Inflammation [Working Title]最新文献

Antiphospholipid Syndrome and Pregnancy-Diagnosis, Complications and Management: An Overview 抗磷脂综合征和妊娠-诊断，并发症和管理:概述

Inflammation [Working Title] Pub Date : 2021-08-31 DOI: 10.5772/intechopen.99283

P. Tsikouras, Christina Tsiggalou, A. Bothou, A. Gerede, I. Apostolou, F. Gaitatzi, A. Chalkidou, X. Anthoulaki, S. Michalopoulos, G. Dragoutsos, Ioannis Tsirkas, I. Babageorgaka, Theopi Nalbanti, Natalia Sachnova, A. Alexiou, K. Nikolettos, C. Tsalikidis, S. Zervoudis, P. Peitsidis, N. Nikolettos

{"title":"Antiphospholipid Syndrome and Pregnancy-Diagnosis, Complications and Management: An Overview","authors":"P. Tsikouras, Christina Tsiggalou, A. Bothou, A. Gerede, I. Apostolou, F. Gaitatzi, A. Chalkidou, X. Anthoulaki, S. Michalopoulos, G. Dragoutsos, Ioannis Tsirkas, I. Babageorgaka, Theopi Nalbanti, Natalia Sachnova, A. Alexiou, K. Nikolettos, C. Tsalikidis, S. Zervoudis, P. Peitsidis, N. Nikolettos","doi":"10.5772/intechopen.99283","DOIUrl":"https://doi.org/10.5772/intechopen.99283","url":null,"abstract":"Antiphospholipid syndrome which is also known as APS is an autoimmune disease which represents an acquired form of thrombophilia. The etiology of APS remains unknown. This disorder occurs when the immune system mistakenly attacks some of the normal human proteins and manifests itself as recurrent arterial or venous thrombosis and it could emerge after abortions or in recurrent pregnancy loss. In APS, the body produces the wrong antibodies against phospholipid-binding proteins, that is present in the blood and plays an important role in coagulation. Antibodies are specific proteins that usually target and neutralize the body’s invaders, such as viruses and bacteria. When antibodies attack phospholipid-binding proteins, blood clots abnormally. Specifically, it could cause blood clots in veins or arteries leading to stroke and various pregnancy complications such as: endometrial death, miscarriage, preeclampsia, intrauterine growth restriction and prematurity. APS is divided into primary and secondary, which is associated with autoimmune diseases and more often with systemic lupus erythematosus (SLE), while antibodies against cardiolipin are detected in many other conditions (infections, malignancies, drugs, etc.). The symptoms of APS, in addition to arterial and/or venous thrombosis and pregnancy complications, are multisystemic and the differential diagnosis of the primary APS from the secondary, in the context of SLE, is of particular clinical interest and is subject of this literature review.","PeriodicalId":208204,"journal":{"name":"Inflammation [Working Title]","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127801738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inflammation in the Pathogenesis of Rheumatoid Arthritis and in Experimental Arthritis: Evaluation of Combinations of Carnosic Acid and Extract of Rhodiola rosea L. with Methotrexate 类风湿关节炎发病机制中的炎症及实验性关节炎:鼠尾草酸、红景天提取物与甲氨蝶呤联合应用的评价

Inflammation [Working Title] Pub Date : 2021-08-09 DOI: 10.5772/intechopen.99073

S. Poništ, K. Pružinská, K. Bauerová

{"title":"Inflammation in the Pathogenesis of Rheumatoid Arthritis and in Experimental Arthritis: Evaluation of Combinations of Carnosic Acid and Extract of Rhodiola rosea L. with Methotrexate","authors":"S. Poništ, K. Pružinská, K. Bauerová","doi":"10.5772/intechopen.99073","DOIUrl":"https://doi.org/10.5772/intechopen.99073","url":null,"abstract":"The host immune response generates the pro-inflammatory immune response as a protective measure against invading pathogens, allergens, and/or trauma. However, dysregulated and chronic inflammation may result in secondary damage to tissues and immune pathology to the host. Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease which primarily involves synovial inflammation, joint pain, immobility, and stiffness. Increased infiltration of inflammatory immune cells and fibroblast-like synoviocytes into joints, form pannus and small blood vessels that lead to synovium and cartilage destruction. In this chapter we will focus on the role of inflammatory cytokines (IL-1β, IL-6 and IL-17), chemokine monocyte chemotactic protein-1 and matrix metalloproteinase-9 in the pathogenesis of experimental arthritis in animals and in human RA. Further, we will be discussing about methotrexate’s (cornerstone of anti-rheumatic therapy) immune suppressing activity, anti-inflammatory properties of carnosic acid and extract of Rhodiola rosea L., and their innovative combination treatments with methotrexate in rat adjuvant arthritis.","PeriodicalId":208204,"journal":{"name":"Inflammation [Working Title]","volume":"152 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114110735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Helminth Induced Immunomodulation against Metainflammation and Insulin Resistance 蠕虫诱导的免疫调节对坏疽和胰岛素抵抗的影响

Inflammation [Working Title] Pub Date : 2021-07-20 DOI: 10.5772/INTECHOPEN.98230

V. Aravindhan, Sibi Joy Manohar

引用次数: 0

Celiac Disease 乳糜泻

Inflammation [Working Title] Pub Date : 2021-07-14 DOI: 10.5772/intechopen.97834

Nour Amin Elsahoryi

引用次数: 0

Islet Inflammation: The Link between Type 2 Diabetes and Pancreatic Cancer 胰岛炎症:2型糖尿病和胰腺癌之间的联系

