Proceedings of the National Academy of Sciences of Belarus, Medical series最新文献

{"title":"Relationship of the expression of the NF1, p53, bcl-2, pRB proteins with DNA/RNA of viruses and mutations of the BRCA 1/2 and hMSH2 genes in liver cancer","authors":"A. E. Kuzniatsou","doi":"10.29235/1814-6023-2023-20-2-126-139","DOIUrl":"https://doi.org/10.29235/1814-6023-2023-20-2-126-139","url":null,"abstract":"","PeriodicalId":20584,"journal":{"name":"Proceedings of the National Academy of Sciences of Belarus, Medical series","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89069327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Significance of the cytokeratin-19 fragment and CXCR1, CXCR2 receptors in the blood for prediction of the relapse-free survival of patients with stage III non-small cell lung cancer","authors":"А.Д. Таганович, Н. Н. Ковганко, В. И. Прохорова, А. В. Колб, О. В. Готько, A. Tahanovich, N. Kauhanka, Violetta I . Prokhorova, Alexander V . Kolb, O. V. Got'ko","doi":"10.29235/1814-6023-2023-20-2-112-125","DOIUrl":"https://doi.org/10.29235/1814-6023-2023-20-2-112-125","url":null,"abstract":"Stage III non-small cell lung cancer (NSCLC) is a heterogeneous group of tumors. The prognosis for patients with stage III NSCLC remains poor, and the 5-year survival rate is not more than 20 %. Therefore, an actual problem is to develop prognostic indicators that would allow predicting the progression of the tumor process in patients in order to correctly build strategy and tactics for their treatment.The objective of the study was to clarify and substantiate the possibility of using laboratory parameters characterizing the level of blood proteins – participants in carcinogenesis in predicting the NSCLC progression in patients with stage III disease.In 1187 patients who were first diagnosed with stage III NSCLC, the duration of the relapse-free period after treatment was analyzed using the observation results for one year. The mean age of patients was 63 ± 23 years. In 89 patients (58 ± 23.5 years), the concentration of CYFRA 21-1, SCC, TPA were determined by electrochemiluminescent method; pyruvate kinase M2, CXCL5, CXCL8 chemokines – by enzyme immunoassay; CXCR1 and CXCR2 receptors– by flow cytometry.A proportional hazards model was used to identify potentially informative indicators for predicting the duration of the relapse-free period in patients with stage III NSCLC: the levels of lymphocytes containing CXCR1 and CYFRA 21-1. Based on the one-year observation results and the graphical analysis of Kaplan-Meier, groups of low (T1N2M0, T3N1M0, T2N2M0, T4N0M0, T3N2M0) and high (T1N3M0, T2N3M0, T3N3M0, T4N1M0, T4N2M0, T4N3M0) risk of tumor progression were identified. High-risk patients had a higher level of CYFRA 21-1, a relative content of the receptor CXCR1 in lymphocytes, and a relative content of the receptor CXCR2 in monocytes compared to low-risk patients (p < 0.05). With their participation, based on the results of logistic regression analysis, an equation was constructed, the calculation of which makes it possible to predict the risk of tumor recurrence. The threshold value of the equation is 0.519. The sensitivity of the prediction model was 80.9 %, the specificity was 83.3 %, and the prediction value of a positive result was 84.4 % and that of a negative result – 79.6 %. The study results give grounds to recommend a set of laboratory parameters in the blood of stage III NSCLC patients, including the CYFRA 21-1 level and the receptors CXCR1 and CXCR2, in order to assess their tumor progression risk.>< 0.05). With their participation, based on the results of logistic regression analysis, an equation was constructed, the calculation of which makes it possible to predict the risk of tumor recurrence. The threshold value of the equation is 0.519. The sensitivity of the prediction model was 80.9 %, the specificity was 83.3 %, and the prediction value of a positive result was 84.4 % and that of a negative result – 79.6 %.The study results give grounds to recommend a set of laboratory parameters in the blood of stage III NSCLC patients, inclu","PeriodicalId":20584,"journal":{"name":"Proceedings of the National Academy of Sciences of Belarus, Medical series","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84026996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ectopic teeth in the maxillary sinus","authors":"Y. Melnichenko, S. Kabak, N. Savrasova, R. S. Mekhtiev","doi":"10.29235/1814-6023-2023-20-2-106-111","DOIUrl":"https://doi.org/10.29235/1814-6023-2023-20-2-106-111","url":null,"abstract":"Dental ectopia is a rare developing anomaly characterized by a change in the normal eruption pathway of a deciduous, permanent or supernumerary tooth. In some cases, ectopic teeth are present in the non-dentate area like maxillary sinus. The article presents cone beam computed tomography data of 7 asymptomatic patients with teeth totally or partially located inside the maxillary sinus. Dentigerous cysts and odontomas can cause displacement of impacted teeth into ectopic positions.","PeriodicalId":20584,"journal":{"name":"Proceedings of the National Academy of Sciences of Belarus, Medical series","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80831028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of NPPB rs198389 and NPPA rs5068 single-nucleotide polymorphisms with natriuretic peptide levels and heart failure progression