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Experimental toxic liver damage and hepatic plasma clearance of 99mTc-mebrofenin (iminodiacetate derivative). II. Recovery from the acute, CCl4-induced liver damage. 99mtc -甲溴非宁(亚氨基二乙酸酯衍生物)的实验性中毒性肝损害及肝脏血浆清除率。2从ccl4引起的急性肝损伤中恢复。
Polish journal of occupational medicine and environmental health Pub Date : 1993-01-01
J Kapuściński, J Kuroszczyk, J Liniecki, M Bieńkiewicz, K Zieliński, K Tuszyner
{"title":"Experimental toxic liver damage and hepatic plasma clearance of 99mTc-mebrofenin (iminodiacetate derivative). II. Recovery from the acute, CCl4-induced liver damage.","authors":"J Kapuściński,&nbsp;J Kuroszczyk,&nbsp;J Liniecki,&nbsp;M Bieńkiewicz,&nbsp;K Zieliński,&nbsp;K Tuszyner","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Liver parenchyma damage was induced in rabbits by the administration of carbon tetrachloride. The animals were serially sacrificed 3, 10, 17 and 31 days post intoxication and examined morphometrically for the extent of necrosis, steatosis and balloon degeneration of hepatocytes. Biochemical indices of the liver damage were studied as well as hepatic clearance of blood plasma from Tc-99m complex of an IDA derivative Tc99m complex (99mTc-mebrofenin--99mTc-MBF) and its uptake and liver transfer characterizing parameters. It was found that toxic effects of CCl4 were conspicuous up to 10 days after administration of carbon tetrachloride. In that period elevated activity of AspAT, ALAT, GGTP and elevated cholesterol and triglycerides were found in the plasma. As in the first paper of this series of works there has been a highly significant statistical association between the Tc-MBF plasma clearance, the uptake and liver transfer of the compound and parenchyma damage in the organ.</p>","PeriodicalId":20359,"journal":{"name":"Polish journal of occupational medicine and environmental health","volume":"6 4","pages":"399-408"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19013334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cadmium, zinc, and copper levels in the kidneys and liver of the inhabitants of north-eastern Poland. 波兰东北部居民肾脏和肝脏中镉、锌和铜的含量。
Polish journal of occupational medicine and environmental health Pub Date : 1993-01-01
E M Bem, J K Piotrowski, E Turzyńska
{"title":"Cadmium, zinc, and copper levels in the kidneys and liver of the inhabitants of north-eastern Poland.","authors":"E M Bem,&nbsp;J K Piotrowski,&nbsp;E Turzyńska","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Concentrations of Cd, Zn, and Cu were determined in the renal cortex and the liver of 79 persons who died in 1991 in Białystok and its vicinity. The mean concentrations were: 30.5 +/- 27.7 micrograms Cd/g, 37.6 +/- 18.5 micrograms Zn/g, 2.6 +/- 2.5 micrograms Cu/g, and 2.1 +/- 2.2 micrograms Cd/g, 52.4 +/- 20.5 micrograms Zn/g, 4.0 +/- 2.1 micrograms Cu/g, respectively, in the renal cortex and the liver, at the mean age of 51.1 +/- 19.1 years. Smokers showed almost twice higher Cd levels in the cortex than non-smokers. The mean whole body retention calculated for cadmium was 18.9 +/- 15.9 mg. Smoking increases it by about 60%--from 13.7 mg in non-smokers to 22.8 mg in smokers. In the inhabitants of the investigated region cadmium levels (kidney, liver, whole body retention) were lower than in persons from Lodz and Katowice regions.</p>","PeriodicalId":20359,"journal":{"name":"Polish journal of occupational medicine and environmental health","volume":"6 2","pages":"133-41"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19208840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The relationship between ciliary muscle fatigue and the type of artificial light used to illuminate the area of visual work. 睫状肌疲劳与用于照亮视觉工作区域的人造光的类型之间的关系。
Polish journal of occupational medicine and environmental health Pub Date : 1993-01-01
H Leśnik, J Poborc-Godlewska
{"title":"The relationship between ciliary muscle fatigue and the type of artificial light used to illuminate the area of visual work.","authors":"H Leśnik,&nbsp;J Poborc-Godlewska","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The relationship between the degree of eye fatigue resulting from visual work and type of light source used to illuminate the field of work was assessed. The tests were performed using artificial light sources: fluorescent lamps, incandescent lamps, high pressure mercury (vapour) and high pressure sodium (vapour) lamps. The assessment was performed on two groups of 10 women each, of which one included women without, and the other with, refraction errors. On the basis of changes of nearer vision point and dispersing lens tolerance, it was found that sodium light produced the highest visual fatigue in the test women, especially in those with refraction errors.</p>","PeriodicalId":20359,"journal":{"name":"Polish journal of occupational medicine and environmental health","volume":"6 3","pages":"287-92"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19133930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Current principles of hygienic standards setting (Part II). 现行卫生标准制定原则(第二部分)。
