Reproductive health of woman最新文献

{"title":"Fetal-maternal gas transport and acid – base balance in preterm labors","authors":"S.S. Leush, M.V. Protsyk, M.I. Antoniuk","doi":"10.30841/2708-8731.5.2023.286770","DOIUrl":"https://doi.org/10.30841/2708-8731.5.2023.286770","url":null,"abstract":"The use of cord blood gases to predict hypoxic stress during high-risk labor has been known since 1958. This diagnostic test is widely used, especially in specialized clinics, and blood indicators in the umbilical artery accurately reflect the condition of the newborn. However, there is a lack of specific diagnostic criteria for premature births.The objective: to study the ratio of indicators of gas exchange and acid-base status between the newborn and the mother depending on the gestational age at the time of delivery.Materials and methods. The levels of pH, pO2, pCO2, bicarbonate ion concentration (HCO3-) and base excess (BE) were analyzed both in mothers (maternal venous blood, v. cubitalis) and in their newborns (venous blood obtained from the umbilical artery).Study groups: I group – 16 postpartum women with newborns at 24–27 weeks of gestation, II group – 36 postpartum women with newborns at 28–34 weeks, III group (control group) – 24 postpartum women with newborns at term physiological delivery (37–41 weeks).Results. The study found no statistically significant differences in maternal venous and umbilical artery of pH, pO2, pCO2, HCO3- and BE levels between the term pregnancy group and the groups of preterm labor. However, extremely preterm neonates were found to have a marked increase in pH and BE in response to hyperventilation during labor.Conclusions. 1. Preterm infants had higher venous blood pH levels obtained from the umbilical artery, which were more pronounced in those who were born at earlier gestational ages (7.36±0.011 at 24–27 weeks gestation and 7.33±0.022 at a gestation period of 28–34 weeks), compared to full-term children (7.29±0.045; p<0.05).2. The difference in the pH levels of the venous blood of the newborn, obtained from the umbilical artery, and the mother’s blood, obtained from the v. cubitalis, is smaller in premature births (for a gestation period of 24–27 weeks – 7.39±0.018 in maternal blood and 7.36± 0.011 – in newborns; for the period of 28–34 weeks – 7.40±0.021 and 7.33±0.022, respectively) compared to the levels in full-term babies (7.43±0.015 – in maternal blood and 7.29±0.045 – in a newborn); p<0.05. This is primarily due to a decrease in the mother’s venous blood pH.","PeriodicalId":21003,"journal":{"name":"Reproductive health of woman","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135357890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of the coronavirus disease transmitted during pregnancy on the course of gestation and changes in the main biotopes of a woman’s organism","authors":"I.A. Zhabchenko, I.S. Lishchenko, O.M. Bondarenko, T.M. Kovalenko","doi":"10.30841/2708-8731.5.2023.286765","DOIUrl":"https://doi.org/10.30841/2708-8731.5.2023.286765","url":null,"abstract":"The article presents literature data on the peculiarities of the pregnancy course and changes in the main biotopes in women who suffered from COVID-19 in different periods of gestation. Certain regularities regarding the association of perinatal complications with the severity of the disease, the presence of somatic and gynecological pathology in these pregnant women, in particular, obesity and chronic inflammatory diseases of the genital organs, were observed.According to research conducted on the basis of the department of pathology of pregnancy and childbirth of the State Institution «Institute of Pediatrics, Obstetrics and Gynecology named after academician O. M. Lukyanova of the National Academy of Sciences of Ukraine», the risk group of a severe course of the coronavirus disease includes all the same factors as for any other diseases, not related to pregnancy: age over 35 years; the presence of concomitant pathology (diabetes, obesity, hypertension), work, lifestyle or housing conditions that increase the risk of infection. More frequent manifestations of obstetric pathology were found in older women and primipara women.Complicated obstetric anamnesis, namely, medical abortions and miscarriages, cervical pathology, previous inflammatory diseases, especially of the genital organs, are considered to be risk factors. The course of pregnancy and childbirth are accompanied by such complications as the threat of early miscarriage; anemia; combination of placental dysfunction, polyhydramnios and fetal distress; anomalies uterine activity, which increases the frequency of pathological childbirth in this contingent of women and requires repeated hospitalization during pregnancy.A review of scientific publications in recent years demonstrates the significant impact of COVID-19 on the composition of biotopes of the human organism. There are convincing data on the close relationship between the infection of the mucous membranes of the upper respiratory tract and the infection of the lungs with the SARS-CoV-2 virus. Lung hypoxia, typical for this infection, causes the growth of anaerobes and