory to determine certain cardiovascular, cerebral and metabolic responses in the resident population. Also, the consequences of the intermittent exposure to high altitudes in workers also deserves attention. This review discusses the physiopathological response to hypo and hyperoxemia, associated with environments with different oxygen concentrations, and brings back the concept of oxygen as a pharmacological mediator in extreme environments such as high altitudes and hyperbaric medicine in divers, decompression sickness, osteonecrosis associated with radiotherapy and sudden sensorineural hearing loss.","PeriodicalId":21360,"journal":{"name":"Revista medica de Chile","volume":"150 10","pages":"1351-1360"},"PeriodicalIF":0.6,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9742111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Frequency of burnout syndrome among health care workers during COVID-19 pandemic]. [COVID-19大流行期间医护人员倦怠综合征的发生频率]。

IF 0.6 4区医学

Revista medica de Chile Pub Date : 2022-10-01 DOI: 10.4067/S0034-98872022001001342

Sebastián Olivares, Claudio Olmos, José Ruiz-Tagle, Gonzalo Campaña

{"title":"[Frequency of burnout syndrome among health care workers during COVID-19 pandemic].","authors":"Sebastián Olivares, Claudio Olmos, José Ruiz-Tagle, Gonzalo Campaña","doi":"10.4067/S0034-98872022001001342","DOIUrl":"https://doi.org/10.4067/S0034-98872022001001342","url":null,"abstract":"Background: COVID-19 pandemic increased the prevalence of burnout syndrome.Aim: To describe the prevalence of burnout syndrome in health care workers of a private clinic in the Metropolitan Region of Chile.Material and methods: Cross-sectional study, the study population were health care workers of a private clinic. An online version of Maslach Burnout Inventory-Human Service Survey was applied during June 2020. Variables such as age, sex, marital status, number of children, service, occupation, and night shift were studied.Results: We collected 846 responses. A 36% (95% confidence intervals (CI) [32,8-39,2]) prevalence of high levels of burnout syndrome was found. Thirty one percent (95% CI [28,1-34,3]) of the respondents had high levels of emotional exhaustion (AE), 33% (95%CI [29,8-36,2]) had low personal fulfillment (RP) and 30% (95%CI [26,6-32,7]) had high levels of depersonalization (DP).Conclusions: Healthcare workers showed concerning levels of burnout syndrome. It is recommended to pay special attention to high levels of emotional exhaustion in nursing and night shift staff. Institutions should develop and apply prevention and emotional support strategies in health personnel.","PeriodicalId":21360,"journal":{"name":"Revista medica de Chile","volume":"150 10","pages":"1342-1350"},"PeriodicalIF":0.6,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10044952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Diagnosis and referral of musculoskeletal tumors]. 肌肉骨骼肿瘤的诊断和转诊。

IF 0.6 4区医学

Revista medica de Chile Pub Date : 2022-10-01 DOI: 10.4067/S0034-98872022001001361

Tomás Zamora, Álvaro Burdiles, Eduardo Botello

引用次数: 0

[Fecal microbiota transplantation in an older patient with Clostridioides difficile recurrent infection. Report of one case]. 粪便菌群移植治疗老年艰难梭菌复发感染1例。报告1例]。

IF 0.6 4区医学

Revista medica de Chile Pub Date : 2022-10-01 DOI: 10.4067/S0034-98872022001001396

Paulina Núñez, Rodrigo Quera, Christian Von Muhlenbrock, Alexandra Concha, Katherine Flores

引用次数: 0

[Off-label use of mycophenolate mofetil in immune-mediated diseases]. 【霉酚酸酯在免疫介导疾病中的超说明书使用】。

IF 0.6 4区医学

Revista medica de Chile Pub Date : 2022-10-01 DOI: 10.4067/S0034-98872022001001317

