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Physiologia Bohemoslovaca最新文献

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Sniffing behaviour, copulatory readiness, copulatory performance and reproductive morphology of adult male rats weaned prematurely. 过早断奶成年雄性大鼠的嗅探行为、交配准备、交配表现和生殖形态。
Physiologia Bohemoslovaca Pub Date : 1989-01-01
Z Hlinák, D Gandalovicová, Z Roth
{"title":"Sniffing behaviour, copulatory readiness, copulatory performance and reproductive morphology of adult male rats weaned prematurely.","authors":"Z Hlinák,&nbsp;D Gandalovicová,&nbsp;Z Roth","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Sexual behaviour of adult male rats weaned prematurely--on day 15 after birth--and of males weaned at the optimal age--on day 28--was compared at two life periods: at the age of 90 days and when the males were one year old. Sexual behaviour was evaluated by means of three characteristics: a) sniffing behaviour, b) copulatory readiness, c) copulatory performance. The differences in sniffing behaviour between prematurely and normally weaned males were assessed in terms of their responsiveness to sccents of unrelated adult males or oestrous females and from the point of view of both housing conditions after weaning and the animals' sexual experience. No differences were found in copulatory readiness as well as in copulatory performance between the two groups of males tested in their interaction with a female exhibiting complete precopulatory pattern. The morphological examination revealed no differences in the weight of reproductive organs and in spermatozoa development. We conclude that the sexual behaviour as well as reproductive organs of male rats are very resistant to early separation of pups from the mother which contrasts with some earlier findings.</p>","PeriodicalId":20547,"journal":{"name":"Physiologia Bohemoslovaca","volume":"38 5","pages":"449-56"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13677620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of naloxone on diurnal polysomnographic manifestations of hypersomnia with sleep apnoea. 纳洛酮对嗜睡伴睡眠呼吸暂停患者多导睡眠图表现的影响。
Physiologia Bohemoslovaca Pub Date : 1989-01-01
K Sonka, B Roth, H Barvírová, O Nevsímal
{"title":"Effect of naloxone on diurnal polysomnographic manifestations of hypersomnia with sleep apnoea.","authors":"K Sonka,&nbsp;B Roth,&nbsp;H Barvírová,&nbsp;O Nevsímal","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A simple blind study with small doses of naloxone (0.8-1.6 mg i.v.) was carried out in 11 patients with hypersomnia with sleep apnoea (HSA). The effect was studied by diurnal polysomnography. It was found that the administration of naloxone was followed by significant prolongation of wakefulness and by significant shortening of the total duration of the second stage of NREM sleep. The duration of the apnoeic episodes was also significantly shortened after naloxone, although their number did not alter. Increased activity of the endorphinergic system (which naloxone inhibits by receptor competition) evidently plays a role in the pathophysiology of HSA.</p>","PeriodicalId":20547,"journal":{"name":"Physiologia Bohemoslovaca","volume":"38 5","pages":"477-9"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13677624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of prostaglandins E2 and F2 alpha on carotid blood flow in rats with renovascular hypertension. 前列腺素E2和F2 α对肾血管性高血压大鼠颈动脉血流的影响。
Physiologia Bohemoslovaca Pub Date : 1989-01-01
L Vacek, P Bravený, L Drápelová
{"title":"The effect of prostaglandins E2 and F2 alpha on carotid blood flow in rats with renovascular hypertension.","authors":"L Vacek,&nbsp;P Bravený,&nbsp;L Drápelová","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effect of i.v. bolus administration of PGE2 and PGF2 alpha on carotid blood flow (Q) and mean arterial blood pressure (MAP) was recorded in 21 anaesthetized normotensive control (N) and 12 rats with 1K1C renovascular hypertension (RH). From the measured parameters the regional vascular impedance (PVI) and the change in blood volume were calculated. In normotensive animals both PGs elicited a dose-dependent initial fast increase of Q (threshold dose 0.4 ng/kg) and a decrease of MAP and PVI (threshold dose 0.4 micrograms/kg). Subsequently, Q decreased below the initial level. MAP and PVI remained depressed after E2 but increased after F2 alpha. The time course of the Q and MAP responses was analyzed in more detail at a standard dose 4 micrograms/kg. The average time to peak of the first phase was 12 s and of the second approximately 80 s. The initial levels of Q and MAP were reestablished within 3 to 4 minutes. The total volume of carotid blood flow obtained by planimetric integration was unaltered after F2 alpha but depressed after E2. In hypertensive animals both phases of the response to E2 were significantly retarded and the Q response was nearly abolished. On the other hand, the time course of the reaction to F2 alpha was unchanged but the magnitude of the second pressoric phase was reduced. Thus, the capacity of the carotid vascular bed to dilate remains the same in RH while the ability to constrict is limited. It is concluded that the response of MAP and Q to both PGs are relatively independent.(ABSTRACT TRUNCATED AT 250 WORDS)</p>","PeriodicalId":20547,"journal":{"name":"Physiologia Bohemoslovaca","volume":"38 6","pages":"481-7"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13678237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Changes in renal haemodynamics in the nephrotic syndrome. 肾病综合征患者肾脏血流动力学的变化。