facultative anaerobes, which are part of the mentioned microbiomes during a person’s life. A significant number of observations have found the correlation of changes in the microbiocenosis of the respiratory tract and intestines in patients with SARS-CoV-2 and convalescents. At the same time, there is also a disorder in the vaginal microbiocenosis after the coronavirus disease, especially during pregnancy. A conclusion was made regarding the correlation between the severity of COVID-19 course and the number of lactobacilli in the vaginal biotope: the more severe course, the worse of the microflora composition. The gestation period is more often complicated by the threat of early pregnancy loss, placental dysfunction, polyhydramnios, fetal distress, and the threat of premature birth in those women who suffered a coronavirus infection in the I trimester. A large rate ","PeriodicalId":21003,"journal":{"name":"Reproductive health of woman","volume":"143 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135357895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peculiarities of the course of seborrheic keratosis of extragenital localization among the female population","authors":"L.O. Cherneda, V.G. Siusiuka, A.V. Golovkin, M.Y. Sergienko","doi":"10.30841/2708-8731.5.2023.286767","DOIUrl":"https://doi.org/10.30841/2708-8731.5.2023.286767","url":null,"abstract":"Seborrheic keratosis (SK) remains the leader among benign skin pathologies. In the classical sense, extragenital foci of this dermatosis look like light or dark brown papules with dense hyperkeratotic or verrucous layers. Such a clinical picture is characteristic of the typical form of foci of skin lesions. The etiopathogenetic mechanisms of SK appearance are not sufficiently studied, because a large number of trigger factors are reported. Given the benign profile of these lesions, practitional doctors very often do not pay much attention to these foci. While for patients, their appearance and increase in size can cause the emergence of obsessive or anxiety states both due to the development of cancer-phobic states due to significant aesthetic discomfort.The objective: to determine the peculiarities of the course of seborrheic keratosis in women, taking into account anamnestic data on the effect of insolation on the skin and phenotypic criteria represented by the skin phototype, as well as to analyze the dermatological quality of life indicator in patients with keratosis depending on the location of neoplasms.Materials and methods. Based on the Educational and Scientific Medical Center «University Clinic» of Zaporizhzhia State Medical and Pharmaceutical University, 50 patients with foci of seborrheic keratosis, whose ages ranged from 27 to 80 years old, were examined. To verify the diagnosis, the following parameters were carried out: a clinical examination of neoplasms with an assessment of the phenotypic criterion – skin phototype according to Fitzpatrick, dermatoscopic and pathomorphological examination. The assessment of the impact of keratosis on the quality of life of patients was based on the calculation of the results of the DLQI (Dermatology Life Quality Index) questionnaire.Results. The studied sample is represented by the majority of representatives of the II phototype – 44 persons and a small number of the III phototype – 6 patients, which amounted to 88% and 12%, respectively. The most frequent localization of keratosis was the head – 18 (36%), torso – 11 (22%), extremities – 13 (26%), and neck – 8 (16%). This location on open areas of the body can be an additional confirmation of the effect of ultraviolet radiation on the occurrence of keratosis. According to the results of the questionnaire with the study of anamnestic data, more than half of the examined patients (58%) had skin burns after a long stay in the open sun. In addition, an insufficient level of use of photoprotective agents was determined. All these factors can be as triggers for the appearance of keratosis foci and negatively affect the self-esteem and aesthetic appeal of patients. Indeed, when efflorescences are located in visual areas of the body, the dominant factor is a decrease in the quality of life.Conclusions. Predominance of patients with II skin phototype (88%) and lack of photoprotection skills (48% never use sunscreen, 32% sometimes) are the most influentia","PeriodicalId":21003,"journal":{"name":"Reproductive health of woman","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135358110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of COL1A1 gene rs1800012 polymorphism and non-differentiated connective tissue dysplasia as predictors of pelvic organ prolapse","authors":"O.M. Proshchenko, D.O. Govseev","doi":"10.30841/2708-8731.5.2023.286771","DOIUrl":"https://doi.org/10.30841/2708-8731.5.2023.286771","url":null,"abstract":"The article presents data on the association of the rs1800012 polymorphism of the procollagen type I alpha (α) 1 COL1A1 gene and the stigma of non-differentiated connective tissue dysplasia with the development of vaginal prolapse in the Ukrainian population.The objective: to determine the prognostic significance of