New Valley Veterinary Journal最新文献

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Seroprevalence and Epidemiological studies of bovine viral diarrhea in cattle in New Valley Province, Egypt. 埃及新谷省牛病毒性腹泻血清流行病学研究。
New Valley Veterinary Journal Pub Date : 2023-08-01 DOI: 10.21608/nvvj.2023.212013.1020
A. Sayed, Yasser F. Elnaker, Osama Ali
{"title":"Seroprevalence and Epidemiological studies of bovine viral diarrhea in cattle in New Valley Province, Egypt.","authors":"A. Sayed, Yasser F. Elnaker, Osama Ali","doi":"10.21608/nvvj.2023.212013.1020","DOIUrl":"https://doi.org/10.21608/nvvj.2023.212013.1020","url":null,"abstract":": Bovine viral diarrhea (BVD) is one of the most imperative worldwide diseases in ruminants leading to substantial damage as well as extensive economic losses for the cattle industry. To our knowledge, there have been no reports about the disease’s situation in New Valley province, so the goal of this study was to estimate the level of bovine viral diarrhea virus (BVDV) infection in cattle herds through serodiagnosis and determining factors influencing the course of infection (current epidemiological situation) which will aid in establishment of control strategy. In this study a total of 1400 cattle of di ff erent ages, sexes and breeds (not previously vaccinated with BVD vaccines) were screened clinically for symptoms of BVD infection. 260 cattle out of totally 1400 screened cattle (18.6%) showing clinical signs arousing suspicion of BVD (49 cattle (18.8%) exhibit respiratory manifestation, 63 (24.2%) cattle su ff ered from diarrhea, 37 (14.2%) with mixed enteric and respiratory signs , 43 (16.5%) with retarded growth, oral lesion was detected in only 6 cattle (2.3%) , While the congenital anomalies were recorded in 18 (6.9%) , abortion occurred in 29 female cattle (11.1%) and only 15 cattle ( 5.8%) su ff ered from infertility trouble ) . Totally 260 clinically diseased cattle undergo Serum Neutralization Test (SNT) for detection of BVDV infection. The results revealed that 83 cattle out of 260 (31.9%) were detected as seropositive (positive for BVDV antibodies), showed clinical signs of BVD infection represented in 17 cattle showed respiratory manifestation (nasal discharge), 22 cattle su ff ered from diarrhea, 12 with mixed enteric and respiratory signs , 6 with retarded growth, oral lesion was detected in Only 2 cattle , While the congenital anomalies were recorded in 5 , abortion occurred in 15 female cattle and only 4 cattle su ff ered from Infertility trouble According to age, the seroprevalence of BVDV for antibodies was higher in in cattle aged ( > 6M to 2 year) (37.50%) and the lowest rate was (21.73%) in cattle aged (1day: 2month). Rendering to sex and breed, female cattle (37.80%) had a greater infection rate than male (21.87%) and infection was higher in Frisian bread (34.05%) than native bread (29.50%). Concerning to season, the highest prevalence of infection was (40.24%) in Winter and the lowest rate was (16.66%) in Autumn. Regarding to locality, the highest prevalence of infection was (45.45%) in EL-Farfara, and the lowest rate was (31%) in Balat. This prevalence of BVDV in cattle of new valley province, Egypt reveals the necessity of further studying BVDV infection in the area","PeriodicalId":210463,"journal":{"name":"New Valley Veterinary Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125592221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Study On the Impact of Amino Acids, Multi-Minerals, and Vitamins Combination Against Small Ruminants With Anemia In New Valley Governorate 氨基酸、多种矿物质和维生素组合对新谷省小反刍动物贫血影响的临床研究
New Valley Veterinary Journal Pub Date : 2023-08-01 DOI: 10.21608/nvvj.2023.215591.1022
S. Galbat, Yasser F. Elnaker, N. Ibrahim, Marwa El-Zeftawy