Physiologia Bohemoslovaca Pub Date : 1989-01-01
J Zabka, J Stríbrná, V Janata, K Matousovic
{"title":"Changes in renal haemodynamics in the nephrotic syndrome.","authors":"J Zabka,&nbsp;J Stríbrná,&nbsp;V Janata,&nbsp;K Matousovic","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>It has repeatedly been found that haemodynamic changes during hypoproteinaemia in the chronic phase of the nephrotic syndrome are different from those during hypoproteinaemia in the acute phase. In our series of patients, a decrease in the filtration fraction and relative hyperperfusion of the kidneys were associated with the presence of the nephrotic syndrome. No significant changes in renal haemodynamics were observed in patients with chronic glomerulonephritis without the nephrotic syndrome or in a group of healthy volunteers. The question of whether relative hyperperfusion of the kidneys in a repeatedly relapsing nephrotic syndrome can lead to the development of focal segmental glomerulosclerosis needs to be elucidated.</p>","PeriodicalId":20547,"journal":{"name":"Physiologia Bohemoslovaca","volume":"38 1","pages":"51-4"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13669567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influence of acute hypoxia upon brilliant cresyl blue-induced disintegration of erythrocytes in rabbits and cats. 急性缺氧对亮甲酚蓝致兔、猫红细胞解体的影响。
Physiologia Bohemoslovaca Pub Date : 1989-01-01
R Tkácová, A Nicák, A Nistiarová, Z Tomori, M Riemerová
{"title":"Influence of acute hypoxia upon brilliant cresyl blue-induced disintegration of erythrocytes in rabbits and cats.","authors":"R Tkácová,&nbsp;A Nicák,&nbsp;A Nistiarová,&nbsp;Z Tomori,&nbsp;M Riemerová","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The disintegration of erythrocytes by brilliant cresyl blue was studied in rabbits and cats during two hypoxic periods resulting in apnoea which was followed by artificial ventilation and recovery. The rate of erythrocyte disintegration was measured after 2 hours' incubation in isotonic NaCl or Krebs-Ringer solution plus brilliant cresyl blue (0.5 mmol.l-1). Significant increases of disintegration rates were found in rabbits during recovery in both incubation solutions. Erythrocytes in cats seemed to be more resistant to acute hypoxia, as their disintegration rate rose only in isotonic NaCl solution, and that only transiently. Brilliant cresyl blue--induced erythrocyte disintegration in cats did not differ from the control values during 10 min of spontaneous breathing after the first and the second period of hypoxia in the isotonic NaCl solution, but it was significantly lower in Krebs-Ringer solution. The possible factors influencing the erythrocyte disintegration rate in acute hypoxia are discussed.</p>","PeriodicalId":20547,"journal":{"name":"Physiologia Bohemoslovaca","volume":"38 3","pages":"283-6"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13673205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dynamic effects of acute cooling in body temperature regulation of the euthermic warm-acclimated golden hamster (Mesocricetus auratus). 急性降温对恒温适应金仓鼠体温调节的动态影响。
Physiologia Bohemoslovaca Pub Date : 1989-01-01
B Stefl
{"title":"Dynamic effects of acute cooling in body temperature regulation of the euthermic warm-acclimated golden hamster (Mesocricetus auratus).","authors":"B Stefl","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>During the dynamic phase of external cooling of euthermic golden hamsters in the initial period of metabolic response, peripheral body temperature is the decisive control variable determining the level of metabolic heat production. Under these conditions the rate as well as the magnitude of the peripheral body temperature change constitute the effectual input to the controller of body temperature. The apparent sensitivity with which the regulator drives the metabolic response to unit change of the peripheral temperature is in an inverse relation to the rate of peripheral temperature change. This parameter, despite its limited significance can serve as a working index characterising the thermoregulatory system in different groups of experimental animals of the same species providing that the actual conditions of the experiment are comporting.</p>","PeriodicalId":20547,"journal":{"name":"Physiologia Bohemoslovaca","volume":"38 2","pages":"171-8"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13674035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Postnatal development of the high-affinity uptake of choline and of the synthesis of acetylcholine in rat heart atria. 出生后大鼠心房对胆碱高亲和力摄取和乙酰胆碱合成的发展。
Physiologia Bohemoslovaca Pub Date : 1989-01-01
J Slavíková, S Tucek