the rs1800012 polymorphism of the procollagen type I alpha (α) 1 COL1A1 gene and the clinical and anamnestic stigmata of non-differentiated connective tissue dysplasia as factors associated with the development of vaginal prolapse in the Ukrainian population.Materials and methods. In order to achieve the research aim, polymorphism in the rs1800012 locus of the COL1A1 gene was studied by polymerase chain reaction in venous blood samples of 120 women. The main group included 60 patients with vaginal prolapse III, IV, who had indications for surgical correction; to the comparison group – 60 women without pelvic floor dysfunction.The diagnostic algorithm included a physical examination, taking the general and gynecological history, evaluation of the state of the pelvic floor and urogenital dysfunction. The severity of pelvic floor prolapse was assessed based on the Pelvic Organ Prolapse Quantification (POP-Q) classification.Results. During the analysis of clinical and anamnestic data in women of both research groups, concomitant pathology with a possible connection with signs of non-differentiated connective tissue dysplasia was identified as risk factors for the development of pelvic floor dysfunction: 37 people in the main group versus 21 patients in the comparison group (χ2=8.5428; p=.003469).The prevalence of rs1800012 polymorphism of the gene procollagen type I alpha (α) 1 COL1A1 in the homozygous variant (TT) in this study was found in the main group in 8 samples (13.33%) and only in 2 (3.33%) – in the comparison group. The presented polymorphism in the heterozygous variant (GT) in the main group was determined in 19 samples (31.67%) and only in 12 (20.00%) – in the comparison group (χ2=7.3199; p=.025734).Conclusions. The association of the rs1800012 polymorphism in the COL1A1 gene (p=.025734) and clinical and anamnestic stigmata of non-differentiated connective tissue dysplasia (NDST) (p=.003469) with the development of pelvic organ prolapse was established, which is evidence of the importance of genetic changes and connective tissue remodeling in the etiology of genital prolapseThe presence of NDST stigma increases the risk of pelvic organ prolapse by 3 times (OR=3.788; 95% CI: 1.664–8.624), polymorphism rs1800012 in the COL1A1 gene – by 2 times with the heterozygous variant (OR=2.400; 95% CI: 1.230–6.633) and 3 times with the homozygous variant (OR=3.275; 95% CI: 1.300–19.969).","PeriodicalId":21003,"journal":{"name":"Reproductive health of woman","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135357892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The modern aspects of the optimal therapeutic strategy of hyperemesis gravidarum","authors":"V.I. Medved, D.H. Konkov, R.O. Tkachenko, O.A. Muntian","doi":"10.30841/2708-8731.5.2023.286769","DOIUrl":"https://doi.org/10.30841/2708-8731.5.2023.286769","url":null,"abstract":"Although, nausea and vomiting in early pregnancy is very common, affecting approximately 80% of pregnancies, hyperemesis gravidarum (HG) is a severe form that complicates up to 2.2% of pregnancies. HG is one of the most common indications for hospitalization during pregnancy. In addition to the insufficient nutrition both for the mother and fetus, the severity of HG symptoms causes a serious psychosocial stress, which leads to depression, anxiety and even the development of perinatal pathology. The aim of this meta-analysis was to study available randomized controlled trials about therapeutic strategies by HG, their evaluation based on both subjective and objective measures of efficacy, maternal and fetal/neonatal safety, and economic costs.A systematic data search was conducted using the databases MEDLINE, ISI Web of Science, PubMed, Scopus, Google Scholar, Cochrane Database of Systematic Reviews and publications in professional editions of Ukraine for 2013–2023. The search was conducted using the following keywords: pregnancy, nausea and vomiting of pregnant women, excessive vomiting of pregnancy, hyperemesis, antiemetic therapy during pregnancy, infusion therapy and the safety profile of medications prescribed during pregnancy in various combinations.The main outcome was: the effectiveness of therapeutic strategies (reduction or stopping nausea/vomiting); detailing by safety profile of antiemetic drugs; optimization of infusion therapy; additional clinical strategies that help to improve the quality of care for pregnant women; adverse effects and side effects of drugs for HG for the mother/fetus/newborn.The results presented in this meta-analysis can be used in the creation of a national clinical guideline, protocol, consensus or clinical recommendations regarding the clinical management of hyperemesis gravidarum.","PeriodicalId":21003,"journal":{"name":"Reproductive health of woman","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135357891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunological disorders in patients with mammary gland pathology in infertility associated with anovulation","authors":"S.