Rejuvenation research最新文献_第9页

Growth Hormone As Antiaging Factor in Old Bones. 生长激素在衰老骨骼中的抗衰老作用。

IF 2.6 4区医学

Rejuvenation research Pub Date : 2021-10-01 Epub Date: 2021-06-04 DOI: 10.1089/rej.2020.2369

Francisco G F Tresguerres, Isabel F Tresguerres, Isabel Leco, Celia Clemente, Rosa Rodríguez-Torres, Jesús Torres, Jorge Carballido, Jesús A F Tresguerres

{"title":"Growth Hormone As Antiaging Factor in Old Bones.","authors":"Francisco G F Tresguerres, Isabel F Tresguerres, Isabel Leco, Celia Clemente, Rosa Rodríguez-Torres, Jesús Torres, Jorge Carballido, Jesús A F Tresguerres","doi":"10.1089/rej.2020.2369","DOIUrl":"https://doi.org/10.1089/rej.2020.2369","url":null,"abstract":"Aging induces changes in bone. Growth hormone (GH) is reduced by aging, and age-related changes observed in old bones might be due to a decrease in the GH/insulin-like growth factor-I (IGF-I) axis. GH administration on aged individuals is controversial. This study aimed to assess the effect of systemic GH treatment on bone properties, bone metabolism, and bone mineral density (BMD) in long bone of old rats. Aged Wistar rats were treated with GH at a dose of 2 mg/kg/day during 10 weeks. Plasma osteocalcin, IGF-I, and carboxy-terminal telopeptide of type I collagen levels were measured. Cross-sectional bone areas and BMD were measured by morphometric and densitometric analysis, respectively. Femora were analyzed by three point-bending testing. t-Test was used for statistical evaluation. p < 0.05 was considered to be significant. Significantly enhanced bone area, at the expense of the cortical area, was found in treated rats. The densitometric analysis showed 11% higher BMD in the experimental group. Significantly higher bone flexural modulus, stiffness, and ultimate load were observed in the treated rats. Plasma osteocalcin and IGF-I levels were significantly increased in the treated group, while the resorption marker concentration remained unchanged. Within the limitations of this experimental study, systemic GH administration has shown to enhance biomechanical properties, BMD, cortical mass, and plasma IGF-I and osteocalcin in old treated rats, compared to the control group; consequently, GH could be considered as an alternative therapy against age-related changes in the bone.","PeriodicalId":20979,"journal":{"name":"Rejuvenation research","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38914012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Ageism Among Physicians and Nurses in Russia. 俄罗斯医生和护士的年龄歧视。

IF 2.6 4区医学

Rejuvenation research Pub Date : 2021-08-01 Epub Date: 2021-04-12 DOI: 10.1089/rej.2020.2376

Boris Punchik, Olga Tkacheva, Nadezda Runikhina, Natalya Sharashkina, Valentina Ostapenko, Tali Samson, Tami Freud, Yan Press

{"title":"Ageism Among Physicians and Nurses in Russia.","authors":"Boris Punchik, Olga Tkacheva, Nadezda Runikhina, Natalya Sharashkina, Valentina Ostapenko, Tali Samson, Tami Freud, Yan Press","doi":"10.1089/rej.2020.2376","DOIUrl":"https://doi.org/10.1089/rej.2020.2376","url":null,"abstract":"The phenomenon of ageism has been studied extensively in the Western world, but there is only a small number of studies among medical staff in Russia. The aim of this study was to assess the prevalence of ageism and to identify variables that can explain ageism in a sample of physicians and nurses in Russia. This is a prospective cross-sectional study of physicians and nurses who participated in a training course in the years 2016-2018 in Russia. Data collected before the start of training included the Fraboni scale of ageism (FSA) questionnaire, and sociodemographic characteristics including age, gender, profession, professional seniority, place of work, and number of older adults treated by the study participant over the past half year. In total, 903 physicians and nurses participated in the study. The mean FSA score was 2.75 ± 0.49, which indicates a moderate degree of ageism. There was a trend to higher scores among nurses compared with physicians (2.78 ± 0.50 vs. 2.76 ± 0.48, p < 0.465). There was a weak, but statistically significant, correlation between ageism and age (r = 0.157, p < 0.0001), professional seniority (r = 0.098, p < 0.003), and the number of older adult patients treated by the participant over the prior half year (r = 0.075, p < 0.025). There were no differences in other characteristics including gender, profession, work setting, or serving as main caregiver for a family member and the magnitude of ageism. The phenomenon of ageism exists among physicians and nurses in Russia. Older participants with greater professional seniority and a larger number of older patients had stronger ageism attitudes.","PeriodicalId":20979,"journal":{"name":"Rejuvenation research","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25473929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

