Revista medica de Panama最新文献_第2页

[Clinical and virological correlation between the cerebrospinal fluid and blood of HIV-infected children]. [艾滋病毒感染儿童脑脊液和血液的临床和病毒学相关性]。

Revista medica de Panama Pub Date : 2001-01-01

X Sáez-Llorens, M C Castrejón de Wong, E Castaño, O de Suman, C Báez de Ulloa, W Redondo, M Espino

{"title":"[Clinical and virological correlation between the cerebrospinal fluid and blood of HIV-infected children].","authors":"X Sáez-Llorens, M C Castrejón de Wong, E Castaño, O de Suman, C Báez de Ulloa, W Redondo, M Espino","doi":"","DOIUrl":"","url":null,"abstract":"Background: Although the neurological manifestations of HIV infection occur at any age, children with perinatal AIDS are affected earlier and with greater impact. There are no published data about a potential association between HIV encephalopathy and viral load in THE CSF OF the pediatric population.Design: Twenty-three children, aged 7 months to 10 years, were studied as part of a multicenter international study that evaluated double versus triple antiretroviral therapy. Samples of CSF and plasma were collected for HIV RNA measurements on day 0 and on follow-up weeks 8, 16, and 48. Neurological assessments, psychological evaluations, and CT scans were done on admission and at study end. Viral isolates were processed for genotypic resistance.Results: No correlation between viral load in CSF and plasma was detected at study onset. Eighty percent of children had >2 log HIV RNA in CSF at day 0 but only 30% at week 16. Eight subjects responded favorably to therapy and their CSF had undetectable viral load during follow-up determinations. On day 0, 72% of children had identical patterns of genotypic resistance in CSF and plasma samples. At week 48, however, only 11% of these subjects had identical patterns. On day 0, 83% of children had abnormal neurological findings but these alterations declined to 35% at week 48 (p = 0.004). Most children with neurological abnormalities had detectable CSF viral loads (65% vs 17%, p = 0.04).Conclusions: The data generated in this study suggest that CSF and plasma behave as two different body compartments in terms of HIV dynamics and resistance mutants. Presence of neurological abnormalities correlate with detection of HIV in CSF and these alterations improve as therapy decreases CSF viral load. These results underscore the importance of using ARV drugs with good CNS penetration for optimal management of HIV-infected young children.","PeriodicalId":21235,"journal":{"name":"Revista medica de Panama","volume":"26 ","pages":"13-8"},"PeriodicalIF":0.0,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25008342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Spinal cord trauma]. [脊髓损伤]。

Revista medica de Panama Pub Date : 2001-01-01

J E Espinosa

引用次数: 0

[Euthanasia, catastrophic disease and the moribund patient]. [安乐死，灾难性疾病和垂死病人]。

Revista medica de Panama Pub Date : 2001-01-01

L A Picard-Ami

引用次数: 0

[Osler-Weber-Rendu disease. A case report]. [Osler-Weber-Rendu疾病。[病例报告]。

Revista medica de Panama Pub Date : 2001-01-01

J D Barrios, R Molino

引用次数: 0

[Evaluation of prognostic factors in breast cancer EC I-II and the importance of local recurrence]. [乳腺癌EC - ii期预后因素评价及局部复发的重要性]。

Revista medica de Panama Pub Date : 2001-01-01

C Castillero

{"title":"[Evaluation of prognostic factors in breast cancer EC I-II and the importance of local recurrence].","authors":"C Castillero","doi":"","DOIUrl":"","url":null,"abstract":"Objective: [corrected] We evaluated the prognostic factors in patients with breast cancer EC-I-II treated in the Instituto Nacional de Cancerología in Mexico and compared patients with or without local or/and systemic recurrence.Method: This is a retrospective study in patients treated with conservative surgery between 1983 and 1993 with a diagnosis of invasive breast cancer and tumors <4 cm All pathological variables were analyzed and we performed studies on c-erb.B2, P53, estrogene and progesterone receivers, cellular ploidy and cellular percentage on face \"S\" of the cellular cycle. All these variables were compared in two groups, one with recurrences and the other without recurrences, with the same symptoms and demographics characteristics.Results: From 1270 patients with breast cancer EC I-II, 139 patients were submitted to conservative surgery, 14 patients of this group recurred and were compared with 32 patients that did not, out of a total of 46 patients. We found that SBR greater than five (P = 0.046), poor differentiated tumors (P = 0.04), tumors with vascular permeability (P = 0.020) and with intraductal characteristics of a comedocarcinoma (P = 0.004) had a worse prognosis and increased the risk of local recurrences.Conclusions: In patients with breast cancer the pathological variants are more important than the so called secondary prognostic variables. Besides the pathological variants, it is acceptable only the use of hormonal receptors and the presence of c-erb-b2.","PeriodicalId":21235,"journal":{"name":"Revista medica de Panama","volume":"26 ","pages":"35-9"},"PeriodicalIF":0.0,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25008782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Sandimmun vs Neoral, comparison between two types of cyclosporine in patients with kidney transplantation]. [Sandimmun与Neoral，两种环孢素在肾移植患者中的比较]。