risks in patients with atrial fibrillation","authors":"M. C. Matsiukevich, V. Snezhitskiy, T. Stepuro","doi":"10.29235/1814-6023-2023-20-2-95-105","DOIUrl":"https://doi.org/10.29235/1814-6023-2023-20-2-95-105","url":null,"abstract":"Natriuretic peptides (NUPs) are the strongest predictors of poor prognosis in patients with heart failure (HF). Single-nucleotide polymorphisms (SNPs) rs198389 of the NPPB gene and rs5068 of the NPPA gene are associated with altered levels of NUP. The role of candidate gene polymorphisms in the activity of the NUP system and the association of NPPA/ NPPB SNPs with the risk of cardiovascular disease (CVD) in individuals with HF and atrial fibrillation (AF) is not well understood.The study aims to evaluate the allele and genotype frequencies of NPPA rs5068 and NPPB rs198389 SNPs in a selective sample of the Belarusian population, to determine the relationship of these SNPs with NUP concentrations, and to assess the prognostic significance of these SNPs on the risk of HF hospitalization in patients with HF and permanent AF.The study involved 187 patients. The main group included 152 patients with HF with left ventricular ejection fraction (LVEF) < 50 %. Group 1 included 48 patients with HF and AF; group 2 – 51 patients with HF and sinus rhythm (SR) and 35 patients in the control group. The levels of atrial and brain natriuretic peptides (ANP and BNP) and the N-terminal fragment of the brain natriuretic peptide (NT-proBNP) were determined. A genetic testing of polymorphic loci of the rs5068 NPPA gene and the rs198389 NPPB gene was performed. The primary endpoint of the study was hospitalization due to HF progression.The average observation period was 12.1 [from 9 to 14] months. The distribution of the genotype and allele frequencies of rs198389 NPPB and rs5068 NPPA in HF patients with LVEF < 50 % is comparable to that in individuals without CVD. In patients with HF and persistent AF, the minor allele C rs198389 NPPB is associated with higher BNP levels compared to patients with HF and SR (542 [333.7; 909.4] pg/ml versus 247.3 [244; 365.2] pg/ml; p < 0.05), but it has no relationship with the NT-proBNP level. In patients with HF and permanent AF, the ANP levels are not associated with rs5068 NPPA.The frequency of the T allele rs198389 NPPB in hospitalized patients was significantly lower compared to patients who were not hospitalized (22 patients (44 %) versus 83 patients (62 %); p = 0.04). The presence of the C allele rs198389 NPPB was associated with a higher risk of HF progression in patients with HF and AF, the odds ratio (OR) = 2.071 [95 % CI from 1.072 to 4.001], p < 0.05.","PeriodicalId":20584,"journal":{"name":"Proceedings of the National Academy of Sciences of Belarus, Medical series","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80997347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Participation of blood valine and L-arginine-NO system in the development of hyperthermia, the formation of thyroid status and prooxidant-antioxidant state under stress due to bacterial endotoxin","authors":"F. Vismont, A. F. Vismont, S. Zhadan, T. Abakumova, F. D. Yakovlev","doi":"10.29235/1814-6023-2023-20-2-147-157","DOIUrl":"https://doi.org/10.29235/1814-6023-2023-20-2-147-157","url":null,"abstract":"","PeriodicalId":20584,"journal":{"name":"Proceedings of the National Academy of Sciences of Belarus, Medical series","volume":"78 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89686308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and immunological significance of quantification of antibodies to type I, II, III collagen and elastin in systemic scleroderma","authors":"A. Trofimenko, O. Emelyanova, O. Rusanova","doi":"10.29235/1814-6023-2023-20-2-140-146","DOIUrl":"https://doi.org/10.29235/1814-6023-2023-20-2-140-146","url":null,"abstract":"","PeriodicalId":20584,"journal":{"name":"Proceedings of the National Academy of Sciences of Belarus, Medical series","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75371816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"30 years of foreign policy of independent Belarus: an interesting and deep analysis","authors":"A. Huryn","doi":"10.29235/2524-2369-2023-68-2-172-176","DOIUrl":"https://doi.org/10.29235/2524-2369-2023-68-2-172-176","url":null,"abstract":"<jats:p>.</jats:p>","PeriodicalId":20584,"journal":{"name":"Proceedings of the National Academy of Sciences of Belarus, Medical series","volume":"78 8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79259089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Theoretical, methodological and practical foundations for developing a joint strategy for trade cooperation between the Republic of Belarus and the Republic of Ecuador","authors":"T. S. Vertinskaya, Pedro Colon Valdivieso Salinas","doi":"10.29235/2524-2369-2023-68-2-160-171","DOIUrl":"https://doi.org/10.29235/2524-2369-2023-68-2-160-171","url":null,"abstract":"The article is devoted to the scientific, methodological and practical aspects of developing a joint strategy for trade cooperation between the Republic of Belarus and the Republic of Ecuador.The review and systematization, taking into account the criteria proposed by the authors (the degree of external openness of the national economy, foreign trade priority, the impact on international trade, methods of its regulation), theories and concepts of foreign trade policy that determine its