Е. Gladenko, I.P. Netskar, O.M. Susidko, O.A. Kovalishin","doi":"10.30841/2708-8731.5.2023.286766","DOIUrl":"https://doi.org/10.30841/2708-8731.5.2023.286766","url":null,"abstract":"The objective: to study the state of the immune system in women with pathology of the mammary glands and infertility, and on the background of menstrual cycle disorders.Materials and methods. The research was performed in two stages. The first (1) stage included examination of women with infertility associated with anovulation who had breast pathology. These patients were divided into three groups: 1.1 group – 44 patients with diffuse fibrocystic breast disease (FBD), 1.2 group – 4 patients with fibroadenoma of the mammary glands, 1.3 group (control one) – 37 patients without pathological changes in the mammary glands.During the second (2) stage of the study, 110 women were examined: 2.1 group – 52 patients with regular menstruations and luteal phase insufficiency (LPI) and 2.2 group – 58 patients with anovulatory cycles.During two research stages, the immune status (CD3, CD4, CD8, immunoregulatory index (CD4/CD8), CD72, CD16, circulating immune complexes) and cytokine profile (IL-1, IL-2, IL-6, TNF-α, INF) in venous blood were determined. Differences were considered statistically significant at p<0.05.Results. A significant increase in the CD8 index was found in the group of patients with normal mammary glands (34.7±6.9 pg/ml; p<0.05) and with a diffuse form of FBD (35.13±6.9 pg/ml; p<0.05) versus its normal level in the group of patients with fibroadenoma (26.5±15.9 pg/ml; p>0.05).During the analysis of the CD16 level, it was determined its significantly increased to 18.8±3.1 pg/ml (р<0.05) in patients with LPI and regular menstrual cycle and to 26.3±4.8 pg/ml (р< 0.05) – in patients with anovulation without LPI, the difference between the groups was significant. The level of CD16 was significantly higher in anovulatory menstrual cycle disorder without LPI compared to patients with menstrual cycle disorder and LPI.The concentration of TNF-α in patients with a regular menstrual cycle (998.1±166.3 pg/ml; p<0.05) and with an anovulatory cycle without LPI (1029.3±187.1 pg/ml; p<0.05) was significantly higher compared to normal values (778.5±64.0 pg/ml). The level of IL-2 was significantly lower than normal indices. Thus, in the group of women with LPI, this indicator was 17.13±2.85 pg/ml (р<0.05), and by anovulation without LPI – 16.84±3.07 pg/ml (р<0.05) versus normal parameter 22.29±0.81 pg/ml.Conclusions. In patients with diseases of the mammary glands and infertility associated with anovulation without LPI, a significant decrease in the activity of T2-helpers (IL-2) and an increase in the activity of T1-helpers (TNF-α) were determined in cases of anovulation without LPI compared with cases of luteal phase insufficiency.","PeriodicalId":21003,"journal":{"name":"Reproductive health of woman","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135358096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Studying the discipline of free choice «Ultrasound Diagnostics in Obstetrics and Gynaecology»","authors":"I.A. Ancheva, I.Z. Gladchuk, E.M. Mokriienko, N.V. Movlyanova, N.V. Lazor","doi":"10.30841/2708-8731.5.2023.286764","DOIUrl":"https://doi.org/10.30841/2708-8731.5.2023.286764","url":null,"abstract":"Today, in the education system, an important opportunity for higher education applicants is the right to form an individual educational trajectory according to the relevant qualification level. Higher education seekers have received not only academic mobility but also the opportunity to study disciplines to consciously choose their specialty and study it more deeply. The skills of ultrasound diagnostics increase the professional level of a doctor of any specialization and open wide diagnostic possibilities.The article reveals the peculiarity of studying one of the subjects of free choice by medical higher education applicants on the basis of Odesa National Medical University – “Ultrasound Diagnostics in Obstetrics and Gynaecology”. The adaptation of the educational process in a mixed format with the possibility of using digital learning technologies and mastering professional skills on ultrasound machines of different classes is described. In the course of studying the discipline, the necessary basic digital skills of using an ultrasound scanner and knowledge of the main visualization modes, adjustment principles, as well as sets of functional capabilities inherent in all modern devices are formed.The method of presentation of theoretical information and the use of case scenarios during the discussion of clinical tasks with mandatory visualization of ultrasound video recordings is described. The applicants’ digital skills are directly related to the course being studied and are necessary to master the proposed professional field. The possibility of learning using the latest medical equipment in combination with the use of digital learning tools and video resources contributes to the acquisition of professional competence and the formation of responsibility and interest of students. In the process of training manual scanning skills, the doctor’s thinking and the ability to analyze and interpret the received ultrasound data are formed. Practical classes help to discuss the most interesting issues for this specific group of higher education applicants in a comfortable and trusting environment. The use of a combined approach in the presentation of the material, the author’s style and the format of the transfer of professional skills by experienced teachers who are engaged in constant practical activities motivate, improve the training process and give a high result.","PeriodicalId":21003,"journal":{"name":"Reproductive health of woman","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135357894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modern approach to transfusion therapy of massive hemorrhage due to abnormally invasive placenta","authors":"О.V. Golyanovskiy, D.