DAHUDER Medical Journal最新文献

Hypereosinophilic syndrome: Case series and review of the literature 嗜酸性粒细胞增多综合征：病例系列和文献综述

DAHUDER Medical Journal Pub Date : 2024-01-08 DOI: 10.56016/dahudermj.1391630

Nazif Yalçin, Aysegul ERTINMAZ OZKAN, N. Koca

{"title":"Hypereosinophilic syndrome: Case series and review of the literature","authors":"Nazif Yalçin, Aysegul ERTINMAZ OZKAN, N. Koca","doi":"10.56016/dahudermj.1391630","DOIUrl":"https://doi.org/10.56016/dahudermj.1391630","url":null,"abstract":"Abstract \u0000Hypereosinophilic Syndrome (HES) is caused by the uncontrolled proliferation of eosinophils generally associated with conditions such as allergic reactions or parasitic infections. This syndrome is characterized by excessive eosinophil production (>1500/mm3) that persists for more than six months and cannot be explained by secondary causes. HES symptoms can affect different body organs, and usually, nonspecific symptoms include fever, malaise, fatigue, rash, shortness of breath, and myalgia. \u0000HES is a rare disease with multiorgan involvement, including the skin, joints, kidneys, vascular system, gastrointestinal tract, cardiac and pulmonary systems. The main feature of this disease is that overproduced eosinophils accumulate in organs and cause organ damage. Cardiac involvement plays a critical role in determining morbidity and mortality, and cardiac and large vessel thrombosis with severe clinical manifestations can also be observed. \u0000Treatment aims to reduce the absolute eosinophil count, improve symptoms, and prevent disease progression. Pharmacologic therapy aims to maintain targeted eosinophil levels below 1.5 x 10^9/L (1500 cells/mcL) to reduce the symptoms of eosinophilic disease and prevent organ damage. Furthermore, indications for emergency treatment should be rapidly assessed and initiated promptly in appropriate patients. \u0000This paper will discuss the diagnosis, clinical manifestations, treatment modalities, and management challenges of HES in detail through two rare case examples.","PeriodicalId":210697,"journal":{"name":"DAHUDER Medical Journal","volume":"167 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139628916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The association between serum Perilipin-2 and kidney disease progression of patients with autosomal dominant polycystic kidney disease 常染色体显性多囊肾患者血清中的 Perilipin-2 与肾病进展之间的关系

DAHUDER Medical Journal Pub Date : 2024-01-03 DOI: 10.56016/dahudermj.1357040

Mustafa Çeti̇n, E. Eroglu, Ç. Karakükçü, Gökmen Zararsız, Ayşenur ÇIRAK GÜRSOY, İsmail Koçyi̇ği̇t

引用次数: 0

The relationship of serum bilirubin level with histopathological parameters in patients with nonalcoholic fatty liver disease 非酒精性脂肪肝患者血清胆红素水平与组织病理学参数的关系

DAHUDER Medical Journal Pub Date : 2023-07-26 DOI: 10.56016/dahudermj.1326075

A. Kırık, C. Erci̇n, Hasan Gürel, A. Çiçek, Ali Cem Yekdeş, Sultan Türel, S. Tapan, T. Doğru

{"title":"The relationship of serum bilirubin level with histopathological parameters in patients with nonalcoholic fatty liver disease","authors":"A. Kırık, C. Erci̇n, Hasan Gürel, A. Çiçek, Ali Cem Yekdeş, Sultan Türel, S. Tapan, T. Doğru","doi":"10.56016/dahudermj.1326075","DOIUrl":"https://doi.org/10.56016/dahudermj.1326075","url":null,"abstract":"Objectives: Non-alcoholic fatty liver disease (NAFLD) is among the most common causes of chronic liver disease and is known as a part of metabolic syndrome (MetS), and the role of bilirubin in the pathogenesis of NAFLD is unclear. This study aimed to evaluate the relationship between bilirubin levels and histopathological findings in patients with NAFLD having no confounding factors such as morbid obesity, diabetes mellitus (DM), and hypertension. \u0000Methods: A retrospective analysis of clinical and laboratory data of patients with biopsy-proven NAFLD was performed. The relationship between the bilirubin levels and histopathologic findings was evaluated. \u0000Results: The subjects in the nonalcoholic steatohepatitis (NASH) group had greater AST (p < 0.001) and ALT (p < 0.001) levels than the non-NASH group. We found no difference between NASH and non-NASH groups regarding bilirubin levels. The levels of AST (p = 0.001), ALT (p = 0.011), insulin (p = 0.029), and HOMA-IR index (p = 0.027) were higher in fibrosis group comparing non-fibrosis group. However, bilirubin levels were not different comparing the fibrosis and non-fibrosis group. We couldn’t find any relation between bilirubin levels and other parameters in correlation analysis. \u0000Conclusion: We couldn’t find any relation between the bilirubin levels and histopathological findings of the patient with NAFLD having no confounding factors such as morbid obesity, DM, and hypertension. The difference, shown in the other studies, may be the effect of other diseases related to MetS.","PeriodicalId":210697,"journal":{"name":"DAHUDER Medical Journal","volume":"58 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129373868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exertional rhabdomyolysis-induced “normokalemic” severe acute kidney injury. A case report and a brief literature review 劳役性横纹肌溶解引起的“等钾血症”严重急性肾损伤。病例报告及简要文献回顾

