C109. RESPIRATORY MUSCLE DYSFUNCTION: MECHANISM AND ASSESSMENT最新文献

{"title":"Ultrasound Assessment of Diaphragmatic Thickening in Patients with ALS","authors":"S. Waheed, C. Cunningham, S. Gogineni, G. Pellegrino, G. Papa, D. E. Kvarnberg, F. Marco, M. Tobin, F. Laghi","doi":"10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5794","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5794","url":null,"abstract":"","PeriodicalId":210544,"journal":{"name":"C109. RESPIRATORY MUSCLE DYSFUNCTION: MECHANISM AND ASSESSMENT","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128182164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transvenous Phrenic-Nerve Diaphragm Stimulation Reduces Lung Inflammation in Non-Injured Porcine Lungs During 50 Hours of Mechanical Ventilation","authors":"E. Rohrs, T. Bassi, K. Fernandez, M. Ornowska, S. Reynolds","doi":"10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5803","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5803","url":null,"abstract":"","PeriodicalId":210544,"journal":{"name":"C109. RESPIRATORY MUSCLE DYSFUNCTION: MECHANISM AND ASSESSMENT","volume":"58 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126235609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone Marrow-Derived Macrophages of Duchenne Muscular Dystrophy (mdx) Mice Are Differentially \"Educated\" Based on Muscle Disease Stage","authors":"S. Bhattarai, F. Liang, Q. Li, E. Kaufmann, M. Divangahi, B. Petrof","doi":"10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5800","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5800","url":null,"abstract":"","PeriodicalId":210544,"journal":{"name":"C109. RESPIRATORY MUSCLE DYSFUNCTION: MECHANISM AND ASSESSMENT","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126741174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MitoQ (Mitoquinone Mesylate) Prevents Sepsis Induced Reductions in Diaphragm Strength and Endurance","authors":"G. Supinski, E. Schroder, Lin Wang, L. Callahan","doi":"10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5806","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5806","url":null,"abstract":"","PeriodicalId":210544,"journal":{"name":"C109. RESPIRATORY MUSCLE DYSFUNCTION: MECHANISM AND ASSESSMENT","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133660432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Qualitative Assessment of the Diaphragm in the Mechanically Ventilated Critically Ill Using Real-Time Shear Wave Ultrasound Elastography","authors":"B. Jung, A. Flatres, Yassir Aarab, N. Molinari, S. Matecki, M. Amalric, Romaric Larcher, S. Jaber, K. Klouche","doi":"10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5798","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5798","url":null,"abstract":"","PeriodicalId":210544,"journal":{"name":"C109. RESPIRATORY MUSCLE DYSFUNCTION: MECHANISM AND ASSESSMENT","volume":"61 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123859729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Vivo Susceptibility of Cystic Fibrosis Mice to Inflammation-Induced Diaphragm and Limb Muscle Dysfunction","authors":"B. Petrof, E. Gusev, F. Liang, D. Radzioch","doi":"10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5804","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5804","url":null,"abstract":"","PeriodicalId":210544,"journal":{"name":"C109. RESPIRATORY MUSCLE DYSFUNCTION: MECHANISM AND ASSESSMENT","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128287132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Restrictive Disease Pattern on Pulmonary Function Testing in Obesity: Can It Be Explained by Diaphragmatic or Neuromuscular Weakness?","authors":"A. Mangardich, O. A. Qarni, E. Becker, S. Mirza","doi":"10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5791","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5791","url":null,"abstract":"","PeriodicalId":210544,"journal":{"name":"C109. RESPIRATORY MUSCLE DYSFUNCTION: MECHANISM AND ASSESSMENT","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117349338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship Between Diaphragmatic Excursion and Maximum Inspiratory Pressure (MIP) in Adults Patients with Guillain Barré Syndrome","authors":"F. J. Ríos, B. V. Rivero","doi":"10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5792","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5792","url":null,"abstract":"","PeriodicalId":210544,"journal":{"name":"C109. RESPIRATORY