О. Dzyuba, О.V. Morozova, T.V. Gerasimova, O.A. Voloshyn, I.M. Golenia, O.P. Kononets","doi":"10.30841/2708-8731.5.2023.286768","DOIUrl":"https://doi.org/10.30841/2708-8731.5.2023.286768","url":null,"abstract":"Abnormally invasive placenta (AIP), or according to modern terminology PAS (placenta accrete spectrum disorders), is one of the most dangerous obstetric pathologies of pregnancy. It is quite often accompanied by massive blood loss during childbirth. Indicators of placenta accretion are increasing sharply, taking into account the frequency of delivery by cesarean section (CS).The objective: to determine the effectiveness of the blood loss recovery program in the case of delivery of pregnant women with AIP according to modern principles of transfusion therapy of massive blood loss with the use of innovative methods of surgical hemostasis.Materials and methods. At the clinical bases of the Department of Obstetrics and Gynecology N 1 of the Shupyk National Healthcare University of Ukraine during 2018–2023, 49 pregnant women with Placenta рercreta 3a,b were operated by fundal SC.The main group included 19 pregnant women with antenatally diagnosed Placenta percreta, who were delivered by fundal SC followed by hysterectomy with fallopian tubes and restoration of blood loss according to the principles of Damage Control Resuscitation – DCR (during 2021–2023) with priority given to transfusion with blood products with minimization infusion therapy; the comparison group included 30 pregnant women with a similar diagnosis and surgical approach, who had the recovery of massive blood loss in accordance with order No. 205 of the Ministry of Health of Ukraine “Obstetric bleeding” with the priority of rapid infusion therapy with crystalloids (2018-2020).Results. All pregnant women from Pl. percreta were delivered by CS and had hysterectomy at 35–37 weeks of pregnancy with lower median laparotomy and endotracheal anesthesia. The study groups did not differ in terms of the volume of surgery, but differed in the program of transfusion therapy to restore blood loss.In the main group, in which the early start of transfusion therapy using single-group fresh-frozen plasma and erythrocyte mass was applied, a significantly lower frequency of the development of the syndrome of disseminated intravascular blood coagulation, relaparotomy, cases of severe postoperative anemia and a shorter length of stay in the obstetric hospital were determined (p<0.05).Conclusions. The use of innovative surgical technologies, tranexamic acid preparations and early initiation of transfusion therapy with blood preparations with minimization of crystalloid infusion, according to the Damage Control Resuscitation strategy, in the development of massive intraoperative bleeding in cases of Placenta percreta allows to reduce the volume of blood loss and to prevent severe intra- and postoperative complication.","PeriodicalId":21003,"journal":{"name":"Reproductive health of woman","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135357898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current global trends in the study of etiology, pathogenesis, diagnosis and treatment of chronic endometritis","authors":"N.V. Kosei, T.F. Tatarchuk, N.V. Vetokh, L.A. Vasylchenko","doi":"10.30841/2708-8731.5.2023.286763","DOIUrl":"https://doi.org/10.30841/2708-8731.5.2023.286763","url":null,"abstract":"The article is devoted to the analysis of scientific information on the problem of chronic endometritis (CE) today. CE is a mysterious, multifactorial disease, the etiology, pathogenesis, and optimal treatment of which have not yet been definitively determined.Endometrial inflammation is a complex part of its physiology that is finely regulated by the balance between pro- and anti-inflammatory mechanisms and is involved in all reproductive events.Chronic inflammation stimulates hormone-independent cell proliferation, suppression of apoptosis processes, activation of tumor growth factors, invasion, tumor angiogenesis, and neovasculogenesis. The transformation of the inflammatory process occurs due to chronic leukocyte infiltration. The chronic inflammatory process provokes the development of dystrophic changes in the epithelium, the infiltration of the stroma by leukocytes and the destruction of intercellular contacts, which, in turn, leads to a decrease in the hermetic function of the epithelium and a violation of the differentiation