DAHUDER Medical Journal Pub Date : 2023-07-25 DOI: 10.56016/dahudermj.1312590

A. Güven, Rüya Özelsancak

引用次数: 0

The value of procalsitonin in determining the severity acute pancreatitis cases 促肾上腺素在判断急性胰腺炎严重程度中的价值

DAHUDER Medical Journal Pub Date : 2023-07-21 DOI: 10.56016/dahudermj.1279501

Ali Zeynetti̇n, I. Demir, H. S. Akay

{"title":"The value of procalsitonin in determining the severity acute pancreatitis cases","authors":"Ali Zeynetti̇n, I. Demir, H. S. Akay","doi":"10.56016/dahudermj.1279501","DOIUrl":"https://doi.org/10.56016/dahudermj.1279501","url":null,"abstract":"Objectives: Many markers and indication systems are being used to indicate the prognosis of acute pancreatitis. Our study was planned to investigate the importance of procalcitonin(PCT) in patients with severe pancreatitis in terms of predicting prognosis by comparing C-reactive protein , modified CT severity index, and duration of hospitalization. \u0000Methods: In our cross-sectional retrospective study, 30 patients who were hospitalized with a diagnosis of A. pancreatitis were included in the study. Our study was conducted from January 2013 to January 2019 at Katip Çelebi University. PCT, CRP, duration of hospitalization, gender, age, CRE, CA, pleural effusion, and modified CT severity scores were recorded in all patients. \u0000Results: Of the 30 patients included in the study,13 (43.33%) were male and 17(56.66%) were female. The presence of stones in 80% of patients was detected in 6.7% of patients due to hypertriglestrimia. The PCT value was found to be a minimum of 0.0 ng/ml, a maximum of 39.68 ng/ml, and an average of 1.97 ng/ml. There is a significant relationship between the PCT value and the length of hospitalization for the patients. The hospitalization period was a minimum of 3 days, a maximum of 23 days, and an average of 10.13 days in the 30 patients studied. It was determined that there was a statistically significant relationship between PCT and length of stay (r = 0.437; p 0.016). \u0000Conclusion: In patients with A. pancreatitis, the evaluation of PCT, CRP, and modified CT severity index can be used to estimate the duration of hospitalization.","PeriodicalId":210697,"journal":{"name":"DAHUDER Medical Journal","volume":"206 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127599023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erythema nodosum: a clinical sign of acute pancreatitis 结节性红斑:急性胰腺炎的临床症状

DAHUDER Medical Journal Pub Date : 2023-07-13 DOI: 10.56016/dahudermj.1263226

Yasemin Çöl, Dilara Turan Gökçe, Meral Akdoğan Kayhan

引用次数: 0

Validity and reliability of the hypoglycemia confidence scale for patients with type 1 diabetes 1型糖尿病患者低血糖置信度量表的效度和信度