{"title":"Postnatal development of the high-affinity uptake of choline and of the synthesis of acetylcholine in rat heart atria.","authors":"J Slavíková,&nbsp;S Tucek","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Isolated heart atria from rats of different ages were incubated in a medium containing (14C)choline and the rates of the uptake of (14C)choline into the tissue and of its conversion to (14C)acetylcholine (ACh) were measured. The synthesis of (14C)ACh (expressed per 1 g of fresh weight) increased from birth until 30 days of age and diminished after 40 days of postnatal life. The rate of (14C)ACh synthesis was considerably diminished when Na+ was omitted from the incubation medium or when hemicholinium-3 was added to it; these effects of the absence of Na+ and of hemicholinium-3 were already manifest on the 1st day after birth, indicating that the sodium-dependent high-affinity uptake of choline is operative and takes part in the synthesis of ACh in the heart from the start of postnatal life (if not earlier). In newborn rats, 4% of the (14C)choline that had been taken up by the atria was converted to (14C)Ach; this proportion rose to 7-9% at the age of 20 and 30 days and in adulthood. The total uptake of (14C)choline expressed per whole atria kept increasing from birth till adulthood when related to the whole atria, but it diminished when related to 1 g of atrial weight.</p>","PeriodicalId":20547,"journal":{"name":"Physiologia Bohemoslovaca","volume":"38 2","pages":"163-70"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13674036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Radiation dose response of some gluconeogenic enzyme activities in rats. 辐射剂量对大鼠糖异生酶活性的影响。
Physiologia Bohemoslovaca Pub Date : 1989-01-01
E Paulíková, E Ahlersová
{"title":"Radiation dose response of some gluconeogenic enzyme activities in rats.","authors":"E Paulíková,&nbsp;E Ahlersová","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Negative correlation was found between the activity of liver glucose-6-phosphatase (EC 3.1.3.9) and the increasing radiation dose 24 h after continuous irradiation of rats. A dose response of increased fructose-1,6-diphosphatase (EC 3.1.3.11) was not confirmed.</p>","PeriodicalId":20547,"journal":{"name":"Physiologia Bohemoslovaca","volume":"38 2","pages":"188-92"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13674038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acidification capacity of the kidneys and aging. 肾脏的酸化能力和衰老。
Physiologia Bohemoslovaca Pub Date : 1989-01-01
O Schück, H Nádvorníková, V Teplan
{"title":"Acidification capacity of the kidneys and aging.","authors":"O Schück,&nbsp;H Nádvorníková,&nbsp;V Teplan","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The authors studied the acidification capacity of the kidneys in 60 healthy subjects aged 18-70 years after a single load of NH4Cl in a dose of 0.1 g/kg. The acidification load was followed by a significant increase in NH4+ excretion in the first five hours afterwards in young individuals (18-30 years). In subjects aged over 50, changes in NH4+ excretion were nonsignificant under these conditions. Titratable acid excretion rose significantly after the given acidification load in subjects aged 18-60 years; in older subjects it no longer increased significantly. Changes in titratable acid excretion displayed a significant correlation to the renal excretion of phosphates. The findings indicate that the diminished capacity of older subjects to increase titratable acid excretion after an acute NH4Cl load is due to an insufficient decrease in the tubular resorption of phosphates. Renal capacity for adequate reduction of the urine pH after a NH4Cl load was unimpaired.</p>","PeriodicalId":20547,"journal":{"name":"Physiologia Bohemoslovaca","volume":"38 2","pages":"117-25"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13674031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antimetrazol action and plasma levels of valproate in developing rats. 发育大鼠抗美唑作用和丙戊酸血浆水平。
Physiologia Bohemoslovaca Pub Date : 1989-01-01
P Mares, S Maresová, D Maresová
{"title":"Antimetrazol action and plasma levels of valproate in developing rats.","authors":"P Mares,&nbsp;S Maresová,&nbsp;D Maresová","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The duration of protective action of valproate (VPA, 400 mg/kg i.p.) against metrazol-induced seizures was studied in rats aged 7, 12, 18 and 90 days. Fifteen, protected. The results differed between the various age groups after longer intervals: The protection was longest in 18-day-old rats--seizures did not appear even six hours after VPA administration. On the contrary, all 7-day-old rat pups exhibited seizures two hours after VPA. Plasma levels of VPA were measured by means of gas chromatography in the same age groups after an identical dose of VPA. After a single injection of VPA a clear-cut two-peak curve of plasma level was found in all young groups, which may be due to an enterohepatic recirculation of VPA. The maximum plasma levels were lowest in 7-day-old rats, the three older groups exhibited similar values. Plasma half-life was longest in the youngest animals (9.24) and decreased with age; values for 18- and 901 day-old rats did not differ (2.57 and 3.05 h respectively). No clear-cut correlation was found between the antimetrazol action and its plasma levels.</p>","PeriodicalId":20547,"journal":{"name":"Physiologia Bohemoslovaca","volume":"38 2","pages":"97-107"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13674039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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