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Revue Du Praticien最新文献

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[What is your diagnosis? Inveterate anterior shoulder dislocation]. 你的诊断是什么?[肩部前脱位]。
Revue Du Praticien Pub Date : 2023-05-01
Mehdi El Aissate, Yassine Ennaboulsi, Amine Bentaher, Salah Eddine El Khader
{"title":"[What is your diagnosis? Inveterate anterior shoulder dislocation].","authors":"Mehdi El Aissate,&nbsp;Yassine Ennaboulsi,&nbsp;Amine Bentaher,&nbsp;Salah Eddine El Khader","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>THERAPEUTIC APPROACHES IN SICKLE CELL DISEASE. Sickle cell disease, the most common genetic disease in France, is still burdened with morbidity and early mortality before the age of 50. When the first-line treatment, hydroxyurea, is insufficient or in the case of organic damage(s) (in particular cerebral vasculopathy), a therapeutic intensification must be considered. New molecules are now available, such as voxelotor and crizanlizumab, but only hematopoietic stem cell (HSC) transplantation can cure the disease. Allogeneic HSC transplantation during childhood with a sibling donor is the reference but it is now possible to perform this procedure in adults with a reduced pre-transplant conditioning. Gene therapy, which consists of an autograft of genetically modified HSCs, has obtained promising results but has not yet demonstrated a complete cure of the disease (protocols underway). The toxicity of myeloablative conditioning (used in pediatrics or for gene therapy), particularly the sterility induced, and the risk of graft-versushost disease (for allogeneic transplantation) are limiting factors of these treatments.</p>","PeriodicalId":21248,"journal":{"name":"Revue Du Praticien","volume":"73 5","pages":"541-543"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9680522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Sickle cell disease]. [镰状细胞病]。
Revue Du Praticien Pub Date : 2023-05-01
Jean-Benoît Arlet
{"title":"[Sickle cell disease].","authors":"Jean-Benoît Arlet","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":21248,"journal":{"name":"Revue Du Praticien","volume":"73 5","pages":"499"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9761244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Epidemiology of sickle cell disease in France and in the world]. [镰状细胞病在法国和世界的流行病学]。
Revue Du Praticien Pub Date : 2023-05-01
Jean-Benoît Arlet
{"title":"[Epidemiology of sickle cell disease in France and in the world].","authors":"Jean-Benoît Arlet","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>EPIDEMIOLOGY OF SICKLE CELL DISEASE IN FRANCE AND IN THE WORLD. In a few decades, sickle cell disease has become the leading rare disease in France, with nearly 30,000 patients. It is the country in Europe where the most patients live. For historical reasons of immigration, half of these French patients live in the Paris area. The number of births of affected children increases every year, which explains the recurrent and increasing hospitalizations for vaso-occlusive crises, impacting the care system. Sub-Saharan African countries, along with India, are the countries most affected by the disease with an incidence of up to 1% of births. While infant mortality has become rare in industrialized countries, it is major in Africa where more than half of the children will not reach the age of 10.</p>","PeriodicalId":21248,"journal":{"name":"Revue Du Praticien","volume":"73 5","pages":"500-504"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9982428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Therapeutic education of patients with sickle cell disease]. [镰状细胞病患者的治疗性教育]。
Revue Du Praticien Pub Date : 2023-05-01
Anne Corbasson, Philippe Blasco, Mariane De Montalembert
{"title":"[Therapeutic education of patients with sickle cell disease].","authors":"Anne Corbasson,&nbsp;Philippe Blasco,&nbsp;Mariane De Montalembert","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":21248,"journal":{"name":"Revue Du Praticien","volume":"73 5","pages":"527-528"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9639364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Reintegrating the humanities into medical studies]. [将人文学科重新纳入医学研究]。
Revue Du Praticien Pub Date : 2023-05-01
Jean-Noël Fabiani-Salmon