{"title":"Clinical Study On the Impact of Amino Acids, Multi-Minerals, and Vitamins Combination Against Small Ruminants With Anemia In New Valley Governorate","authors":"S. Galbat, Yasser F. Elnaker, N. Ibrahim, Marwa El-Zeftawy","doi":"10.21608/nvvj.2023.215591.1022","DOIUrl":"https://doi.org/10.21608/nvvj.2023.215591.1022","url":null,"abstract":": Anemia syndrome is defined as a reduction in erythrocyte mass, hematocrit, and hemoglobin (Hb) concentration and sometimes leads to tissue hypoxia. Domesticated sheep and goats are essential to food security and the national economy. The present study aimed to determine the clinical impact of anemia in sheep and goats from di ff erent localities in the New Valley governorate. 150 sheep and 360 goats were clinically examined. Blood and fecal samples were collected from multiple locations. Hematological variables, serum iron (Fe + 2 ), copper (Cu + 2 ), and vitamin B 12 concentrations were estimated. Moreover, blood film and fecal examination were analyzed. Furthermore, the e ff ect of amino acids, multi-minerals, and vitamins combination (AMVC) administration was studied on clinically anemic sheep and goats. The results revealed significant improvement in Hb, red blood cells count, mean corpuscular volume, and mean corpuscular Hb in anemic sheep and goats administrated AMVC compared to anemic ones. Moreover, serum Fe + 2 , Cu + 2 , and vitamin B 12 levels were elevated. The current research found that anemic syndrome had significant detrimental e ff ects on the health of sheep and goats in the New Valley governorate; however, using multivitamins, minerals, and essential amino acids in the ration can restore these e ff ects.","PeriodicalId":210463,"journal":{"name":"New Valley Veterinary Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130469976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Supplementing Levocarnitine and Thymosin V To improve Growth and Immunity in Broiler Chickens 饲粮中添加左卡尼汀和胸腺素V促进肉仔鸡生长和免疫
New Valley Veterinary Journal Pub Date : 2023-08-01 DOI: 10.21608/nvvj.2023.215420.1021
M. Soliman, M. Abdelhafez
{"title":"Supplementing Levocarnitine and Thymosin V To improve Growth and Immunity in Broiler Chickens","authors":"M. Soliman, M. Abdelhafez","doi":"10.21608/nvvj.2023.215420.1021","DOIUrl":"https://doi.org/10.21608/nvvj.2023.215420.1021","url":null,"abstract":": Objective: This study aimed to investigate the e ff ects of supplementing broiler chickens’ drinking water with levocarnitine and thymosin V on their growth, immunological condition, and performance. Methods: One hundred one-day-old non-vaccinated cobb broiler chicks were randomly divided into four groups. The control group received no treatment, Group 2 received levocarnitine-infused water, Group 3 received thymosin V-infused water, and Group 4 received both levocarnitine and thymosin V-infused water. Body weight, feed intake, lymphoid organ weight, hematological parameters, phagocytic activity, and interleukin 2 (IL-2) levels were measured and compared among the groups. Results: Levocarnitine supplementation resulted in increased body weight gain and feed intake. Thymosin V supplementation led to enhanced lymphoid organ weight and improved hematological parameters. All treated groups showed higher phagocytic activity and phagocytic index values compared to the control group. IL-2 levels were significantly increased in the treated groups. Conclusion: The supplementation of levocarnitine and thymosin V in broiler chickens’ drinking water positively influenced growth performance and immune function. Levocarnitine improved body weight gain and nutrient utilization, while thymosin V enhanced immune-related parameters. These findings suggest that levocarnitine and thymosin V have potential as dietary supplements to enhance broiler chicken production and immune response. Further research is needed to optimize their usage and understand the underlying mechanisms.","PeriodicalId":210463,"journal":{"name":"New Valley Veterinary Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123294442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation Of Some Locally Fermented Milk Products In New Valley Governorate 新谷省一些地方发酵乳制品的评价
New Valley Veterinary Journal Pub Date : 2023-01-01 DOI: 10.21608/nvvj.2023.158263.1011
Reem Eid, E. Mohamed, Rania Ewida
