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Reviews in Endocrine and Metabolic Disorders最新文献

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Carney complex: A familial lentiginosis predisposing to a variety of tumors. 卡尼综合征：一种易患多种肿瘤的家族性小透镜体病。
Reviews in Endocrine and Metabolic Disorders Pub Date : 2016-09-01 DOI: 10.1007/s11154-016-9400-1
Constantine A Stratakis
{"title":"Carney complex: A familial lentiginosis predisposing to a variety of tumors.","authors":"Constantine A Stratakis","doi":"10.1007/s11154-016-9400-1","DOIUrl":"10.1007/s11154-016-9400-1","url":null,"abstract":"<p><p>Carney complex is a familial lentiginosis syndrome; these disorders cover a wide phenotypic spectrum ranging from a benign inherited predisposition to develop cutaneous spots not associated with systemic disease to associations with several syndromes. Carney complex is caused by PRKAR1A mutations and perturbations of the cyclic AMP-dependent protein kinase (PKA) signaling pathway. In addition to the cutaneous findings, the main tumors associated with Carney complex are endocrine: 1) primary pigmented nodular adrenocortical disease, a bilateral adrenal hyperplasia leading to Cushing syndrome; 2) growth-hormone secreting pituitary adenoma or pituitary somatotropic hyperplasia leading to acromegaly; 3) thyroid and gonadal tumors, including a predisposition to thyroid cancer. Other tumors associated with Carney complex include: 1) myxomas of the heart, breast and other sites; 2) psamommatous melanotic schwannomas which can become malignant; 4) a predisposition to a variety of cancers.</p>","PeriodicalId":21105,"journal":{"name":"Reviews in Endocrine and Metabolic Disorders","volume":"20 1","pages":"367-371"},"PeriodicalIF":0.0,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192557/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88073143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hereditary syndromes predisposing to endocrine tumors and their skin manifestations. 易患内分泌肿瘤的遗传综合征及其皮肤表现。
Reviews in Endocrine and Metabolic Disorders Pub Date : 2016-09-01 DOI: 10.1007/s11154-016-9401-0
Constantine A Stratakis
{"title":"Hereditary syndromes predisposing to endocrine tumors and their skin manifestations.","authors":"Constantine A Stratakis","doi":"10.1007/s11154-016-9401-0","DOIUrl":"10.1007/s11154-016-9401-0","url":null,"abstract":"<p><p>We often think of the lentiginoses, phacomatoses and other neurocutaneous syndromes as conditions that affect the skin and also predispose to a variety of tumors. However, we rarely think of Peutz-Jeghers syndrome (PJS), Carney complex (CNC), Cowden disease (CD), neurofibromatosis type-1 (NF-1) or tuberous sclerosis (TSC) as conditions that are multiple endocrine neoplasias (MEN). Indeed, all of these conditions predispose to a variety of endocrine tumors, in addition to many other neoplasms. On the other hand, the classic MENs, type 1 and 2 (MEN-1 and MEN-2, respectively) are almost never thought in terms of their skin manifestations. In this review, we present extensively the MEN-1, MEN-2 and PJS syndromes, and briefly refer to CD, NF-1, and TSC. CNC is discussed in another article in this journal issue.</p>","PeriodicalId":21105,"journal":{"name":"Reviews in Endocrine and Metabolic Disorders","volume":"12 1","pages":"381-388"},"PeriodicalIF":0.0,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5181789/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91030360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Skin manifestations of Cushing's syndrome. 库欣综合征的皮肤表现。
Reviews in Endocrine and Metabolic Disorders Pub Date : 2016-09-01 DOI: 10.1007/s11154-016-9399-3
Constantine A Stratakis
