Research journal of pharmaceutical, biological and chemical sciences最新文献_第2页

Fibers as nutraceuticals: A review 纤维作为营养保健品:综述

Research journal of pharmaceutical, biological and chemical sciences Pub Date : 2023-01-15 DOI: 10.18231/j.jpbs.2022.011

A. Sharma, Nikhil Sharma, Tanya, Jaiprakash Verma, Ankur

引用次数: 1

Development of UV-Visible spectrophotometric method for the estimation of vildagliptin in different medium 紫外可见分光光度法测定维格列汀在不同介质中的含量

Research journal of pharmaceutical, biological and chemical sciences Pub Date : 2023-01-15 DOI: 10.18231/j.jpbs.2022.016

Sheetal Sheetal Mane, M. Khan

{"title":"Development of UV-Visible spectrophotometric method for the estimation of vildagliptin in different medium","authors":"Sheetal Sheetal Mane, M. Khan","doi":"10.18231/j.jpbs.2022.016","DOIUrl":"https://doi.org/10.18231/j.jpbs.2022.016","url":null,"abstract":"A simple, accurate, precise, cost effective, rapid and sensitive UV/visible spectrophotometric method was developed for the determination of Vildagliptin in active pharmaceutical dosage form. The developed method was validated as per ICH guidelines.The purity of Vildagliptin was characterized by melting point, Fourier Transform Infra-Red and DSC. The drug was analyzed using UV/visible spectrophotometric method was validated in terms of linearity and range. The solvents used was water, 0.1 N HCl and phosphate buffer pH 7.4 and the wavelength corresponding to maximum absorbance of the drug were found at 210 nm.Melting point of drug was found 151.67°C nearly corresponds to its actual melting range. The linear response for concentration range of 2-12 µg/ml of vildagliptin for water, 0.1 N HCl and phosphate buffer pH 7.4 was recorded each with regression coefficient R = 0.9998, 0.9994 and 0.9991 respectively.The drug was confirmed by interpretation of UV spectra. Hence, proposed method stands out validated and shows a linear relationship and thus may be used for routine analysis of Vildagliptin in pharmaceutical dosage forms.","PeriodicalId":21014,"journal":{"name":"Research journal of pharmaceutical, biological and chemical sciences","volume":"102 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79625877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ethosome as a potential transdermal drug delivery system 乙醇体作为一种潜在的透皮给药系统

Research journal of pharmaceutical, biological and chemical sciences Pub Date : 2023-01-15 DOI: 10.18231/j.jpbs.2022.014

S. Khanam, Sumon Sheel, Poulomi Biswas, Varnita Karmakar

{"title":"Ethosome as a potential transdermal drug delivery system","authors":"S. Khanam, Sumon Sheel, Poulomi Biswas, Varnita Karmakar","doi":"10.18231/j.jpbs.2022.014","DOIUrl":"https://doi.org/10.18231/j.jpbs.2022.014","url":null,"abstract":"Ethosomes are elastic nanovesicles with phospholipid bases that are noninvasive delivery vehicles and have a high ethanol concentration (20–45%). As transdermal drug delivery confers poor penetration, the major obstacle is the low diffusion rate of drugs across the stratum corneum. The sophisticated ethosomal delivery systems enable drugs to reach the deep skin layers and/or the systemic circulation. The development of these new carriers involves the employment of several preparatory processes. Ethosomal dispersions are added to gels, patches, and creams for ease of use and stability. Ethanol is known as an efficient permeation enhancer and has been added in the vesicular systems to prepare elastic nanovesicles. It has the potential to interact with the polar head group region of lipid molecules, lowering the melting point of the stratum corneum lipid and raising lipid fluidity and cell membrane permeability as a result. Ethosomes' special structure allows them to enclose and transmit through the skin highly lipophilic substances like propranolol and trihexyphenidil as well as cationic medicines like testosterone and minoxidil. This article provides a detailed review of the ethosomal structure, mechanism of penetration along with various methods of preparation. Also, the article focuses on the applications of ethosomal carriers and opportunities for the research and future development of novel improved therapies.","PeriodicalId":21014,"journal":{"name":"Research journal of pharmaceutical, biological and chemical sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90359511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanotechnology- based target drug delivery system 基于纳米技术的靶向给药系统

Research journal of pharmaceutical, biological and chemical sciences Pub Date : 2023-01-15 DOI: 10.18231/j.jpbs.2022.010

Virender Kumar, N. Kumar, Manithu Shilsut, J. Kumar

引用次数: 0

Phytonanotechnology Phytonanotechnology

Research journal of pharmaceutical, biological and chemical sciences Pub Date : 2023-01-15 DOI: 10.18231/j.jpbs.2022.009

