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Proceedings of the YSU B: Chemical and Biological Sciences最新文献

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STUDY OF THE BIOLOGICAL PROPERTIES OF SEMI- AND THIOSEMICARBAZONES OF CARBONYL DERIVATIVES OF 4-BUTANOLIDES 4-丁内酯羰基衍生物半氨基脲和硫代氨基脲的生物学性质研究
Proceedings of the YSU B: Chemical and Biological Sciences Pub Date : 2021-08-30 DOI: 10.46991/pysu:b/2021.55.2.103
T. Ghochikyan, A. Galstyan, Hrachik M. Stepanyan, I. Korpakova, A. S. Kinzirsky
{"title":"STUDY OF THE BIOLOGICAL PROPERTIES OF SEMI- AND THIOSEMICARBAZONES OF CARBONYL DERIVATIVES OF 4-BUTANOLIDES","authors":"T. Ghochikyan, A. Galstyan, Hrachik M. Stepanyan, I. Korpakova, A. S. Kinzirsky","doi":"10.46991/pysu:b/2021.55.2.103","DOIUrl":"https://doi.org/10.46991/pysu:b/2021.55.2.103","url":null,"abstract":"Based on carbonyl derivatives of 4-substituted-4-butanolides, the appropriate semi- and thiosemicarbazones have been synthesized. It has been found that some representatives of thiosemicarbazones have pronounced algicidal activity against filamentous green alga Cladophora and blue-green alga (cyanobacterium) Synechocystis and some of the semi- and thiosemicarbazones exhibit moderate antitumor activity. The assessment of the antitumor activity of the compounds was carried out using strains of syngeneic and allogeneic tumor systems as test-objects: lymphocytic leukemia P-388, Lewis lung carcinoma, B16 melanoma and Ehrlich’s ascites tumor. It has also been established that some representatives of thiosemi­carbazones exhibit antimutagenic properties. It has been reliably proven that with the formation of a thiazole ring, all properties disappear and a new property in the series of thiazololactones is revealed – antibacterial․","PeriodicalId":20692,"journal":{"name":"Proceedings of the YSU B: Chemical and Biological Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73035582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DETERMINATION OF FUNGI RESISTANCE OF SEVERAL SAMPLES OF NATURAL LEATHER IN CONDITIONS OF ARMENIA 亚美尼亚条件下几种天然皮革样品抗真菌性的测定
Proceedings of the YSU B: Chemical and Biological Sciences Pub Date : 2021-08-30 DOI: 10.46991/pysu:b/2021.55.2.172
Iren V. Shahazizyan, Inessa M. Eloyan, Ruzanna E. Matevosyan, Siranoush G. Nanagyulyan
{"title":"DETERMINATION OF FUNGI RESISTANCE OF SEVERAL SAMPLES OF NATURAL LEATHER IN CONDITIONS OF ARMENIA","authors":"Iren V. Shahazizyan, Inessa M. Eloyan, Ruzanna E. Matevosyan, Siranoush G. Nanagyulyan","doi":"10.46991/pysu:b/2021.55.2.172","DOIUrl":"https://doi.org/10.46991/pysu:b/2021.55.2.172","url":null,"abstract":"In this work we studied the effect of microscopic soil fungi on some lather samples. The species composition of micromycetes inhabiting the samples under study was revealed, and an assessment of the fungal resistance of the materials under study was given. In the process of work, species of microscopic soil fungi were isolated and identified from the soil. In order to determine the degree of resistance to fungi for the infection of samples, a water-spore suspension was obtained. The leather materials were partially destroyed by microscopic fungi, and mold resistance ranged from 2 to 3 on a 5-point scale.","PeriodicalId":20692,"journal":{"name":"Proceedings of the YSU B: Chemical and Biological Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74248878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
QUANTITATIVE DETERMINATION OF SELENIUM IN ASTRAGALUS AND THYME OFFICINAL PLANTS 黄芪、百里香药用植物中硒的定量测定
Proceedings of the YSU B: Chemical and Biological Sciences Pub Date : 2021-08-30 DOI: 10.46991/pysu:b/2021.55.2.196
H. H. Darbinyan, H. H. Khachatryan