{"title":"Skin manifestations of Cushing's syndrome.","authors":"Constantine A Stratakis","doi":"10.1007/s11154-016-9399-3","DOIUrl":"10.1007/s11154-016-9399-3","url":null,"abstract":"<p><p>Among the most common diagnostic manifestations of Cushing's syndrome (CS) are those involving the skin; they include violaceous striae, facial acne, hirsutism, acanthosis nigricans (AN), fungal infections, hyperpigmentation (Hp) and easy bruisability. Fortunately, most resolve within a year or two after cure of CS, although light-colored striae can persist for years depending on the age of the patients. AN, Hp, and bruisability usually resolve within months after cure in almost all ages. Facial plethora (along with acne and other facial skin changes) is a typical sign of CS that is due to increased perfusion. It resolves immediately after curative therapy of CS. Typically, the severity of the manifestations does not correlate with the biochemical indices of the disease, pointing to age, gender, genetic and skin-type differences that determine the cutaneous manifestations of CS.</p>","PeriodicalId":21105,"journal":{"name":"Reviews in Endocrine and Metabolic Disorders","volume":"68 1","pages":"283-286"},"PeriodicalIF":0.0,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5181654/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86067591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Flushing in (neuro)endocrinology. （神经）内分泌学中的脸红。
Reviews in Endocrine and Metabolic Disorders Pub Date : 2016-09-01 DOI: 10.1007/s11154-016-9394-8
Fady Hannah-Shmouni, Constantine A Stratakis, Christian A Koch
{"title":"Flushing in (neuro)endocrinology.","authors":"Fady Hannah-Shmouni, Constantine A Stratakis, Christian A Koch","doi":"10.1007/s11154-016-9394-8","DOIUrl":"10.1007/s11154-016-9394-8","url":null,"abstract":"<p><p>Cutaneous flushing is a common presenting complaint in endocrine disorders. The pathophysiology of flushing involves changes in cutaneous blood flow triggered by multiple intrinsic factors that are either related to physiology or disease. Flushing can be divided into episodic or persistent causes. Episodic flushing is mediated by the release of endogenous vasoactive mediators or medications, while persistent flushing results in a fixed facial erythema with telangiectasia and cyanosis due to slow-flowing deoxygenated blood in large cutaneous blood vessels. The differential diagnosis of cutaneous flushing in neuroendocrine disorders is limited, yet encompasses a broad spectrum of benign and malignant entities, including carcinoid syndrome, pheochromocytoma, Cushing syndrome, medullary thyroid cancer, and pancreatic neuroendocrine tumors. In this review, we provide a concise and up-to-date discussion on the differential diagnosis and approach of flushing in neuroendocrinology.</p>","PeriodicalId":21105,"journal":{"name":"Reviews in Endocrine and Metabolic Disorders","volume":"164 ","pages":"373-380"},"PeriodicalIF":0.0,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161029/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91520830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Understanding the metabolic and health effects of low-calorie sweeteners: methodological considerations and implications for future research. 了解低热量甜味剂的代谢和健康影响：方法学考虑和对未来研究的影响。
Reviews in Endocrine and Metabolic Disorders Pub Date : 2016-06-01 DOI: 10.1007/s11154-016-9344-5
Allison C Sylvetsky, Jenny E Blau, Kristina I Rother
{"title":"Understanding the metabolic and health effects of low-calorie sweeteners: methodological considerations and implications for future research.","authors":"Allison C Sylvetsky, Jenny E Blau, Kristina I Rother","doi":"10.1007/s11154-016-9344-5","DOIUrl":"10.1007/s11154-016-9344-5","url":null,"abstract":"<p><p>Consumption of foods, beverages, and packets containing low-calorie sweeteners (LCS) has increased markedly across gender, age, race/ethnicity, weight status, and socio-economic subgroups. However, well-controlled intervention studies rigorously evaluating the health effects of LCS in humans are limited. One of the key questions is whether LCS are indeed a beneficial strategy for weight management and prevention of obesity. The current review discusses several methodological considerations in the design and interpretation of these studies. Specifically, we focus on the selection of study participants, inclusion of an appropriate control, importance of considering habitual LCS exposure, selection of specific LCS, dose and route of LCS administration, choice of study outcomes, and the context and generalizability of the study findings. These critical considerations will guide the design of future studies and thus assist in understanding the health effects of LCS.</p>","PeriodicalId":21105,"journal":{"name":"Reviews in Endocrine and Metabolic Disorders","volume":"23 1","pages":"187-94"},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010791/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89981660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Perivascular adipose tissue: An unique fat compartment relevant for the cardiometabolic syndrome 血管周围脂肪组织:与心脏代谢综合征相关的独特脂肪隔室
