Porphyrin Science by Women最新文献_第9页

Synthesis and photo-bactericidal properties of a cationic porphyrin grafted onto kraft pulp fibers 硫酸盐浆纤维接枝阳离子卟啉的合成及其光杀菌性能

Porphyrin Science by Women Pub Date : 2019-04-01 DOI: 10.1142/S1088424619500330

Z. Khaldi, Jean K. Nzambe Takeki, T. Ouk, R. Lucas, R. Zerrouki

引用次数: 4

Carbene insertion to N–H bonds of 2-aminothiazole and 2-amino-1,3,4-thiadiazole derivatives catalyzed by iron phthalocyanine 酞菁铁催化2-氨基噻唑和2-氨基-1,3,4-噻二唑衍生物的N-H键插入卡宾

Porphyrin Science by Women Pub Date : 2019-04-01 DOI: 10.1142/S1088424619500354

Lucie P. Cailler, A. Martynov, Yulia G. Gorbunova, A. Tsivadze, A. Sorokin

引用次数: 2

Advances in aPDT based on the combination of a porphyrinic formulation with potassium iodide: Effectiveness on bacteria and fungi planktonic/biofilm forms and viruses 基于卟啉制剂与碘化钾组合的aPDT的进展:对细菌和真菌浮游/生物膜形式和病毒的有效性

Porphyrin Science by Women Pub Date : 2019-04-01 DOI: 10.1142/S1088424619500408

Cátia Vieira, Adriele Santos, Mariana Q. Mesquita, A. Gomes, M. Neves, M. Faustino, A. Almeida

{"title":"Advances in aPDT based on the combination of a porphyrinic formulation with potassium iodide: Effectiveness on bacteria and fungi planktonic/biofilm forms and viruses","authors":"Cátia Vieira, Adriele Santos, Mariana Q. Mesquita, A. Gomes, M. Neves, M. Faustino, A. Almeida","doi":"10.1142/S1088424619500408","DOIUrl":"https://doi.org/10.1142/S1088424619500408","url":null,"abstract":"The increasing world-wide rate of antibiotic resistance as well as the capacity of microorganisms to form biofilms, have led to a higher incidence of mortal infections that require alternative methods for their control. Antimicrobial photodynamic therapy (aPDT) emerged as an effective solution against resistant strains. The present work aims to evaluate the aPDT efficiency of a photosensitizer (PS) based on a low-cost formulation constituted by five cationic porphyrins (FORM) and its potentiation effect by KI on a broad spectrum of microorganisms under white light (380–700 nm, 25 W/m[Formula: see text]. The aPDT assays were performed with different concentrations of FORM (0.1 to 5.0 [Formula: see text]M) and 100 mM of KI on planktonic and biofilm forms of gram-positive (methicillin resistant Staphylococcus aureus–MRSA) and gram-negative (Escherichia coli resistant to chloramphenicol and ampicillin) bacteria, of the fungi Candida albicans and on a T4-like bacteriophage as a mammalian virus model. The results indicate that the FORM alone is an efficient PS to photoinactivate not only gram-negative and gram-positive bacteria, but also C. albicans, in planktonic and biofilm forms, and T4-like phage at low concentrations (<5.0 [Formula: see text]M). The presence of KI enhanced the photodynamic effect of this FORM for all microorganisms on the planktonic form, allowing the reduction of PS concentration and treatment time. The results also show that the combination FORM/KI is highly efficient in the elimination of already well-established biofilms of E. coli,S. aureus and C. albicans. This effect is probably associated with longer-lived iodine reactive species produced during the aPDT treatment.","PeriodicalId":20283,"journal":{"name":"Porphyrin Science by Women","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82629788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 37

p-Phenylene-bridged zinc phthalocyanine-dimer as hole-transporting material in perovskite solar cells 对苯桥酞菁锌二聚体在钙钛矿太阳能电池中的空穴传输材料