{"title":"QUANTITATIVE DETERMINATION OF SELENIUM IN ASTRAGALUS AND THYME OFFICINAL PLANTS","authors":"H. H. Darbinyan, H. H. Khachatryan","doi":"10.46991/pysu:b/2021.55.2.196","DOIUrl":"https://doi.org/10.46991/pysu:b/2021.55.2.196","url":null,"abstract":"The content of selenium organic forms in Astragalus and Thyme officinal plants was determined by means of spectrophotometry method using phenylthiourea as a reagent. The selenium content estimated spectrophotometrically is equal to: 11750 μg/kg in Astragalus and 450 μg/kg in Thyme. The amount of selenium in these plants determined earlier by means of mass-spectrometry method is equal to 12000 μg/kg and 600 μg/kg, respectively.","PeriodicalId":20692,"journal":{"name":"Proceedings of the YSU B: Chemical and Biological Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82129999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
THE EFFECT OF DIMETHYLSULFOXIDE ON THE FLUORESCENCE PROPERTIES OF SOME 4-HYDROXYQUINOLINES 二甲亚砜对某些4-羟基喹啉类化合物荧光性质的影响
Proceedings of the YSU B: Chemical and Biological Sciences Pub Date : 2021-08-30 DOI: 10.46991/pysu:b/2021.55.2.112
K. Grigoryan, H. Shilajyan, I. Aleksanyan, Z. L. Grigoryan, L. Hambardzumyan
{"title":"THE EFFECT OF DIMETHYLSULFOXIDE ON THE FLUORESCENCE PROPERTIES OF SOME 4-HYDROXYQUINOLINES","authors":"K. Grigoryan, H. Shilajyan, I. Aleksanyan, Z. L. Grigoryan, L. Hambardzumyan","doi":"10.46991/pysu:b/2021.55.2.112","DOIUrl":"https://doi.org/10.46991/pysu:b/2021.55.2.112","url":null,"abstract":"Fluorescence properties of 4-hydroxy-2-methylquinoline (1) and 2-(5-mercapto-1,3,4-oxadiazol-2-yl)-6-methylquinoline-4-ol (2) were studied in dimethylsulfoxide (DMSO) aqueous solutions. The fluorescence properties of 1 and 2 exhibit substantial dependence on the DMSO concentration. The fluorescence quantum yield $(Phi_f)$ of 1 decreases upon adding DMSO due to the shift in the keto-enol (E) tautomeric equilibrium toward E form․ On the contrary 2 demonstrates a tendency of increase of $Phi_f$ upon adding DMSO due to intermolecular charge transfer from DMSO to the aromatic ring of quinoline, which increases the electron density on the ring and hence the fluorescence efficiency.","PeriodicalId":20692,"journal":{"name":"Proceedings of the YSU B: Chemical and Biological Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82557999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
THE ROLE OF PROTON ATPase SPECIFIC INHIBITOR $N,N'$-DICYCLOHEXYLCARBODIIMIDE AND EXTERNAL FORMATE CONCENTRATION ON $E.~COLI$ GROWTH DURING MIXED CARBON SOURCES FERMENTATION AT DIFFERENT pHs. 质子atp酶特异性抑制剂$N， $N ' -双环己基碳二亚胺和外部甲酸盐浓度对$E的作用。在不同ph值的混合碳源发酵过程中~大肠杆菌的生长。
Proceedings of the YSU B: Chemical and Biological Sciences Pub Date : 2021-04-28 DOI: 10.46991/pysu:b/2021.55.1.067
H. Gevorgyan, A. Vassilian, K. Trchounian
{"title":"THE ROLE OF PROTON ATPase SPECIFIC INHIBITOR $N,N'$-DICYCLOHEXYLCARBODIIMIDE AND EXTERNAL FORMATE CONCENTRATION ON $E.~COLI$ GROWTH DURING MIXED CARBON SOURCES FERMENTATION AT DIFFERENT pHs.","authors":"H. Gevorgyan, A. Vassilian, K. Trchounian","doi":"10.46991/pysu:b/2021.55.1.067","DOIUrl":"https://doi.org/10.46991/pysu:b/2021.55.1.067","url":null,"abstract":"This research is focused on the investigation of specific growth rate changes of $E.~coli$ wild type and mutant strains with defect of Hyd, FDH enzymes and FhlA regulatory protein in the presence of $N,N'$-dicyclohexylcarbodiimide (DCCD) and external formate various concentration during co-fermentation of glucose, glycerol and formate at pHs $5.5-7.5.$ The highest value of SGR was observed at pH 7.5. It was revealed that SGR depends on external formate concentration at all pHs. DCCD inhibitory effect was shown mainly at pH 7.5 and partially at pH 6.5 and 5.5. In the case of the F0F1-ATPase inhibition FhlA compensatory effect on SGR was revealed.","PeriodicalId":20692,"journal":{"name":"Proceedings of the YSU B: Chemical and Biological Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75563271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