The Potential Role of Airways Periostin in the Clinical Practice of Patients Affected by Idiopathic Pulmonary Fibrosis. 气道骨膜蛋白在特发性肺纤维化患者临床中的潜在作用。

IF 2.6 4区医学

Rejuvenation research Pub Date : 2021-08-01 Epub Date: 2021-05-04 DOI: 10.1089/rej.2020.2401

Giovanna Elisiana Carpagnano, Piera Soccio, Giulia Scioscia, Grazia Pia Palladino, Maria Pia Foschino Barbaro, Donato Lacedonia

{"title":"The Potential Role of Airways Periostin in the Clinical Practice of Patients Affected by Idiopathic Pulmonary Fibrosis.","authors":"Giovanna Elisiana Carpagnano, Piera Soccio, Giulia Scioscia, Grazia Pia Palladino, Maria Pia Foschino Barbaro, Donato Lacedonia","doi":"10.1089/rej.2020.2401","DOIUrl":"https://doi.org/10.1089/rej.2020.2401","url":null,"abstract":"Idiopathic pulmonary fibrosis (IPF) is a chronic debilitating fibrotic lung disease leading to respiratory failure and ultimately to death. Noninvasive biomarkers, for the early diagnosis, differential diagnosis, prognosis, and prediction of therapeutic response, are needed. Previous studies support a role for periostin in lung fibrosis. The aim of our study was to analyze periostin levels in the airways of patients with IPF and to investigate its role as a useful predictive biomarker of the disease. We enrolled 30 IPF patients and 5 control subjects. All subjects underwent all standard radiological, functional, and biological examinations for IPF diagnosis and staging and exhaled breath condensate (EBC) collection. Periostin was assessed by an enzyme-linked immunosorbent assay kit on EBC. Periostin was dosable in the EBC of all subjects enrolled. We found higher exhaled periostin levels in IPF patients than healthy controls (65.5 ± 23.5 pg/mL vs. 33 ± 21.4 pg/mL, p < 0.05). Moreover, in receiver operating characteristic analysis, the clinical reference value of periostin was 37.88 pg/mL to discriminate patients with IPF from healthy subjects, with the area under the curve of 0.8815. There was no significant correlation between periostin levels and gender or pulmonary function tests. These preliminary results support our working hypothesis that periostin is dosable in the airways of patients with IPF. As the circulating periostin, also airways periostin may be a potential biomarker to support IPF diagnosis and to monitor disease progression during follow-up.","PeriodicalId":20979,"journal":{"name":"Rejuvenation research","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25502916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Red Blood Cell Distribution Width Trajectory During a Multicomponent Exercise in Hospitalized Older Adults: A Secondary Analysis of a Randomized Clinical Trial. 住院老年人多组分运动期间红细胞分布宽度轨迹:一项随机临床试验的二次分析

IF 2.6 4区医学

Rejuvenation research Pub Date : 2021-08-01 Epub Date: 2021-04-16 DOI: 10.1089/rej.2020.2405

Nicolás Martínez-Velilla, Robinson Ramírez-Vélez, Mikel L Sáez de Asteasu, Fabricio Zambom-Ferraresi, Antonio García-Hermoso, Itxaso Marín-Epelde, Mikel Izquierdo

