Point of Care: The Journal of Near-Patient Testing & Technology最新文献

{"title":"The Use of Patient Self-Testing in Low- and Middle-Income Countries: A Systematic Scoping Review","authors":"Sbongile Joyce Makhudu, Desmond Kuupiel, Nonjabulo Gwala, T. Mashamba-Thompson","doi":"10.1097/POC.0000000000000179","DOIUrl":"https://doi.org/10.1097/POC.0000000000000179","url":null,"abstract":"Background Improving access to health through use of innovative health technologies such as points-of-care testing is 1 global health priority. Patient self-testing (PST) is one of the point-of-care testing strategies that was shown to have an ability to improve access to diagnostic testing, autonomy and allow access to health care for hard-to-reach populations in resource-limited settings. However, the level of evidence on the use of PST for diagnosis and management of diseases in low- and middle-income countries (LMICs) is unknown. We mapped literature on evidence of the use of PST in LMICs. Methods Data were sourced from the following databases: PubMed; EBSCOhost (Medline, health source: Nursing), WEB of Science; Science Direct; and Google Scholar. Eligibility criteria for this study included: studies that focused on PST, reported on evidence on use of PST, conducted in LMICs, comparing PST with facility-based testing. Thematic analysis was performed to identify the patterns of use of PST. The mixed method quality appraisal tool version 2011 was used to assess the quality of the included primary studies. Results Eight studies met the inclusion criteria. Studies included populations from the following LMICs: Kenya; South Africa; Uganda; Bulgaria; and Malawi. Of the 18,816 total participants in all included primary studies, 57% were males. Overall, 7 (87.5%) of the 8 included studies reported on human immunodeficiency virus (HIV) self-testing using the following: oral fluid HIV self-test (HIVST), OraQuick in Home Rapid HIV-1/2 Antibody Test, OraQuick O-HIVST, oral fluid, and Fingerstick HIV self-tests. One (12.5%) of the 8 included studies reported on colorectal carcinoma using rapid immunochemical fecal occult blood tests. Although the findings of this study shows high usage of HIVST, it also demonstrates poor level of use of PST for other communicable and noncommunicable diseases in LMICs. We extracted the following themes; use of PST, feasibility of PST, and linkage to care from the included studies. Of the 8 included studies, 5 scored the highest quality (76–100%) from the methodological quality assessment. Conclusions The findings of the review revealed a high level of research evidence on the use of HIV self-testing compared to other communicable diseases and noncommunicable diseases in LMICs. Increased implementation of PST for communicable diseases is recommended, particularly for high-risk and hard-to-reach populations.","PeriodicalId":20262,"journal":{"name":"Point of Care: The Journal of Near-Patient Testing & Technology","volume":"44 1","pages":"9–16"},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84868881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Invited Product Profile: The Mitra Microsampling Device","authors":"E. Dameron","doi":"10.1097/POC.0000000000000181","DOIUrl":"https://doi.org/10.1097/POC.0000000000000181","url":null,"abstract":"B lood sampling has been an essential diagnostic tool for many years.Up to 70%of allmedical decisions are guided by diagnostic test results that include blood sample evaluations. Although traditional blood sampling techniques are still necessary, they are not always practical. For example, in remote areas that are a great distance frommedical facilities, access to sampling facilities may be limited. Bloodmicrosampling is a simplifiedmethod of blood sampling that even allows participants to draw their own specimens and mail them to the laboratory for analysis. Microsampling is a procedure for capturing and analyzing minute samples of blood for analysis. The samples collect 10 to 20 μL of blood volume. A conventional sample drawn by venipuncture may consist of sample volumes of up to 10mL, as much as 500 to 1000 times the size of microsamples. The sampling event requires a simple prick of the finger, allowing a drop of blood to rise to the skin surface. Using a device such as this one, the samples are captured in the absorbent tip of the collection devices. The samples are then folded into the attached protective case and can be mailed without refrigeration or special handling to the laboratory (Fig. 1).","PeriodicalId":20262,"journal":{"name":"Point of Care: The Journal of Near-Patient Testing & Technology","volume":"18 1","pages":"26–32"},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84848017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Invited Product Profile – Alere DDS2 Mobile Forensic Test System","authors":"Fred Delfino","doi":"10.1097/POC.0000000000000174","DOIUrl":"https://doi.org/10.1097/POC.0000000000000174","url":null,"abstract":"","PeriodicalId":20262,"journal":{"name":"Point of Care: The Journal of Near-Patient Testing & Technology","volume":"79 