Porphyrin Science by Women Pub Date : 2019-04-01 DOI: 10.1142/S1088424619500457

Desiré Molina, M. A. Ruiz‐Preciado, Faranak Sadegh, M. J. Álvaro‐Martins, M. Grätzel, A. Hagfeldt, Á. Sastre‐Santos

引用次数: 9

Macromolecular hexa-asymmetric zinc(II) phthalocyanines bearing triazole-modified triphenylene core: Synthesis, spectroscopy and analysis towards volatile organic compounds on Surface Acoustic Wave devices 大分子六不对称三唑修饰三苯基酞菁锌:表面声波器件上挥发性有机化合物的合成、光谱学和分析

Porphyrin Science by Women Pub Date : 2019-04-01 DOI: 10.1142/S1088424619500342

F. Kus, Cihat Tasaltin, Mohamad Albakour, A. Gürek, İ. GÜrol

{"title":"Macromolecular hexa-asymmetric zinc(II) phthalocyanines bearing triazole-modified triphenylene core: Synthesis, spectroscopy and analysis towards volatile organic compounds on Surface Acoustic Wave devices","authors":"F. Kus, Cihat Tasaltin, Mohamad Albakour, A. Gürek, İ. GÜrol","doi":"10.1142/S1088424619500342","DOIUrl":"https://doi.org/10.1142/S1088424619500342","url":null,"abstract":"The synthesis and characterization of novel asymmetric zinc(II) phthalocyanines (4–9) and their linking through peripheral and nonperipheral positions on the phthalocyanine ring via click coupling to alkyne-functionalized 2,3,6,7,10,11-hexakis(prop-2-ynyloxy)triphenylene core are described for the first time. These phthalocyanines (Pcs) (4–12) were characterized by elemental analysis and different spectroscopic techniques such as UV-vis, 1H-NMR, FT-IR and mass spectroscopy. Furthermore, the utilization of thin films of novel Pcs as a sensitive layer for detection of lung cancer from exhaled human breath at room temperature under exposure to marker volatile organic compounds (VOCs) are presented. The developed sensors were tested for acetone, ethanol, [Formula: see text]-hexane, toluene, chloroform and isoprene in a range of 300–14560 ppm. The obtained results have confirmed the possibility of utilization of Pc-based Surface Acoustic Wave (SAW) sensors for medical diagnosis based on exhaled breath analysis.","PeriodicalId":20283,"journal":{"name":"Porphyrin Science by Women","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90908205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

How protoporphyrinogen IX oxidase inhibitors and transgenesis contribute to elucidate plant tetrapyrrole pathway 原卟啉原IX氧化酶抑制剂和转基因如何有助于阐明植物四吡咯途径

Porphyrin Science by Women Pub Date : 2019-04-01 DOI: 10.1142/S1088424619300076

Veronica Ambrosini, Mohammad Issawi, Stéphanie Leroy-Lhez, C. Riou

{"title":"How protoporphyrinogen IX oxidase inhibitors and transgenesis contribute to elucidate plant tetrapyrrole pathway","authors":"Veronica Ambrosini, Mohammad Issawi, Stéphanie Leroy-Lhez, C. Riou","doi":"10.1142/S1088424619300076","DOIUrl":"https://doi.org/10.1142/S1088424619300076","url":null,"abstract":"Several families of herbicides, especially diphenyl ether (DPE) and pyrimidinedione, target the plant tetrapyrrole biosynthesis pathways and in particular one key enzyme, protoporphyrinogen IX oxidase (PPO). When plants are treated with DPE or pyrimidinedione, an accumulation of protoporphyrin IX, the first photosensitizer of this pathway, is observed in cytosol where it becomes very deleterious under light. Indeed these herbicides trigger plant death in two distinct ways: (i) inhibition of chlorophylls and heme syntheses and (ii) a huge accumulation of protoporphyrin IX in cytosol. Recently, a strategy based on plant transgenesis that induces deregulation of the tetrapyrrole pathway by up- or down-regulation of genes encoding enzymes, such as glutamyl-[Formula: see text]RNA reductase, porphobilinogen deaminase and PPO, has been developed. Against all expectations, only transgenic crops overexpressing PPO showed resistance to DPE and pyrimidinedione. This herbicide resistance of transgenic crops leads to the hypothesis that the overall consumption of herbicides will be reduced as previously reported for glyphosate-resistant transgenic crops. In this review, after a rapid presentation of plant tetrapyrrole biosynthesis, we show how only PPO enzyme can be the target of DPE and how transgenic crops can be further resistant not only to herbicide but also to abiotic stress such as drought or chilling. Keeping in mind that this approach is mostly prohibited in Europe, we attempt to discuss it to interest the scientific community, from plant physiologists to chemists, who work on the interface of photosensitizer optimization and agriculture.","PeriodicalId":20283,"journal":{"name":"Porphyrin Science by Women","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88637896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Truncated vitamin B12 derivative with the phosphate group retained 保留磷酸基的截断维生素B12衍生物