Alvaro Danza, Diego Graña, Cecilia Casas, Viviana Domínguez, Martín Rebella

{"title":"[Off-label use of mycophenolate mofetil in immune-mediated diseases].","authors":"Alvaro Danza, Diego Graña, Cecilia Casas, Viviana Domínguez, Martín Rebella","doi":"10.4067/S0034-98872022001001317","DOIUrl":"https://doi.org/10.4067/S0034-98872022001001317","url":null,"abstract":"Background: Mycophenolate mofetil (MMF) is a largely used immunosuppressive agent in the prevention of transplant rejection and lupus nephritis. Its use has been extended to other immune-mediated diseases (ID).Aim: To assess the off-label use of MMF, its performance as a glucocorticoid sparing agent, the therapeutic response, and its adverse effects.Material and methods: A retrospective study was performed. One hundred-seven patients aged 58 ± 16 years (83% females) who received MMF for ID in off label uses between 2016 and 2018 were included. The study variables were cause of MMF indication, sex, age, use as a first- or second-line treatment and maintenance dosing. The cumulative doses of glucocorticoids six months before and after MMF indication were compared.Results: MMF was used as a second-line therapy in 66 patients (62%). The mean maintenance dose of MMF was 1,500 ± 540 mg/day. Prednisone cumulative doses were 3,908 ± 2,173 and 1,672 ± 1,083 milligrams six months before and six months after starting MMF, respectively (p < 0.01). Adverse effects were identified in 21 (20%) cases, none of them serious.Conclusions: Mycophenolate has a favorable response profile as a second line immunosuppressive agent. It is effective as a glucocorticoid sparing drug. The safety profile is also favorable as adverse effects were scanty and mild.","PeriodicalId":21360,"journal":{"name":"Revista medica de Chile","volume":"150 10","pages":"1317-1324"},"PeriodicalIF":0.6,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9742115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Feeding the poor and sick during the 18th century. The register of purchases at a hospital of La Serena, Chile]. 在18世纪为穷人和病人提供食物。智利拉塞雷纳一家医院的购买记录。

IF 0.6 4区医学

Revista medica de Chile Pub Date : 2022-10-01 DOI: 10.4067/S0034-98872022001001380

Alex Ovalle Letelier

引用次数: 0

[Short and medium term results of the surgical management of ileocecal Crohn's disease]. [回盲部克罗恩病手术治疗的中短期结果]。

IF 0.6 4区医学

Revista medica de Chile Pub Date : 2022-10-01 DOI: 10.4067/S0034-98872022001001310

Andrés Iglesias B, Catalina San Martín C, Camila Olivares R, Manuel Álvarez L, Álvaro Zúñiga D, Felipe Bellolio R

{"title":"[Short and medium term results of the surgical management of ileocecal Crohn's disease].","authors":"Andrés Iglesias B, Catalina San Martín C, Camila Olivares R, Manuel Álvarez L, Álvaro Zúñiga D, Felipe Bellolio R","doi":"10.4067/S0034-98872022001001310","DOIUrl":"10.4067/S0034-98872022001001310","url":null,"abstract":"Background: The treatment of Crohn's disease (CD) is based on medical therapy and surgery is reserved for failure of medical management or complications.Aim: To evaluate endoscopic, clinical, and surgical recurrence of CD after surgery.Material and methods: In a prospectively maintained database, consecutive patients older than 15 years subjected to an ileocecal resection for ileocolic disease from January 2011 to April 2021, were identified. The diagnosis of CD was confirmed with the pathologic report. Patients with less than one year of follow-up were excluded. Information was obtained retrospectively from the database and clinical records.Results: Fourteen patients were identified. The mean age at the time of surgery was 38 years. Surgery was performed at a median of 41.5 months (0-300) after the diagnosis of CD, nine elective and five emergency procedures. In five patients there were four major and two minor postoperative complications, with no anastomotic leakage. Six patients had endoscopic recurrence and seven had clinical recurrence (50%) at a mean of 15 months, one of whom required a second operation. There was no mortality.Conclusions: After the surgical treatment of CD, the clinical and endoscopic recurrence rate continues to be high.","PeriodicalId":21360,"journal":{"name":"Revista medica de Chile","volume":"150 10","pages":"1310-1316"},"PeriodicalIF":0.6,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10044947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[On Dr. Rudolf Amandus Philippi (1808-1904), the Revista Médica de Chile, the blooming desert and medicinal plants]. [关于Rudolf Amandus Philippi博士(1808-1904)，智利的复兴，盛开的沙漠和药用植物]。

IF 0.6 4区医学

Revista medica de Chile Pub Date : 2022-10-01 DOI: 10.4067/S0034-98872022001001410

Manuel E Cortés

引用次数: 0