{"title":"Evaluation Of Some Locally Fermented Milk Products In New Valley Governorate","authors":"Reem Eid, E. Mohamed, Rania Ewida","doi":"10.21608/nvvj.2023.158263.1011","DOIUrl":"https://doi.org/10.21608/nvvj.2023.158263.1011","url":null,"abstract":"One hundred and forty random samples of yoghurt and Laban raib, seventy of each, were collected from different localities and villages in El-Kharga city, New Valley Governorate, Egypt, for chemical and bacteriologic examination. The obtained results of yoghurt samples showed that the average values of acidity%, total coliforms and fecal coliform , S. Aureus , yeasts, and molds were 1.13, 6.8×10 4 , 5.5×10 4 , 1.42×10 4 , 7.2×107 and 4.9×10 6 CFU/ml, respectively. On the other hand, in Laban raib samples, they were 1.13, 1.6×10 5 , 1.1×10 5 , 2.4×10 3 , 2.1×107 and 2.8×10 5 CFU/ml, respectively. The prevalence of E. coli and anaerobic bacteria in yoghurt samples was 11.4 and 2.8 %, while in Laban raib samples was 8.5 and 4.3%. Enterococci couldn’t be detected in all examined yoghurt and Laban raib samples. The aim of this research was to investigate the chemical and bacteriological characteristics of locally produced yoghurt and Laban raib in El-Kharga city, New Valley governorate, Egypt. Based on the results, both yoghurt and Laban raib samples showed high levels of total coliforms , fecal coliforms , and molds. Additionally, the prevalence of E. coli was relatively high in both types of samples, which may indicate poor hygiene practices during production or handling. However, the absence of Enterococci in all examined samples is a positive finding. These results suggest the need for improved hygiene and quality control measures in the production of these dairy products in the region. In conclusion, this study highlights the importance of monitoring the quality of locally produced dairy products and implementing appropriate measures to ensure their safety and hygiene","PeriodicalId":210463,"journal":{"name":"New Valley Veterinary Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121959952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stress Dampening Effect of Common Salt on Oreochromis Niloticus During Transport 普通盐对尼罗褐虾运输过程中的应激抑制作用
New Valley Veterinary Journal Pub Date : 2023-01-01 DOI: 10.21608/nvvj.2023.202116.1018
Heba Hana, M. Abd El-Galil, M. Mousa, Rasha Abd El-Lateif, A. Osman, Arafa Emam
{"title":"Stress Dampening Effect of Common Salt on Oreochromis Niloticus During Transport","authors":"Heba Hana, M. Abd El-Galil, M. Mousa, Rasha Abd El-Lateif, A. Osman, Arafa Emam","doi":"10.21608/nvvj.2023.202116.1018","DOIUrl":"https://doi.org/10.21608/nvvj.2023.202116.1018","url":null,"abstract":"","PeriodicalId":210463,"journal":{"name":"New Valley Veterinary Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129823646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of the underground water on health state and growth rate of Nile Tilapia fish (Oreochromis niloticus) in the New Valley Governorate. 新河谷省地下水对尼罗罗非鱼健康状况和生长速度的影响
New Valley Veterinary Journal Pub Date : 2023-01-01 DOI: 10.21608/nvvj.2023.179535.1014
S. Sotohy, Rasha M. Hassan, Ayman Abd-Elmaguid, Mahmoud Arafaa, Mahmoud Mohamed
{"title":"Effect of the underground water on health state and growth rate of Nile Tilapia fish (Oreochromis niloticus) in the New Valley Governorate.","authors":"S. Sotohy, Rasha M. Hassan, Ayman Abd-Elmaguid, Mahmoud Arafaa, Mahmoud Mohamed","doi":"10.21608/nvvj.2023.179535.1014","DOIUrl":"https://doi.org/10.21608/nvvj.2023.179535.1014","url":null,"abstract":"Twenty water samples were collected from El-Dakhlah City in the New valley governorate, five from fishpond. Metal analyses were carried out in Animal Health Research Institute, Dokki, Giza, Egypt. A total of 200 unsexed 8 months Tilapia fish were used in this study. Fifty fish were collected randomly from each pond and then weighed. The results of this study showed that lead, cadmium, and iron were higher than permissible limits of WHO, on the other hand Iodine, copper and zinc were lower than permissible limits of WHO. Manganese was higher than permissible limits mostly in all examined ponds . The concentration of heavy metals and trace elements in fish tissue showed that Lead, cadmium, iron, zinc, copper, and iodine were lower than permissible limits while Manganese was higher than permissible limits. The average body weight gain of Tilapia fish was high in the filtered water ponds than other ponds.","PeriodicalId":210463,"journal":{"name":"New Valley Veterinary Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125049275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influence of different sources of groundwater on broiler performance in New Valley governorate. 新谷省不同地下水来源对肉鸡生产性能的影响
