Journal of Clinical & Anatomic Pathology最新文献

{"title":"Molecular Lymph Node Staging with One-Step Nucleic Acid Amplification in Colon Cancer and its Prognostic Value","authors":"B. Weixler, M. Zuber","doi":"10.47275/2332-4864-114","DOIUrl":"https://doi.org/10.47275/2332-4864-114","url":null,"abstract":"One-step nucleic acid amplification (OSNA) was introduced as a method to detect tumor specific mRNA in sentinel lymph nodes (SLN) of patients undergoing surgery for breast cancer [1]. With OSNA, cytokeratin 19 (CK19) mRNA is amplified based on reverse transcription-loopmediated isothermal amplification and a threshold of ≥ 250 mRNA copies /μL is considered as a positive lymph node [2]. In the evaluation of SLN from patients with breast cancer OSNA shows a sensitivity of 87.5-100% and a specificity of 90.5-100% [3,4]. Molecular lymph node work-up with OSNA is nowadays a validated diagnostic and prognostic adjunct in breast cancer surgery [5]. Therefore, its diagnostic and prognostic capabilities seemed to be promising for the staging of colon cancer.","PeriodicalId":210142,"journal":{"name":"Journal of Clinical & Anatomic Pathology","volume":"74 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126979248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Germline Evolution in Cancer as Explained by the Germ and Soma Theory of Dual Cell Systems","authors":"V. Niculescu","doi":"10.47275/2332-4864-113","DOIUrl":"https://doi.org/10.47275/2332-4864-113","url":null,"abstract":"researchers","PeriodicalId":210142,"journal":{"name":"Journal of Clinical & Anatomic Pathology","volume":"343 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133809658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Next Generation Sequencing in the Breast Cancer Prognosis","authors":"Neelima Dandamudi","doi":"10.47275/2332-4864-125","DOIUrl":"https://doi.org/10.47275/2332-4864-125","url":null,"abstract":"","PeriodicalId":210142,"journal":{"name":"Journal of Clinical & Anatomic Pathology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125666714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Haemophilia in Cam: Allopathic Perspective","authors":"Nitish Nichenametla, Kaipa Anjan Kumar, Sri Ram Charan G","doi":"10.47275/2332-4864-121","DOIUrl":"https://doi.org/10.47275/2332-4864-121","url":null,"abstract":"","PeriodicalId":210142,"journal":{"name":"Journal of Clinical & Anatomic Pathology","volume":"107 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123043879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combination Functional and Structural Imaging for the Diagnosis of Neurodegenerative Dementias – A Suggested Imaging Strategy","authors":"Duignan Ja, Ryan Dt, McNeill G, Killeen Rp","doi":"10.47275/2332-4864-119","DOIUrl":"https://doi.org/10.47275/2332-4864-119","url":null,"abstract":"","PeriodicalId":210142,"journal":{"name":"Journal of Clinical & Anatomic Pathology","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125348027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early and Safe Management of Hypocalcemia after Thyroidectomy","authors":"Abdalla Y. Bashir","doi":"10.47275/2332-4864-112","DOIUrl":"https://doi.org/10.47275/2332-4864-112","url":null,"abstract":"","PeriodicalId":210142,"journal":{"name":"Journal of Clinical & Anatomic Pathology","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116886540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unmodified Gold Nanoparticles as Potential Diagnostic Agents for Colorimetric Detection of Pathogenic Infections","authors":"Nupur Garg, F. Ahmad","doi":"10.47275/2332-4864-120","DOIUrl":"https://doi.org/10.47275/2332-4864-120","url":null,"abstract":"Global outbreaks of infections have called for the development of rapid and sensitive in vitro diagnostic methods. Highly virulent and transmissible diseases are responsible for the increased rate of morbidities and fatalities worldwide. An infectious spread is best contained by early diagnosis, disease-load monitoring, and contact tracing. Ordinary diagnostic methods are expensive, laborious, time-consuming","PeriodicalId":210142,"journal":{"name":"Journal of Clinical & Anatomic Pathology","volume":"85 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126243565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding the Clinical Spectrum of Dermal Hyperneury","authors":"G. V","doi":"10.47275/2332-4864-123","DOIUrl":"https://doi.org/10.47275/2332-4864-123","url":null,"abstract":"Abstract","PeriodicalId":210142,"journal":{"name":"Journal of Clinical & Anatomic Pathology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117233190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathological Prognostic Factors and Classification of Breast Cancer","authors":"A. López","doi":"10.47275/2332-4864-124","DOIUrl":"https://doi.org/10.47275/2332-4864-124","url":null,"abstract":"Breast cancer (BC) is a diverse collection of tumors that range greatly in terms of their molecular makeup, biological behavior, clinical presentation, and therapeutic response when it is categorized according to the disease's outward symptoms and indicators. Mid-18th century ideas for early surgical excision of the breast tumor before something reached the lymph node nodes resulted from the fact that cancer was a confined illness that developed in phases instead of a de novo systemic disease. Resulting in recommendations for doing an early surgical excision of the breast tumor before it had axillary lymph nodes were affected by the spread. Trastuzumab (Herceptin), the first specific anti-HER2 (human epidermal growth factor 2) medication, a drug used to treat metastatic BC, was approved [1]. Together with these adjustments, the pathologic diagnostic and prognostic categorization of BC significantly improved. It assessed hormone receptors, receptors for HER2, and extensive histomorphological data. With the discovery of intrinsic molecular subtypes and the creation of multigene signatures, the idea of molecular categorization of BC was established, marking a significant advancement in our understanding of BC. Despite the significance of well characterized morphological prognostic markers in BC, subsequent histological categorization is often determined by the kind and degree of differentiation at first diagnostic and verification of a basic breast tumor. staining slides with hematoxylin and eosin (HandE), taking gross observations into account and if required, enabling special staining, immunohistochemistry, and other molecular analyses the diagnosis of BC (Figure 1) is completed by the evaluation of prognostic indicators as well as other factors such tumor stage, vascular invasion, margin status, and the presence of concurrent and prior lesions [2]. Normal clinical care for breast cancer presently relies on the availability of trustworthy medical and pathological prognostic and predictive indicators to enable clinician and patient decision-making because there are an increasing number of potentially successful treatment options. Histological grade, which reflects the morphological evaluation of tumor biological features and has been shown to be able to produce significant information linked to the clinical behavior of BCs, is one of the best-established prognostic variables in BC. For instance, proof of lymph node metastases or vascular invasion establishes both the tumor's invasiveness and its prognostic relevance. Similar to this, the analysis of BCs molecular features, which is primarily done for prognosis purposes, may be useful for both diagnostic and prognostic purposes [3]. Modern medicine's advancement has resulted in the creation of cutting-edge therapeutic alternatives including hormonal, targeted, and chemotherapies. Treatment of triple negative BC and overcoming medication resistance are two ongoing therapeutic problems.","PeriodicalId":210142,"journal":{"name":"Journal of Clinical & Anatomic Pathology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122749243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Critical Aspects of SARS-CoV-2 Testing During the Pandemic","authors":"J. Petersen, D. Jhala","doi":"10.47275/2332-4864-115","DOIUrl":"https://doi.org/10.47275/2332-4864-115","url":null,"abstract":"","PeriodicalId":210142,"journal":{"name":"Journal of Clinical & Anatomic Pathology","volume":"198 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127504079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}