Pediatric Discovery最新文献

Human papillomavirus vaccine delivery practices among pediatricians and pediatric trainees in a tertiary hospital in Singapore 新加坡一家三级医院的儿科医生和儿科实习生接种人类乳头瘤病毒疫苗的做法

Pediatric Discovery Pub Date : 2024-07-26 DOI: 10.1002/pdi3.102

Grace Yan Ling Ler, Sudipta Roy Chowdhury

{"title":"Human papillomavirus vaccine delivery practices among pediatricians and pediatric trainees in a tertiary hospital in Singapore","authors":"Grace Yan Ling Ler, Sudipta Roy Chowdhury","doi":"10.1002/pdi3.102","DOIUrl":"https://doi.org/10.1002/pdi3.102","url":null,"abstract":"Human Papillomavirus (HPV) is the most common sexually transmitted infection and is associated with cervical, anogenital, and oropharyngeal cancers. It is crucial to improve vaccination uptake in both genders as primary prevention for these conditions. Pediatricians play an active role in advocating for HPV vaccination and our study aims to assess the level of knowledge, attitudes, barriers, and practices among pediatric trainees and general pediatricians regarding HPV infection and vaccination. A survey‐questionnaire was administered to our target groups. It comprised 14 questions regarding demographics of the healthcare provider, knowledge of HPV infection and vaccination, practices and barriers of recommending HPV vaccination, and effective strategies for improving HPV vaccine uptake. Among survey respondents, majority did not recommend for HPV vaccination (66.7%) or receive any enquiry about it (80.6%) within the preceding 12 months. The most common perceived barrier was inadequate knowledge, which was consistent with the misconceptions regarding HPV infection and vaccination that were identified in this survey. Strategies which physicians felt would be most effective in increasing vaccine uptake include educating and providing resources for both physicians and caregivers as well as making the vaccine free. Our study revealed a low advocacy rate for HPV vaccination. Physicians need to be equipped with the knowledge, skills, and resources to better counsel caregivers as well as focus our efforts on vaccinating male patients in order to increase vaccine uptake in both genders.","PeriodicalId":209836,"journal":{"name":"Pediatric Discovery","volume":"34 35","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141800491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of respiratory microflorae colonization on short and long‐time outcomes of respiratory syncytial virus infection in children: A scoping review 呼吸道微生物定植对儿童呼吸道合胞病毒感染短期和长期结果的影响：范围界定综述

Pediatric Discovery Pub Date : 2024-07-16 DOI: 10.1002/pdi3.97

Lidan Gan, Enmei Liu, Yu Deng

{"title":"Effect of respiratory microflorae colonization on short and long‐time outcomes of respiratory syncytial virus infection in children: A scoping review","authors":"Lidan Gan, Enmei Liu, Yu Deng","doi":"10.1002/pdi3.97","DOIUrl":"https://doi.org/10.1002/pdi3.97","url":null,"abstract":"Respiratory syncytial virus (RSV) is an essential cause of lower respiratory tract infection in children under 2 years of age, especially under 6 months. In decades, studies have shown that the respiratory tract microflorae with RSV infection were related to disease severity and played a role in the development of recurrent wheezing, but the effect of respiratory microflorae on RSV infection are still underestimated. This study aims to conclude the effect of respiratory microflorae colonization on RSV infectious disease severity and recurrent wheezing and provide suggestions for future research directions from the perspective of respiratory tract florae. We conducted a scoping review. Studies were eligible if they reported on the effect of microflorae on RSV infectious diseases among children. We exacted the following information: title, publication time, first author's country, and article type. We finally included 33 articles in this scoping review. The number of studies rapidly increased since 2013 and the highest number of hospitalizations were reported in children <2 years. More than half (69.70%) were conducted in America and most studies are original studies (57.58%). The Review highlighted that the respiratory microflorae played an important role in RSV infectious disease severity and recurrent wheezing. We found that Streptococcus pneumoniae (S.pn), Haemophilus influenza (HI), Moraxella catarrhalis (M.ca), and Staphylococcus aureus (SA) were the dominant profiles in children with RSV infection. Understanding the respective role of respiratory microflorae on RSV infection and its mechanisms would improve prevention and treatment strategies from the perspective of microflorae.","PeriodicalId":209836,"journal":{"name":"Pediatric Discovery","volume":" 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141832251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Newly formed and ruptured infectious intracranial aneurysm in few days following first intracranial aneurysm embolization concurrent with middle cerebral artery occlusion: A regrettable case in a baby child 首次颅内动脉瘤栓塞术并发大脑中动脉闭塞术后数天内新形成并破裂的感染性颅内动脉瘤：一个令人遗憾的婴儿病例

