Rheumatology最新文献_第2页

Lipids in SLE. 系统性红斑狼疮中的血脂。

IF 4.7 2区医学

Rheumatology Pub Date : 2024-10-01 DOI: 10.1093/rheumatology/keae221

Johan Frostegård

引用次数: 0

Breaking down statin myopathy: understanding the self-limited and autoimmune subtypes. 分解他汀类药物肌病：了解自限性和自身免疫亚型。

IF 4.7 2区医学

Rheumatology Pub Date : 2024-10-01 DOI: 10.1093/rheumatology/keae284

Joel Wright, Lisa Christopher-Stine

引用次数: 0

Bi-directional association of rheumatoid arthritis and chronic obstructive pulmonary disease: linking arthritis, inflammation, smoking, airways disease, and emphysema. 类风湿性关节炎与慢性阻塞性肺病的双向关联：将关节炎、炎症、吸烟、气道疾病和肺气肿联系起来。

IF 4.7 2区医学

Rheumatology Pub Date : 2024-10-01 DOI: 10.1093/rheumatology/keae137

Julia A Ford, Michael H Cho, Jeffrey A Sparks

引用次数: 0

2023 ACR/EULAR classification criteria in existing research cohorts: an international study. 现有研究队列中的 2023 ACR/EULAR 分类标准：一项国际研究。

IF 4.7 2区医学

Rheumatology Pub Date : 2024-10-01 DOI: 10.1093/rheumatology/keae058

Silvia G Foddai, Massimo Radin, Irene Cecchi, Elena Rubini, Alice Barinotti, Paula Alba, Carla Gimen Alonso, Daniela Rossi, Dario Roccatello, Savino Sciascia

{"title":"2023 ACR/EULAR classification criteria in existing research cohorts: an international study.","authors":"Silvia G Foddai, Massimo Radin, Irene Cecchi, Elena Rubini, Alice Barinotti, Paula Alba, Carla Gimen Alonso, Daniela Rossi, Dario Roccatello, Savino Sciascia","doi":"10.1093/rheumatology/keae058","DOIUrl":"10.1093/rheumatology/keae058","url":null,"abstract":"Objective: To assess the impact of the updated ACR/EULAR APS classification criteria on two large research cohorts.Methods: Consecutive patients who tested persistently positive for at least one aPL in the last three years were enrolled. The first APS Sydney index event was considered and computed for the comparison between Sydney and 2023 APS criteria. When computing the 2023 APS criteria, additional manifestations were also considered.Results: The cohort comprised 249 patients (185 with APS and 64 aPL carriers according to Sydney criteria). The 185 patients had as first index event venous thrombosis in 55 cases (29.8%), arterial thrombosis in 63 (34%) and pregnancy morbidity in 67 (36.2%). When applying the updated criteria, 90 subjects (48.7%) failed to reach the composite score of the new criteria. The percentage of thrombotic APS per Sydney criteria decreased from 47.3% to 34.9% because of high cardiovascular risk in 23 cases, IgM aPL profile in six cases and in two patients for both reasons. Patients with pregnancy morbidity decreased from 26.9% to 3.2% (39 cases of recurrent early pregnancy loss and 20 of fetal losses). Consequently, the percentage of aPL carriers increased from 26% to 61%. When looking at the disease evolution at follow-up, 32 additional patients out of 90 (35.6%) fulfilled the new APS criteria, after developing additional clinical manifestation following index event.Conclusion: When applying the new APS criteria to our research cohorts, not-negligible differences exist in patients' classification. A multidisciplinary approach will be mandatory to assess the impact of the new criteria on research and, ultimately, patients' care.","PeriodicalId":21255,"journal":{"name":"Rheumatology","volume":null,"pages":null},"PeriodicalIF":4.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139642856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum protein profiling reveals distinct patient clusters in giant cell arteritis. 血清蛋白分析揭示了巨细胞动脉炎患者的独特群集。

IF 4.7 2区医学

Rheumatology Pub Date : 2024-10-01 DOI: 10.1093/rheumatology/keae072

Flavia Zingg, Fabio S Ryser, Andrea D Gloor, Christos Polysopoulos, Peter M Villiger, Britta Maurer, Lisa Christ

