Revista KranionPub Date : 2021-11-19DOI: 10.24875/kranion.m21000005
Alexandra Pérez Soriano
{"title":"Atrofia multisistémica","authors":"Alexandra Pérez Soriano","doi":"10.24875/kranion.m21000005","DOIUrl":"https://doi.org/10.24875/kranion.m21000005","url":null,"abstract":"Multiple system atrophy (MSA), a term introduced in 1969 by Graham and Oppenheimer, is a neurodegenerative disease, progressive, witch occurs sporadically, characterized by parkinsonism, autonomic, cerebellar and pyramidal signs, in various combinations. This disease begins, usually, in the fifth decade. Pathologically, MSA is characterized by progessive cell loss and oligodendroglial cytoplasmatic inclusions in numerous sites in the central nervous system. Because the parkinsonism is the most frequent features of the disease, usually this patients are missdiagnosed as suffering Parkinson’s disease. To make diagnosis easier, a consensus conference was held in 1998, and the experts established diagnostic criteria for the disease.","PeriodicalId":21238,"journal":{"name":"Revista Kranion","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76471172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Revista KranionPub Date : 2021-11-19DOI: 10.24875/kranion.m21000004
Carla Abdelnour Ruiz
{"title":"Demencia con cuerpos de Lewy","authors":"Carla Abdelnour Ruiz","doi":"10.24875/kranion.m21000004","DOIUrl":"https://doi.org/10.24875/kranion.m21000004","url":null,"abstract":"La demencia con cuerpos de Lewy y la demencia de la enfermedad de Parkinson son reconocidas ahora como dos entidades distintas que forman parte del espectro de una misma enfermedad: Enfermedad por cuerpos de Lewy. Ambas, se caracterizan patológicamente por el depósito de la proteína sinucleína, y clínicamente por una mixtura variable de características cognitivas, neuropsiquiátricas y extra-piramidales. Es importante diferenciarlas de la enfermedad de Alzheimer y de otras demencias degenerativas, y en ello es útil las guías prácticas publicadas por la Academia Americana de Neurología y el Consorcio para el diagnóstico de Demencia con cuerpos de Lewy. No obstante, las respuestas clínicas son impredecibles, los inhibidores de colinesterasas han demostrado brindar beneficios cognitivos, funcionales y conductuales; pero sobre todo que no afectan las características motoras del parkinsonismo. Teniendo claro, que el manejo clínico actual de ambas entidades es meramente sintomático, los principales retos en el futuro son mejorar el conocimiento de la fisiopatología, determinar la expresión fenotípica clínica y desarrollar terapias que modifiquen el curso de la enfermedad.","PeriodicalId":21238,"journal":{"name":"Revista Kranion","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90273110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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