Pediatric Discovery Pub Date : 2024-06-04 DOI: 10.1002/pdi3.80

Yunying Yang, Hongtu Ma, Hui Hu, Lusheng Li, Jun Tang

{"title":"Newly formed and ruptured infectious intracranial aneurysm in few days following first intracranial aneurysm embolization concurrent with middle cerebral artery occlusion: A regrettable case in a baby child","authors":"Yunying Yang, Hongtu Ma, Hui Hu, Lusheng Li, Jun Tang","doi":"10.1002/pdi3.80","DOIUrl":"https://doi.org/10.1002/pdi3.80","url":null,"abstract":"Infectious intracranial aneurysm (IIA) and embolic cerebral infarction are well‐known devastating complications of children suffering infective endocarditis. In this report, we describe a successfully embolized IIA concurrent with bilateral middle cerebral artery (MCA) occlusion. Unfortunately, a newly formed IIA located in the contralateral MCA bifurcation ruptured at the seventh day following embolization. A 6‐month‐old female child was admitted to hospital 3 days following acute right limb mobility disorder. An interventional surgery history of congenital heart disease was confirmed. She was immediately started on antibiotic therapy and the computed tomography agiography (CTA) scan showed occlusion of the upper branch of the left MCA. Unfortunately an IIA was located in the distal artery region (DAR) of the ipsilateral anterior cerebral artery. Angiography (digital subtraction angiography) was performed and the DAR IIA was embolized by OnyX‐18 with Magic 1.2 Fr. microcatheter. On the sixth day, magnetic resonance imaging during the hospital stay showed reduced infarction area with no other special sign. Desperately, a major seizure with opisthotonos attacked the baby on the seventh day after embolization. An immediate CTA scan showed massive hematoma in the right basal ganglia and a ruptured bifurcate aneurysm of the right MCA. The parents refused positive treatment and discharged in considering the critical situation. It should be noted that IIA can be fast formed anywhere in cerebral artery and dynamic angio‐image should be performed as supervision.","PeriodicalId":209836,"journal":{"name":"Pediatric Discovery","volume":"10 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141266437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neonatal hepatitis B vaccination: Reevaluating timing and adjuvants for enhanced safety and effectiveness 新生儿乙型肝炎疫苗接种：重新评估时间和佐剂以提高安全性和有效性

Pediatric Discovery Pub Date : 2023-12-11 DOI: 10.1002/pdi3.47

Aleksandar Cirovic, A. Ćirović, A. Ivanovski, P. Ivanovski

{"title":"Neonatal hepatitis B vaccination: Reevaluating timing and adjuvants for enhanced safety and effectiveness","authors":"Aleksandar Cirovic, A. Ćirović, A. Ivanovski, P. Ivanovski","doi":"10.1002/pdi3.47","DOIUrl":"https://doi.org/10.1002/pdi3.47","url":null,"abstract":"Our aim is an achievement of a 100 percent vaccination rate without toxic vaccine effects. We did a comprehensive literature review on aluminum neurotoxicity and early neonatal hepatitis B vaccination. We analyzed indications for introduction of early neonatal hepatitis B vaccination and the data on experimental and clinical aluminum‐induced neurotoxicity. It is justified very early hepatitis B vaccination to be carried out in high‐risk endemic areas. In those countries there is a large number of hepatitis B positive individuals, including pregnant women, which leads to a great number of vertical, mother‐to‐child, transmissions of the virus during pregnancy. There is also a serious risk of perinatal Hepatitis B virus infections in such countries. Early neonatal hepatitis B vaccination is also carried out in low‐risk countries, where the number of hepatitis B positive pregnant women is extremely small, making the number of newborns who require the prevention of hepatitis B infection extremely small as well. It is necessary for all vaccines which contain aluminum as an adjuvant to be immediately suspended as children vaccination until they start walking and until aluminum is replaced with calcium, zinc or a nonmetallic adjuvant such as microcrystalline tyrosine or monosodium urate. Meanwhile sustained efforts should be made to create the so‐called mucosal vaccines against diphtheria, pertussis, measles, mumps and rubella. At the same time, all the children born to hepatitis B positive mothers, regardless of their place of birth must be vaccinated against hepatitis B as the benefits from vaccines by far outweigh potential harm caused by adjuvant aluminum.","PeriodicalId":209836,"journal":{"name":"Pediatric Discovery","volume":"5 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138979474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of ChatGPT's performance in providing treatment recommendations for pediatric diseases 评估 ChatGPT 在提供儿科疾病治疗建议方面的表现

