Revista Brasileira de Hematologia e Hemoterapia最新文献

{"title":"Acute myeloid leukemia with e1a2 BCR-ABL1 fusion gene: two cases with peculiar molecular and clinical presentations","authors":"Fernanda Borges da Silva , João Agostinho Machado-Neto , Luisa Corrêa de Araujo Koury , Virginia Helena Leira Lipoli Bertini , Cristina Alonso Ratis , Maria de Lourdes Lopes Ferrari Chauffaille , Elvira Deolinda Rodrigues Pereira Velloso , Belinda Pinto Simões , Eduardo Magalhães Rego , Fabiola Traina","doi":"10.1016/j.bjhh.2017.07.001","DOIUrl":"10.1016/j.bjhh.2017.07.001","url":null,"abstract":"","PeriodicalId":21233,"journal":{"name":"Revista Brasileira de Hematologia e Hemoterapia","volume":"39 4","pages":"Pages 379-384"},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bjhh.2017.07.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35259385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Body composition of Fanconi anemia patients after hematopoietic stem cell transplantation","authors":"Priscilla Peixoto Policarpo da Silva,&nbsp;Daniella Schmit,&nbsp;Carmem Bonfim,&nbsp;Denise Johnsson Campos,&nbsp;Estela Iraci Rabito,&nbsp;Regina Maria Vilela","doi":"10.1016/j.bjhh.2017.06.004","DOIUrl":"10.1016/j.bjhh.2017.06.004","url":null,"abstract":"<div><h3>Introduction</h3><p>Fanconi anemia is a rare genetic disease linked to bone marrow failure; a possible treatment is hematopoietic stem cell transplantation. Changes in the nutritional status of Fanconi anemia patients are not very well known. This study aimed to characterize body composition of adult, children and adolescent patients with Fanconi anemia who were submitted to hematopoietic stem cell transplantation or not.</p></div><div><h3>Methods</h3><p>This cross-sectional study enrolled 63 patients (29 adults and 34 children and adolescents). Body composition was assessed based on diverse methods, including triceps skin fold, arm circumference, arm muscle area and bioelectrical impedance analysis, as there is no established consensus for this population. Body mass index was also considered as reference according to age.</p></div><div><h3>Results</h3><p>Almost half (48.3%) of the transplanted adult patients were underweight considering body mass index whereas eutrophic status was observed in 66.7% of the children and adolescents submitted to hematopoietic stem cell transplantation and in 80% of those who were not. At least 50% of all groups displayed muscle mass depletion. Half of the transplanted children and adolescents presented short/very short stature for age.</p></div><div><h3>Conclusion</h3><p>All patients presented low muscle stores, underweight was common in adults, and short stature was common in children and adolescents. More studies are needed to detect whether muscle mass loss measured at the early stages of treatment results in higher risk of mortality, considering the importance of muscle mass as an essential body component to prevent mortality related to infectious and non-infectious diseases and the malnutrition inherent to Fanconi anemia.</p></div>","PeriodicalId":21233,"journal":{"name":"Revista Brasileira de Hematologia e Hemoterapia","volume":"39 4","pages":"Pages 318-324"},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bjhh.2017.06.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35563255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"For survival, the emergence of oligoclonal bands after multiple myeloma treatment is less important than achieving complete remission","authors":"Luiza Soares Vieira da Silva ,&nbsp;Edvan de Queiroz Crusoe ,&nbsp;Lais Rocha Guimarães de Souza ,&nbsp;Carlos Sérgio Chiattone ,&nbsp;Vânia Tietsche de Moraes Hungria","doi":"10.1016/j.bjhh.2017.05.010","DOIUrl":"10.1016/j.bjhh.2017.05.010","url":null,"abstract":"<div><h3>Background</h3><p>The emergence of oligoclonal bands, proteins differing from those originally identified at diagnosis, has been reported in multiple myeloma patients after high-dose chemotherapy followed by autologous stem cell transplantation and after successful conventional chemotherapy. The clinical relevance of oligoclonal bands remains unclear, but their emergence has been associated with better prognosis. The aim of the present study was to determine the prevalence, clinical characteristics and prognostic impact of the presence of oligoclonal bands in multiple myeloma patients.</p></div><div><h3>Methods</h3><p>A retrospective cohort study was conducted. The study included newly diagnosed multiple myeloma patients with at least very good partial response after conventional dose or high-dose chemotherapy followed by autologous stem cell transplantation. The emergence of oligoclonal bands was identified using serum protein electrophoresis as well as serum and urine immunofixation techniques.