types, are carried out.The features of the foreign trade policy of the Republic of Ecuador are highlighted: orientation towards regional integration; establishing bilateral relations with third countries and concluding free trade agreements with non-Latin American (extra-regional) partners; strengthening economic cooperation at the level of integration groupings, etc.The methodological basis of the joint strategy of the Belarusian-Ecuadorian trade cooperation has been developed, which contains three stages.The key priorities of trade cooperation between Belarus and Ecuador were determined: increasing the volume of mutual trade according to the existing product range and commodity diversification of export baskets of partner countries; expansion of mutual trade on the basis of partners entering the markets of regional economic associations, of which Belarus and Ecuador are members; development and inclusion of the creative economy sector in the Belarusian-Ecuadorian relations; creation of joint institutions to support Belarusian-Ecuadorian trade relations, as well as increasing the efficiency of existing structures.Measures recommended for inclusion in the joint action plan for the development of Belarusian-Ecuadorian trade cooperation in the following areas are proposed: a) diplomatic support for mutual trade; b) implementation of special support measures in the field of the creative (orange) economy as a factor in international trade; c) cooperation with the world’s leading retail chains; d) revitalization of the activities of chambers of commerce and industry; e) creation of additional conditions for Belarusian-Ecuadorian trade cooperation at the level of regional associations, etc.","PeriodicalId":20584,"journal":{"name":"Proceedings of the National Academy of Sciences of Belarus, Medical series","volume":"82 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76626612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artistic interpretation of the socialization of personality in a foreign cultural society in the novel by Elena Bravo “Curfew for swallows”","authors":"L. V. Aleinik","doi":"10.29235/2524-2369-2023-68-2-140-148","DOIUrl":"https://doi.org/10.29235/2524-2369-2023-68-2-140-148","url":null,"abstract":"The author examines the autobiographical novel “Curfew for Swallows” by the modern Belarusian writer Elena Bravo. The stages, functional components, the general structure of the processes of socialization and inculturation of personality, which are reflected in the literary text, are considered. The problems are identified and the cause-and-effect relationships of basic socialization and subsequent adaptation of the individual in a foreign cultural society are established. The article substantiates the increased relevance of autobiographical prose in connection with the processes of global globalization and industrialization of modern society, the main object of which is the younger generation. The article analyzes the general role of fiction as a socio-cultural practice that promotes the development of cultural competence and productive socialization of the individual, since the fundamental civilizational values and their semantic models are codified and transmitted in society largely through such phenomena as text and book. It is revealed that the autobiographical work of E. Bravo psychologically reliably reflects the content of socialization – a kind of convention between a person and society, a two-way process of mastering social norms and cultural values by an individual and their reproduction. It is argued that the story “Curfew for swallows” has a high socializing potential, is an effective catalyst for the reflexive activity of the reader, a stimulator of creative thinking, an indirect way of comprehending the norms and rules of social and social existence. ","PeriodicalId":20584,"journal":{"name":"Proceedings of the National Academy of Sciences of Belarus, Medical series","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74983332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The constitutional right to health care: the content, legal mechanisms to ensure in the paradigm of modern realities","authors":"A. N. Bodak","doi":"10.29235/2524-2369-2023-68-2-149-159","DOIUrl":"https://doi.org/10.29235/2524-2369-2023-68-2-149-159","url":null,"abstract":"This article deals with the actual facets of the constitutional right to health care in view of the provisions of the updated Constitution of the Republic of Belarus. It tracks the main approaches revealing the normative content of the right in question based on the constitutional principles and rules, the constitutional case-law of the Republic of Belarus. The author comes from the historical aspect of the constitutional and legal grounds of the right to health care in Belarus and also applies the foreign practice of its constitutional context. In analyzing the legal essence of this right the author calls for the constitutional and legal mechanisms to ensure it to be improved. Some conclusions and considerations are backed up by the legal positions of the Constitutional Court of the Republic of Belarus and the foreign constitutional practice. ","PeriodicalId":20584,"journal":{"name":"Proceedings of the National Academy of Sciences of Belarus, Medical series","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85467003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}