Pediatric Discovery Pub Date : 2023-11-20 DOI: 10.1002/pdi3.42

Qiuhong Wei, Yanqin Wang, Zhengxiong Yao, Ying Cui, Bo Wei, Tingyu Li, Ximing Xu

{"title":"Evaluation of ChatGPT's performance in providing treatment recommendations for pediatric diseases","authors":"Qiuhong Wei, Yanqin Wang, Zhengxiong Yao, Ying Cui, Bo Wei, Tingyu Li, Ximing Xu","doi":"10.1002/pdi3.42","DOIUrl":"https://doi.org/10.1002/pdi3.42","url":null,"abstract":"With the advance of artificial intelligence technology, large language models such as ChatGPT are drawing substantial interest in the healthcare field. A growing body of research has evaluated ChatGPT's performance in various medical departments, yet its potential in pediatrics remains under‐studied. In this study, we presented ChatGPT with a total of 4160 clinical consultation questions in both English and Chinese, covering 104 pediatric conditions, and repeated each question independently 10 times to assess the accuracy of its responses in pediatric disease treatment recommendations. ChatGPT achieved an overall accuracy of 82.2% (95% CI: 81.0%–83.4%), with superior performance in addressing common diseases (84.4%, 95% CI: 83.2%–85.7%), offering general treatment advice (83.5%, 95% CI: 81.9%–85.1%), and responding in English (93.0%, 95% CI: 91.9%–94.1%). However, it was prone to errors in disease definitions, medications, and surgical treatment. In conclusion, while ChatGPT shows promise in pediatric treatment recommendations with notable accuracy, cautious optimism is warranted regarding the potential application of large language models in enhancing patient care.","PeriodicalId":209836,"journal":{"name":"Pediatric Discovery","volume":"6 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139257668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Importance of early follow‐up of Mycoplasma pneumoniae pneumonia in pediatric patients: A case series 儿科患者肺炎支原体肺炎早期随访的重要性:一个病例系列

Pediatric Discovery Pub Date : 2023-09-07 DOI: 10.1002/pdi3.27

Hua Deng, Qin Xie, Wen-qi Wu

引用次数: 0

Pediatrics in the era of precision medicine and precision epidemiology 精准医学和精准流行病学时代的儿科学

Pediatric Discovery Pub Date : 2023-09-06 DOI: 10.1002/pdi3.28

J. Estill

引用次数: 0

Research progress on risk factors of postoperative functional defecation disorder in anorectal malformation 肛肠畸形术后功能性排便障碍危险因素的研究进展

Pediatric Discovery Pub Date : 2023-08-30 DOI: 10.1002/pdi3.24

C. Xiang, Xiao Xiang, Weigui Feng, Yi Wang

{"title":"Research progress on risk factors of postoperative functional defecation disorder in anorectal malformation","authors":"C. Xiang, Xiao Xiang, Weigui Feng, Yi Wang","doi":"10.1002/pdi3.24","DOIUrl":"https://doi.org/10.1002/pdi3.24","url":null,"abstract":"Anorectal malformation (ARM) is a common congenital gastrointestinal malformation in neonates, which has complex pathological changes and unclear etiology. The only treatment modality currently available for ARMs is through surgical treatment to correct the deformity of the anal morphology and restore normal defecation function. In addition, the mortality rates of children with ARMs have significantly decreased as a result of recent advances in medical technology. It is important to note that despite the treatment of perianal anatomical deformities, approximately one‐third of ARM patients continue to experience functional defecation disorder (FDD), which includes fecal incontinence and constipation and negatively impacts the patient's quality of life. There are still numerous questions regarding the exact cause of FDD in ARM patients following surgery. It is generally accepted that the occurrence of FDD may be related to clinical staging, structural changes in the perianal rectal muscles, anomalies of the enteric nervous system, surgical injury, etc. However, some of these factors are still controversial and require additional study to be confirmed. In this paper, we review the risk factors for FDD following surgery in ARMs, which will help us to subsequently develop appropriate interventions to enhance the anal function and improve quality of life of children with ARMs.","PeriodicalId":209836,"journal":{"name":"Pediatric Discovery","volume":"129 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128774427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maternal SARS‐CoV‐2 infection: The potential vertical transmission of SARS‐CoV‐2 and impact on neonates: A review 母体SARS - CoV - 2感染:SARS - CoV - 2的潜在垂直传播及其对新生儿的影响:综述