{"title":"Serum protein profiling reveals distinct patient clusters in giant cell arteritis.","authors":"Flavia Zingg, Fabio S Ryser, Andrea D Gloor, Christos Polysopoulos, Peter M Villiger, Britta Maurer, Lisa Christ","doi":"10.1093/rheumatology/keae072","DOIUrl":"10.1093/rheumatology/keae072","url":null,"abstract":"Objectives: We investigated the potential of serum proteins for distinguishing clinical and molecular subtypes in patients with GCA.Methods: Proximity extension assays were used to analyse 1463 proteins in serum samples from patients with new-onset GCA (n = 16) and patients who have achieved remission (n = 13). Unsupervised and supervised cluster analyses were performed.Results: Unsupervised cluster analysis identified three distinct clusters based on the protein signature. Compared with cluster 2, patients of cluster 1 had fewer PMR symptoms, increased levels of macrophage migration inhibitory factor (MIF) and pronounced NF-κB, STAT5 and IL-1 signalling. The changes in serum proteins upon remission differed between cluster 1 and 2.Patients with cranial GCA were characterized by altered endothelial and Th17 signalling, whereas patients not responding to treatment within the GUSTO-trial showed increased Th1 and diminished B cell signalling. Patients with anterior ischaemic optic neuropathy displayed higher levels of CHI3L1 (YKL40) and MMP12, and reduced levels of TIMP3.Conclusion: Protein profiling identified patient clusters in GCA with distinct proteomic features and therefore likely different pathophysiology. These unique proteomic footprints might lead to more targeted treatments in future.","PeriodicalId":21255,"journal":{"name":"Rheumatology","volume":null,"pages":null},"PeriodicalIF":4.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139698191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transcriptomic features of systemic lupus erythematosus patients in flare and changes during acute in-hospital treatment. 爆发期系统性红斑狼疮患者的转录组特征及急性住院治疗期间的变化

IF 4.7 2区医学

Rheumatology Pub Date : 2024-10-01 DOI: 10.1093/rheumatology/kead704

Zhongyi Liu, Li Shao, Fei Hou, Weiyang Li, Yong-Fei Wang, Hong Feng, Frank Qingyun Wang, Yao Lei, Lichuan Zheng, Rui Liang, Jian Li, Xianghua Guo, Lili Zhang, Yanfang Zhang, Jing Yang, Xiao Qin, Wei Wei, Xingtian Yang, Xiao Dang, Wen Ma, Chun Hing She, Qingsheng Kong, Jing Yang, Bo Ban, Yu Lung Lau, Qin Song, Wanling Yang

{"title":"Transcriptomic features of systemic lupus erythematosus patients in flare and changes during acute in-hospital treatment.","authors":"Zhongyi Liu, Li Shao, Fei Hou, Weiyang Li, Yong-Fei Wang, Hong Feng, Frank Qingyun Wang, Yao Lei, Lichuan Zheng, Rui Liang, Jian Li, Xianghua Guo, Lili Zhang, Yanfang Zhang, Jing Yang, Xiao Qin, Wei Wei, Xingtian Yang, Xiao Dang, Wen Ma, Chun Hing She, Qingsheng Kong, Jing Yang, Bo Ban, Yu Lung Lau, Qin Song, Wanling Yang","doi":"10.1093/rheumatology/kead704","DOIUrl":"10.1093/rheumatology/kead704","url":null,"abstract":"Objectives: Systemic lupus erythematosus (SLE) is a complex autoimmune disease with varying symptoms and multi-organ damage. Relapse-remission cycles often persist for many patients for years with the current treatment. Improved understanding of molecular changes caused by SLE flare and intensive treatment may result in more targeted therapies.Methods: RNA sequencing was performed on peripheral blood mononuclear cells (PBMCs) from 65 SLE patients in flare, collected both before (SLE1) and after (SLE2) in-hospital treatment, along with 15 healthy controls (HC). Differentially expressed genes (DEGs) were identified among the three groups. Enriched functions and key molecular signatures of the DEGs were analysed and scored to elucidate the transcriptomic changes during treatment.Results: Few upregulated genes in SLE1 vs HC were affected by treatment (SLE2 vs SLE1), mostly functional in interferon signalling (IFN), plasmablasts and neutrophils. IFN and plasmablast signatures were repressed, but the neutrophil signature remained unchanged or enhanced by treatment. The IFN and neutrophil scores together stratified the SLE samples. IFN scores correlated well with leukopenia, while neutrophil scores reflected relative cell compositions but not cell counts.Conclusions: In-hospital treatment significantly relieved SLE symptoms with expression changes of a small subset of genes. Notably, IFN signature changes matched SLE flare and improvement, while enhanced neutrophil signature upon treatment suggested the involvement of low-density granulocytes (LDG) in disease development.","PeriodicalId":21255,"journal":{"name":"Rheumatology","volume":null,"pages":null},"PeriodicalIF":4.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139032548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MRVAS-introducing a standardized magnetic resonance scoring system for assessing the extent of inflammatory burden in giant cell arteritis. MRVAS 评分--引入标准化磁共振评分系统，评估巨细胞动脉炎的炎症负担程度。