Porphyrin Science by Women Pub Date : 2019-04-01 DOI: 10.1142/S1088424619500421

Sidra Hassan, Agnieszka Jackowska, D. Gryko

引用次数: 1

Update of the situation of clinical photodynamic therapy in Europe in the 2003–2018 period 2003-2018年欧洲临床光动力疗法的最新情况

Porphyrin Science by Women Pub Date : 2019-04-01 DOI: 10.1142/S1088424619300027

C. Frochot, S. Mordon

{"title":"Update of the situation of clinical photodynamic therapy in Europe in the 2003–2018 period","authors":"C. Frochot, S. Mordon","doi":"10.1142/S1088424619300027","DOIUrl":"https://doi.org/10.1142/S1088424619300027","url":null,"abstract":"Photodynamic therapy has become of interest in many European countries. Since, most of national authorities and all medical journals require the registration of the clinical study on the database ClinicalTrials. gov in order to be published, information regarding clinical studies are now available. This article aims to synthetize data gathered thanks to this database. The keywords used for this analysis was: (i) status: “All studies “(recruiting, completed, terminated, we did not take into account unknown status), (ii) condition or disease: “Photodynamic Therapy”, (iii) country: name of each European country. Since 2003, 76 clinical trials were registered in Europe. Most clinical studies are performed in Germany (22), France (20) and UK (19). These 3 countries represent 80% of all studies performed in Europe. However 21 European countries have one or more studies on PDT. Clinical studies were mainly performed on skin. Actinic Keratosis treatment (20 studies) represents more than 45% of all studies. 21% were focused on eye, mainly on Age Macular Degeneration (AMD) (8 studies). In 2018, ten (10) clinical trials are in the recruitment phase. On November, 10, 2017, Padeliporfin (STEBA Biotech S.A, Luxembourg) obtained the marketing authorization throughout the European Union. Despite the critical importance of trial registration, compliance with requirements from governmental regulators which mandate the prospective registration of clinical trials has been imperfect. Besides, a large proportion of registry entries are never updated to reflect study completion. However, this review clearly demonstrated that PDT is progressively used in most European countries.","PeriodicalId":20283,"journal":{"name":"Porphyrin Science by Women","volume":"85 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83491067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 39

Synthetic aspects of carbazole containing porphyrins and porphyrinoids 含卟啉和类卟啉的咔唑的合成方面

Porphyrin Science by Women Pub Date : 2019-04-01 DOI: 10.1142/S1088424619300052

Sudipta Das, Iti Gupta

引用次数: 9

Hydrogen bond directed molecular recognition in water in a strapped-porphyrin-cyclodextrin assembly 氢键导向的分子识别在水的带状-卟啉-环糊精组装

Porphyrin Science by Women Pub Date : 2019-04-01 DOI: 10.1142/S1088424619500494

Hiroaki Kitagishi, K. Ohara, Daiki Shimoji, Maxime Vonesch, J. Weiss, J. Wytko

引用次数: 2