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91502261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Approach to Pseudohyperglycemia in Point-of-Care-Testing Glucose Monitoring","authors":"Amarasinghe Arachchige Don Nalin Samandika Saparamadu, L. Lam, J. Lee","doi":"10.1097/POC.0000000000000171","DOIUrl":"https://doi.org/10.1097/POC.0000000000000171","url":null,"abstract":"","PeriodicalId":20262,"journal":{"name":"Point of Care: The Journal of Near-Patient Testing & Technology","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87551262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The TAP Integrated Capillary Blood Collection System","authors":"T. Richards","doi":"10.1097/POC.0000000000000176","DOIUrl":"https://doi.org/10.1097/POC.0000000000000176","url":null,"abstract":"T he drive for health care providers to streamline workflow, improve efficiency, and reduce costs has never been greater. At the same time, the trend toward decentralized health care is accelerating, most notably within consumer-focused care across all settings. The result is an emerging demand for rapid, reliable blood collection and diagnostic capabilities both inside and outside traditional clinical settings to improve access to high-quality diagnostic information. So far, however, much of the transition has been slowed by the limitations inherent in phlebotomy and finger-stick sampling. Both require trained personnel, involve multiple steps, disrupt workflow, and are the primary source of preanalytical errors in diagnostic testing. Worse, these methods are inconvenient as well as create anxiety and discomfort for patients. It is estimated that at least 10% of the US population suffer from needle phobia, and the number is reported to be much greater as sufferers tend to avoid medical treatment altogether. This is a significant impediment to a patient's ability to access the health care system. To address the limitations of both venipuncture and fingerstick sampling, Seventh Sense Biosystems set out to create a blood collection device that can be easily self-administered and is a painless method for collecting blood both within and outside traditional health care settings. Seventh Sense's TAP platform is designed to address theworkflow and quality challenges; facilitate the shift to decentralized, self-administered blood collection; and most importantly expand the reach of blood-based diagnostics to those who need it.","PeriodicalId":20262,"journal":{"name":"Point of Care: The Journal of Near-Patient Testing & Technology","volume":"9 1","pages":"132–135"},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89934447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acceptability of Home-Based Human Immunodeficiency Virus Testing and Counseling in Low- and Middle-Income Countries: A Systematic Scoping Review","authors":"Moshoeu Prisca Sekgaila, Desmond Kuupiel, T. Mashamba-Thompson","doi":"10.1097/POC.0000000000000172","DOIUrl":"https://doi.org/10.1097/POC.0000000000000172","url":null,"abstract":"Abstract Evidence on the acceptability of home-based human immunodeficiency virus testing and counseling (HB-HTC) in low- and middle-income countries (LMICs) remains unclear. We aimed to map evidence on the acceptability of HB-HTC in LMICs. We searched PubMed, EBSCOhost, Google Scholar, Science Direct, World Health Organization library database, and UNAIDS databases from January 2013 to October 2017. Two independent reviewers screened the studies using the eligibility criteria both at abstract and full article screening stages as well as performing quality assessment of the included articles. Discrepancies at the abstract stage were resolved through discussions while a third reviewer was involved at the full article screening stage. The risk of bias of included studies was appraised using Mixed Methods Appraisal Tool version 2011. Thematic content analysis was performed to identify patterns of acceptability of HB-HTC. Of 620 studies identified from the data bases searched, 30 studies were included for data extraction. All included studies were published between 2013 and 2017. Most of the study participants from these included studies were aged between 18 months to 100 years comprising of males (59%) and females (41%). These included studies were conducted in diverse locations including South Africa, Kenya, Lesotho, Malawi, China, Zimbabwe, Zambia, Uganda, and Brazil. Most of the studies were conducted in South Africa (9) and Kenya (7). Evidence showed that HB-HTC was most accepted by the female population compared with males in LMICs. In conclusion, there is adequate evidence on acceptability of HB-HTC in LMICs and linkage to care. This study additionally demonstrates that HB-HTC approach was more acceptable compared with facility-based HTC.","PeriodicalId":20262,"journal":{"name":"Point of Care: The Journal of Near-Patient Testing & Technology","volume":"40 1","pages":"112–122"},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73552024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Invited Product Profile – Cobas Liat System: CLIA-Waived PCR Analyzer for Infectious