</p></div><div><h3>Results</h3><p>A total of 101 patients were included with a median follow-up of 42 months. In total, 55% were male, and the median age was 58 years (29–87 years). Fifty-one (50.5%) patients developed oligoclonal bands. They comprised 60% (45/75) of patients treated with autologous stem cell transplantation and 23% (6/26) of those who were not transplanted. Patients with oligoclonal bands showed better progression-free survival than those without the emergence of oligoclonal bands (<em>p</em>-value<!--> <!-->=<!--> <!-->0.0075).</p></div><div><h3>Conclusion</h3><p>The prevalence of oligoclonal bands in this study population was 50.5% with its frequency being greater in cases treated with autologous stem cell transplantation and in those attaining complete remission. Complete remission was more important than the emergence of oligoclonal bands on progression-free survival.</p></div>","PeriodicalId":21233,"journal":{"name":"Revista Brasileira de Hematologia e Hemoterapia","volume":"39 4","pages":"Pages 331-336"},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bjhh.2017.05.010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35563257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hodgkin's lymphoma in developing countries: can we go further?","authors":"Rafael Dezen Gaiolla","doi":"10.1016/j.bjhh.2017.08.004","DOIUrl":"10.1016/j.bjhh.2017.08.004","url":null,"abstract":"","PeriodicalId":21233,"journal":{"name":"Revista Brasileira de Hematologia e Hemoterapia","volume":"39 4","pages":"Pages 299-300"},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bjhh.2017.08.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35563305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lack of association between Kidd blood group system and chronic kidney disease","authors":"Tiago Verri Capriolli,&nbsp;Jeane Eliete Laguila Visentainer,&nbsp;Ana Maria Sell","doi":"10.1016/j.bjhh.2017.05.007","DOIUrl":"10.1016/j.bjhh.2017.05.007","url":null,"abstract":"<div><h3>Background</h3><p>The Kidd blood group system has three antigens, Jk^a, Jk^b and Jk3, found on red blood cells and on endothelial cells of the inner lining of blood vessels in the renal medulla. These are known as urea transporter B (UT-B). Researchers have found that individuals carrying the Jk(a<!--> <!-->−<!--> <!-->b−) or Jk-null (UT-B null) phenotypes have a lower urine-concentrating capability and risk of severe renal impairment. This study evaluated the distribution of the Kidd phenotypes in patients with chronic kidney disease and a possible association of Kidd antigens with the development of renal disease.</p></div><div><h3>Methods</h3><p>Jk^a and Jk^b antigens were phenotyped using the gel column agglutination test (ID-cards Bio-RAD) in 197 patients with chronic kidney disease and 444 blood donors, as the control group. The phenotype and antigen frequencies between patients and controls were evaluated using the Chi-square method with Yates correction and logistic regression after adjustments for gender and age.</p></div><div><h3>Results</h3><p>No differences were observed between the Kidd phenotypes frequency distribution between patients with chronic kidney disease and blood donors [Jk(a<!--> <!-->−<!--> <!-->b+)<!--> <!-->=<!--> <!-->22.3% and 27.2%; Jk(a<!--> <!-->+<!--> <!-->b−)<!--> <!-->=<!--> <!-->30.5% and 24.3%; Jk(a<!--> <!-->+<!--> <!-->b+)<!--> <!-->=<!--> <!-->47.25% and 48.4%, respectively].</p></div><div><h3>Conclusion</h3><p>The distribution of Kidd phenotypes found in the studied population is expected for Caucasians; Jk^a and Jk^b antigens and phenotypes were not found to be related to susceptibility for chronic kidney disease.</p></div>","PeriodicalId":21233,"journal":{"name":"Revista Brasileira de Hematologia e Hemoterapia","volume":"39 4","pages":"Pages 301-305"},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bjhh.2017.05.007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35563306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of criteria of manual blood smear review following automated complete blood counts in a large university hospital","authors":"Samuel Ricardo Comar,&nbsp;Mariester Malvezzi,&nbsp;Ricardo Pasquini","doi":"10.1016/j.bjhh.2017.06.007","DOIUrl":"10.1016/j.bjhh.2017.06.007","url":null,"abstract":"<div><h3>Background</h3><p>There is great interest in reducing the number of automated complete blood counts requiring manual blood smear reviews without sacrificing the quality of patient care. This study was aimed at evaluating and establishing appropriate screening criteria for manual blood smear reviews to improve the performance in a hematology laboratory.