DAHUDER Medical Journal Pub Date : 2023-06-01 DOI: 10.56016/dahudermj.1253273

Ismail Demir, Gokhan Sahin, B. Pamuk

{"title":"Validity and reliability of the hypoglycemia confidence scale for patients with type 1 diabetes","authors":"Ismail Demir, Gokhan Sahin, B. Pamuk","doi":"10.56016/dahudermj.1253273","DOIUrl":"https://doi.org/10.56016/dahudermj.1253273","url":null,"abstract":"Background: This study aims to assess the validation and reliability of the Turkish adaptation of the Hypoglycemic Confident Scale and to investigate its relationship between the Hypoglycemia Fear survey, WHO Well-Being Index, Hba1c, sociodemographic characteristics and variables. \u0000Methods: The survey consists of a total of 81 questions concerning the sociodemographic status, clinic status variables, and the Hypoglycemic Confidence Scale formed by 35 standard questions and 46 scale questions. \u0000Result: In this study, assessment of the reliability of the scale was achieved by internal consistency and test-retest methods, and the Cronbach alpha internal consistency reliability coefficients were 0.814 in the first test and 0.885 in the second test. It was observed that the responses given to the items of the Hypoglycemic Confidence Scale at two separate times were consistent with one another. The overall correlation of the scale (r = 0.927, p < 0.0001) was positive and highly significant (p < 0001). A significant, inverse, and moderate correlation was found between HbA1c values and Hypoglycemic Confidence Scale total scores (p < 0,0001, r = -0,479). Similarly, a higher hypoglycemic confidence score was observed to be associated with higher WHO Well-Being Index score and lower hypoglycemic fear. \u0000Conclusion: This study shows that the Hypoglycemia Confidence Scale created by Polonsky et al. is a valid and reliable scale that can be put into use in our country.1 The Hypoglycemic Confidence Scale may be beneficial in diabetic patient follow-up and achieving treatment goals in diabetic patients.","PeriodicalId":210697,"journal":{"name":"DAHUDER Medical Journal","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126432975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The atherogenic index of plasma complicates the thrombotic tendency of chronic myeloproliferative disorders: A retrospective cohort study 血浆的动脉粥样硬化指数使慢性骨髓增生性疾病的血栓形成倾向复杂化:一项回顾性队列研究

DAHUDER Medical Journal Pub Date : 2023-04-26 DOI: 10.56016/dahudermj.1249255

M. Karadeniz, Ozge Ozcan Abacioglu, Ü. Malkan, İ. C. Haznedaroğlu

{"title":"The atherogenic index of plasma complicates the thrombotic tendency of chronic myeloproliferative disorders: A retrospective cohort study","authors":"M. Karadeniz, Ozge Ozcan Abacioglu, Ü. Malkan, İ. C. Haznedaroğlu","doi":"10.56016/dahudermj.1249255","DOIUrl":"https://doi.org/10.56016/dahudermj.1249255","url":null,"abstract":"Objectives: Chronic myeloproliferative diseases (CMPD) are neoplastic disorders leading to hypercoagulability and thrombosis. The critical hemostatic abnormalities include alterations in the blood viscosity and a history of recent thrombus. The aim of this study is to assess the interrelationships among the atherogenic index of plasma (AIP) and thromboembolism of CMPD with JAK2 V617F mutation. \u0000Methods: Ninety-two patients diagnosed as CMPD with JAK2 V617F mutation and 73 controls were included into the study. The patients were evaluated for the presence of any venous or arterial thromboembolic events. AIP was calculated by using the formula log (Tg/HDL) from serum triglyceride and high-density lipoprotein values. \u0000Results: The study group consisted of 30 patients (33%) with myelofibrosis (MF), 42 patients (46%) with polycythemia vera (PV) and 20 patients (21%) with essential thrombocythemia (ET). Two study groups were similar in terms of sex, age and other comorbidities (p > 0.05). CMPD group had higher levels of right blood cell count (RBC), red blood cell distribution width (RDW), platelets (PLT), hemotocrit (Hct) and AIP. Univariate and multivariate logistic regression analysis revealed that platelet count, RBC and AIP were independent predictors for thrombosis in both groups. The comparison of ROC curve analysis disclosed that AIP was superior to platelet count and RBC in predicting thrombosis. \u0000Conclusion: AIP can be used to determinate higher risk of thromboembolism in patients with CMPD. As a reliable and ‘easy-to-assess’ diagnostic tool, AIP could be useful for the determination of thrombotic events in CMPD clinicobiological disease course.","PeriodicalId":210697,"journal":{"name":"DAHUDER Medical Journal","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126078783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current pharmacological approaches in obesity treatment 当前肥胖治疗的药理学方法