IF 4.7 2区医学

Rheumatology Pub Date : 2024-10-01 DOI: 10.1093/rheumatology/keae056

Matthias Froehlich, Konstanze V Guggenberger, Marius Vogt, Patrick W Mihatsch, Giulia Dalla Torre, Rudolf A Werner, Michael Gernert, Patrick P Strunz, Jan Portegys, Andreas M Weng, Marc Schmalzing, Thorsten A Bley

{"title":"MRVAS-introducing a standardized magnetic resonance scoring system for assessing the extent of inflammatory burden in giant cell arteritis.","authors":"Matthias Froehlich, Konstanze V Guggenberger, Marius Vogt, Patrick W Mihatsch, Giulia Dalla Torre, Rudolf A Werner, Michael Gernert, Patrick P Strunz, Jan Portegys, Andreas M Weng, Marc Schmalzing, Thorsten A Bley","doi":"10.1093/rheumatology/keae056","DOIUrl":"10.1093/rheumatology/keae056","url":null,"abstract":"Objectives: Our aim was to introduce a standardized system for assessing the extent of GCA on MRI, i.e. the Magnetic Resonance Vasculitis Activity Score (MRVAS). To obtain a comprehensive view, we used an extensive MRI protocol including cranial vessels and the aorta with its branches. To test reliability, MRI was assessed by four readers with different levels of experience.Methods: A total of 80 patients with suspected GCA underwent MRI of the cranial arteries and the aorta and its branches (20 vessel segments). Every vessel was rated dichotomous [inflamed (coded as 1) or not (coded as 0)], providing a summed score of 0-20. Blinded readers [two experienced radiologists (ExR) and two inexperienced radiologists (InR)] applied the MRVAS on an individual vessel and an overall level (defined as the highest score of any of the individual vessel scores). To determine interrater agreement, Cohen's κ was calculated for pairwise comparison of each reader for individual vessel segments. Intraclass correlation coefficients (ICCs) were used for the MRVAS.Results: Concordance rates were excellent for both subcohorts on an individual vessel-based (GCA: ICC 0.95; non-GCA: ICC 0.96) and overall MRVAS level (GCA: ICC 0.96; non-GCA: ICC 1.0). Interrater agreement yielded significant concordance (P < 0.001) for all pairs (κ range 0.78-0.98). No significant differences between ExRs and InRs were observed (P = 0.38).Conclusion: The proposed MRVAS allows standardized scoring of inflammation in GCA and achieved high agreement rates in a prospective setting.","PeriodicalId":21255,"journal":{"name":"Rheumatology","volume":null,"pages":null},"PeriodicalIF":4.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139672488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In the search for an accurate and early diagnosis of psoriatic arthritis: is the key in ultrasound? 寻找银屑病关节炎的早期准确诊断方法：关键在于超声波吗？

IF 4.7 2区医学

Rheumatology Pub Date : 2024-10-01 DOI: 10.1093/rheumatology/keae159

Rubén Queiro, Estefanía Pardo

引用次数: 0

Diagnosis of large vessel vasculitis in the community: a specific benefit from a non-specific symptom pathway. 社区大血管炎诊断：非特异性症状途径的特异性益处。

IF 4.7 2区医学

Rheumatology Pub Date : 2024-10-01 DOI: 10.1093/rheumatology/keae205

Russell Machin, Tom Sulkin, Giles Maskell, Mark Hughes

引用次数: 0

Human genetic evidence supports fibroblast growth factor 21 as a novel therapeutic target for gout. 人类遗传学证据支持成纤维细胞生长因子 21 (FGF21) 成为痛风的新型治疗靶点。

IF 4.7 2区医学

Rheumatology Pub Date : 2024-10-01 DOI: 10.1093/rheumatology/keae210

Sizheng Steven Zhao, Daniel J Cuthbertson, Uazman Alam

引用次数: 0