Polish journal of pharmacology最新文献_第5页

Modulatory effects of curcumin on lipid peroxidation and antioxidant status during nicotine-induced toxicity. 姜黄素对尼古丁中毒过程中脂质过氧化和抗氧化状态的调节作用。

Polish journal of pharmacology Pub Date : 2004-09-01

C Kalpana, V P Menon

引用次数: 0

2R,4R-APDC influence on hypoxia-induced impairment of learning and memory processes in passive avoidance test. 2R、4R-APDC对被动回避实验中缺氧致学习记忆障碍的影响。

Polish journal of pharmacology Pub Date : 2004-09-01

H Car, R J Wiśniewska, K Wiśniewski

{"title":"2R,4R-APDC influence on hypoxia-induced impairment of learning and memory processes in passive avoidance test.","authors":"H Car, R J Wiśniewska, K Wiśniewski","doi":"","DOIUrl":"","url":null,"abstract":"We investigated the effects of 2R,4R-APDC, a selective group II metabotropic glutamate receptor (II mGluR) agonist, on certain behaviors in rats subjected and non-subjected to hypoxia. Short-term hypoxia was used as a model of experimentally induced amnesia. 2R,4R-APDC given intracerebroventricularly (icv) at doses of 1 mumol and 100 nmol decreased the number of crossings and rearings in the open field, impaired acquisition and consolidation but improved retrieval in the passive avoidance tests. It also shortened the time spent in open arms and prolonged the time spent in closed arms, reduced the number of open and closed arms entries in an elevated \"plus\" maze, which is a measure of anxiety. Four-minute hypoxia (2% O(2), 98% N(2)) retrieval of conditioned responses, and exhibited an anxiogenic effect in the elevated \"plus\" maze in rats, i.e. it reduced the time spent in open arms and the number of entries to closed and open arms. 2R,4R-APDC effect on locomotor and exploratory activity was not changed after hypoxia, i.e. we observed inhibition of motility. This agonist of II mGluRs used at both doses before hypoxia significantly improved acquisition and retrieval, and had dual effect on consolidation, viz. at a dose of 1 mumol, it impaired this process and at a dose of 100 nmol it improved it. In the elevated \"plus\" maze, rats pretreated with 2R,4R-APDC and then subjected to hypoxia shortened the time spent in open arms and prolonged the time spent in closed arms, reduced the time spent in open arms, i.e. the drug exhibited anxiogenic effect. We conclude, therefore, that 2R,4R-APDC itself impaired acquisition and consolidation, enhanced retrieval but in rats undergoing hypoxia, it improved acquisition, retrieval and when used at the dose of 100 nmol enhanced consolidation. 2R,4R-APDC had beneficial effect in hypoxia-induced memory impairment in passive avoidance test.","PeriodicalId":20292,"journal":{"name":"Polish journal of pharmacology","volume":"56 5","pages":"527-37"},"PeriodicalIF":0.0,"publicationDate":"2004-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24855460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pentoxifylline does not affect nociception if administered postoperatively. 如果术后给药，己酮茶碱不会影响伤害感觉。

Polish journal of pharmacology Pub Date : 2004-09-01

A M Szczepanik, J Wordliczek, W Serednicki, M Siedlar, A Czupryna

引用次数: 0

Aging decreases phosphatidylinositol-4,5-bisphosphate level but has no effect on activities of phosphoinositide kinases. 衰老降低了磷脂酰肌醇-4,5-二磷酸水平，但对磷脂肌醇激酶的活性没有影响。

Polish journal of pharmacology Pub Date : 2004-09-01

A Zambrzycka

引用次数: 0

Participation of endogenous corticosteroids in inflammatory response in type 2 streptozotocin diabetic rats. 内源性糖皮质激素参与2型链脲佐菌素糖尿病大鼠的炎症反应。

Polish journal of pharmacology Pub Date : 2004-09-01

G A N de Melo, J L Sartoretto, S M Caparroz-Assef, C A Bersani-Amado, Z B Fortes, R K N Cuman

引用次数: 0

Elevated nitric oxide production mediates beta-amyloid-induced mitochondria failure. 一氧化氮产生升高介导β -淀粉样蛋白诱导的线粒体衰竭。

Polish journal of pharmacology Pub Date : 2004-09-01

U Keil, A Bonert, C A Marques, J B Strosznajder, F Müller-Spahn, W E Müller, A Eckert

引用次数: 0

Influence of the absolute configuration on pharmacological activity of antihypertensive and antiarrhythmic drugs. 绝对构型对抗高血压和抗心律失常药物药理活性的影响。

