Africa Health Research Organization最新文献

Ibudilast and octreotide can ameliorate acute pancreatitis via downregulation of the inflammatory cytokines and Nuclear Factor- Kappa B expression 伊布司特和奥曲肽可以通过下调炎症细胞因子和核因子- κ B的表达来改善急性胰腺炎

Africa Health Research Organization Pub Date : 2019-09-01 DOI: 10.36295/asro.2019.22041

A. Ghazi, Sameer H Abood, Hassan Alaqouli, N. Hadi, S. M. Janabi

{"title":"Ibudilast and octreotide can ameliorate acute pancreatitis via downregulation of the inflammatory cytokines and Nuclear Factor- Kappa B expression","authors":"A. Ghazi, Sameer H Abood, Hassan Alaqouli, N. Hadi, S. M. Janabi","doi":"10.36295/asro.2019.22041","DOIUrl":"https://doi.org/10.36295/asro.2019.22041","url":null,"abstract":"Background: Acute pancreatitis (AP) is severe inflammation of the pancreas that can be of two major types: mild AP and severe AP. In this case, some pancreatic cells can produce various pro-inflammatory cytokines and transcription factors thereby affecting the function of pancreas. Objective: to study the efficacy of Ibudilast in comparison with octreotide, in a rat model of AP. Methods: A total of 48 male rats were randomly divided into 8 groups (6 per each). AP was induced by Larginine model which has a high reproducibility. Octreotide and Ibudilast were administered individually or in combination at 0, 8or 16 hr after induction. After 24 hr of treatment, each rat was weighed and blood samples were collected for measurement of biochemical markers, and then the pancreas was extracted to obtain the pancreatic weight to the total body weight (PW/TBW) ratio and for vertical gel electrophoresis experiments. Results: In both octreotide-treated group and ibudilast-treated group, there were statistically significant decrease in serum pro-calcitonin (PCT) and tumor necrosis factor-alpha (TNF-α) when compared to control group or sham group, as well as, a decrease in PW/TBW ratio and in nuclear factor kappa B (NFB)protein level using vertical gel electrophoresis. However, in octreotide + ibudilast-treated group there was no statistically significant difference when compared with groups treated with either agents. Conclusion: Ibudilast and octreotide can significantly attenuate the local and systemic effect of AP. The efficacy of ibudilast and octreotide are almost the same. Co-treatment of rats with both Ibudilast and octreotide has no preferential effect when compared with rats treated with the individual agent.","PeriodicalId":210200,"journal":{"name":"Africa Health Research Organization","volume":"63 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115664177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Early pregnancy vitamin D deficiency and risk of preterm Birth 妊娠早期维生素D缺乏和早产风险

Africa Health Research Organization Pub Date : 2019-09-01 DOI: 10.36295/asro.2019.22043

Noorhan Shakir, Ahmed S. Al-Hilli, Affifa Hamed Saffa, M.B.Ch., Dog

引用次数: 5

Histological study of testis tissue of male golden hamster (Mesocricetusauratus) in different time points of Diabetes 糖尿病不同时间点雄性金仓鼠睾丸组织的组织学研究

Africa Health Research Organization Pub Date : 1900-01-01 DOI: 10.36295/asro.2019.22046

M. AL-Murshidi

{"title":"Histological study of testis tissue of male golden hamster (Mesocricetusauratus) in different time points of Diabetes","authors":"M. AL-Murshidi","doi":"10.36295/asro.2019.22046","DOIUrl":"https://doi.org/10.36295/asro.2019.22046","url":null,"abstract":"Previous studies have reported that hyperglycemia can induce cell death in many tissues like brain, liver, kidneys, and testis. Recent studies have indicated that diabetes can trigger male infertility. In this study we explain the histological analysis of testicular tissue after induced diabetes in hamsters. Testicular tissues were examined in the control group and in diabetic hamsters groups at different time periods after diabetes induction. Hyperglycemia was induced in experimental male hamsters by intraperitoneal injection of streptozotocin drug (STZ). At different time points (4, 8 and 20 weeks) after diabetes induction, hamsters were euthanized and the testicular tissues were removed for the histological analysis. Testis tissues were fixed in formalin (10%) and then processed for histological analysis, and examined under light microscope. The histological results showed reduction in cell density in the testis, which indicated that diabetes and hyperglycemic conditions defect normal cell density in the testis tissues. The testicular histology of the diabetic animals showed acute reduction in cell density occurred after 20 weeks. In conclusion, the induced diabetes condition provides evidence that hyperglycemia plays an important role in the pathogenesis of diabetes, and it also indicated that chronic hyperglycemia eventually leads to cell death and then male infertility.","PeriodicalId":210200,"journal":{"name":"Africa Health Research Organization","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125173416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bardoxolone Ameliorates Cerebral Ischemia/ Reperfusion Injury in Male Rats 巴多隆改善雄性大鼠脑缺血再灌注损伤

Africa Health Research Organization Pub Date : 1900-01-01 DOI: 10.36295/asro.2019.220415

Rihab H. Al-Mudhaffer, L. M. Al-Huseini, Saif M. Hassan, N. Hadi

引用次数: 5

Study of some parameters of pregnant women with diabetes as well as anemia 妊娠合并糖尿病及贫血的一些指标的研究