DAHUDER Medical Journal Pub Date : 2023-04-22 DOI: 10.56016/dahudermj.1271677

Pelin Ti̇ryaki̇oğlu, H. Yilmaz, İsmail Yilmaz, Ismail Demir

{"title":"Current pharmacological approaches in obesity treatment","authors":"Pelin Ti̇ryaki̇oğlu, H. Yilmaz, İsmail Yilmaz, Ismail Demir","doi":"10.56016/dahudermj.1271677","DOIUrl":"https://doi.org/10.56016/dahudermj.1271677","url":null,"abstract":"Obesity is a complex disorder and affected by so many factors in which the balance between food consumption and calorie usage is disrupted. Drugs that act on appetite, food intake, calorie absorption or calorie consumption, or a combination of these, are basically central or peripheral agents. Diethylpropion and phentermine are preferred for short-term obesity treatment. Orlistat, lorcaserin, topiramate/phentermine, naltrexone/bupropion, and liraglutide are preferred for long-term obesity treatment. The main drugs whose experimental and clinical phase studies are still ongoing are cemelanotide, zonisamide/bupropion, neuropeptide Y antagonists, semaglutide and oral glucagon-like peptide (GLP)-1 agonists, cannabinoid type-1 receptor inhibitors, amylin mimetics, amylin/calcitonin activators. receptor, glucose-linked insulin-like acting peptide analogues, dual-acting GLP-1/glucagon receptor agonists, peptide YY, leptin analogues, beloranib, cetilistat, tenofensin, fibroblast growth factor-21 and obesity vaccines. While managing the treatment of an obese patient, considering the large costs of the disease and the high incidence of disorder, pharmacotherapeutic agents are not enough to meet the clinic spectrum like adverse effects and contraindications, but new drugs and studies in this field offer hope to the medical world in terms of efficacy and safety profile. However, it would not be rational to expect miracles from drugs without a change in lifestyle in the magement of this disorder.","PeriodicalId":210697,"journal":{"name":"DAHUDER Medical Journal","volume":"87 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133650005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Initial values of skeletal muscle parameters in patients presenting with acute pancreatitis 急性胰腺炎患者骨骼肌参数的初始值

DAHUDER Medical Journal Pub Date : 2023-04-12 DOI: 10.56016/dahudermj.1246248

A. Isiklar, T. Y. Kuzan

{"title":"Initial values of skeletal muscle parameters in patients presenting with acute pancreatitis","authors":"A. Isiklar, T. Y. Kuzan","doi":"10.56016/dahudermj.1246248","DOIUrl":"https://doi.org/10.56016/dahudermj.1246248","url":null,"abstract":"Objective: Predicting the clinical course of acute pancreatitis has been discussed previously on the basis of visceral adipose tissue. This study was conducted to determine the relationship between clinical outcomes of acute pancreatitis and changes in skeletal muscle parameters. \u0000Method: This is a single-center, cross-sectional, retrospective study. Patients who were diagnosed with acute pancreatitis between 01-28 February 2019 and had abdominal computed tomography (CT) taken in the first week of their hospitalization were included in the study. L3 level of abdominal CT images were used to evaluate skeletal muscle parameters. \u0000Results: During the hospital database scanning, 127 patients newly diagnosed with acute pancreatitis were included in the study. The median age was 50 (18-88) years, 47% were male, and 53% were female. The median body mass index (BMI) was 26,42 (19.4-46.8) kg/m2. Fifty-one % of patients were diagnosed with biliary acute pancreatitis, and 48.8% were diagnosed with non-biliary acute pancreatitis. At the same time, acute pancreatitis severity was classified according to revised Atlanta criteria, 67.7% were mild (n = 86), 28.3% were moderate (n = 36) and 5 (3.9%) patients were severe. Skeletal muscle mass was evaluated using the total psoas index (TPI) and, skeletal muscle density calculated by HU. Median TPI was 6.3 (2.5-13.7). The median of Hounsfield Unit (HU) average calculation was 18.9 (3.8-28.5) (Table 1). There were no statistically significant differences on sex, age, BMI, skeletal muscle parameters, and acute pancreatitis clinical outcome (Table 2). \u0000Conclusion: Skeletal muscle parameters determined by TPI and HU were not a predictor of the clinical course, and viewing them always cannot effectively investigate their effect on acute pathologies. So, this way couldn't be proposed as a perfect method for predicting the clinical outcome of acute pancreatitis.","PeriodicalId":210697,"journal":{"name":"DAHUDER Medical Journal","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116977747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0