</p></div><div><h3>Method</h3><p>A total of 1977 consecutive samples from the daily workload were used to evaluate four sets of screening criteria for manual blood smear reviews to identify samples with positive smear findings. Three sets of screening criteria were arbitrarily proposed in this study: Group 1 (narrow ranges), Group 2 (intermediate ranges), and Group 3 (wide limits) and one set (Group 4) was adapted from the International Society for Laboratory Hematology. All samples were run on Sysmex hematology analyzers and were investigated using manual blood smear reviews. Diagnostic accuracy and agreement were performed for each set of screening criteria, including an investigation of microscopic review rate and efficiency.</p></div><div><h3>Results</h3><p>The microscopic review rates for Groups 1, 2, 3 and 4 were 73.85%, 54.52%, 46.33% and 46.38%, respectively; the false-negative rates were 0.50%, 1.97%, 2.73% and 3.95%, respectively. The efficiency and negative predictive values of Group 3 were 73.04% and 4.91%, respectively.</p></div><div><h3>Conclusions</h3><p>Group 3 had the best relationship between safety (false-negative rate: ≤3%) and efficiency to estimate the limits of automation in performing complete blood counts. This study strengthens the importance of establishing screening criteria for manual blood smear reviews, which account for the different contexts in which hematological determinations are performed. Each laboratory should optimize the screening criteria for manual blood smear reviews in order to maximize their efficiency and safety.</p></div>","PeriodicalId":21233,"journal":{"name":"Revista Brasileira de Hematologia e Hemoterapia","volume":"39 4","pages":"Pages 306-317"},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bjhh.2017.06.007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35563307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrent thromboembolism after splenectomy in a patient with complex hemoglobin disease: a case report","authors":"Laura Maria Silva Thiersch ,&nbsp;André Rolim Belisario ,&nbsp;Suely Meireles Rezende","doi":"10.1016/j.bjhh.2017.04.006","DOIUrl":"10.1016/j.bjhh.2017.04.006","url":null,"abstract":"","PeriodicalId":21233,"journal":{"name":"Revista Brasileira de Hematologia e Hemoterapia","volume":"39 4","pages":"Pages 354-356"},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bjhh.2017.04.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35563261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autoimmune hemolytic anemia and hyperglobulinemia leading to the diagnosis of multiple myeloma","authors":"Rafael Lopes Pacca ,&nbsp;Jiviane Beatriz Cunha Barretto da Silva ,&nbsp;Kallen de Carvalho e Souza ,&nbsp;Rebeca Barbosa Carbinatto","doi":"10.1016/j.bjhh.2017.07.005","DOIUrl":"10.1016/j.bjhh.2017.07.005","url":null,"abstract":"","PeriodicalId":21233,"journal":{"name":"Revista Brasileira de Hematologia e Hemoterapia","volume":"39 4","pages":"Pages 357-359"},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bjhh.2017.07.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35563262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Passenger lymphocyte syndrome in liver transplantation","authors":"Denise M. Brunetta ,&nbsp;Lilian M. de Albuquerque ,&nbsp;Andressa H. de Morais Batista ,&nbsp;Lhais Helenne O. Santos ,&nbsp;Dirk Schreen ,&nbsp;Clébia A. de Lima ,&nbsp;Denissa F.G. Mesquita ,&nbsp;Luciana Maria de B. Carlos ,&nbsp;José Huygens P. Garcia","doi":"10.1016/j.bjhh.2017.07.006","DOIUrl":"10.1016/j.bjhh.2017.07.006","url":null,"abstract":"","PeriodicalId":21233,"journal":{"name":"Revista Brasileira de Hematologia e Hemoterapia","volume":"39 4","pages":"Pages 364-367"},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bjhh.2017.07.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35563264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DNA microarray expression profiling of a new t(8;13) AML case allows identification of possible leukemogenic transformation markers","authors":"Aline Rangel Pozzo ,&nbsp;Fernanda Costas Casal de Faria ,&nbsp;Luize Otero de Carvalho ,&nbsp;Marcos Barcelos de Pinho ,&nbsp;Raquel Ciuvalschi Maia","doi":"10.1016/j.bjhh.2017.06.003","DOIUrl":"10.1016/j.bjhh.2017.06.003","url":null,"abstract":"","PeriodicalId":21233,"journal":{"name":"Revista Brasileira de Hematologia e Hemoterapia","volume":"39 4","pages":"Pages 368-371"},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bjhh.2017.06.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35563265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}