Africa Health Research Organization Pub Date : 1900-01-01 DOI: 10.36295/asro.2019.22047

K. Mohammad

引用次数: 0

Association of Cortisol with severity and duration of depression in male and female 皮质醇与男性和女性抑郁症的严重程度和持续时间的关系

Africa Health Research Organization Pub Date : 1900-01-01 DOI: 10.36295/asro.2019.220410

Meena M. Abdul− Hussain, Noor K. Habash, Mahir M.Alramahy, Noor M. Shamkhi

引用次数: 0

Electronic study of fresh enzyme complexes of antifungal drugs-P450 and Aspergillus kojic acid biosynthesis. W: w saccharose flavus: fructose as a substratum 抗真菌药物新鲜酶复合物p450与曲霉酸生物合成的电子研究。W:糖黄:果糖作为基质

Africa Health Research Organization Pub Date : 1900-01-01 DOI: 10.36295/asro.2019.22048

Khansaa Basem Fadhil, Moazaz Abd Alrida Majeed, M. Mustafa

{"title":"Electronic study of fresh enzyme complexes of antifungal drugs-P450 and Aspergillus kojic acid biosynthesis. W: w saccharose flavus: fructose as a substratum","authors":"Khansaa Basem Fadhil, Moazaz Abd Alrida Majeed, M. Mustafa","doi":"10.36295/asro.2019.22048","DOIUrl":"https://doi.org/10.36295/asro.2019.22048","url":null,"abstract":"Aspergillus(A) flavus cell contain the natural product cytochrome p450 enzyme, which is made up of from 400-500 amino acids and containing single heme group with single ferric ion, this enzyme destroyed by and reacted potentially with the used antifungal structures to yield new complexes with different electronic stability which related to the quality of the drug. The new complexes were studied by spectrophotometric technique. The theory on application it on the complexes indicated the following: low spin (LS) complexes with high crystal field stabilization energy (CFSE), octahedral shape and paramagnetic. Calculation and discussion pointed that the p450-triazole complex is the most stable and have higher stabilization energy. A flavus was grown on a carbon source formed from a combination of 1w:1w sucrose: fructose substrate to produce kojic acid by shake flask fermentation. The acid is detected and then identified by its physical properties as yellow crystalline material, odorless, melting point (m.p.) = 155-158(°C), lambda λmax=272nanometer (nm) in distilled water as pure solvent.","PeriodicalId":210200,"journal":{"name":"Africa Health Research Organization","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127119060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Histopathological study of hepatic and pulmonary sheep's hydatidosis 羊肝肺包虫病的组织病理学研究

Africa Health Research Organization Pub Date : 1900-01-01 DOI: 10.36295/asro.2019.220411

I. K. Al-Aubaidi, Ali N. Yaseen, Maha A. Gathwan

引用次数: 2

RFLP- PCR for identification of dermatophytes and Candida species from clinical isolates of hair and skin 头发和皮肤临床分离物中皮肤真菌和念珠菌种类的RFLP- PCR鉴定

Africa Health Research Organization Pub Date : 1900-01-01 DOI: 10.36295/asro.2019.22049

Karrema Al-Khafajii, Kawther Mohammed Ali Hasan

引用次数: 1

Histopathological performance of an HPV18 KSHV co-infection with Kisspeptin expression in cervical precancer and cancer tissues HPV18 KSHV联合Kisspeptin表达在宫颈癌前期和癌组织中的组织病理学表现

Africa Health Research Organization Pub Date : 1900-01-01 DOI: 10.36295/asro.2019.220413

J. Muhsin, A. Hadi, S. H. Abbas

{"title":"Histopathological performance of an HPV18 KSHV co-infection with Kisspeptin expression in cervical precancer and cancer tissues","authors":"J. Muhsin, A. Hadi, S. H. Abbas","doi":"10.36295/asro.2019.220413","DOIUrl":"https://doi.org/10.36295/asro.2019.220413","url":null,"abstract":"Background: Cervical cancer (CC) is one of the most 12 th recurrent neoplasia among Iraqi women turning it into significant health issue, it had been currently supposed that the co-infection of High-risk human papillomavirus (HPV) and Kaposi sarcoma-associated herpesvirus (KSHV) which both share some transmission routes from one side, and the disruption of Kisspeptin expression in cervical tissues from the other side, which are collectivelyact as a causative agents and co-factors of cervical cancer progression. Aim: to compare the infection and or co-infection of HPV18 KSHV and the dysregulation of Kisspeptin expression between cervical dysplasia (pre-cancerous tissues) and cervical cancer (cancerous tissues) progression. Results: Overall, results showed a significant association between infection and or co-infection of HPV18 KSHV with both types of test tissues (pre-cancerous and cancerous), although the detection rate of KSHV DNA was very low in comparing with HPV18 DNA in both cervical tissue samples. Furthermore, a significant interaction of Kisspeptin low expression in cancerous samples compared to pre-cancerous tissues with viruses existence seem to involve significantly in Kisspeptin expression of CC. Conclusions: Data suggest KSHV co-infection may act as co-factor in the development of HPV related cervical carcinogenesis. Besides, the defect of low Kisspeptin expression serves as a great candidate for cervical carcinoma progression or maybe as a therapeutic target for CC.","PeriodicalId":210200,"journal":{"name":"Africa Health Research Organization","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116336843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0