ABSORPTION AND FLUORESCENCE SPECTRA OF THE COMPLEXES OF METHYLENE BLUE AND ACRIDINE ORANGE WITH POLY(rA)-POLY(rU) 聚(rA)-聚(rU)亚甲基蓝-吖啶橙配合物的吸收光谱和荧光光谱
Proceedings of the YSU B: Chemical and Biological Sciences Pub Date : 2021-01-01 DOI: 10.46991/pysu:b/2021.55.2.151
M. Shahinyan, Z. Movsisyan, G. Hovhannisyan, P. Vardevanyan
{"title":"ABSORPTION AND FLUORESCENCE SPECTRA OF THE COMPLEXES OF METHYLENE BLUE AND ACRIDINE ORANGE WITH POLY(rA)-POLY(rU)","authors":"M. Shahinyan, Z. Movsisyan, G. Hovhannisyan, P. Vardevanyan","doi":"10.46991/pysu:b/2021.55.2.151","DOIUrl":"https://doi.org/10.46991/pysu:b/2021.55.2.151","url":null,"abstract":"The interaction of methylene blue (MB) and acridine orange (AO) with poly(rA)-poly(rU) was studied using absorption and fluorescence spectroscopy methods. The absorption and fluorescence spectra of complexes of these ligands with a polynucleotide were obtained, similar to those of complexes of these ligands with double-stranded (ds-) DNA. It was revealed that the isosbestic point in the spectra of the AO-poly(rA)-poly(rU) and MB-poly(rA)-poly(rU) complexes is not formed, although the binding of AO and MB with ds-RNA by intercalation mode is not excluded.","PeriodicalId":20692,"journal":{"name":"Proceedings of the YSU B: Chemical and Biological Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82615512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
BINDING PECULIARITIES OF POLY(rA)-POLY(rU) WITH MINOR GROOVE LIGAND HOECHST 33258 聚(rA)-聚(rU)与小槽配体的结合特性
Proceedings of the YSU B: Chemical and Biological Sciences Pub Date : 2021-01-01 DOI: 10.46991/pysu:b/2021.55.2.144
M. Parsadanyan, M. Shahinyan, Z. Movsisyan, A. Antonyan
{"title":"BINDING PECULIARITIES OF POLY(rA)-POLY(rU) WITH MINOR GROOVE LIGAND HOECHST 33258","authors":"M. Parsadanyan, M. Shahinyan, Z. Movsisyan, A. Antonyan","doi":"10.46991/pysu:b/2021.55.2.144","DOIUrl":"https://doi.org/10.46991/pysu:b/2021.55.2.144","url":null,"abstract":"Study on the interaction of DNA-specific ligands – classical intercalator acridine orange (AO) and groove binding compound Hoechst 33258 (H33258) with poly(rA)-poly(rU), being a model for double-stranded (ds-) RNA, has been carried out. The absorption and fluorescence spectra of the complexes of these ligands with ds-polynucleotide were obtained. It was revealed that the optic and fluorescent characteristics of the complexes of both ligands with ds-RNA are similar with those at the complex-formation with DNA.","PeriodicalId":20692,"journal":{"name":"Proceedings of the YSU B: Chemical and Biological Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72846207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
STUDY OF INTERACTION OF HOECHST 33258 WITH DNA AND HUMAN SERUM ALBUMIN UNDER THE INFLUENCE OF MILLIMETER RANGE ELECTROMAGNETIC WAVES 毫米波影响下hoechst 33258与DNA及人血清白蛋白相互作用的研究
Proceedings of the YSU B: Chemical and Biological Sciences Pub Date : 2021-01-01 DOI: 10.46991/pysu:b/2021.55.2.136
P. O. Vardevanyan, M. Shahinyan, A. Vardanyan, S. Grigoryan
{"title":"STUDY OF INTERACTION OF HOECHST 33258 WITH DNA AND HUMAN SERUM ALBUMIN UNDER THE INFLUENCE OF MILLIMETER RANGE ELECTROMAGNETIC WAVES","authors":"P. O. Vardevanyan, M. Shahinyan, A. Vardanyan, S. Grigoryan","doi":"10.46991/pysu:b/2021.55.2.136","DOIUrl":"https://doi.org/10.46991/pysu:b/2021.55.2.136","url":null,"abstract":"In this work the effect of millimeter range electromagnetic waves (MM EMW) with the frequency 64.5 GHz on the complexes of Hoechst 33258 (H33258) with DNA and human serum albumin (HSA) has been studied by the methods of absorption and fluorescence spectroscopies. It was shown that the irradiation results in weakening of H33258 interaction with both macromolecules, which is connected with the fact that the frequency 64.5 GHz, being resonant for water, leads to the structurizing of water component around DNA and HSA, due to which the binding becomes weaker. This conclusion is based on the values of both binding constants and Stern–Volmer constants.","PeriodicalId":20692,"journal":{"name":"Proceedings of the YSU B: Chemical and Biological Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90134448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