{"title":"[Reintegrating the humanities into medical studies].","authors":"Jean-Noël Fabiani-Salmon","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":21248,"journal":{"name":"Revue Du Praticien","volume":"73 5","pages":"467"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9639365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Sickle cell disease: 10 key messages]. [镰状细胞病:10个关键信息]。
Revue Du Praticien Pub Date : 2023-05-01
Jean-Benoît Arlet
{"title":"[Sickle cell disease: 10 key messages].","authors":"Jean-Benoît Arlet","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":21248,"journal":{"name":"Revue Du Praticien","volume":"73 5","pages":"540"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9761243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Management of acute complications of sickle cell disease]. 镰状细胞病急性并发症的处理
Revue Du Praticien Pub Date : 2023-05-01
Corinne Guitton, Pierre Cougoul
{"title":"[Management of acute complications of sickle cell disease].","authors":"Corinne Guitton,&nbsp;Pierre Cougoul","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>MANAGEMENT OF ACUTE COMPLICATIONS OF SICKLE CELL DISEASE. Acute complications are the most frequent causes of hospitalization and morbidity in patients with sickle cell disease. Vaso-occlusive crisis are responsible of more than 90% of hospitalization, but numerous acute complications can affect multiples organ or function, that may be life-threatening. Thus, a single reason for hospitalization may include many complications such as worsening of an anemia, vascular disease (stroke, thrombosis, priapism), acute chest syndrome, liver or spleen sequestration. Evaluation of acute complications includes the understanding of chronic complications, particularities related to patient's age, the search for a triggering factor and a differential diagnosis. Analgesia and venous access difficulties, post transfusion immunization, medical history of the patient can make the management of acute complication particularly complex.</p>","PeriodicalId":21248,"journal":{"name":"Revue Du Praticien","volume":"73 5","pages":"516-521"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9982425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Folliculitis decalvans on a cutis verticis gyrata]. 【旋转角质层上的毛囊炎贴花】。
Revue Du Praticien Pub Date : 2023-05-01
Sara Bouabdella, Soraya Aouali, Siham Dikhaye, Nada Zizi
{"title":"[Folliculitis decalvans on a cutis verticis gyrata].","authors":"Sara Bouabdella,&nbsp;Soraya Aouali,&nbsp;Siham Dikhaye,&nbsp;Nada Zizi","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":21248,"journal":{"name":"Revue Du Praticien","volume":"73 5","pages":"544"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9680513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Diplopia: diagnostic orientation]. [复视:诊断取向]。
Revue Du Praticien Pub Date : 2023-05-01
Claude Speeg-Schatz
{"title":"[Diplopia: diagnostic orientation].","authors":"Claude Speeg-Schatz","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":21248,"journal":{"name":"Revue Du Praticien","volume":"73 5","pages":"563-569"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9680521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Therapeutic advances in HER2+ breast cancer]. HER2+乳腺癌的治疗进展。
Revue Du Praticien Pub Date : 2023-04-01
Marie Alexandre, William Jacot
{"title":"[Therapeutic advances in HER2+ breast cancer].","authors":"Marie Alexandre,&nbsp;William Jacot","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>THERAPEUTIC ADVANCES IN HER2+ BREAST CANCER. 58,000 new cases of breast cancer occured in France in 2018, of which 15-20% are HER2-positive. HER2-targeted therapies deeply modified the management of these tumors, first by the introduction of monoclonal antibodies such as trastuzumab and pertuzumab and tyrosine kinase inhibitors such as tucatinib, and more recently by antibody drug conjugates (ADC), with trastuzumab-deruxtecan in the forefront. In the localized stage, neoadjuvant chemotherapy associated with trastuzumab is now the standard strategy, allowing the adjuvant strategy to be adapted to the therapeutic response, with the use of another ADC, T-DM1, in the absence of pathological complete response. These various therapeutic advances have led to a significant improvement in the prognosis of HER2-positive breast cancer, whether at the metastatic or localized stage.</p>","PeriodicalId":21248,"journal":{"name":"Revue Du Praticien","volume":"73 4","pages":"355-359"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9608049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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