Diseases","authors":"J. Phillips","doi":"10.1097/POC.0000000000000175","DOIUrl":"https://doi.org/10.1097/POC.0000000000000175","url":null,"abstract":"R espiratory tract infections are a worldwide public health problem caused by ubiquitous organisms (viruses and bacteria). Several notable pathogens that can cause respiratory infections are influenza A/B, respiratory syncytial virus (RSV), and group A streptococcus (GAS). Influenza viruses cause annual epidemics typically between November andMarch in the northern hemisphere and are responsible for 3000 to 49,000 deaths in the United States each year. Respiratory syncytial virus is the most common cause of bronchiolitis and pneumonia, with most individuals recovering in a week or two. However, RSV can be serious in infants and older adults. The majority of patients seeking care for influenza and other respiratory viruses typically present to emergency departments or other urgent care settings, where rapid diagnosis is critical. Group A streptococcus is a pervasive human-specific pathogen responsible for more than 10 million infections each year in the United States, with typical human-to-human transmission occurring via respiratory droplets or skin contact. Without proper treatment, GAS can progress into acute rheumatic fever, rheumatic heart disease, and other potentially life-threatening conditions. A significant overlap exists in the clinical manifestations of the different types of respiratory infections, making it difficult for clinicians to properly diagnose on the basis of clinical symptoms alone. In addition, the treatments are markedly different. Thus, the need for an accurate in vitro diagnostic test that health care professionals can use at the point of care to differentiate the pathogens that cause respiratory infections is paramount.","PeriodicalId":20262,"journal":{"name":"Point of Care: The Journal of Near-Patient Testing & Technology","volume":"24 1","pages":"129–131"},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87942574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Point-of-Care Diagnosis of Acute Myocardial Infarction in Central Vietnam: International Exchange, Needs Assessment, and Spatial Care Paths: Erratum","authors":"","doi":"10.1097/poc.0000000000000177","DOIUrl":"https://doi.org/10.1097/poc.0000000000000177","url":null,"abstract":"","PeriodicalId":20262,"journal":{"name":"Point of Care: The Journal of Near-Patient Testing & Technology","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77174826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Sputum Screening Test to Rule Out Pneumonia at an Early Stage With High Negative Predictive Value","authors":"A. Ramezani, Lars Eng, M. Turkina, A. Theodorsson, F. Nayeri","doi":"10.1097/POC.0000000000000170","DOIUrl":"https://doi.org/10.1097/POC.0000000000000170","url":null,"abstract":"Background Pneumonia is a serious and widespread cause of morbidity and mortality. At an early stage, the symptoms are similar to other respiratory disorders, and there is no single criterion standard for diagnosis. Antibiotics are used too often as a precaution. Objectives The objective of this study was to perform an assessment and clinical evaluation of a rapid sputum screening test (index test) to rule out pneumonia. Methods Leftover sputum samples (467) collected at the Department of Microbiology from November 2016 to March 2017 were blindly analyzed within 72 hours with the index test. The clinical accuracy of the test was estimated for pneumonia by comparison with the established diagnosis by independent physicians (International Classification of Diseases, 10th Revision). Hepatocyte growth factor and calprotectin were measured on random samples (80), and layman volunteers (40) were asked to perform the test on artificial samples. Results Two of 73 cases of pneumonia (community-acquired and nosocomial) showed negative results by the sputum strip test (97% sensitivity and 94% negative predictive value). The test results were highly correlated to hepatocyte growth factor and calprotectin concentrations in samples (R2 = 67% respective 39%). Importantly, all of the volunteers were able to estimate the correct positive and negative results. Conclusions The novel rapid sputum test represents a feasible tool for screening and ruling out the overwhelming majority of nonsevere respiratory infections at primary care settings, at home or when properly equipped laboratories are not available.","PeriodicalId":20262,"journal":{"name":"Point of Care: The Journal of Near-Patient Testing & Technology","volume":"140 1","pages":"101–108"},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81147380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Orchard Trellis Invited Product Profile","authors":"Kim Futrell","doi":"10.1097/poc.0000000000000169","DOIUrl":"https://doi.org/10.1097/poc.0000000000000169","url":null,"abstract":"","PeriodicalId":20262,"journal":{"name":"Point of Care: The Journal of Near-Patient Testing & Technology","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75649491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}