of epithelial cells during the process of metaplasia. This process is accompanied by a disturbance of local humoral immunityMetabolic disorders such as diabetes, dyslipidemia, hypertension, and obesity have also been found to overactivate the immune system, causing leukocyte activation with increased numbers of their proinflammatory phenotypes, which explains the susceptibility to chronic inflammatory diseases.Infectious agents should no longer be considered the sole cause of CE. Any condition that disrupts the balance of the immune system can lead to temporary, recurrent, or persistent CE. The last one can have various dangerous clinical and paraclinical consequences.To date, there are no recommendations that would provide proper analysis or treatment of endometrial inflammation. Therefore, the definition of clinical signs for the assessment of the global risk of development of CE for female patients is relevant. The clinical assessment of the patient’s condition should take into account her age, lifestyle, body mass index, blood pressure, atopy, stress factor, signs of chronic inflammation, as well as history of diseases mediated by inflammation.Further research into this pathological condition and the development of effective ways to prevent it are particularly relevant, which can contribute to the improvement of women’s reproductive health and their fertility.","PeriodicalId":21003,"journal":{"name":"Reproductive health of woman","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135358115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peculiarities of the vagina microbiome and functional activity of epithelial cells in cervical intraepithelial neoplasia of the cervix in women of perimenapausal age","authors":"V. O. Beniuk, V.M. Goncharenko, T.G. Laskava, O. Shcherba, L. Lastovetska, T. R. Nykoniuk, I. Maidannyk, Y.I. Veretelnyk","doi":"10.30841/2708-8731.4.2023.285767","DOIUrl":"https://doi.org/10.30841/2708-8731.4.2023.285767","url":null,"abstract":"According to the data of the National Cancer Registry of Ukraine for 2021, the incidence of cervical cancer was 17.9 and the mortality rate was 7.9 per 100,000 female population. Therefore, in modern conditions, timely diagnosis, effective treatment and prevention of precancerous processes, which include cervical intraepithelial neoplasia (CIN) of the cervix, is one of the important tasks of a gynecologist. Women in perimenopause, who are traditionally considered to be at risk, deserve special attention.Today, there is information in the literature that multifactorial diseases account for 90–95% of all diseases, including cervical cancer. Epidemiological factors associated with human papillomavirus (HPV) prevalence are well known. The role of microbial-protozoan-viral associations in contributing to the occurrence of intraepithelial lesions and cervical cancer is being actively investigated.The objective: to assess the state of microbiocenosis and the functional activity of epithelial cells in perimenopausal women with recurrent CIN of the cervix.Materials and methods. 60 women of perimenopausal age with recurrent CIN of the cervix, which occurred after treatment with surgical methods (main group) and 38 healthy women of the appropriate age (control group) were examined. All patients were examined in accordance with the regulatory orders of the Ministry of Health of Ukraine, immunological studies, as well as determination of the electrokinetic activity of epithelial cells of the vagina and cervix according to the method of V. I. Shakhbazov in modification of V. O. Beniuk and co-authors.Results. The data of the anamnesis and clinical examination of the patients were evaluated, which allows to identify a risk group among women of perimenopausal age, according to the development of recurrent CIN of the cervix. During the study of the species composition of the vaginal microbiome in patients of the main group, a decrease in the number or complete absence of lactobacilli, a predominance of opportunistic vaginal flora in the cases with HPV infection was established. Peptostreptococci were found in 46.7 %, corynebacterial – in 61.7%, epidermal staphylococcus – in 66.7%, gardnerella – in 53.3%, Candida spp. – in 46.7% of cases and some specific pathogens versus the control group (7.9%, 23.7%, 10.5%, 15.8%, 5.3%, respectively). Also, in the main group, a significant decrease in the level of interferon-α (IFN) by 1.6 and IFN-γ by 1.9 times in blood serum was found.Studies of the electrokinetic activity of the epithelial cells of the vagina and cervix revealed a decrease of more than 2 times the corresponding indicators in the main group compared to the control group.Conclusions. In perimenopausal women with recurrent CIN of the cervix, profound violations of the vaginal microbiocenosis with the predominance of opportunistic flora, as well as insufficiency of interferonogenesis, decreased functional activity of epithelial cells, were determined.In general, ","PeriodicalId":21003,"journal":{"name":"Reproductive health of woman","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88664996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}