Polish journal of pharmacology Pub Date : 2004-09-01

K Kulig, P Nowicki, B Malawska

引用次数: 0

Abstracts of the XVth International Congress of the Polish Pharmacological Society. Poznan, Poland, September 12-14, 2004. 波兰药理学学会第十五届国际大会摘要。波兰波兹南，2004年9月12日至14日。

Polish journal of pharmacology Pub Date : 2004-09-01

引用次数: 0

Doxepin inhibits CYP2D6 activity in vivo. 多虑平在体内抑制CYP2D6活性。

Polish journal of pharmacology Pub Date : 2004-07-01

Monika Szewczuk-Bogusławska, Andrzej Kiejna, Jan A Beszłej, Krystyna Orzechowska-Juzwenko, Piotr Milejski

{"title":"Doxepin inhibits CYP2D6 activity in vivo.","authors":"Monika Szewczuk-Bogusławska, Andrzej Kiejna, Jan A Beszłej, Krystyna Orzechowska-Juzwenko, Piotr Milejski","doi":"","DOIUrl":"","url":null,"abstract":"Objective: Doxepin is a tricyclic antidepressant formulated as a mixture of E-(trans) and Z-(cis) stereoisomers. Cytochrome P450 2D6 (CYP2D6) catalyzes the hydroxylation of E-doxepin and E-N-desmethyldoxepin stereospecically. There is evidence that tricyclic antidepressants might inhibit CYP2D6 activity but there is no data about the influence of doxepin on CYP2D6.Materials and methods: Eleven patients diagnosed with depression according to ICD-10 criteria were included in the study. After wash-out period, before doxepin treatment, sparteine metabolic ratio (MR1) was assessed. After 2-weeks of doxepin treatment, MR2 was estimated. Sparteine and its metabolites were determined in urine by gas chromatographic method of Eichelbaum et al.Results: Based on MR1 values, 10 patients were classified as EM (extensive metabolizers) and 1 patient as PM (poor metabolizer). During the study, after doxepin treatment, none of patients has changed phenotype status. However, MR2 values were statistically significantly higher than MR1.Conclusion: These results show the inhibitory effect of doxepin on CYP2D6 activity and may be of clinical value, especially in polymedicated patients treated with other CYP2D6 substrates or inhibitors.","PeriodicalId":20292,"journal":{"name":"Polish journal of pharmacology","volume":"56 4","pages":"491-4"},"PeriodicalIF":0.0,"publicationDate":"2004-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24794530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epirubicin HCl toxicity in human-liver derived hepatoma G2 cells. 表柔比星HCl对人肝源性肝癌G2细胞的毒性。

Polish journal of pharmacology Pub Date : 2004-07-01

Aysun Ozkan, Kayahan Fişkin

{"title":"Epirubicin HCl toxicity in human-liver derived hepatoma G2 cells.","authors":"Aysun Ozkan, Kayahan Fişkin","doi":"","DOIUrl":"","url":null,"abstract":"Epirubicin HCl is a new anthracycline analog and derivative of doxorubicin. Doxorubicin is a potent anticancer agent, the use of which is limited by its cumulative dose-dependent cardiotoxicity. Epirubicin HCl has more favorable therapeutic index than doxorubicin and possesses less hematologic and cardiac toxicity at comparable doses. Hepatoma G2 cells are a valuable model to study hepatocellular carcinoma and the liver, where drugs are metabolized. The goal of our study was to evaluate the cytotoxic effect of epirubicin HCl on viability of Hep G2 cells measured using the MTT cytotoxicity test. Epirubicin HCl produced a concentration- and time-dependent cytotoxicity to Hep G2 cells. The mechanism of cytotoxicity of epirubicin HCl (IC(50) value of 1.6 mug/ml within 24 h) appeared to involve a production of free radical species since activities of free radical scavenging enzymes (SOD, catalase, Se-dependent GPx) were increased. Addition of SOD prevented cytotoxicity of epirubicin HCl, and also counteracted the apoptosis. DNA fragmentation was determined to evaluate apoptosis. Western blot analysis indicated a decrease in GST-pi expression and increased activity of NADPH-dependent cytochrome P450 reductase which is a major enzyme in the conversion of epirubicin HCl to a free radical. It is proposed that production of reactive oxygen species increased by the treatment with epirubicin HCl can cause lipid peroxidation, which subsequently promotes apoptosis and reduces cell viability. Superoxide dismutase, catalase and glutathione peroxidase must be considered as a part of the intracellular antioxidant defense mechanism of Hep G2 cells against single electron reducing quinone-containing anticancer antibiotics.","PeriodicalId":20292,"journal":{"name":"Polish journal of pharmacology","volume":"56 4","pages":"435-44"},"PeriodicalIF":0.0,"publicationDate":"2004-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24792470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0