F. Tamboli

引用次数: 0

The ICH guidelines in practices: Stress degradation studies on botulinum toxin and validation of developed stability-indicating HPLC method ICH实践指南:肉毒毒素的应激降解研究和已开发的指示稳定性的高效液相色谱法的验证

Research journal of pharmaceutical, biological and chemical sciences Pub Date : 2023-01-15 DOI: 10.18231/j.jpbs.2022.013

S. Bhale

引用次数: 0

A study on assessment of knowledge and attitude about generic medicines among interns in a tertiary care hospital 某三级医院实习生对仿制药知识和态度的评价

Research journal of pharmaceutical, biological and chemical sciences Pub Date : 2023-01-15 DOI: 10.18231/j.jpbs.2022.017

B. Jyothi, R. Shetty, Mohandas Rai

{"title":"A study on assessment of knowledge and attitude about generic medicines among interns in a tertiary care hospital","authors":"B. Jyothi, R. Shetty, Mohandas Rai","doi":"10.18231/j.jpbs.2022.017","DOIUrl":"https://doi.org/10.18231/j.jpbs.2022.017","url":null,"abstract":"According to a WHO report, approximately 55 million people in India are still living in poverty as a result of household out-of-pocket expenses for health care, particularly medications. Thus, it is imperative to keep healthcare costs as low as possible without limiting access to high-quality care. Increasing the use of generic medications can raise affordability of healthcare without sacrificing the standard of care. Doctors' prescriptions play an extremely significant role. In order to identify potential obstacles to the use of generic drugs, it may be helpful to understand the doctor's perspective about generic drugs.A cross-sectional study was carried out using a validated questionnaire that included questions to evaluate the participant’s knowledge and attitude on generic medicines. Data was collected using google forms and Chi square test was used to list association of knowledge and attitude.It was observed that attitude among interns were extremely significant whereas the knowledge was insignificant.According to the study, knowledge about generic drugs were not significant however they had significant attitude towards it so educating interns and medical students about generic drugs will promote more awareness about prescribing generic medicine.","PeriodicalId":21014,"journal":{"name":"Research journal of pharmaceutical, biological and chemical sciences","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90345815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factor Xa inhibitors, Era to replace traditional anticoagulants Xa因子抑制剂，Era取代传统抗凝剂

Research journal of pharmaceutical, biological and chemical sciences Pub Date : 2022-07-15 DOI: 10.18231/j.jpbs.2022.004

S. Chaudhry

引用次数: 0

Current trends in pharmaceutical and biological sciences 制药和生物科学的当前趋势

Research journal of pharmaceutical, biological and chemical sciences Pub Date : 2022-07-15 DOI: 10.18231/j.jpbs.2022.001

F. Tamboli

引用次数: 1

Studies on the combinations of some herbals with various chemical entities as a potent antifungal agents 一些草药与不同化学实体联合作为有效抗真菌剂的研究

Research journal of pharmaceutical, biological and chemical sciences Pub Date : 2021-11-15 DOI: 10.18231/j.jpbs.2021.014

N. Kolhe, V. Bhaskar, Shubham Ghosh, Sanskruti Kharavtekar, Savni Prabhu, Prathamesh Gangurde, Prachi Navale

{"title":"Studies on the combinations of some herbals with various chemical entities as a potent antifungal agents","authors":"N. Kolhe, V. Bhaskar, Shubham Ghosh, Sanskruti Kharavtekar, Savni Prabhu, Prathamesh Gangurde, Prachi Navale","doi":"10.18231/j.jpbs.2021.014","DOIUrl":"https://doi.org/10.18231/j.jpbs.2021.014","url":null,"abstract":"A widespread increase in the prevalence of fungal infections has been documented in recent decades. Candida albicans infections, which are frequently refractory and linked with high morbidity and mortality, place a significant burden on public health, despite the fact that existing antifungal medicines are restricted and associated with toxicity. Fungi are one of the most underappreciated killers, as evidenced by the fact that Amphotericin B and other commercially available antifungal therapies are still recognized as gold standards. The majority of commonly used antifungal medications have toxicity, effectiveness, and cost disadvantages. As a result of these limitations, there is a growing demand for the development of a novel antifungal medication treatment that acts selectively on new targets while having the fewest adverse effects. Natural goods, whether as pure phytocompounds or regulated plant extracts, give prospects for the development of lead compounds that may subsequently be turned into diverse synthetic medications with the appropriate alterations. These herbs can also be used as a component of a herbal synthetic combination, lowering the minimum required dose of the synthetic medicine (when taken singly) and reducing the risk of adverse effects. The goal of this research is to reduce the minimum required concentrations of today's antifungal medications by mixing them with a few less well-known herbal extracts while maintaining their efficacy.","PeriodicalId":21014,"journal":{"name":"Research journal of pharmaceutical, biological and chemical sciences","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78075151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0