Polish journal of occupational medicine and environmental health Pub Date : 1993-01-01
S Czerczak, J A Indulski, Z Kowalski
{"title":"Current principles of hygienic standards setting (Part II).","authors":"S Czerczak,&nbsp;J A Indulski,&nbsp;Z Kowalski","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The paper presents general principles of setting the hygienic standards for substances of threshold effect and nonthreshold agents. The authors introduced the mathematical models used for quantitative risk assessment and models for assessment of the dose-response relationship according to the physiological principles.</p>","PeriodicalId":20359,"journal":{"name":"Polish journal of occupational medicine and environmental health","volume":"6 3","pages":"245-61"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19134012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Experimental assessment of the effect of coal dust with polymetallic salts on the respiratory tract epithelium. 含多金属盐煤尘对呼吸道上皮影响的实验研究。
Polish journal of occupational medicine and environmental health Pub Date : 1992-01-01
B Białas, M Sośnierz-Spangenberg, H Trzeciak
{"title":"Experimental assessment of the effect of coal dust with polymetallic salts on the respiratory tract epithelium.","authors":"B Białas,&nbsp;M Sośnierz-Spangenberg,&nbsp;H Trzeciak","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Experimental assessment of the effect of coal dust from the Debiensko coal mine on the rat respiratory tract epithelium was carried out. The coal mine there contains up to 0.6 per cent of polymetallic salts including such heavy metals as Co, Cu, Mn, Ni, Pb, Sr, Zn. Inflammation of the upper respiratory tract caused by the coal dust was proved as well as mucous membrane ulceration and epithelial dysplasia.</p>","PeriodicalId":20359,"journal":{"name":"Polish journal of occupational medicine and environmental health","volume":"5 1","pages":"71-6"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12564582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The past and present of the Polish National Health Services. Reform project. 波兰国家卫生服务的过去和现在。改革项目。
Polish journal of occupational medicine and environmental health Pub Date : 1992-01-01
M M Smoleń
{"title":"The past and present of the Polish National Health Services. Reform project.","authors":"M M Smoleń","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This paper presents a short historical outline of the national health service (NHS) system in Poland. Consecutive stages of the NHS system reform are described (up to October 1991), including the period of early 80's and the Round Table Conference. The general principles of the project of the Polish NHS system reform, which is intended to be implemented with support from the World Bank, are presented. These principles are related particularly to the scope of the questions assigned to the task forces established to solve the basic problems of the present system. Those include: 1. Health Promotion Task Force, 2. Primary Health Care Task Force, 3. Occupational Health Task Force, 4. Health Information System Task Force, 5. Cost Accounting Task Force, 6. Resource Allocation Task Force, 7. Pharmaceutical Monitoring and Drug Control Task Force, 8. Management Development Task Force, 9. Regional Health Services (Consortia) Task Force.</p>","PeriodicalId":20359,"journal":{"name":"Polish journal of occupational medicine and environmental health","volume":"5 1","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12564771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Occupational medicine in the eastern European journals of 1991; Part 1. 1991年东欧期刊中的职业医学;第1部分。
Polish journal of occupational medicine and environmental health Pub Date : 1992-01-01
{"title":"Occupational medicine in the eastern European journals of 1991; Part 1.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":20359,"journal":{"name":"Polish journal of occupational medicine and environmental health","volume":"5 2","pages":"185-203"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12566024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transformation of field monitoring results into miners' annual exposures to radon progeny. 现场监测结果转化为矿工氡子体年暴露量。
Polish journal of occupational medicine and environmental health Pub Date : 1992-01-01
D Kluszczyński
{"title":"Transformation of field monitoring results into miners' annual exposures to radon progeny.","authors":"D Kluszczyński","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This paper presents the theory of estimating miners' radiation hazard, using the values of radon daughters' concentration in the work-environment. All measurement results can be obtained with any technique beginning with instant measurement and ending with long-term dosimetry. The measurements carried out in metal ore mines show that the seasonal changes in radon daughters' concentration have their main influence in the estimation of the miners' hazard. The estimation of the hazard which was obtained from equations, was compared with the results given from the computer simulation.</p>","PeriodicalId":20359,"journal":{"name":"Polish journal of occupational medicine and environmental health","volume":"5 1","pages":"77-86"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12564583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The toxic effects of combined exposure to toluene and m-xylene in animals. IV. Liver ultrastructure after subchronic inhalatory exposure. 动物同时接触甲苯和间二甲苯的毒性作用。亚慢性吸入暴露后的肝脏超微结构。