New Valley Veterinary Journal Pub Date : 2023-01-01 DOI: 10.21608/nvvj.2023.171760.1013
{"title":"Influence of different sources of groundwater on broiler performance in New Valley governorate.","authors":"","doi":"10.21608/nvvj.2023.171760.1013","DOIUrl":"https://doi.org/10.21608/nvvj.2023.171760.1013","url":null,"abstract":"","PeriodicalId":210463,"journal":{"name":"New Valley Veterinary Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124182454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of the efficacy of vaccine in coccidiosis in broilers in New Valley governorate 新谷省肉鸡球虫病疫苗效果评价
New Valley Veterinary Journal Pub Date : 2023-01-01 DOI: 10.21608/nvvj.2023.183405.1015
Wafaa Mahmoud, Esraa Mahmoud, M. Soliman, M. A. E. Abd El Hafez
{"title":"Evaluation of the efficacy of vaccine in coccidiosis in broilers in New Valley governorate","authors":"Wafaa Mahmoud, Esraa Mahmoud, M. Soliman, M. A. E. Abd El Hafez","doi":"10.21608/nvvj.2023.183405.1015","DOIUrl":"https://doi.org/10.21608/nvvj.2023.183405.1015","url":null,"abstract":"Avian coccidiosis is the primary parasitic disease that afflicts poultry and is responsible for significant economic losses. Vaccination has emerged as a viable alternative to chemical treatments for controlling broiler coccidiosis and has shown considerable potential for mitigating its impact. This study aimed to evaluate the effectiveness of Fortegra ® vaccination in controlling coccidiosis in broiler chickens. A total of 245 unsexed one-day-old broiler chickens obtained from Masr poultry were divided into seven groups, with 35 birds in each group. Four groups (GA1, GA2, GA3, and GA4) were vaccinated with Fortegra ® while three groups (GB1, GB2, and GB3) served as non-vaccinated controls. At 6 days of age, all chicks in the vaccinated group were administered Fortegra ® , while all groups except GA3 and GB3 were infected with coccidia at day 22. The results showed that vaccination did not prevent infection but resulted in lower lesion scores compared to the conventional and control groups. Body weight in the vaccinated group (GA) was lower than that of the non-vaccinated (GB) groups. Microscopic examination of fecal samples collected at different ages confirmed coccidia infection in all experimental groups. Broiler intestinal mucosa scrapings revealed typical forms of Eimeria species, leading to bloody diarrhea and petechial hemorrhage. After a 72-hour period at 30ºC with forced aeration, sporulation occurred, and oocysts were stored in a potassium dichromate solution. Microscopic examination confirmed the presence and shape of oocysts, and experimental samples displayed a 500 bp amplicon size specific to Eimeria spp. While Fortegra ® vaccination did not prevent infection, it resulted in lower lesion scores compared to the conventional and control groups. Thus, vaccination may serve as an effective approach for controlling coccidiosis in broiler chickens, but further research is necessary to optimize vaccination protocols and evaluate its long-term effects on broiler production.","PeriodicalId":210463,"journal":{"name":"New Valley Veterinary Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131915737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical and Laboratory Studies on Emaciation and Ill-thriftiness in Cattle in New Valley Governorate 新谷省牛的消瘦和不节俭的临床和实验室研究
New Valley Veterinary Journal Pub Date : 2022-11-11 DOI: 10.21608/nvvj.2022.268688
S. Galbat, Yasser F. Elnaker, Rabab El-Zoghby, E. Mohamed
{"title":"Clinical and Laboratory Studies on Emaciation and Ill-thriftiness in Cattle in New Valley Governorate","authors":"S. Galbat, Yasser F. Elnaker, Rabab El-Zoghby, E. Mohamed","doi":"10.21608/nvvj.2022.268688","DOIUrl":"https://doi.org/10.21608/nvvj.2022.268688","url":null,"abstract":"Cattle have an economic importance in New Valley governorate. Emaciation and poor production of cattle were the main complains of farmers. The aim of the present work is to identify the real causes of ill-thriftiness in cattle in New-Valley Governorate And evaluate the relation between emaciation and clinical sign, the hematological, biochemical parameters in blood serum of cattle and parasitology for fecal sample of emaciated cattle. This study was conducted for