MUSCLE DYSFUNCTION: MECHANISM AND ASSESSMENT","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130744314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Peritoneal Dialysis on the Dynamic Functions of the Diaphragm","authors":"K. Supraja, J. Arulneyam, P. Rajeevalochana, S. Sharmila, N. Karthick, G. Abraham","doi":"10.1164/AJRCCM-CONFERENCE.2019.199.1_MEETINGABSTRACTS.A5787","DOIUrl":"https://doi.org/10.1164/AJRCCM-CONFERENCE.2019.199.1_MEETINGABSTRACTS.A5787","url":null,"abstract":"Aim: Peritoneal dialysis (PD) is an accepted mode of renal replacement therapy in chronic kidney disease (CKD) patients. With increasing longevity, the duration of PD goes up to several years. Diaphragm is the most important muscle for inspiration during resting state. The functions of this muscle can be assessed by invasive electromyography and stimulation of phrenic nerve. In this study, we have recorded the neural function with Surface Electromyography (SEMG). Objective: This is a prospective study in patients undergoing chronic PD. We set to find out if diaphragm movement was affected in patients on peritoneal dialysis and compared it with the diaphragm movement in hemodialysis patients. Secondly, we looked for impact of diaphragmatic movements on the ultrafiltration. Methods: CKD patients enrolled on PD for more than 3 months were observed for diaphragmatic movements (surface EMG of diaphragm, NCS), airway function (PFT) and PD characteristics (ultrafiltration amount, percentage of dialysate, urine output and Serum Hemoglobin, Albumin). Volume of dwell in all subjects was 2 liters and dwell time varied between 6-8 hours. Results: Thirty-six patients underwent the study with 12 females and 24 males. The duration of PD varied between 3 months to 16 years. Mean age was 60.3 (SD ± 14.4). The mean resting EMG of diaphragm in PD subjects was 13.7 μV and in hemodialysis subjects was 13.47 μV (Normal:10-20 μV). Nine subjects were on 2L icodextrin as single dwell. NCS of phrenic nerve was abnormal in most subjects. Association of SEMG was significant for Gender (p 0.007), BMI (p 0.00), FEV1 (p 0.00) and hemoglobin (0.0059). Logistic regression analysis showed negative association between gender and hemoglobin. No correlation was observed between diaphragm movement and ultrafiltration and residual renal function. Conclusion: We conclude that diaphragmatic EMG is preserved in subjects undergoing CAPD and is comparable with that of subjects in HD group. Even though NCS of phrenic nerve showed severe sensory-motor neuropathy in most PD patients, normal resting surface EMG highlights the fact that intrinsic muscle action potential is retained. There is no impact of diaphragmatic movement on the ultrafiltration irrespective of the concentration of dialysate used in PD. Also, we hypothesize that sensory-motor neuropathy is probably is secondary to diabetes rather than due to CAPD. *Correspondence to: Supraja Kalyanaraman, Department of Clinical Research, The Madras Medical Mission, 4-A, Dr. J. Jayalalitha Nagar, Mogappair, Chennai-600037, India, Tel: 950-004-9868; E-mail: drsk02@gmail.com Received: January 10, 2019; Accepted: February 18, 2019; Published: February 21, 2019 Introduction Continuous ambulatory Peritoneal Dialysis (CAPD) has become an accepted method of renal replacement in chronic kidney disease (CKD), and the number of subjects on PD is on the rise. Without complications, these catheters can be maintained and used for many years. The abdomen ","PeriodicalId":210544,"journal":{"name":"C109. RESPIRATORY MUSCLE DYSFUNCTION: MECHANISM AND ASSESSMENT","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128687968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of TLR4 Receptor in Lipopolysaccharide-Induced Decrease of Thiamine Transporter Expression in C2C12 Cells","authors":"C. Sassoon, E. Zhu, L. Fang, H. M. Said","doi":"10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5808","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5808","url":null,"abstract":"","PeriodicalId":210544,"journal":{"name":"C109. RESPIRATORY MUSCLE DYSFUNCTION: MECHANISM AND ASSESSMENT","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129413538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}