Pediatric Discovery Pub Date : 2023-08-22 DOI: 10.1002/pdi3.22

W. Xia, Z. Peng

{"title":"Maternal SARS‐CoV‐2 infection: The potential vertical transmission of SARS‐CoV‐2 and impact on neonates: A review","authors":"W. Xia, Z. Peng","doi":"10.1002/pdi3.22","DOIUrl":"https://doi.org/10.1002/pdi3.22","url":null,"abstract":"Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), a large, lipid‐enveloped, single‐stranded RNA virus, is a highly contagious virus that caused coronavirus disease 2019 (COVID‐19), declared a pandemic by the World Health Organization on March 11, 2020. Pregnant women are usually considered at high risk for infectious diseases, including COVID‐19. Maternal SARS‐CoV‐2 infection can adversely affect the pregnancy and birth outcomes, such as abortion, intrauterine growth restriction, and prematurity. Some meta‐analysis suggested that the outcomes of newborns are different between symptomatic and asymptomatic pregnant women but similar in asymptomatic and SARS‐CoV‐2 negative group. Maternal infection increases the risk of vertical transmission; also the presence of SARS‐CoV‐2 or its RNA in maternal samples in some case reports raised the possibility of intrauterine transmission. Also, contact transmission during delivery and postnatal transmission are discussed. Although most infected newborns are asymptomatic or mildly symptomatic, there are case reports of severe neonatal SARS‐CoV‐2 infection, including cardiorespiratory failure and death. Otherwise, some studies suggested that the COVID‐19 pandemic was associated with a reduction for preterm birth during the pandemic compared with the prepandemic period. We conduct this review to try to make a conclusion about the vertical transmission of SARS‐CoV‐2 and impact on neonates due to Maternal SARS‐CoV‐2 infection.","PeriodicalId":209836,"journal":{"name":"Pediatric Discovery","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123982833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Pediatric Discovery Pub Date : 2023-08-14 DOI: 10.1002/pdi3.25

Chunfeng Mou, Sha Liu, Yetao Luo, Yu Xue, Jia Liu, Dapeng Chen, Xiaoqiang Li, Han Wang

{"title":"Ependymin‐related protein 1 levels are elevated in children with obesity and correlated with metabolic disorders","authors":"Chunfeng Mou, Sha Liu, Yetao Luo, Yu Xue, Jia Liu, Dapeng Chen, Xiaoqiang Li, Han Wang","doi":"10.1002/pdi3.25","DOIUrl":"https://doi.org/10.1002/pdi3.25","url":null,"abstract":"Ependymin‐related protein 1 (EPDR1) has been found in the secretory body of adipocytes where it plays a role in lipid binding, transportation, and catabolism. The aim of this study was to investigate serum EPDR1 levels in children with obesity and normal‐weight children and to compare the levels of EPDR1 between children with obesity, with and without metabolic‐associated fatty liver disease (MAFLD). Thirty‐four normal‐weight children and 49 children with obesity (15 with MAFLD) were included in the study. Circulating EPDR1, IL‐1β, and TNF‐α were measured using enzyme‐linked immunosorbent assays. Anthropometric and biochemical measurements related to obesity, blood lipids, and insulin resistance were performed on all participants. The serum EPDR1 levels of children with obesity were significantly higher than those of the control group. There was no difference in EPDR1 levels between the patients with and without MAFLD. Circulating EPDR1 was positively correlated with body mass index (BMI), BMI z‐score, insulin, glucose, homeostatic model assessment insulin resistance index (HOMA‐IR), triglycerides, white blood cells, and neutrophils. Binary logistic regression analysis showed a significant increase in the odds ratio of obesity with increasing EPDR1 levels. EPDR1 is strongly associated with obesity and may also be associated with metabolic disorders. This trial is registered with ChiCTR2300070951.","PeriodicalId":209836,"journal":{"name":"Pediatric Discovery","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124518772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0