引用次数: 3

Topical Erythropoietin Accelerates Wound Closure in Patients with Diabetic Foot Ulcers: A Prospective, Multicenter, Single-Blind, Randomized, Controlled Trial. 局部促红细胞生成素加速糖尿病足溃疡患者伤口愈合:一项前瞻性、多中心、单盲、随机对照试验。

IF 2.6 4区医学

Rejuvenation research Pub Date : 2021-08-01 Epub Date: 2021-04-01 DOI: 10.1089/rej.2020.2397

Saher Hamed, Yehuda Ullmann, Mark Belokopytov, Aziz Shoufani, Hoda Kabha, Suher Masri, Zeev Feldbrin, Leonid Kogan, Danny Kruchevsky, Roger Najjar, Paul Y Liu, Jean-Charles Kerihuel, Sadanori Akita, Luc Teot

{"title":"Topical Erythropoietin Accelerates Wound Closure in Patients with Diabetic Foot Ulcers: A Prospective, Multicenter, Single-Blind, Randomized, Controlled Trial.","authors":"Saher Hamed, Yehuda Ullmann, Mark Belokopytov, Aziz Shoufani, Hoda Kabha, Suher Masri, Zeev Feldbrin, Leonid Kogan, Danny Kruchevsky, Roger Najjar, Paul Y Liu, Jean-Charles Kerihuel, Sadanori Akita, Luc Teot","doi":"10.1089/rej.2020.2397","DOIUrl":"https://doi.org/10.1089/rej.2020.2397","url":null,"abstract":"The diabetic foot ulcer (DFU) is a major disabling complication of diabetes mellitus. Growing evidence suggests that topical erythropoietin (EPO) can promote wound healing. The aim of this study is to clinically assess the efficacy of a proprietary topical EPO-containing hydrogel for treating DFUs. We conducted a randomized, controlled trial in 20 patients with DFUs. After a 14-day screening period, the DFUs of 20 eligible participants who fulfilled the inclusion criteria were randomly assigned (1:1) to either a 12-week of daily treatment with topical EPO and standard-of-care (SOC) or SOC treatment alone. The DFUs were assessed weekly until week 12. The primary outcome was 75% ulcer closure or higher. After 12 weeks of treatment, 75% ulcer closure was achieved in 6 of the 10 patients whose DFUs were treated with topical EPO and in one of the 8 patients whose DFUs were treated with SOC alone. The mean area of the DFUs that were treated with topical EPO and SOC was significantly smaller than those treated with SOC alone (1.2 ± 1.4 cm2 vs. 4.2 ± 3.4 cm2; p = 0.023). Re-epithelialization was faster in the topically EPO-treated DFUs than in the SOC-treated DFUs. There were no treatment-related adverse events. We conclude that topical EPO is a promising treatment for promoting the healing of DFUs. Clinical Trial Registration number: NCT02361931.","PeriodicalId":20979,"journal":{"name":"Rejuvenation research","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38867272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Response to Hypoxia in Cognitive Decline. 认知衰退患者对缺氧的反应。