a period from July 2021 to June 2022. A total number of 200 cattle of different ages, sexes, and breeds from different localities in new valley governorate; EI-Karga, EL-Dakhla and Balat, classified into two groups first one includes 170 emaciated cattle and second group include (30) cattle is consider as healthy cattle (control). My study carried out on body condition score (1, 2). Clinical examination showed decrease in body weight, not increase in BW, dehydration, pale conjunctival mucous membranes (signs of anemia), infertility, reduced milk production, pica, and heavy infestation by tick. The results of hematological analysis showed that significant decrease of RBC and Hb concentration in BCS1 and BCS2, Additionally, HCT and ESINO showed significant increase in BCS1 While the results of biochemical serum analysis explained that significant decrease of serum Ca 2+ , P 3+ , Cu 2+ , Fe 2++ and Gl in BCS1. On the other hand, there was significant decrease of serum P 3+ , Cu2+, Fe 2++ , and Gl concentrations were decreased in BCS2 when compared to control. The activity of liver enzymes was noted there was significant decrease of AST activity in BCS1and BCS2. While serum creatinine was significant decrease in BCS1 when compared toBCS2 and control. The results of fecal examination showed that the highest prevalence of infection was infected by protozoa, followed by infected by nematode and the lowest rate was infected by trematode. The results of the present study indicate that ill-thriftiness in cattle occur because of bad management, nutritional deficiency, and failure to use anthelmintic regularly in periodic system for eliminate both external and internal parasites, Also the nature of the soil, water, and climate in the New Valley Governorate. Identification of the risk factors associated with ill-thrift may provide useful information, which assist to construct the suitable preventive measures.","PeriodicalId":210463,"journal":{"name":"New Valley Veterinary Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133265325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
N-Acetyl cysteine alleviates carbon-tetrachloride induced acute liver injury in rats n-乙酰半胱氨酸减轻四氯化碳所致大鼠急性肝损伤
New Valley Veterinary Journal Pub Date : 2022-08-11 DOI: 10.21608/nvvj.2022.152184.1007
Hasnaa Mansour, Marwa El-Zeftawy, M. Aboubakr, Rabab R Elzoghby
{"title":"N-Acetyl cysteine alleviates carbon-tetrachloride induced acute liver injury in rats","authors":"Hasnaa Mansour, Marwa El-Zeftawy, M. Aboubakr, Rabab R Elzoghby","doi":"10.21608/nvvj.2022.152184.1007","DOIUrl":"https://doi.org/10.21608/nvvj.2022.152184.1007","url":null,"abstract":"The liver is a vital organ that performs most of the body's metabolic and detoxifying functions. There are various exogenous and endogenous factors that might cause liver issues. Carbon tetrachloride (CCL 4 ) is non-inflammable colorless organic compound and employed in a variety of industrial fields. N-acetylcysteine (NAC) is one of the prospective pharmaceutical candidates possesses multiple clinical applications. The purpose of this study is to determine whether NAC has a protective effect in cases of liver injury or not. Thirty male albino rats were involved in the study, which lasted one month. They were categorized into three groups: control, liver injury group (0.5 ml/kg rat body weight (Bwt) CCL 4 administered orally twice a week), and protective group (150 mg/kg Bwt NAC supplied orally). Serum lipid and protein profiles and liver enzymes activities were evaluated. Antioxidant, oxidative stress, and anti-inflammatory parameters were also assessed. Additionally, hepatic tissue was subjected to a histopathological investigation. The biochemical and histopathological results revealed dramatic improvement of studied parameters in NAC protective group comparing to liver injury one. Hence, we can conclude that, NAC shown a great potential in attenuating liver injury induced by CCL 4 via refinement tumor necrosis factor-alpha, interleukin-6 and reduced glutathione pathway.","PeriodicalId":210463,"journal":{"name":"New Valley Veterinary Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128698638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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