Polish journal of occupational medicine and environmental health Pub Date : 1992-01-01
K Rydzyński, Z Korsak, U Jedlińska, J A Sokal
{"title":"The toxic effects of combined exposure to toluene and m-xylene in animals. IV. Liver ultrastructure after subchronic inhalatory exposure.","authors":"K Rydzyński,&nbsp;Z Korsak,&nbsp;U Jedlińska,&nbsp;J A Sokal","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effects of combined inhalatory exposure to m-xylene and toluene on the rat hepatocytes were investigated. Limited proliferation of smooth endoplasmic reticulum and increase of the number of lysosomes were observed in hepatocytes after 3-months of single exposure to 1000 ppm of m-xylene and toluene. Moreover, mitochondria increased in most of hepatocytes. After combined exposure to mixture of m-xylene and toluene at concentrations of 500 + 500 ppm, respectively, the types of ultrastructural changes in hepatocytes followed the pattern observed after exposure of each of the single organic solvent. However, proliferation of the smooth endoplasmic reticulum was more eminent. The hepatocytes ultrastructure of rats exposed to 100 ppm of m-xylene and toluene for 6 months were similar to that observed in rats exposed to 1000 ppm of m-xylene for 3 months. In rats exposed to a mixture of m-xylene and toluene for 6 months, the ultrastructural changes in hepatocytes were a combination of those observed after a single exposure to each of the organic solvent. It may be concluded that changes in the hepatocytes ultrastructure were an adaptive rather than a toxic effect. Because in the case of combined exposures the doses were half of those used in single exposures, the additive effect on the proliferation of smooth endoplasmic reticulum was observed in the rat liver after combined exposure to toluene and m-xylene using electron microscopy.</p>","PeriodicalId":20359,"journal":{"name":"Polish journal of occupational medicine and environmental health","volume":"5 1","pages":"35-42"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12564774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correlation between polycyclic aromatic hydrocarbons concentration and airborne particle mutagenicity in the rubber factory. 橡胶厂空气微粒致突变性与多环芳烃浓度的关系。
Polish journal of occupational medicine and environmental health Pub Date : 1992-01-01
B Barański, J Palus, T Rogaczewska, W Szymczak, E Spiechowicz
{"title":"Correlation between polycyclic aromatic hydrocarbons concentration and airborne particle mutagenicity in the rubber factory.","authors":"B Barański,&nbsp;J Palus,&nbsp;T Rogaczewska,&nbsp;W Szymczak,&nbsp;E Spiechowicz","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The study was undertaken to evaluate the correlation between benzo[a]pyrene and coal tar pitch volatiles concentrations and mutagenic activity of airborne particles sampled at different workplaces of the factory producing various types of tires. The solid phase of aerosols was collected on Whatman glass-fibers filters using Staplex pumps. Coal tar pitch volatiles (CTPVs) were extracted from sample filters using ultrasonic-benzene extraction and determined by the gravimetric method. Benzo[a]pyrene (BaP) analysis was performed using high performance liquid chromatography with a spectrofluorimetric detector. The mutagenic substances were extracted from collected material with acetone. The mutagenic properties were estimated with the Ames' test using S. typhimurium strain TA98 without and with S9 fraction. At nearly all workplaces the concentrations of BaP and CTPVs were within the range of 4-61 ng/m3 and 0.11-1.26 mg/m3, respectively. Only at weighing were they much higher and amounted to 172-2261 ng/m3 for BaP and 3.05-4.07 mg/m3 for CTPVs. The highest exposure to mutagenic airborne particulate matter was found at weighing (1500 rev/m3), the mixers loading level (> 500 rev/m3) and the carbon black station (> 150 rev/m3). The air mutagenic activity at other workplaces, especially at the extruder mill of the mixer (> 90 rev/m3), the two-roll mill of mixers (> 70 rev/m3), mixer I loading (> 70 rev/m3), calendering (> 70 rev/m3) and fender vulcanizing (> 80 rev/m3) was even much more higher than that found in the urban indoor and outdoor air (2-9 rev/m3).(ABSTRACT TRUNCATED AT 250 WORDS)</p>","PeriodicalId":20359,"journal":{"name":"Polish journal of occupational medicine and environmental health","volume":"5 4","pages":"357-62"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12473094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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