IF 2.6 4区医学

Rejuvenation research Pub Date : 2021-08-01 DOI: 10.1089/rej.2021.0051

James W Larrick, Jasmine W Larrick, Andrew R Mendelsohn

{"title":"Response to Hypoxia in Cognitive Decline.","authors":"James W Larrick, Jasmine W Larrick, Andrew R Mendelsohn","doi":"10.1089/rej.2021.0051","DOIUrl":"https://doi.org/10.1089/rej.2021.0051","url":null,"abstract":"Inflammaging, the increase of proinflammatory processes with increasing age, has multiple mechanisms from increasing numbers of senescent cells secreting cytokines to changes in metabolic processes. Alterations of oxygen metabolism with aging, especially decreased levels of O2 with age resulting from endocrine and cardiovascular dysfunction as well as desensitization of cellular response to hypoxia, may exacerbate inflammaging, which in turn creates further oxygen metabolic dysfunction. During aging, decline in levels of erythrocyte 2,3-bisphosphoglycerate (2,3-BPG), BPG mutase, and adenosine A2B receptor, a key adenosine signaling receptor that can augment 2,3-BPG expression, may fail to protect sensitive brain tissue from subtly reduced O2 levels, in turn resulting in increased numbers of activated microglia and secretion of proinflammatory cytokines, ultimately promoting inflammaging and senescence of endothelial cells. Interventions to restore O2 levels directly or via increasing 2,3-BPG may help promote cognitive health in old age, but significant work to quantify the degree of reduced O2 during aging in mammals, and especially humans, needs to be pursued.","PeriodicalId":20979,"journal":{"name":"Rejuvenation research","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39227641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Ameliorate HaCaT Cell Photo-Aging. 脐带间充质干细胞衍生外泌体改善HaCaT细胞光老化。

IF 2.6 4区医学

Rejuvenation research Pub Date : 2021-08-01 Epub Date: 2021-05-06 DOI: 10.1089/rej.2020.2313

Shi-Jie Liu, Ming-Yao Meng, Shen Han, Hui Gao, Yi-Yi Zhao, Yang Yang, Zhu-Ying Lin, Li-Rong Yang, Kai Zhu, Rui Han, Wen-Wen Huang, Run-Qing Wang, Li-Li Yang, Wen-Ju Wang, Lin Li, Xiao-Dan Wang, Zong-Liu Hou, Li-Wei Liao, Li Yang

{"title":"Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Ameliorate HaCaT Cell Photo-Aging.","authors":"Shi-Jie Liu, Ming-Yao Meng, Shen Han, Hui Gao, Yi-Yi Zhao, Yang Yang, Zhu-Ying Lin, Li-Rong Yang, Kai Zhu, Rui Han, Wen-Wen Huang, Run-Qing Wang, Li-Li Yang, Wen-Ju Wang, Lin Li, Xiao-Dan Wang, Zong-Liu Hou, Li-Wei Liao, Li Yang","doi":"10.1089/rej.2020.2313","DOIUrl":"https://doi.org/10.1089/rej.2020.2313","url":null,"abstract":"Umbilical cord mesenchymal stem cells (UCMSCs) have been identified as a potentially ideal cell type for use in regenerative therapeutic contexts owing to their excellent paracrine secretory abilities and other desirable properties. Previous work has shown that stem cell-derived exosomes can effectively reduce skin aging, but few studies have specifically focused on the role of UCMSC-derived exosomes in this context. In this study, we isolated exosomes derived from UCMSCs grown in a three-dimensional culture system and explored their ability to modulate the photo-aging of HaCaT keratinocytes. Cell viability and proliferation were assessed using CCK8 assay, whereas wound healing and transwell assays were used to assess cell migratory capabilities. UVB irradiation (60 mJ/cm2) was used to induce photo-aging of HaCaT cells. TUNEL and SA-β-Gal staining were used to explore HaCaT cell apoptosis and senescence, respectively, whereas real-time quantitative PCR was used to assess the expression of relevant genes at the mRNA level. We found that UCMSC-derived exosomes were able to enhance normal HaCaT cell proliferation and migration while also inhibiting UVB-induced damage to these cells. These exosomes also reduced HaCaT cell apoptosis and senescence, increasing collagen type I expression and reducing matrix metalloproteinase (MMP1) expression in photo-aged HaCaT cells. Together, these findings indicate that UCMSC-derived exosomes have the potential to be used therapeutically to suppress skin aging.","PeriodicalId":20979,"journal":{"name":"Rejuvenation research","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25391097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

Gazing Long into a Clinical and Social Abyss? Treating Hypertrophic Scarring and Keloids. 长期凝视临床和社会的深渊?治疗增生性瘢痕和瘢痕疙瘩。

IF 2.6 4区医学

Rejuvenation research Pub Date : 2021-08-01 Epub Date: 2021-07-08 DOI: 10.1089/rej.2021.0037

Alison R Carter, Benjamin M Davies, David A Brindley