Reviews in Endocrine and Metabolic Disorders Pub Date : 2016-03-19 DOI: 10.1007/s11154-016-9346-3
D. Siegel-Axel, H. Häring
{"title":"Perivascular adipose tissue: An unique fat compartment relevant for the cardiometabolic syndrome","authors":"D. Siegel-Axel, H. Häring","doi":"10.1007/s11154-016-9346-3","DOIUrl":"https://doi.org/10.1007/s11154-016-9346-3","url":null,"abstract":"","PeriodicalId":21105,"journal":{"name":"Reviews in Endocrine and Metabolic Disorders","volume":"67 1","pages":"51-60"},"PeriodicalIF":0.0,"publicationDate":"2016-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83118210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 54
Glucose variability, HbA1c and microvascular complications 血糖变异性、糖化血红蛋白和微血管并发症
Reviews in Endocrine and Metabolic Disorders Pub Date : 2016-03-15 DOI: 10.1007/s11154-016-9347-2
J. Škrha, J. Šoupal, J. Škrha, M. Prázný
{"title":"Glucose variability, HbA1c and microvascular complications","authors":"J. Škrha, J. Šoupal, J. Škrha, M. Prázný","doi":"10.1007/s11154-016-9347-2","DOIUrl":"https://doi.org/10.1007/s11154-016-9347-2","url":null,"abstract":"","PeriodicalId":21105,"journal":{"name":"Reviews in Endocrine and Metabolic Disorders","volume":"32 1","pages":"103-110"},"PeriodicalIF":0.0,"publicationDate":"2016-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76536187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 106
Cardiometabolic crosstalk in obesity-associated arterial hypertension 肥胖相关性高血压的心脏代谢串扰
Reviews in Endocrine and Metabolic Disorders Pub Date : 2016-03-09 DOI: 10.1007/s11154-016-9348-1
J. Jordan, A. Birkenfeld
{"title":"Cardiometabolic crosstalk in obesity-associated arterial hypertension","authors":"J. Jordan, A. Birkenfeld","doi":"10.1007/s11154-016-9348-1","DOIUrl":"https://doi.org/10.1007/s11154-016-9348-1","url":null,"abstract":"","PeriodicalId":21105,"journal":{"name":"Reviews in Endocrine and Metabolic Disorders","volume":"63 1","pages":"19-28"},"PeriodicalIF":0.0,"publicationDate":"2016-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91441477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
The role of innate immunity in the regulation of brown and beige adipogenesis 先天免疫在褐色和米色脂肪形成调控中的作用
Reviews in Endocrine and Metabolic Disorders Pub Date : 2016-02-24 DOI: 10.1007/s11154-016-9342-7
V. Alexaki, T. Chavakis
{"title":"The role of innate immunity in the regulation of brown and beige adipogenesis","authors":"V. Alexaki, T. Chavakis","doi":"10.1007/s11154-016-9342-7","DOIUrl":"https://doi.org/10.1007/s11154-016-9342-7","url":null,"abstract":"","PeriodicalId":21105,"journal":{"name":"Reviews in Endocrine and Metabolic Disorders","volume":"21 1","pages":"41-49"},"PeriodicalIF":0.0,"publicationDate":"2016-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80061698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 15
Atherogenicity of postprandial hyperglycemia and lipotoxicity 餐后高血糖的动脉粥样硬化性和脂肪毒性
Reviews in Endocrine and Metabolic Disorders Pub Date : 2016-02-16 DOI: 10.1007/s11154-016-9341-8
A. Ceriello, S. Genovese
{"title":"Atherogenicity of postprandial hyperglycemia and lipotoxicity","authors":"A. Ceriello, S. Genovese","doi":"10.1007/s11154-016-9341-8","DOIUrl":"https://doi.org/10.1007/s11154-016-9341-8","url":null,"abstract":"","PeriodicalId":21105,"journal":{"name":"Reviews in Endocrine and Metabolic Disorders","volume":"65 1","pages":"111-116"},"PeriodicalIF":0.0,"publicationDate":"2016-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78391734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 50
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