Inflammation [Working Title] Pub Date : 2021-06-14 DOI: 10.5772/intechopen.98538

Alpana Mukhuty

{"title":"Islet Inflammation: The Link between Type 2 Diabetes and Pancreatic Cancer","authors":"Alpana Mukhuty","doi":"10.5772/intechopen.98538","DOIUrl":"https://doi.org/10.5772/intechopen.98538","url":null,"abstract":"The role of islet inflammation in type 2 diabetes (T2DM) and pancreatic ductal adenocarcinoma (PDAC) is complex. About 80% of pancreatic cancer patients have glucose intolerance or T2D. Chronic type 2 diabetes increases risk for pancreatic cancer, but the mechanisms are unknown. In this context two hypotheses exist: (i) pancreatic cancer causes diabetes and (ii) diabetes promotes the development of pancreatic cancer. Pancreatic ductal adenocarcinoma is the most common and deadly form of pancreatic cancer that is associated with diabetes. There are many possibilities by which obesity links to pancreatic cancer. These possibilities include insulin resistance, hyperinsulinemia and inflammation. Adipose tissue deposition near pancreas (peri-pancreatic depot) increase proinflammatory response to a high fat or high calorie containing diet. Inflammatory processes in the islets act as main mediators during the development and progression of pancreatic cancer. Recently, studies have been carried out to investigate the underlying mechanisms that contribute to tumorigenesis induced by inflammation. Tumor-elicited inflammation, secretion of pro-inflammatory cytokines and migration of immune cells play the key roles in initiation, promotion and progression of malignant metastasis in pancreatic cancer. Initiation and progression of islet inflammation in diabetes and pancreatic cancer occurs as a result of various protein–protein interactions and genetic events. The increase in pancreatic cancer cases may be attributed to the obesity endemic and obesity mediated Type 2 diabetes. The existence of link between islet inflammation in chronic diabetes and pancreatic cancer cannot be ignored, although the details about the underlying mechanisms are not clear, and must be studied in detail.","PeriodicalId":208204,"journal":{"name":"Inflammation [Working Title]","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114200770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sialoendoscopy in Juvenile Recurrent Parotitis That Could be Primary Pediatric Sjogren’s Syndrome 可能是原发性小儿干燥综合征的青少年复发性腮腺炎的涎腺内镜检查

Inflammation [Working Title] Pub Date : 2021-01-21 DOI: 10.5772/INTECHOPEN.94193

Brigida Iorio, R. Luca, G. Tartaro, G. Colella

引用次数: 0

Non-Allergic Rhinitis 非过敏性鼻炎

Inflammation [Working Title] Pub Date : 2020-11-30 DOI: 10.5772/intechopen.94544

Erkan Yıldız

引用次数: 0

The Role of Neutrophil Extracellular Traps (NETs) in the Pathogenesis and Complications of Malignant Diseases 中性粒细胞胞外陷阱(NETs)在恶性疾病的发病机制和并发症中的作用

Inflammation [Working Title] Pub Date : 2020-10-19 DOI: 10.5772/intechopen.93651

Sheniz Yuzeir, L. Gercheva

{"title":"The Role of Neutrophil Extracellular Traps (NETs) in the Pathogenesis and Complications of Malignant Diseases","authors":"Sheniz Yuzeir, L. Gercheva","doi":"10.5772/intechopen.93651","DOIUrl":"https://doi.org/10.5772/intechopen.93651","url":null,"abstract":"It was recently proved that neutrophils and platelets are active participants in some inflammatory processes as well as a number of pathological conditions, including neoplastic diseases and thrombosis. It has been found that circulating neutrophils actively affect the mechanisms of tumour genesis, and along with platelets, act as independent regulators of different complications in infectious and malignant diseases. A few years ago, it was found that neutrophils have the ability to release extracellular traps (called neutrophil extracellular traps or NETs). Thus, neutrophils use both intracellular and extracellular mechanisms to limit inflammatory complications. Several recent studies confirmed that NETs increase considerably in malignant diseases, demonstrating that tumour-induced NETosis is a clinically significant process. It is recognised as an element of tumour biology, as it participates in tumour progression and angiogenesis. Neutrophils and the NETs released from them are stimulators of thrombotic processes in physiological and pathological conditions. Several reports demonstrate the connection between NETs and thrombosis. The presence of NETosis serves as a potential risk factor for thrombotic complications in malignant diseases. This chapter summarises the current knowledge of NETosis and the mechanisms that lead to the formation of NETs, including the role of circulating platelet–neutrophil complexes as regulators of tumour-induced NETosis in malignant diseases.","PeriodicalId":208204,"journal":{"name":"Inflammation [Working Title]","volume":"63 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130809596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peripheral Edema: Differential Diagnosis 外周水肿:鉴别诊断

Inflammation [Working Title] Pub Date : 2020-10-06 DOI: 10.5772/intechopen.82400

S. Michelini, A. Failla, G. Moneta, A. Fiorentino, Cardone Marco

引用次数: 0

Neutrophil Gelatinase-Associated Lipocalin as a Promising Biomarker in Acute Kidney Injury 中性粒细胞明胶酶相关脂钙蛋白作为急性肾损伤的有希望的生物标志物

Inflammation [Working Title] Pub Date : 2020-09-21 DOI: 10.5772/INTECHOPEN.93650

C. Lima, M. D. F. Vattimo, E. Macedo

引用次数: 3