PREDICTING THE FUTURE ECOLOGICAL NICHE OF $CULEX$ $PIPIENS$ AND ASSOCIATED BIORISKS IN ARMENIA 预测亚美尼亚库蚊未来生态位及相关生物风险
Proceedings of the YSU B: Chemical and Biological Sciences Pub Date : 2021-01-01 DOI: 10.46991/pysu:b/2021.55.2.181
L. Niazyan
{"title":"PREDICTING THE FUTURE ECOLOGICAL NICHE OF $CULEX$ $PIPIENS$ AND ASSOCIATED BIORISKS IN ARMENIA","authors":"L. Niazyan","doi":"10.46991/pysu:b/2021.55.2.181","DOIUrl":"https://doi.org/10.46991/pysu:b/2021.55.2.181","url":null,"abstract":"West Nile virus disease is an emerging infectious vector borne disease. Of registered invasive species of mosquitoes in Armenia, Culex pipiens is the most implicated one in the potential transmission of West Nile virus (WNV). In previous years (1985–1999), research on circulation of mosquito-borne arboviruses in Armenia was conducted by the research Institute of Epidemiology and WNV, Batai, Sindbis, Tahyna and Gheta were found in mosquitoes. The only mosquito-borne disease historically registered in Armenia was malaria, without autochtonous cases since 2006. However, per retrospective medical chart review study (2016–2019) in the Nork Infection Clinical Hospital, about 30% of febrile patients is diagnosed as “Fever of Unknown Origin”. We hypothesize that these arboviruses are circulating in Armenia and largely mis-diagnosed and/or under reported. Based on the geographical locations of mosquitoes, the MaxEnt model with 19 bioclimatic variables was developed to predict future ecological niche of C. pipiens and potential high-risk areas for West Nile virus disease. It is the first step for the implementation of a statistically rigorous system for real-time alert of biorisk.","PeriodicalId":20692,"journal":{"name":"Proceedings of the YSU B: Chemical and Biological Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83293117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
FEATURES OF CHANGES IN CARDIAC ACTIVITY UNDER VIBRATION EXPOSURE 振动暴露下心脏活动变化的特征
Proceedings of the YSU B: Chemical and Biological Sciences Pub Date : 2021-01-01 DOI: 10.46991/pysu:b/2021.55.2.189
Siranush M. Minasyan, E. Gevorkyan, Ts. I. Adamyan, Susanna H. Sargsyan, L. Ghukasyan
{"title":"FEATURES OF CHANGES IN CARDIAC ACTIVITY UNDER VIBRATION EXPOSURE","authors":"Siranush M. Minasyan, E. Gevorkyan, Ts. I. Adamyan, Susanna H. Sargsyan, L. Ghukasyan","doi":"10.46991/pysu:b/2021.55.2.189","DOIUrl":"https://doi.org/10.46991/pysu:b/2021.55.2.189","url":null,"abstract":"The results of the study have shown that when exposed to vibration, changes in cardiac activity occur in rabbits, the nature and direction of which depend on the parameters of the dynamic factor. Vibration with a frequency of 20 Hz causes moderate tachycardia, and 40 and 80 Hz – severe tachycardia. Three months of vibration in the first month of exposure causes tachycardia, and after three months of exposure, bradycardia. There is also a reduction in respiratory movements and a decrease in the activity of the enzyme succinate dehydrogenase.","PeriodicalId":20692,"journal":{"name":"Proceedings of the YSU B: Chemical and Biological Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76114189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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